Interferon-α Induces Neurotoxicity Through Activation of the Type I Receptor and the GluN2A Subunit of the NMDA Receptor

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Interferon and Cytokine Research

• Publication date

  2015-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/jir.2014.0105PMID 25517826PMCID PMC4389917
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Subcutaneous Interferon β-1a May Protect against Cognitive Impairment in Patients with Relapsing–Remitting Multiple Sclerosis: 5-Year Follow-up of the COGIMUS Study

  2013cited by this paper
• The effects of long-term interferon-beta-1b treatment on cognitive functioning in multiple sclerosis: a 16-year longitudinal study

  2013cited by this paper
• Association of innate immune activation with latent Epstein-Barr virus in active MS lesions

  2012cited by this paper
• Interferon-α (IFNα) neurotoxicity.

  2012cited by this paper
• Interferon-α Causes Neuronal Dysfunction in Encephalitis

  2009cited by this paper
• Comparable potency of IFNα2 and IFNβ on immediate JAK/STAT activation but differential down-regulation of IFNAR2

  2007cited by this paper
• Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2.

  2007cited by this paper
• NMDA receptor subunits: function and pharmacology.

  2007cited by this paper
• Cognitive dysfunction in HIV encephalitic SCID mice correlates with levels of Interferon-α in the brain

  2007cited by this paper
• Interferon-beta is neuroprotective against the toxicity induced by activated microglia.

  2007cited by this paper
• Cognitive impairment in patients with chronic hepatitis treated with interferon alpha (IFNalpha): results from a prospective study.

  2006cited by this paper
• Culturing hippocampal neurons

  2006cited by this paper
• Cognitive impairment in patients with chronic hepatitis treated with interferon alpha (IFNα): results from a prospective study

  2006cited by this paper
• Apomorphine: A Rapid Rescue Agent for the Management of Motor Fluctuations in Advanced Parkinson Disease

  2006cited by this paper
• Effect of amantadine on depressive symptoms in chronic hepatitis C patients treated with pegylated interferon: a randomized, controlled pilot study.

  2006cited by this paper
• Interferon alpha (IFNalpha) and psychiatric syndromes: a review.

  2002cited by this paper
• Interferon alpha (IFNα) and psychiatric syndromes: A review

  2002cited by this paper
• Mechanisms and management of toxicities associated with high-dose interferon alfa-2b therapy.

  2002cited by this paper
• Pathways to neuronal injury and apoptosis in HIV-associated dementia

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• NFkappaB activation, TNF-alpha expression, and apoptosis in the AIDS-Dementia-Complex.

  2000cited by this paper
• Interferon-a inhibits long-term potentiation and unmasks a long-term depression in the rat hippocampus * ́ ́

  2000cited by this paper
• Human interferon-α induces immobility in the mouse forced swimming test: involvement of the opioid system

  2000cited by this paper
• NFKB activation, TNF-α expression, and apoptosis in the AIDS-Dementia-Complex

  2000cited by this paper
• Structural and functional neuropathology in transgenic mice with CNS expression of IFN-α1

  1999cited by this paper
• Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha.

  1999cited by this paper
• Is interferon-alpha a neuromodulator?

  1998cited by this paper
• Mood and cognitive side effects of interferon-alpha therapy.

  1998cited by this paper
• Mood and cognitive side effects of interferon-α therapy

  1998cited by this paper
• Aicardi‐Goutières syndrome: An update and results of interferon‐α studies

  1998cited by this paper
• Is interferon-α a neuromodulator?

  1998cited by this paper
• Side effects of high-dose interferon therapy for chronic hepatitis C.

  1996cited by this paper
• Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor.

  1996cited by this paper
• Roles of cytokines in the neural-immune interactions: modulation of NMDA responses by IFN-alpha.

  1995cited by this paper
• Characterization of NMDA Receptor Subunit‐Specific Antibodies: Distribution of NR2A and NR2B Receptor Subunits in Rat Brain and Ontogenic Profile in the Cerebellum

  1995cited by this paper
• A potential role for interferon-α in the pathogenesis of hiv-associated dementia

  1995cited by this paper
• A potential role for interferon-alpha in the pathogenesis of HIV-associated dementia.

  1995cited by this paper
• Repeated injections of interferon-alpha A/D in Balb/c mice: behavioral effects.

  1993cited by this paper
• Repeated Injections of Interferon-α A/D in Balb/c Mice: Behavioral Effects

  1993cited by this paper
• Interferon-alpha in lupus psychosis.

  1992cited by this paper
• Different pathways mediate virus inducibility of the human IFN-α1 and IFN-β genes

  1990cited by this paper
• Different pathways mediate virus inducibility of the human IFN-alpha 1 and IFN-beta genes.

