The human tumour suppressor LATS1 is activated by human MOB1 at the membrane.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2006-06-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.BBRC.2006.03.244PMID 16674920
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• NDR kinases regulate essential cell processes from yeast to humans

  2006cited by this paper
• Drosophila Mob family proteins interact with the related tricornered (Trc) and warts (Wts) kinases.

  2005cited by this paper
• Regulation of NDR Protein Kinase by Hydrophobic Motif Phosphorylation Mediated by the Mammalian Ste20-Like Kinase MST3

  2005cited by this paper
• Human NDR Kinases Are Rapidly Activated by MOB Proteins through Recruitment to the Plasma Membrane and Phosphorylation

  2005cited by this paper
• The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

  2005influential reference
• The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death

  2005cited by this paper
• Down-Regulation of LATS1 and LATS2 mRNA Expression by Promoter Hypermethylation and Its Association with Biologically Aggressive Phenotype in Human Breast Cancers

  2005cited by this paper
• The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.

  2005cited by this paper
• Human LATS1 is a mitotic exit network kinase.

  2005influential reference
• Control of cell proliferation and apoptosis by mob as tumor suppressor, mats.

  2005cited by this paper
• The tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with furry during Drosophila wing hair development.

  2004cited by this paper
• Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons.

  2004cited by this paper
• Initiation of Cytokinesis Is Controlled through Multiple Modes of Regulation of the Sid2p-Mob1p Kinase Complex

  2004cited by this paper
• Regulation of NDR2 Protein Kinase by Multi-site Phosphorylation and the S100B Calcium-binding Protein*

  2004cited by this paper
• LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

  2004cited by this paper
• Mechanism of Activation of NDR (Nuclear Dbf2-related) Protein Kinase by the hMOB1 Protein*

  2004cited by this paper
• Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function

  2004cited by this paper
• Mechanism of Ca2+-mediated Regulation of NDR Protein Kinase through Autophosphorylation and Phosphorylation by an Upstream Kinase*

  2003cited by this paper
• Inhibition of Cell Growth by Conditional Expression of kpm, a Human Homologue of Drosophila warts/lats Tumor Suppressor*

  2003cited by this paper
• The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis.

  2003cited by this paper
• Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL

  2003cited by this paper
• The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila

  2003cited by this paper
• Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

  2003cited by this paper
• hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.

  2003cited by this paper
• Lats2, a putative tumor suppressor, inhibits G1/S transition

  2003cited by this paper
• The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.

  2003cited by this paper
• Allelic imbalance in selected chromosomal regions in ovarian cancer.

  2002cited by this paper
• Molecular Alterations of h-warts/LATS1 Tumor Suppressor in Human Soft Tissue Sarcoma

  2002cited by this paper
• salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.

  2002cited by this paper
• Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

  2002cited by this paper
• Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G2/M arrest or apoptosis

  2001cited by this paper
• Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex

  2001cited by this paper
• Zyxin, a Regulator of Actin Filament Assembly, Targets the Mitotic Apparatus by Interacting with H-Warts/Lats1 Tumor Suppressor

  2000cited by this paper
• Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

  1999cited by this paper
• Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

  1999cited by this paper
• A human homolog of Drosophila warts tumor suppressor, h‐warts, localized to mitotic apparatus and specifically phosphorylated during mitosis

  1999cited by this paper
• Ndr Protein Kinase Is Regulated by Phosphorylation on Two Conserved Sequence Motifs*

  1999cited by this paper
• Calcium regulation of Ndr protein kinase mediated by S100 calcium‐binding proteins

  1998cited by this paper
• Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase.

  1995cited by this paper
• The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.

  1995cited by this paper
• Tumor suppressor genes encoding proteins required for cell interactions and signal transduction in Drosophila.

  1993cited by this paper

• Cytosolic nucleic acid sensing triggers type I interferon activation via the Hippo kinase LATS1.

  2026cites this paper
• Fubylation as a Druggable Ubiquitin-Like Conjugation System Controlling Hippo Pathway Activity

  2025cites this paper
• Kibra knockdown inhibits the aberrant Hippo pathway, suppresses renal cyst formation and ameliorates renal fibrosis in nphp1 KO mice

  2025cites this paper
• XMU-MP-1, Inhibitor of STE20-like MST1/2 Kinases of the Hippo Signaling Pathway, Suppresses the Cell Cycle, Activates Apoptosis and Autophagy, and Induces Death of Hematopoietic Tumor Cells

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  2024cites this paper
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• A review on decoding the roles of YAP/TAZ signaling pathway in cardiovascular diseases: Bridging molecular mechanisms to therapeutic insights.

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• Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges.

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• Negative regulation of hippo-mediated antiviral response targeted WSSV in Penaeus vannamei

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• The Role of the Mechanosensor Protein YAP in Embryonic Development: From Oogenesis to Neurulation

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• Role of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer

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• A Non-Canonical Hippo Pathway Represses the Expression of ΔNp63

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• Association Study between SNPs in MST1 and MST2 and H. pylori Infection as well as Noncardia Gastric Carcinogenesis

  2024cites this paper
• Serine/Threonine Protein Kinase-3 Promotes Oral Squamous Cell Carcinoma by Activating Ras-MAPK Mediated Cell Cycle Progression

  2023cites this paper
• MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression

  2023influential citation
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  2023cites this paper
• LATS in cancer repression: Extracting its role in hippo pathway and beyond

  2023cites this paper
• A non-canonical Hippo pathway represses the expression of ΔNp63

  2023influential citation
• Lipid kinase PIP5Kα contributes to Hippo pathway activation via interaction with Merlin and by mediating plasma membrane targeting of LATS1

  2023cites this paper
• Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex

  2023cites this paper
• Current Model Systems for Investigating Epithelioid Haemangioendothelioma

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  2022cites this paper
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  2022cites this paper
• Identification of Components of the Hippo Pathway in Hydra and Potential Role of YAP in Cell Division and Differentiation

  2021cites this paper
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  2021cites this paper
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• The Hippo Pathway: Biology and Pathophysiology.

  2019cites this paper
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