The Oncogenic RNA-Binding Protein Musashi1 Is Regulated by HuR via mRNA Translation and Stability in Glioblastoma Cells

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Molecular Cancer Research

• Publication date

  2012-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1541-7786.MCR-11-0208PMID 22258704PMCID PMC3265026
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Computational Systems Biology

  2013cited by this paper
• mRNA stability alterations mediated by HuR are necessary to sustain the fast growth of glioma cells

  2012influential reference
• The hallmarks of cancer

  2012cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• The oncogenic RNA-binding protein Musashi1 is regulated by tumor suppressor miRNAs

  2011influential reference
• Genomic Analyses of the RNA-binding Protein Hu Antigen R (HuR) Identify a Complex Network of Target Genes and Novel Characteristics of Its Binding Sites*

  2011cited by this paper
• RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation

  2011cited by this paper
• The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance

  2011cited by this paper
• Circuitry of mRNA regulation

  2010cited by this paper
• Residual tumor cells are unique cellular targets in glioblastoma

  2010cited by this paper
• Posttranscriptional regulation of cancer traits by HuR

  2010influential reference
• Notch signaling in glioblastoma: a developmental drug target?

  2010cited by this paper
• Molecular networks in drug discovery.

  2010cited by this paper
• Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival

  2010cited by this paper
• Genomic Analyses of Musashi1 Downstream Targets Show a Strong Association with Cancer-related Processes*

  2009cited by this paper
• Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence

  2009cited by this paper
• The Expression of RNA-Binding Protein HuR in Non-Small Cell Lung Cancer Correlates with Vascular Endothelial Growth Factor-C Expression and Lymph Node Metastasis

  2009cited by this paper
• Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation

  2009cited by this paper
• HuR recruits let-7/RISC to repress c-Myc expression.

  2009cited by this paper
• Regulation of Bcl-2 Expression by HuR in HL60 Leukemia Cells and A431 Carcinoma Cells

  2009cited by this paper
• Musashi1 Modulates Mammary Progenitor Cell Expansion through Proliferin-Mediated Activation of the Wnt and Notch Pathways

  2008cited by this paper
• Coupling caspase cleavage and proteasomal degradation of proteins carrying PEST motif.

  2008cited by this paper
• Signaling pathways in medulloblastoma

  2008cited by this paper
• RNA‐binding proteins and post‐transcriptional gene regulation

  2008influential reference
• Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy

  2008cited by this paper
• Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence

  2008cited by this paper
• Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo.

  2008cited by this paper
• Musashi1: A stem cell marker no longer in search of a function

  2008cited by this paper
• Faculty Opinions recommendation of Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.

  2008cited by this paper
• Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells

  2008cited by this paper
• Network motifs: theory and experimental approaches

  2007cited by this paper
• Analysis of Turnover and Translation Regulatory RNA-Binding Protein Expression through Binding to Cognate mRNAs

  2007cited by this paper
• Posttranscriptional Orchestration of an Anti-Apoptotic Program by HuR

  2007cited by this paper
• Stabilization of Snail by HuR in the process of hydrogen peroxide induced cell migration.

  2007cited by this paper
• A robustness-based approach to systems-oriented drug design

  2007cited by this paper
• Adult neural stem cells and central nervous system repair.

  2006cited by this paper
• Translational Control of Cytochrome c by RNA-Binding Proteins TIA-1 and HuR

  2006cited by this paper
• Expression of RNA-binding protein Musashi in hair follicle development and hair cycle progression.

  2006cited by this paper
• A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of Msi1 mRNA

  2006cited by this paper
• AU-rich elements and associated factors: are there unifying principles?

  2006cited by this paper
• Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.

  2006cited by this paper
• Enhanced therapeutic efficacy of oncolytic herpes vector G207 against human non‐small cell lung cancer—expression of an RNA‐binding protein, Musashi1, as a marker for the tailored gene therapy

  2006cited by this paper
• Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.

  2005cited by this paper
• Antiapoptotic function of RNA‐binding protein HuR effected through prothymosin α

  2005cited by this paper
• Isolation and characterization of human mammary stem cells

  2005cited by this paper
• Isolation of cancer stem cells from adult glioblastoma multiforme

  2004cited by this paper
• Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs

  2004cited by this paper
• Identification of a target RNA motif for RNA-binding protein HuR.

