Isolation of the cyclosporin-sensitive T cell transcription factor NFATp.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Science

• Publication date

  1993-10-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/SCIENCE.8235597PMID 8235597
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

  1993cited by this paper
• Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter

  1993cited by this paper
• Analysis of the preexisting and nuclear forms of nuclear factor of activated T cells.

  1993cited by this paper
• Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

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• Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc

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• Fos is a preferential target of glucocorticoid receptor inhibition of AP-1 activity in vitro

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• FK506 and cyclosporin, molecular probes for studying intracellular signal transduction.

  1993cited by this paper
• The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.

  1993cited by this paper
• The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB

  1993cited by this paper
• NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs.

  1993cited by this paper
• Nuclear factor of activated T cells contains Fos and Jun

  1992cited by this paper
• Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

  1992cited by this paper
• Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

  1992cited by this paper
• A high-capacity column for affinity purification of sequence-specific DNA-binding proteins

  1992cited by this paper
• A T cell nuclear factor resembling NF-AT binds to an NF-kappa B site and to the conserved lymphokine promoter sequence "cytokine-1".

  1992cited by this paper
• cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1

  1992cited by this paper
• The mechanism of action of cyclosporin A and FK506.

  1992cited by this paper
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  1991cited by this paper
• Complete amino acid sequence of the FK506 and rapamycin binding protein, FKBP, isolated from calf thymus

  1991cited by this paper
• Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.

  1991cited by this paper
• Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

  1991cited by this paper
• Cyclosporin A suppresses the expression of the interleukin 2 gene by inhibiting the binding of lymphocyte‐specific factors to the IL‐2 enhancer.

  1990cited by this paper
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  1990cited by this paper
• The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.

  1990cited by this paper
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  1990cited by this paper
• Fos and jun cooperate in transcriptional regulation via heterologous activation domains

  1990cited by this paper
• Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly.

  1990cited by this paper
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  1990cited by this paper
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