Growth factors and the control of folliculogenesis.

There is increasing evidence that growth factors modulate folliculogenesis. However their precise role in the processes of follicular growth, differentiation and atresia is still unknown. Growth factors belong to complex systems, including all the factors structurally and functionally related, their receptor(s) and, in most cases, binding proteins or proteoglycans. In this review, the insulin-like growth factor (IGF) system is presented as a paradigm for the study of other growth factor systems in the ovary. IGFs are probably positive regulators of follicular development, as they enhance both proliferation and differentiation and amplify the action of gonadotrophins on follicular cells. In the ovaries of most mammals, there is little or no change in intrafollicular IGF concentrations during terminal follicular growth and atresia. By contrast, the concentrations of IGF-binding proteins < 40 kDa (mainly IGFBP-2, -4 and -5) decrease markedly during terminal follicular growth, but increase in atretic follicles. These variations could result from both changes in expression of these IGFBPs by follicular cells and in local degradation by gonadotrophin-induced specific protease(s). Experiments in vitro showed that these IGFBPs, present in a soluble form in follicular fluid, could play an important role by sequestrating the IGFs and decreasing their bioavailability. More generally, biological actions of growth factors critically depend on their bioavailability in the vicinity of the cell, resulting from the concentrations of the factors themselves, their binding proteins and the ability of specific proteases to degrade binding proteins or to cleave latent forms of growth factors. These mechanisms and their control by gonadotrophins throughout follicular development have now to be investigated for the different growth factor systems.

• Publication year

  2019

• Venue

  Journal of reproduction and fertility. Supplement

• Publication date

  2019-04-05

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1530/BIOSCIPROCS.3.025PMID 7542711
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of insulin-like growth factors and epidermal growth factor-related peptides in intraovarian regulation in the pig ovary.

  2020cited by this paper
• Measuring insulin-like growth factors

  1994cited by this paper
• Stage-limited expression of myc oncoprotein in the human ovary during follicular growth, regression and atresia.

  1994cited by this paper
• Uncoupling between proliferation and differentiation of ovine granulosa cells in vitro.

  1994cited by this paper
• Expression of the genes encoding the insulin-like growth factors (IGF-I and II), the IGF and insulin receptors, and IGF-binding proteins-1-6 and the localization of their gene products in normal and polycystic ovary syndrome ovaries.

  1994cited by this paper
• Measuring insulin-like growth factors: why, where and how?

  1994cited by this paper
• Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein

  1994cited by this paper
• Changes in insulin-like growth factor-II/mannose-6-phosphate receptor during growth and atresia of ovine ovarian follicles.

  1994cited by this paper
• Heparan sulphate: functional role as a modulator of fibroblast growth factor activity.

  1993cited by this paper
• Changes in insulin-like growth factor-I (IGF-I), IGF-II, and their binding proteins during growth and atresia of ovine ovarian follicles.

  1993cited by this paper
• TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice.

  1993cited by this paper
• Expression of insulin-like growth factor-I (IGF-I) and IGF-II and the IGF-I, IGF-II, and insulin receptor genes and localization of the gene products in the human ovary.

  1993cited by this paper
• Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate

  1993cited by this paper
• Proteolytic modification of insulin-like growth factor-binding proteins: comparison of conditioned media from human cell lines, circulating proteases and characterized enzymes.

  1993cited by this paper
• Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I

  1993cited by this paper
• Synthetic antiestrogens modulate induction of pS2 and cathepsin-D messenger ribonucleic acid by growth factors and adenosine 3',5'-monophosphate in MCF7 cells.

  1993cited by this paper
• Role of insulin-like growth factors in embryonic and postnatal growth.

  1993cited by this paper
• Insulin-like growth factor binding proteins.

  1993cited by this paper
• Development of specific antibodies to rat insulin-like growth factor-binding proteins (IGFBP-2 to -6): analysis of IGFBP production by rat granulosa cells.

  1993cited by this paper
• Insulin-like growth factor II in follicular fluid of the patients with in vitro fertilization and embryo transfer.