  1990cited by this paper
• Multiple sclerosis: Involvement of interferons in lesion pathogenesis

  1988cited by this paper

• Rationale for investigating the use of anifrolumab in neuropsychiatric systemic lupus erythematosus: a combined narrative and case-based systematic literature review.

  2026cites this paper
• Herpes simplex virus 1 ICP34.5 acts to maintain latency in human and mouse neurons.

  2025cites this paper
• Interferon-α2b Modulates AMPA and Kainate Receptors and Alters Cross Talk of AMPA and NMDA Receptors in the Frog Vestibular Epithelium.

  2025cites this paper
• Bisphenol S interrupted axonogenesis on a human embryonic stem cells derived neural differentiation model: Conserved axon guidance and WNT signaling pathway involved.

  2025cites this paper
• Regulation of the innate immune response in human neurons by ICP34.5 maintains herpes simplex virus 1 latency

  2025cites this paper
• The impact of disease activity and interferon-α on the nervous system in systemic lupus erythematosus

  2025cites this paper
• Uncovering immune characteristics of neurons in the context of multiple sclerosis and experimental autoimmune encephalomyelitis

  2024cites this paper
• Viruses - a major cause of amyloid deposition in the brain

  2023cites this paper
• The Impact of Innate Components on Viral Pathogenesis in the Neurotropic Coronavirus Encephalomyelitis Mouse Model

  2023cites this paper
• Breaking down the cellular responses to type I interferon neurotoxicity in the brain

  2023cites this paper
• ISGylation is induced in neurons by demyelination driving ISG15-dependent microglial activation

  2022cites this paper
• Microglia shield the murine brain from damage mediated by the cytokines IL-6 and IFN-α

  2022cites this paper
• Supramolecular organizing centers at the interface of inflammation and neurodegeneration

  2022cites this paper
• What Is the Role of the Cytosolic DNA Response in Neurodegeneration?

  2021cites this paper
• Outside-in induction of the IFITM3 trafficking system by infections, including SARS-CoV-2, in the pathobiology of Alzheimer’s disease

  2021cites this paper
• A new insight into mechanisms of interferon alpha neurotoxicity: Expression of GRIN3A subunit of NMDA receptors and NMDA-evoked exocytosis.

  2021cites this paper
• Duck Tembusu virus induces stronger cellular responses than Japanese encephalitis virus in primary duck neurons and fibroblasts

  2021cites this paper
• ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia

  2021cites this paper
• Interferon-β suppresses inflammatory pain through activating µ-opioid receptor

  2021cites this paper
• HIV and the Nervous System

  2020cites this paper
• Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging.

  2020cites this paper
• Potential pharmacological approaches for the treatment of HIV-1 associated neurocognitive disorders

  2020cites this paper
• Compromised Hippocampal Neuroplasticity in the Interferon-α and Toll-like Receptor-3 Activation-Induced Mouse Depression Model

  2020cites this paper
• Targeting Cannabinoid Receptor 2 on Peripheral Leukocytes to Attenuate Inflammatory Mechanisms Implicated in HIV-Associated Neurocognitive Disorder

  2020cites this paper
• Antineuroinflammatory drugs in HIV-associated neurocognitive disorders as potential therapy

  2019cites this paper
• Prevention and reversal of Alzheimer's disease: treatment protocol

  2018cites this paper
• Reversing interferon-alpha neurotoxicity in a HIV-associated neurocognitive disorder mouse model

  2018cites this paper
• Chimeric Antigen Receptor T Cell-Mediated Neurotoxicity in Nonhuman Primates.

  2018cites this paper
• Maternal Overnutrition Programs Central Inflammation and Addiction-Like Behavior in Offspring

  2018cites this paper
• Title: Cerebrospinal Fluid Interferon alpha Levels Correlate with Neurocognitive Impairment in Ambulatory HIV-infected Individuals

  2017cites this paper
• Type I interferon pathway in CNS homeostasis and neurological disorders

  2017cites this paper
• In vitro and Ex vivo Neurotoxic Effects of Efavirenz are Greater than Those of Other Common Antiretrovirals

  2017cites this paper
• Meralgia Paresthetica in Subcutaneous Interferon Alpha Treatment.

  2016cites this paper
• Neuropathology of mood disorders: do we see the stigmata of inflammation?

  2016cites this paper
• Interferon-β1a modulates glutamate neurotransmission in the CNS through CaMKII and GluN2A-containing NMDA receptors.

  2016cites this paper
• Cerebrospinal fluid interferon alpha levels correlate with neurocognitive impairment in ambulatory HIV-Infected individuals

  2016cites this paper