Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Immunology

• Publication date

  2012-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.1202121PMID 23144495PMCID PMC3518757
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

  2012influential reference
• Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

  2012influential reference
• Human FasL Gene Is a Target of β-Catenin/T-Cell Factor Pathway and Complex FasL Haplotypes Alter Promoter Functions

  2011cited by this paper
• RIP3 mediates the embryonic lethality of caspase-8-deficient mice

  2011cited by this paper
• Caspase signalling controls microglia activation and neurotoxicity

  2011cited by this paper
• Intracellular sensing of microbes and danger signals by the inflammasomes

  2011cited by this paper
• Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways

  2011cited by this paper
• Inflammasome activation and IL-1β and IL-18 processing during infection.

  2011cited by this paper
• The sterile inflammatory response.

  2010cited by this paper
• Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1

  2009cited by this paper
• The many roles of FAS receptor signaling in the immune system.

  2009cited by this paper
• AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC

  2009cited by this paper
• Cutting Edge: Necrosis Activates the NLRP3 Inflammasome1

  2009cited by this paper
• Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

  2008cited by this paper
• Pathogen-Associated Molecular Patterns Sensitize Macrophages to Fas Ligand-Induced Apoptosis and IL-1β Release1

  2003cited by this paper
• Requirement of Fas expression in B cells for tolerance induction

  2002cited by this paper
• The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis.

  2001cited by this paper
• Apoptosis-inducing Membrane Vesicles

  2001cited by this paper
• Fas Ligand Engagement of Resident Peritoneal Macrophages In Vivo Induces Apoptosis and the Production of Neutrophil Chemotactic Factors1

  2001cited by this paper
• The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways

  2000cited by this paper
• The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways.

  2000cited by this paper
• Opposing Effects of Transmembrane and Soluble FAS Ligand Expression on Inflammation and Tumor Cell Survival

  2000cited by this paper
• Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

  2000cited by this paper
• FAS Engagement Induces the Maturation of Dendritic Cells (Dcs), the Release of Interleukin (Il)-1β, and the Production of Interferon γ in the Absence of IL-12 during Dc–T Cell Cognate Interaction

  2000cited by this paper
• Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice.

  1999cited by this paper
• Fas-FasL interactions modulate host defense against systemic Candida albicans infection.

  1999cited by this paper
• Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand

  1998cited by this paper
• Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells

  1995cited by this paper
• Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand.

  1994cited by this paper
• Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

  1992cited by this paper
• Brief Definitive Report Stimulation of Toll-like Receptor 3 and 4 Induces Interleukin-1 ␤ Maturation by Caspase-8

  year unknowncited by this paper

• B cells inhibit IL-1 family cytokine production and Mycobacterium tuberculosis growth in human CD14+ cells

  2025cites this paper
• Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth

  2025cites this paper
• 10 things you wish you knew about inflammatory caspases: A holistic review of their biochemistry, activation, and signalling

  2025cites this paper
• IL-18 in atopic dermatitis - A multifaceted driver of skin inflammation.

  2025cites this paper
• Three decades of caspases and RIPKs in life and death.

  2025cites this paper
• Utilizing bioinformatics to identify biomarkers and analyze their expression in relation to immune cell ratios in femoral head necrosis.

  2025cites this paper
• Expression of interleukin-18 in primary Sjögren syndrome and its potential mechanisms with disease: A systematic review and meta-analysis

  2025cites this paper
• Regulation of inflammatory processes by caspases

  2025cites this paper
• IL-18 drives the Bhlhe40-mediated pathogenic Th17 cell response and exacerbates autoimmune disease progression

  2025cites this paper
• Empagliflozin alleviates hepatic ischemia-reperfusion injury by inhibiting c-Myc through the JAK1-STAT3 signaling pathway.

  2025cites this paper
• Inflammasome-Mediated Mechanisms Of Systemic Inflammation In COVID-19 And Asthma

  2024cites this paper
• Cytomegalovirus Biology Viewed Through a Cell Death Suppression Lens

  2024cites this paper
• Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21.3+ activation in multi-inflammatory syndrome in children

  2024cites this paper
• Adipose tissue IL‐18 production is independent of caspase‐1 and caspase‐11

  2024cites this paper
• Unanticipated Loss of Inflammasomes in Birds

  2024cites this paper
• A Narrative Review of the IL-18 and IL-37 Implications in the Pathogenesis of Atopic Dermatitis and Psoriasis: Prospective Treatment Targets