  1993cited by this paper
• Regulation of insulin-like growth factor binding protein production by human luteinizing granulosa cells cultured in defined medium.

  1993cited by this paper
• Expression of the mRNAs for the insulin-like growth factors and their binding proteins during development of porcine ovarian follicles.

  1993cited by this paper
• Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

  1993cited by this paper
• Inhibition of basic fibroblast growth factor-induced growth promotion by overexpression of syndecan-1.

  1993cited by this paper
• Phosphorylation of insulin-like growth factor-binding protein-1 increases in human amniotic fluid and decidua from early to late pregnancy.

  1993cited by this paper
• Potentiation of insulin-like growth factor action by insulin-like growth factor binding protein-3: studies of underlying mechanism.

  1993cited by this paper
• Evidence that limited proteolysis of insulin-like growth factor binding protein-3 (IGFBP-3) occurs in the normal state outside of the bloodstream.

  1993cited by this paper
• Potentiation of insulin-like growth factor (IGF) action by IGF-binding protein-3: studies of underlying mechanism.

  1992cited by this paper
• Apoptotic cell death induced by c-myc is inhibited by bcl-2

  1992cited by this paper
• Ontogeny and cellular localization of 125I-labeled insulin-like growth factor-I, 125I-labeled follicle-stimulating hormone, and 125I-labeled human chorionic gonadotropin binding sites in ovaries from bovine fetuses and neonatal calves.

  1992cited by this paper
• The intra-ovarian IGF system.

  1992cited by this paper
• Expression of insulin-like growth factor-binding protein-2 and -3 messenger ribonucleic acid in the porcine ovary: localization and physiological changes.

  1992cited by this paper
• Insulin-like growth factor-I (IGF-I) may not be essential for ovarian follicular development: evidence from IGF-I deficiency.

  1992cited by this paper
• Localization of insulin-like growth factor-binding protein-5 messenger ribonucleic acid in rat ovaries during the estrous cycle.

  1992cited by this paper
• Insulin-like growth factors and ovarian follicular development.

  1992cited by this paper
• Insulin-like growth factor binding protein profiles in human ovarian follicular fluid correlate with follicular functional status.

  1992cited by this paper
• Control of proliferation and differentiation of ovine granulosa cells by insulin-like growth factor-I and follicle-stimulating hormone in vitro.

  1992cited by this paper
• Relationships among concentrations of steroids, inhibin, insulin-like growth factor-1 (IGF-1), and IGF-binding proteins during follicular development in weaned sows.

  1992cited by this paper
• Regulation of proto-oncogene expression and deoxyribonucleic acid synthesis in granulosa cells of perifused immature rat ovaries.

  1992cited by this paper
• Luteinizing hormone pulses, follicle-stimulating hormone and control of follicle selection in sheep.

  1992cited by this paper
• Granulosa cell-derived insulin-like growth factor (IGF) binding proteins are inhibitory to IGF-I hormonal action. Evidence derived from the use of a truncated IGF-I analogue.

  1992cited by this paper
• Gonadotropins induce accumulation of insulin-like growth factor I mRNA in pig granulosa cells in vitro.

  1992cited by this paper
• Concentrations of insulin-like growth factor-I in follicular fluid and blood plasma of mares during early and late oestrus

  1991cited by this paper
• Cellular pattern of insulin-like growth factor-I (IGF-I) and IGF-I receptor gene expression in the developing and mature ovarian follicle.

  1991cited by this paper
• Reciprocal modulation of binding of lysosomal enzymes and insulin-like growth factor-II (IGF-II) to the mannose 6-phosphate/IGF-II receptor.

  1991cited by this paper
• Parental imprinting of the mouse insulin-like growth factor II gene.

  1991cited by this paper
• Tissue-specific expression of four insulin-like growth factor-binding proteins (1, 2, 3, and 4) in the rat ovary.

  1991cited by this paper
• Mediation of follicle-stimulating hormone action on follicular deoxyribonucleic acid synthesis by epidermal growth factor.

  1991cited by this paper
• Characterization of insulin-like growth factor-binding proteins of porcine ovarian follicular fluid.

