Reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Carcinogenesis

• Publication date

  2006-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/CARCIN/BGL053PMID 16632868
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Colorectal Cancer*

  2005cited by this paper
• 15-Hydroxyprostaglandin dehydrogenase can be induced by dexamethasone and other glucocorticoids at the therapeutic level in A549 human lung adenocarcinoma cells.

  2005cited by this paper
• 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.

  2004cited by this paper
• NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer.

  2004cited by this paper
• Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2.

  2003cited by this paper
• Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference

  2003cited by this paper
• Cyclooxygenase 2: a molecular target for cancer prevention and treatment.

  2003cited by this paper
• Tristetraprolin Binds to the 3′-Untranslated Region of Cyclooxygenase-2 mRNA

  2003cited by this paper
• Agents that elevate cyclic AMP induce receptor phosphorylation primarily at serine 331 in HEK 293 cells overexpressing human thromboxane receptor alpha.

  2002cited by this paper
• Prostaglandin catabolizing enzymes.

  2002cited by this paper
• Analysis of gene function in somatic mammalian cells using small interfering RNAs.

  2002cited by this paper
• Expression profiling of primary non-small cell lung cancer for target identification

  2002cited by this paper
• COX‐2 and cancer: a new approach to an old problem

  2001cited by this paper
• Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells.

  2001cited by this paper
• Indomethacin, a cox inhibitor, enhances 15-PGDH and decreases human tumoral C cells proliferation.

  2001cited by this paper
• The 3′-Untranslated Region of Murine Cyclooxygenase-2 Contains Multiple Regulatory Elements That Alter Message Stability and Translational Efficiency*

  2001cited by this paper
• Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer.

  2001cited by this paper
• Cyclooxygenases: structural, cellular, and molecular biology.

  2000cited by this paper
• Dexamethasone inhibits the induction of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase by phorbol ester in human promonocytic U937 cells.

  2000cited by this paper
• Identification of the NAD(+)-binding fold of glyceraldehyde-3-phosphate dehydrogenase as a novel RNA-binding domain.

  2000cited by this paper
• TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha.

  2000cited by this paper
• The human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene promoter is controlled by Ets and activating protein-1 transcription factors and progesterone.

  2000cited by this paper
• Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells.

  2000cited by this paper
• TIA‐1 is a translational silencer that selectively regulates the expression of TNF‐α

  2000cited by this paper
• Interleukin-10 modifies the effects of interleukin-1beta and tumor necrosis factor-alpha on the activity and expression of prostaglandin H synthase-2 and the NAD+-dependent 15-hydroxyprostaglandin dehydrogenase in cultured term human villous trophoblast and chorion trophoblast cells.

  1999cited by this paper
• In vitro modulation of the expression of 15-hydroxy-prostaglandin dehydrogenase by trophoblast differentiation.

  1999cited by this paper
• Cyclooxygenase in biology and disease

  1998cited by this paper
• Expression of cyclooxygenase-2 in human lung carcinoma.

  1998cited by this paper
• Cyclooxygenases 1 and 2.

  1998cited by this paper
• Characterization of the genomic structure and promoter of the mouse NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene.

  1997cited by this paper
• 1,25-dihydroxyvitamin D3 induces NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase in human neonatal monocytes.

  1997cited by this paper
• Loss of adipocyte-type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas.

  1996cited by this paper
• Prostaglandin synthase 2.

  1996cited by this paper
• Stimulation of prostaglandin E2 synthesis by interleukin-1beta is amplified by interferons but inhibited by interleukin-4 in human amnion-derived WISH cells.

  1996cited by this paper
• Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes.

  1995cited by this paper
• 15-Hydroxyprostaglandin dehydrogenase.

  1995cited by this paper
• Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2.

  1994cited by this paper
• Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.

  1994cited by this paper
• Gene therapy for vascular diseases.

  1994cited by this paper
• Sequence-specific binding of transfer RNA by glyceraldehyde-3-phosphate dehydrogenase.

  1993cited by this paper
• Stimulation of synthesis de novo of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase in human promyelocytic leukaemia (HL-60) cells by phorbol ester.

  1991cited by this paper
• Regulation of synthesis and activity of NAD(+)-dependent 15-hydroxy-prostaglandin dehydrogenase (15-PGDH) by dexamethasone and phorbol ester in human erythroleukemia (HEL) cells.