  2024cites this paper
• Unraveling the Role of the NLRP3 Inflammasome in Lymphoma: Implications in Pathogenesis and Therapeutic Strategies

  2024cites this paper
• Cellular Dynamics of Fas-Associated Death Domain in the Regulation of Cancer and Inflammation

  2024cites this paper
• IKKε and TBK1 prevent RIPK1 dependent and independent inflammation

  2024cites this paper
• Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes

  2024cites this paper
• CD14 is a decision-maker between Fas-mediated death and inflammation

  2024cites this paper
• Modulation of Inflammatory Response by Electromagnetic Field Stimulation in Traumatic Brain Injury in Yucatan Swine

  2024cites this paper
• Alloreactive memory CD4 T cells promote transplant rejection by engaging DCs to induce innate inflammation and CD8 T cell priming

  2024cites this paper
• Mycobacterium tuberculosis Utilizes Serine/Threonine Kinase PknF to Evade NLRP3 Inflammasome-driven Caspase-1 and RIPK3/Caspase-8 Activation in Murine Dendritic Cells.

  2024cites this paper
• Unraveling the blood microbiome: novel insights into inflammasome responses in Crohn’s disease

  2024cites this paper
• Porcine γδ T cells express cytotoxic cell-associated markers and display killing activity but are not selectively cytotoxic against PRRSV- or swIAV-infected macrophages

  2024cites this paper
• IL-18 biology in severe asthma

  2024cites this paper
• [Autoinflammatory diseases associated with IL-18].

  2024cites this paper
• IL-18 in Autoinflammatory Diseases: Focus on Adult Onset Still Disease and Macrophages Activation Syndrome

  2023cites this paper
• The Possible Role of NLRP3 Inflammasome in Depression and Myocardial Infarction Comorbidity

  2023cites this paper
• Hyperuricemia remodels the serum proteome toward a higher inflammatory state

  2023cites this paper
• The CaSR/TRPV4 coupling mediates pro‐inflammatory macrophage function

  2023cites this paper
• The role of caspase-8 in inflammatory signalling and pyroptotic cell death.

  2023cites this paper
• Pyroptosis and gasdermins—Emerging insights and therapeutic opportunities in metabolic dysfunction-associated steatohepatitis

  2023cites this paper
• Investigating the Potential Mechanisms and Therapeutic Targets of Inflammatory Cytokines in Post-stroke Depression

  2023cites this paper
• Gasdermins and pyroptosis in the kidney

  2023cites this paper
• Recent advances on the role of pro-inflammatory cytokine interleukin-18 in post-stroke depression

  2023cites this paper
• Activation of inflammasomes and their effects on neuroinflammation at the microelectrode-tissue interface in intracortical implants.

  2023cites this paper
• Imbalanced IL-1B and IL-18 Expression in Sézary Syndrome

  2023cites this paper
• Comparative transcriptome analysis of E. coli & Staphylococcus aureus infected goat mammary epithelial cells reveals genes associated with infection.

  2023cites this paper
• Constitutive secretion of pro-IL-18 allows keratinocytes to initiate inflammation during bacterial infection

  2023cites this paper
• A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation

  2023cites this paper
• Involvement of inflammasomes in tumor microenvironment and tumor therapies

  2023cites this paper
• Biological and clinical roles of IL-18 in inflammatory diseases

  2023cites this paper
• High RIPK3 expression is associated with a higher risk of early kidney transplant failure

  2023cites this paper
• The Role of the Interleukin-1 Family in Complications of Prematurity

  2023cites this paper
• Ambivalent role of FasL in murine acute graft-versus-host-disease.

  2023cites this paper
• Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

  2023influential citation
• A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3

  2023cites this paper
• Cell-based and cell-free immunotherapies for glioblastoma: current status and future directions

  2023cites this paper
• Interleukin-18 and IL-18BP in inflammatory dermatological diseases

  2023cites this paper
• No longer married to inflammasome signaling: the diverse interacting pathways leading to pyroptotic cell death

  2022cites this paper
• Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors

  2022cites this paper
• Soluble factors and suppressive monocytes can predict early development of sepsis in acute‐on‐chronic liver failure

  2022cites this paper
• Interaction of Mycobacteria With Host Cell Inflammasomes

  2022cites this paper
• L-methionine enhances neuroinflammation and impairs neurogenesis: Implication for Alzheimer's disease.