  1991cited by this paper
• Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.

  1991cited by this paper
• Insulin-like growth factor I in follicular development and function in postpartum beef cows.

  1991cited by this paper
• Binding of insulin-like growth factor II (IGF-II) by human cation-independent mannose 6-phosphate receptor/IGF-II receptor expressed in receptor-deficient mouse L cells.

  1990cited by this paper
• Intracrine regulation at the nucleus--a further mechanism of growth factor activity?

  1990cited by this paper
• Insulin-like growth factor-I (IGF-I) and IGF-II hormonal action in cultured rat granulosa cells: mediation via type I but not type II IGF receptors.

  1990cited by this paper
• Evidence of enzymatic degradation of insulin-like growth factor-binding proteins in the 150K complex during pregnancy.

  1990cited by this paper
• Concentrations of insulin-like growth factor-I in blood and ovarian follicular fluid of cattle selected for twins.

  1990cited by this paper
• Localization, characterization, and quantification of insulin-like growth factor-I-binding sites in the ewe ovary.

  1989cited by this paper
• The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

  1989cited by this paper
• Immunoreactive insulin-like growth factor I in human follicular fluid.

  1989cited by this paper
• Characterization of insulin-like growth factor binding proteins in ovine tissue fluids.

  1989cited by this paper
• Ovarian epidermal growth factor-like activity. Concentrations in porcine follicular fluid during follicular enlargement.

  1987cited by this paper
• Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and the cholesterol side-chain-cleavage enzyme, P450scc [corrected], in human steroidogenic tissues.

  1987cited by this paper
• Synergistic actions of estradiol and the insulin-like growth factor somatomedin-C on swine ovarian (granulosa) cells.

  1986cited by this paper
• Relationships between bovine follicular fluid glycosaminoglycans and steroids.

  1985cited by this paper
• Proteins of human follicular fluid: the blood-follicle barrier.

  1973cited by this paper
• Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and the cholesterol side-chain-cleavage enzyme, P450ssc, in human steroidogenic tissues

  year unknowncited by this paper

• Morphological profile of the ovaries of high-yielding cows on day 0 of the induced sexual cycle

  2023cites this paper
• Impact of different hormonal protocols for the treatment of smooth inactive ovaries (SIO) and the subsequent reproductive performance in dairy cows

  2023cites this paper
• Investigating and Modelling an Engineered Millifluidic In Vitro Oocyte Maturation System Reproducing the Physiological Ovary Environment in the Sheep Model

  2022cites this paper
• Relationship between ovarian ultrasonographic findings on the seventh post-estrus day and plasma progesterone concentration, nutritional metabolic factors, and pregnancy outcome in dairy cows

  2022cites this paper
• Effects of short-term dietary supplementation on the number of ovarian follicles, quantity and quality of oocytes, and in vitro embryo production in Japanese Black cows

  2022cites this paper
• Comparative Study For The Treatment Of Inactive Ovary In Local Iraqi Breed Cow By Using Massage Method Of The Ovaries And Gnrh

  2021cites this paper
• PEPTIDE PROFILE OF BUFFALO OVARIAN FOLLICULAR FLUID

  2020cites this paper
• Induction and Synchronization of Estrus

  2020cites this paper
• Effect of Sweet Potato Vine on the Onset of Puberty and Follicle Development in Chinese Meishan Gilts

  2019cites this paper
• Current Perspectives on Insulin-like Growth Factor Binding Protein (IGFBP) Research

  2019cites this paper
• Differentiation and Function of the Female Reproductive System

  2018cites this paper
• Insulin-Like Growth Factor Binding Proteins and IGFBP Proteases: A Dynamic System Regulating the Ovarian Folliculogenesis

  2018cites this paper
• Transcriptomic Analysis for Differentially Expressed Genes in Ovarian Follicle Activation in the Zebrafish

  2018cites this paper
• Impacts of stocking density on development and puberty attainment of replacement beef heifers.

  2017cites this paper
• The theory of follicle selection in cattle.

