Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Journal of Neurophysiology

• Publication date

  1999-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1152/JN.1999.82.6.3347PMID 10601466
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neuropathy

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  1997influential reference
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  1992influential reference
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  1992cited by this paper
• Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons.

  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1983cited by this paper
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  1983influential reference
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• Functional variation in dermatomes in the macaque monkey following dorsal root lesions

  1970cited by this paper
• The release of deep pain by nerve injury.

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• Henry HEAD'S work on sensation.

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