  2022cites this paper
• Impact of IL-21-associated peripheral and brain crosstalk on the Alzheimer’s disease neuropathology

  2022cites this paper
• Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

  2022cites this paper
• Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses

  2022cites this paper
• Inflammasome Activation in Myeloid Malignancies—Friend or Foe?

  2022cites this paper
• Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis

  2022cites this paper
• Innate immune mechanisms of mRNA vaccines

  2022cites this paper
• RIPK1 and RIPK3 in antibacterial defence.

  2022cites this paper
• Interleukin-18 in metabolism: From mice physiology to human diseases

  2022cites this paper
• Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment

  2022cites this paper
• Exosomes Regulate NLRP3 Inflammasome in Diseases

  2022cites this paper
• EV-A71 induced IL-1β production in THP-1 macrophages is dependent on NLRP3, RIG-I, and TLR3

  2022cites this paper
• Generation of antagonistic monoclonal antibodies against the neoepitope of active mouse interleukin (IL)-18 cleaved by inflammatory caspases.

  2022cites this paper
• Assessment of In Vitro Immunostimulatory Activity of an Adjuvanted Whole-Cell Inactivated Neisseria gonorrhoeae Microparticle Vaccine Formulation

  2022cites this paper
• Immune signature of acute pharyngitis in a Streptococcus pyogenes human challenge trial

  2022cites this paper
• Great balls of fire: activation and signalling of inflammatory caspases

  2021cites this paper
• Characterization of the turbot (Scophthalmus maximus) interleukin-18: Identification of splicing variants, phylogeny, synteny and expression analysis.

  2021cites this paper
• Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection

  2021cites this paper
• The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

  2021cites this paper
• Inflammasomes in Dendritic Cells: Friend or Foe?

  2021cites this paper
• Brucella Outer Membrane Lipoproteins 19 and 16 Differentially Induce IL-18 Response or Pyroptosis in Human Monocytic Cells.

  2021cites this paper
• Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics

  2021influential citation
• Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

  2021cites this paper
• Regulation of Caspase-8 Activity at the Crossroads of Pro-Inflammation and Anti-Inflammation

  2021cites this paper
• Role for IL-1 Family Cytokines in Fungal Infections

  2021cites this paper
• The FasLane to ocular pathology—metalloproteinase cleavage of membrane‐bound FasL determines FasL function

  2021cites this paper
• Balance between Interleukin-18 and Interleukin-18 binding protein in auto-inflammatory diseases.

  2021cites this paper
• The inflammasome-activated cytokine IL-1β is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential

  2021cites this paper
• Instructions for Flow Cytometric Detection of ASC Specks as a Readout of Inflammasome Activation in Human Blood

  2021cites this paper
• Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes

  2021cites this paper
• The Card19 locus of murine chromosome 13 regulates terminal cell lysis downstream of caspase activation and Gasdermin-D cleavage Card19 locus regulates caspase-dependent cell lysis

  2021cites this paper
• Balancing life and death: BCL‐2 family members at diverse ER–mitochondrial contact sites

  2021cites this paper
• Mycoplasma ovipneumoniae induces caspase-8-dependent extrinsic apoptosis and p53- and ROS-dependent intrinsic apoptosis in murine alveolar macrophages

  2021cites this paper
• In vitro Evaluation of Programmed Cell Death in the Immune System of Pacific Oyster Crassostrea gigas by the Effect of Marine Toxins

  2021cites this paper
• Limonin Attenuates LPS-Induced Hepatotoxicity by Inhibiting Pyroptosis via NLRP3/Gasdermin D Signaling Pathway.

  2021cites this paper
• Pro-IL-18 secreted by keratinocytes detects the group A streptococcal protease SpeB

  2021cites this paper
• The involvement of CgCaspase-8-2 in regulating the expressions of cytokines, antibacterial peptide and autophagy-related genes in oysters.

  2021cites this paper
• Environmental Allergens Trigger Type 2 Inflammation Through Ripoptosome Activation

  2021cites this paper
• Emerging Roles for Interleukin-18 in the Gastrointestinal Tumor Microenvironment.

  2020cites this paper
• Role of Inflammasomes in Kidney Diseases via Both Canonical and Non-canonical Pathways

  2020cites this paper
• Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo.

  2020cites this paper
• Caspases in Cell Death, Inflammation, and Gasdermin-Induced Pyroptosis.

  2020cites this paper
• Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implications

  2020cites this paper
• Caspase-8: The double-edged sword.

  2020cites this paper
• Only IL‐1β release is inflammasome‐dependent upon ultraviolet B irradiation although IL‐18 is also secreted

  2020cites this paper