  2016cites this paper
• Chapter 2 In Vitro Fertilization (IVF)

  2016cites this paper
• Expression of mRNA Encoding IGF-I, IGF-II, Type-I, and II IGF-Receptors and IGF-Binding Proteins-1-4 during Ovarian Follicular Development in Buffalo (Bubalus bubalis)

  2015cites this paper
• The meat goat industry in Australia: geographical, seasonal and nutritional influences on reproduction in female goats

  2015cites this paper
• HIF1 Activity in Granulosa Cells Is Required for FSH-Regulated Vegfa Expression and Follicle Survival in Mice1

  2014cites this paper
• Anestrus in cattle and buffalo: Indian perspective.

  2014cites this paper
• Genomics Control of Folliculogenesis in Animals with Emphasis to Buffaloes

  2014cites this paper
• Assessment of Single Nucleotide Polymorphism in the 5'-Flanking Region of Insulin-Like Growth Factor-I (IGF-I) Gene as a Potential Genetic Marker for Fertility in Holstein Dairy Cows

  2013cites this paper
• Cultura de células da granulosa humanas com fenótipo de fase folicular: influência do sistema quimicamente definido na morfologia, ultraestrutura, secreção de esteroides e relaxina

  2013cites this paper
• Ovarian Follicular Dynamics During the Estrous Cycle in the

  2012cites this paper
• Functional Recovery of a Whole Ovary Transplanted Into Syngenic Testis

  2012cites this paper
• Ovarian Follicular Dynamics During the Estrous Cycle in the Mare

  2012cites this paper
• Uticaj energetskog bilansa na endokrini i metabolički status krava

  2012cites this paper
• Influence of insulin-like growth factor-binding proteins-2 and -3 in the pathogenesis of cystic ovarian disease in cattle.

  2011cites this paper
• THE FLUSHING EFFECT AND EXPRESSION OF FOLLICLE STIMULATING HORMONE RECEPTOR VARIANTS IN SHEEP

  2011influential citation
• The Effect of Insulin-Like Growth Factor System on Embryo Growth and Development

  2011cites this paper
• Regulation of folliculogenesis and the determination of ovulation rate in ruminants.

  2011cites this paper
• Comparative Study on Efficacy of Different Medicaments on Postpartum Anestrus Dairy Cows

  2011cites this paper
• Putative role of cocaine- and amphetamine-regulated transcript (CARTPT) in dominant follicle selection in cattle.

  2010cites this paper
• Insulin-like growth factor-II and insulin-like growth factor-binding proteins in bovine cystic ovarian disease.

  2010cites this paper
• Nutritional studies on some different sources of iodine on productive performance, ruminal fermentation and blood constituents of Buffalo. 1 – Effect of two different iodine levels on productive and reproductive performance of buffalo cows

  2010cites this paper
• EFECTO DE LA CONDICIÓN CORPORAL Y NIVEL DE ALIMENTACIÓN SOBRE LA ACTIVIDAD OVÁRICA, INVOLUCIÓN UTERINA Y EXPRESIÓN DEL IGF-I EN VACAS MESTIZAS DURANTE EL POSPARTO

  2010cites this paper
• Effect of progesterone priming on ovarian angiogenic factors during late follicular and early luteal development

  2009cites this paper
• Development of fresh and cryopreserved early-stage ovarian follicles, with special attention to ruminants.

  2009cites this paper
• Characteristics of FSH peaks and antral follicular wave dynamics in sheep

  2009cites this paper
• The effect of follicular aging on gene expression in oocytes and granulosal cells.

  2008cites this paper
• CLINICAL AND ENDOCRINE RESPONSES TO OVARIAN HYPERSTIMULATION IN FLARE AND LUTEAL GONADOTROPIN-RELEASING HORMONE AGONIST (GnRHa) PROTOCOLS by TUAN-ANH THI NGUYEN M.D, University of Training Center for Health Care Professionals, Vietnam, 2001 A THESIS SUBMITTED IN PARTIAL FULFILMENT OF THE REQUIREMENT

  2008cites this paper
• Effects of growth hormone and insulin-like growth factor 1 on progesterone production in human luteinized granulosa cells.