  2004cited by this paper
• Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization

  2004cited by this paper
• Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR.

  2003cited by this paper
• Candidate markers for stem and early progenitor cells, Musashi‐1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine

  2003cited by this paper
• RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation

  2003cited by this paper
• Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines.

  2002cited by this paper
• ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.

  2002cited by this paper
• Computational systems biology

  2002cited by this paper
• HuR and mRNA stability

  2001cited by this paper
• Expression of the neural RNA‐binding protein Musashi1 in human gliomas

  2001cited by this paper
• Musashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity.

  2001cited by this paper
• HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3' untranslated regions of cytokine and angiogenic factor mRNAs.

  2001cited by this paper
• The Neural RNA-Binding Protein Musashi1 Translationally Regulates Mammalian numb Gene Expression by Interacting with Its mRNA

  2001cited by this paper
• Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR*

  1998influential reference
• Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell.

  1996cited by this paper
• Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells (*)

  1995cited by this paper
• Musashi, a neural RNA-binding protein required for Drosophila adult external sensory organ development.

  1994cited by this paper
• Messenger RNA-protein complexes and newly synthesized ribosomal subunits: analysis of free particles and components of polyribosomes.

  1968cited by this paper

• Old players and new insights: unraveling the role of RNA-binding proteins in brain tumors

  2025cites this paper
• Identification and classification of glioma subtypes based on RNA-binding proteins

  2024cites this paper
• Multifaceted Nature of HuR in Atherosclerosis Development.

  2024cites this paper
• A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation

  2023cites this paper
• Tackling the HuRdle of radioresistance: a radiation perspective on the RNA-binding protein HuR

  2023cites this paper
• Surmounting Cancer Drug Resistance: New Perspective on RNA-Binding Proteins

  2023cites this paper
• LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3

  2023cites this paper
• Correlation between DNA Methylation and Cell Proliferation Identifies New Candidate Predictive Markers in Meningioma

  2022cites this paper
• Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma

  2022cites this paper
• RNA Binding Proteins (RBPs) and their role in DNA Damage and radiation response in cancer.

  2022cites this paper
• RNA-binding Proteins in Regulating mRNA Stability and Translation: Roles and Mechanisms in Cancer.

  2022cites this paper
• Integral Analysis of the RNA Binding Protein-associated Prognostic Model for Renal Cell Carcinoma

  2021cites this paper
• References

  2021cites this paper
• Musashi–1—A Stemness RBP for Cancer Therapy?

  2021cites this paper
• Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes

  2021cites this paper
• Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis

  2020cites this paper
• Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction

  2020cites this paper
• RNA-Targeted Therapies and High-Throughput Screening Methods

  2020influential citation
• An RNA-Binding Protein, Hu-antigen R, in Pancreatic Cancer Epithelial to Mesenchymal Transition, Metastasis, and Cancer Stem Cells

  2020cites this paper
• Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells

  2020cites this paper
• Human antigen R: A potential therapeutic target for liver diseases.

  2020cites this paper
• Effects of RNA Binding Proteins on the Prognosis and Malignant Progression in Prostate Cancer

  2020cites this paper
• Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis

  2020cites this paper
• RNA-Binding Proteins in Cancer: Functional and Therapeutic Perspectives

  2020cites this paper
• Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development

  2019influential citation
• Cancer The 'RBP'eutics - RNA-Binding Proteins as Therapeutic Targets for Cancer.

  2019cites this paper
• RNA-Binding Proteins MSI-1 (Musashi) and EXC-7 (HuR) Regulate Serotonin-Mediated Behaviors in C. elegans

  2019cites this paper
• Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

  2019cites this paper
• Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

  2018cites this paper
• Upregulation of miR-324-5p Inhibits Proliferation and Invasion of Colorectal Cancer Cells by Targeting ELAVL1

  2018cites this paper
• miR-122 Regulates LHR Expression in Rat Granulosa Cells by Targeting Insig1 mRNA

  2018cites this paper
• Investigating HIV-Human Interaction Networks to Unravel Pathogenic Mechanism for Drug Discovery: A Systems Biology Approach.