  1991cited by this paper
• Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells.

  1990cited by this paper
• Monoclonal antibodies that inhibit the enzyme activity of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.

  1990cited by this paper
• Cloning and sequence analysis of the cDNA for human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.

  1990cited by this paper
• Enzymatic synthesis of (15s)-[15-3h]prostaglandins and their use in the development of a simple and sensitive assay for 15-hydroxyprostaglandin dehydrogenase.

  1976cited by this paper
• The Distribution of 15-Hydroxy Prosta-glandin Dehydrogenase and Prostaglandin-Δ13-Reductase in Tissues of the Swine

  1971cited by this paper
• The distribution of 15-hydroxy prostaglandin dehydrogenase and prostaglandin-delta 13-reductase in tissues of the swine.

  1971cited by this paper

• Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

  2025cites this paper
• The tumor suppressor role and epigenetic regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in cancer and tumor microenvironment (TME).

  2025cites this paper
• Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4

  2024cites this paper
• Nicotinamide N-Methyltransferase Remodeled Cell Metabolism and Aggravated Proinflammatory Responses by Activating STAT3/IL1β/PGE2 Pathway

  2022cites this paper
• Robust COX-2-mediated prostaglandin response may drive arthralgia and bone destruction in patients with chronic inflammation post-chikungunya

  2021cites this paper
• Association between COX‐2 and 15‐PGDH polymorphisms and SLE susceptibility

  2020cites this paper
• Spilanthol Inhibits COX-2 and ICAM-1 Expression via Suppression of NF-κB and MAPK Signaling in Interleukin-1β-Stimulated Human Lung Epithelial Cells

  2018cites this paper
• mPGES-1 and ALOX5/-15 in tumor-associated macrophages

  2018cites this paper
• Regulation of HPGD and SLCO2A1 in colorectal cancer development

  2018influential citation
• Insights into the Cyclooxygenase Pathway in a Progressive Rat Model of Parkinson’s Disease Induced by Prostaglandin J2: Protection with Ibuprofen

  2018cites this paper
• RATIONAL DESIGN, SYNTHESIS, AND CHARACTERIZATION OF NOVEL mPGES-1 INHIBITORS AS NEXT GENERATION OF ANTI-INFLAMMATORY DRUGS

  2017cites this paper
• Elucidating the metabolism of n-3 polyunsaturated fatty acids and formation of bioactive lipid mediators in human skin

  2017cites this paper
• Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer

  2016cites this paper
• HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells

  2016cites this paper
• Correlation of 15-prostagladin dehydrogenase expression with clinicopathological factors and survival rate in gastric adenocarcinoma.

  2015cites this paper
• Damage control: Harnessing prostaglandin E2 as a potential healing factor of tissue injuries

  2015cites this paper
• Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer.

  2015cites this paper
• Postnatal regulation of 15-hydroxyprostaglandin dehydrogenase in the rat kidney.

  2014cites this paper
• Persisting eicosanoid pathways in rheumatic diseases

  2014cites this paper
• Cyclooxygenase pathways.

  2014influential citation
• Expression of 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase-2 in non-small cell lung cancer: Correlations with angiogenesis and prognosis

  2014cites this paper
• Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway.

  2014cites this paper
• Effect of hypertension on the structural and functional integrity of the young and aged brain in an inducible transgenic model

  2014cites this paper
• 15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPARγ-mediated activation of p21WAF1/Cip1

  2013cites this paper
• 15-Hydroxyprostaglandin Dehydrogenase-derived 15-Keto-prostaglandin E2 Inhibits Cholangiocarcinoma Cell Growth through Interaction with Peroxisome Proliferator-activated Receptor-γ, SMAD2/3, and TAP63 Proteins*

  2013cites this paper
• Discovery and Characterization of Novel Inhibitors of the Prostaglandin E2 Pathway

  2013cites this paper
• Lentivirus-mediated shRNA interference targeting cyclooxygenase-2 inhibits growth of human non-small cell lung cancer.

  2013cites this paper
• Characterization of the PGE2 pathway in arthritis and inflammation : mPGES-1 as a therapeutic target

  2013cites this paper
• Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue

  2012cites this paper
• 15-PGDH is reduced and induces apoptosis and cell cycle arrest in gastric carcinoma.

  2012cites this paper
• 15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy.