  2008cites this paper
• CRECIMIENTO FOLICULAR OVÁRICO EN ANIMALES DOMÉSTICOS: UNA REVISIÓN

  2007cites this paper
• Intraovarian Localization of Growth Factors in Induced Cystic Ovaries in Rats

  2007cites this paper
• PAPEL DEL FACTOR DE CRECIMIENTO SEMEJANTE A LA INSULINA (IGF-) EN LA REGULACIÓN DE LA FUNCIÓN OVÁRICA *

  2007cites this paper
• FACTORES DE CRECIMIENTO EN EL DESARROLLO FOLICULAR, EMBRIONARIO TEMPRANO E IMPLANTACIÓN. IMPLICACIONES EN LA PRODUCCIÓN DE EMBRIONES BOVINOS

  2007cites this paper
• Folliculogenesis following syngeneic transplantation of young murine ovaries into the testes

  2006cites this paper
• Formation of ovarian follicular fluid.

  2006cites this paper
• Therapeutic Management of Anoestrus Cows with Diluted Logul ’ s Iodine and Massage on Reproductive Organs-uncontrolled Case Study

  2006cites this paper
• Effects of growth hormone and gonadotrophin releasing hormone antagonists on ovarian follicle growth in sheep.

  2006cites this paper
• Follicle selection in cattle and horses: role of intrafollicular factors.

  2006influential citation
• Expression of mRNAs encoding insulin-like growth factor (IGF) ligands, IGF receptors and IGF binding proteins during follicular growth and atresia in the ovine ovary throughout the oestrous cycle.

  2006cites this paper
• Formation of mammalian oocytes and their growth, differentiation and maturation within ovarian follicles.

  2005cites this paper
• A SOMATOTROFINA BOVINA (bST) E SUA RELAÇÃO COM O RECRUTAMENTO FOLICULAR OVARIANO DURANTE O CICLO ESTRAL DE VACAS

  2005cites this paper
• Dynamics and regulation of ovarian antral follicular waves in sheep

  2004cites this paper
• Ovarian follicular expression of mRNA encoding the type I IGF receptor and IGF-binding protein-2 in sheep following five days of nutritional supplementation with glucose, glucosamine or lupins.

  2004cites this paper
• COMPARATIVE STUDY ON THE EFFICACY OF HORMONAL AND NON HORMONAL TREATMENT METHODS IN OVARIAN AFUNCTION AFFECTED DAIRY COWS

  2004cites this paper
• Co-expression of messenger ribonucleic acids encoding IGF-I, IGF-II, type I and II IGF receptors and IGF-binding proteins (IGFBP-1 to -6) during follicular development in the ovary of seasonally anoestrous ewes.

  2004cites this paper
• EFECTO DEL FACTOR DE CRECIMIENTO EPIDERMAL (EGF) DURANTE LA MADURACIÓN DE OOCITOS SOBRE LA PRODUCCIÓN IN VITRO DE EMBRIONES BOVINOS Effect of Epidermal Growth Factor (EGF) During Oocyte Maturation on in vitro Production of Bovine Embryos

  2004cites this paper
• Immunomodulation of reproductive function in domestic ruminants

  2004cites this paper
• Minireview Selection of the Dominant Follicle in Cattle'

  2004cites this paper
• Follicle-Stimulating Hormone and lntracellular Second Messengers Regulate Steroidogenic Acute Regulatory Protein Messenger Ribonucleic Acid in Luteinized Porcine Granulosa Cells1

  2004cites this paper
• Human ovarian follicular dynamics during natural menstrual cycles and oral contraception cycles

  2003cites this paper
• The insulin-like growth factor system: a key determinant role in the growth and selection of ovarian follicles? a comparative species study.

  2003cites this paper
• Effect of nutrition on follicle development and ovulation rate in the ewe

  2003cites this paper
• Intraovarielles Insulin-like growth Faktor-System

  2002cites this paper
• Insulin-like growth factor-I as a possible hormonal mediator of nutritional regulation of reproduction in cattle.