  2018cites this paper
• The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro

  2017cites this paper
• RNA-Binding Proteins in Cancer: Old Players and New Actors.

  2017cites this paper
• RNA processing as an alternative route to attack glioblastoma

  2017cites this paper
• HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells

  2017cites this paper
• Hu antigen R (HuR) multimerization contributes to glioma disease progression

  2017cites this paper
• Handshakes and Fights: The Regulatory Interplay of RNA-Binding Proteins

  2017cites this paper
• MicroRNA-195 acts as an anti-proliferative miRNA in human melanoma cells by targeting Prohibitin 1

  2017cites this paper
• RNA Binding Protein as an Emerging Therapeutic Target for Cancer Prevention and Treatment

  2017cites this paper
• Overexpression of Musashi-1 protein is associated with progression and poor prognosis of gastric cancer

  2017cites this paper
• Chapter 7 – Big Offensive and Defensive Mechanisms in Systems Immunity From System Modeling and Big Data Mining

  2017cites this paper
• Msi1 promotes tumor progression by epithelial-to-mesenchymal transition in cervical cancer.

  2017cites this paper
• Musashi1 Impacts Radio-Resistance in Glioblastoma by Controlling DNA-Protein Kinase Catalytic Subunit.

  2016cites this paper
• Regulation of Stem Cell Self-Renewal and Oncogenesis by RNA-Binding Proteins.

  2016cites this paper
• Investigating the molecular mechanisms and functions of the Musashi-2 RNA-binding protein

  2016cites this paper
• RNA Processing

  2016cites this paper
• NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548

  2016cites this paper
• Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma

  2016influential citation
• miR-761 inhibits tumor progression by targeting MSI1 in ovarian carcinoma

  2016cites this paper
• The Regulation of Musashi RNA Binding Proteins and the Implications for Cancer Therapy

  2015cites this paper
• A Mouse Model of Targeted Musashi1 Expression in Whole Intestinal Epithelium Suggests Regulatory Roles in Cell Cycle and Stemness

  2015cites this paper
• RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma

  2015cites this paper
• Identification and validation of novel small molecule disruptors of HuR-mRNA interaction.

  2015cites this paper
• Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation

  2015cites this paper
• Tumor suppressive microRNA-137 negatively regulates Musashi-1 and colorectal cancer progression

  2015cites this paper
• Downregulation of Msi1 suppresses the growth of human colon cancer by targeting p21cip1.

  2015cites this paper
• Musashi signaling in stem cells and cancer.

  2015cites this paper
• Regulation of AU-Rich Element RNA Binding Proteins by Phosphorylation and the Prolyl Isomerase Pin1

  2015cites this paper
• Fas, FasL, and cleaved caspases 8 and 3 in glioblastomas: a tissue microarray-based study.

  2014cites this paper
• A Feedback Loop Couples Musashi-1 Activity to Omega-9 Fatty Acid Biosynthesis: A Dissertation

  2014influential citation
• RNA binding protein HuR regulates the expression of ABCA1[S]

  2014cites this paper
• Genomic Analyses Reveal Broad Impact of miR-137 on Genes Associated with Malignant Transformation and Neuronal Differentiation in Glioblastoma Cells

  2014cites this paper
• Cancer Stem Cell Marker Musashi-1 rs2522137 Genotype Is Associated with an Increased Risk of Lung Cancer

  2014influential citation
• Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development.

  2014influential citation
• The Role of HuR in the Post-Transcriptional Regulation of Interleukin-3 in T Cells

  2014cites this paper
• ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages.

  2014cites this paper
• Clinical significance of HuR expression in human malignancy

  2014cites this paper
• Adaptive resistance to targeted therapies in cancer.

  2013influential citation
• A complex network of interactions and reciprocal regulations in cancer

  2013cites this paper
• Musashi1 as a potential therapeutic target and diagnostic marker for lung cancer

  2013cites this paper
• microRNAs and RNA-binding proteins

  2013cites this paper
• The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer-related genes and is an indicator of poor prognosis.

  2012cites this paper
• Tumorigenesis and Neoplastic Progression The RNA-Binding Protein Musashi 1 Affects Medulloblastoma Growth via a Network of Cancer-Related Genes and Is an Indicator of Poor Prognosis

  2012cites this paper