  2011cites this paper
• Epithelial to Mesenchymal Transition by TGFβ-1 Induction Increases Stemness Characteristics in Primary Non Small Cell Lung Cancer Cell Line

  2011cites this paper
• Cyclooxygenase-2 and Gastric Cancer

  2011cites this paper
• Pharmacological induction of leukotriene B4-12-hydroxydehydrogenase suppresses the oncogenic transformation of human hepatoma HepG2 cells.

  2011cites this paper
• Prostaglandin catabolic enzymes as tumor suppressors

  2011cites this paper
• Overexpression of cyclooxygenase‐2 in NCI‐H292 human alveolar epithelial carcinoma cells: Roles of p38 MAPK, ERK‐1/2, and PI3K/PKB signaling proteins

  2011cites this paper
• Utilization of thermal imaging for monitoring in vitro processes

  2011cites this paper
• ROLE OF PROSTAGLANDIN E2 IN THE REGULATION OF PANCREATIC STELLATE CELLS HYPER ACTIVITY ASSOCIATED WITH PANCREATIC CANCER

  2011cites this paper
• Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 by head and neck squamous cell carcinoma

  2011cites this paper
• ω-3 PUFAs and Other Cancers

  2010cites this paper
• Interleukin-4 up-regulates 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in human lung cancer cells.

  2010cites this paper
• Chemoprevention of lung pathologies by dietary n-3 polyunsaturated fatty acids.

  2010cites this paper
• Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo.

  2010cites this paper
• Loss of 15-Hydroxyprostaglandin Dehydrogenase Increases Prostaglandin E2 in Pancreatic Tumors

  2010cites this paper
• Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 in head and neck squamous cell carcinoma.

  2010cites this paper
• Altered Expression of 15-Hydroxyprostaglandin Dehydrogenase in Tumor-Infiltrated CD11b Myeloid Cells: A Mechanism for Immune Evasion in Cancer

  2009cites this paper
• Effekter av PPARδ agonist og NSAIDs i cellelinjer fra coloncancer : Medieres effekter av NSAIDs via PPARδ?

  2009cites this paper
• 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells.

  2009cites this paper
• 15-Hydroxyprostaglandin Dehydrogenase Is Down-regulated in Gastric Cancer

  2009cites this paper
• Mechanism for Immune Evasion in Cancer Tumor-Infiltrated CD 11 b Myeloid Cells : A 15-Hydroxyprostaglandin Dehydrogenase in Altered Expression of and

  2009cites this paper
• Involvement of PGE2 and PGDH but not COX-2 in thrombin-induced cortical neuron apoptosis.

  2009cites this paper
• Inhibition of TNF‐α‐induced Cyclooxygenase‐2 Expression by Mycobacterium bovis BCG in Human Alveolar Epithelial A549 Cells

  2009cites this paper
• Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling.

  2008cites this paper
• Euphorbiae Humifusae Inhibits Egr-1, NF-κB and COX-2 Activity Stimulated by Phorbol 12-myristate-13-acetate

  2008cites this paper
• Bioactivation of Xenobiotics in Lung: Role of CYPs and FMOs

  2008cites this paper
• Opposite Effect of Phorbol Ester PMA on PTGS2 and PGDH mRNA Expression in Human Chorion Trophoblast Cells

  2008cites this paper
• Expression of 15-PGDH is downregulated by COX-2 in gastric cancer.

  2008cites this paper
• Effect of calcium ionophore A23187 on prostaglandin synthase type 2 and 15-hydroxy-prostaglandin dehydrogenase expression in human chorion trophoblast cells.

  2008cites this paper
• Suppression of Invasive Properties of Colorectal Carcinoma SW480 Cells by 15-Hydroxyprostaglandin Dehydrogenase Gene

  2008cites this paper
• Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors

  2008influential citation
• HIV-1 Activates Proinflammatory and Interferon-Inducible Genes in Human Brain Microvascular Endothelial Cells: Putative Mechanisms of Blood—Brain Barrier Dysfunction

  2008cites this paper
• Activation of thromboxane receptor alpha induces expression of cyclooxygenase-2 through multiple signaling pathways in A549 human lung adenocarcinoma cells.

  2007cites this paper
• 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and lung cancer.

  2007cites this paper
• Extracellular nucleotides induce COX-2 up-regulation and prostaglandin E2 production in human A549 alveolar type II epithelial cells.

  2007cites this paper
• Getting familiar with familial colon cancer

  2007cites this paper