MicroRNA‐320a inhibits cell proliferation, migration and invasion by targeting BMI‐1 in nasopharyngeal carcinoma

In the present study, we investigated the roles and molecular mechanisms of miR‐320a in human nasopharyngeal carcinoma (NPC). miR‐320a expression was strongly reduced in NPC tissues and cell lines. Overexpression of miR‐320a significantly suppressed NPC cell growth, migration, invasion and tumor growth in a xenograft mouse model. A luciferase reporter assay revealed that miR‐320a could directly bind to the 3′ UTR of BMI‐1. Overexpression of BMI‐1 rescued miR‐320a‐mediated biological function. BMI‐1 expression was found to be up‐regulated and inversely correlated with miR‐320a expression in NPC. Collectively, our data indicate that miR‐320a plays a tumor suppressor role in the development and progression of NPC and may be a novel therapeutic target against NPC.

• Publication year

  2014

• Venue

  FEBS Letters

• Publication date

  2014-10-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2014.08.021PMID 25171860
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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