  2002cites this paper
• An investigation of conventional oestrous synchronization techniques in the ewe

  2002cites this paper
• Expression and localization of IGF family members in bovine antral follicles during final growth and in luteal tissue during different stages of estrous cycle and pregnancy.

  2002cites this paper
• Regulation of ovarian folliculogenesis by IGF and BMP system in domestic animals.

  2002cites this paper
• Folliculogenesis and ovarian expression of mRNA encoding aromatase in anoestrous sheep after 5 days of glucose or glucosamine infusion or supplementary lupin feeding.

  2002cites this paper
• Novel demonstration of a physiologic/pharmacologic role of insulin-like growth factor-1 in ovulation in rats and action on cumulus oophorus

  2001cites this paper
• Follicle Selection in Monovular Species

  2001cites this paper
• Long-term follicular dynamics and biochemical characteristics of dominant follicles in dairy cows subjected to acute heat stress.

  2001cites this paper
• A Potential Role for Insulin-Like Growth Factor Binding Protein-4 Proteolysis in the Establishment of Ovarian Follicular Dominance in Cattle1

  2001cites this paper
• Selection and Maintenance of the Dominant Follicle: An Introduction

  2001cites this paper
• Importance of the IGF system in early folliculogenesis.

  2000cites this paper
• A combination of EGF and IGF-I accelerates the progression of meiosis in bovine follicular oocytes in vitro and fetal calf serum neutralizes the acceleration effect.

  2000cites this paper
• Ovine follicular fluid inhibits aromatase activity.

  2000cites this paper
• Consequences of the Presence of the Booroola F Gene on the Intraovarian Insulin-Like Growth Factor System and Terminal Follicular Maturation in Mérinos d'Arles Ewes1

  2000cites this paper
• The Effects of Equine Somatotropin (eST) on Reproductive Function in the Domestic Mare.

  2000cites this paper
• Expression of mRNA encoding IGF-I, IGF-II and type 1 IGF receptor in bovine ovarian follicles.

  2000cites this paper
• Historical perspective of turnover of dominant follicles during the bovine estrous cycle: key concepts, studies, advancements, and terms.

  2000cites this paper
• Regulation of Fas Antigen (Fas, CD95)-Mediated Apoptosis of Bovine Granulosa Cells by Serum and Growth Factors1

  2000cites this paper
• Examination of the relative role of FSH and LH in the mechanism of ovulatory follicle selection in sheep.

  1999cites this paper
• Presence of an aromatase inhibitor, possibly heat shock protein 90, in dominant follicles of cattle.

  1999cites this paper
• An evaluation of the success of MOET in two breeds of hill sheep maintained under normal systems of hill flock management

  1999cites this paper
• Development of a sensitive enzymeimmunoassay (EIA) for FSH determination in bovine plasma.

  1999cites this paper
• La maturation de l'ovocyte de mammifères.

  1999cites this paper
• The insulin-related ovarian regulatory system in health and disease.

  1999cites this paper
• Intrafollicular insulin-like growth factor-binding protein levels in equine ovarian follicles during preovulatory maturation and regression.

  1998cites this paper
• The phylogeny of the insulin-like growth factors.

  1998cites this paper
• Control of ovarian function; effect of local interactions and environmental influences on follicular turnover in cattle: a review

  1998cites this paper
• Developmental and hormonal regulation of keratinocyte growth factor expression and action in the ovarian follicle.

  1998cites this paper
• Dynamics of follicle growth in the sheep

  1997cites this paper
• Cloning of the functional promoter for human insulin-like growth factor binding protein-4 gene: endogenous regulation.

  1997cites this paper
• Lack of effects of growth hormone administration on ovarian function of lactating goats.

  1997cites this paper
• Growth factors and antral follicular development in domestic ruminants

  1997cites this paper
• Follicle-stimulating hormone and intracellular second messengers regulate steroidogenic acute regulatory protein messenger ribonucleic acid in luteinized porcine granulosa cells.

  1997cites this paper
• Involvement of insulin-like growth factors in the interactions between nutrition and reproduction in female mammals.

  1997cites this paper