Bmi‐1 is related to proliferation, survival and poor prognosis in pancreatic cancer

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cancer Science

• Publication date

  2010-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1349-7006.2010.01577.xPMID 20426791PMCID PMC11159722
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway.

  2010cited by this paper
• BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer

  2010cited by this paper
• Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma

  2009cited by this paper
• TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway.

  2009cited by this paper
• Targeted depletion of BMI1 sensitizes tumor cells to P53-mediated apoptosis in response to radiation therapy

  2009cited by this paper
• A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development

  2009cited by this paper
• The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma

  2009cited by this paper
• Oncoprotein BMI‐1 induces the malignant transformation of HaCaT cells

  2009cited by this paper
• Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma.

  2009cited by this paper
• Expression and clinical significance of the stem cell marker CD133 in hepatocellular carcinoma

  2008cited by this paper
• Cancer Statistics, 2008

  2008cited by this paper
• Downregulation of BMI-1 enhances 5-fluorouracil-induced apoptosis in nasopharyngeal carcinoma cells.

  2008cited by this paper
• Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer.

  2008cited by this paper
• Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis.

  2008cited by this paper
• Bmi‐1 expression predicts prognosis for patients with gastric carcinoma

  2008cited by this paper
• Retracted: TW‐37, a small‐molecule inhibitor of Bcl‐2, inhibits cell growth and invasion in pancreatic cancer

  2008cited by this paper
• Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways.

  2007cited by this paper
• The Bcl-2 apoptotic switch in cancer development and therapy

  2007cited by this paper
• Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.

  2007cited by this paper
• Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells.

  2006cited by this paper
• Polycomb silencers control cell fate, development and cancer

  2006cited by this paper
• Dysregulated Expression of Stem Cell Factor Bmi1 in Precancerous Lesions of the Gastrointestinal Tract

  2006cited by this paper
• Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death

  2006cited by this paper
• BMI-1 is Highly Expressed in M0-Subtype Acute Myeloid Leukemia

  2005cited by this paper
• Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.

  2005cited by this paper
• Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors.

  2005cited by this paper
• Adenovirus-mediated Ink4a/ARF gene transfer significantly suppressed the growth of pancreatic carcinoma cells

  2005cited by this paper
• Current diagnosis and treatment of pancreatic cancer in China.

  2005cited by this paper
• Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer.

  2004cited by this paper
• The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins.

  2004cited by this paper
• Bmi1, stem cells, and senescence regulation.

  2004cited by this paper
• Polycomb Group Proteins in Cell Cycle Progression and Cancer

  2004cited by this paper
• Overexpression of G1-S Cyclins and Cyclin-Dependent Kinases during Multistage Human Pancreatic Duct Cell Carcinogenesis

  2004cited by this paper
• Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

  2003cited by this paper
• Pancreatic cancer mortality in China (1991-2000).

  2003cited by this paper
• Influence of p53 status on radiation and 5-flourouracil synergy in pancreatic cancer cells.

  2002cited by this paper
• Polycomb repression: from cellular memory to cellular proliferation and cancer.

  2002cited by this paper
• Pancreatic cancer biology and genetics

  2002cited by this paper
• Lymphomas Hematological Malignancies Occur Mainly in Mantle Cell Gene Amplification and Overexpression in BMI-1 Updated Version

  2001cited by this paper
• Bcl‐2 expression in pancreas development and pancreatic cancer progression

  2001cited by this paper
• Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

  1999cited by this paper
• Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus

  1999cited by this paper
• Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase.

  1999cited by this paper
• Both p16 and p21 Families of Cyclin-dependent Kinase (CDK) Inhibitors Block the Phosphorylation of Cyclin-dependent Kinases by the CDK-activating Kinase (*)

  1995cited by this paper
• Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.

  1991cited by this paper
• Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging.

  1991cited by this paper
• Cáncer

  1939cited by this paper

• UPSST: Unsupervised Pathology Domain Identification by Integrating Tissue Morphology, Imputing and Clustering of Spatial Transcriptomics With GAT

  2025cites this paper
• Epigenetic reprogramming in pancreatic premalignancy and clinical implications

  2023cites this paper
• Histone Modifications Represent a Key Epigenetic Feature of Epithelial-to-Mesenchyme Transition in Pancreatic Cancer

  2023influential citation
• Identification of proline-rich protein 11 as a major regulator in mouse spermatogonia maintenance via an increase in BMI1 protein stability

  2022cites this paper
• The Crucial Roles of Bmi-1 in Cancer: Implications in Pathogenesis, Metastasis, Drug Resistance, and Targeted Therapies

  2022cites this paper
• Evaluation of miR-330-3p and BMI1 Expression in Colorectal Cancer Patients, Healthy Adjacent Tissues, and Polypoid Adenomatous Lesions

  2022cites this paper
• SOX9 Triggers Different Epithelial to Mesenchymal Transition States to Promote Pancreatic Cancer Progression

  2022cites this paper
• Hyperglycemia Enhances Immunosuppression and Aerobic Glycolysis of Pancreatic Cancer Through Upregulating Bmi1-UPF1-HK2 Pathway

  2022cites this paper
• EPS8 supports pancreatic cancer growth by inhibiting BMI1 mediated proteasomal degradation of ALDH7A1.

  2021cites this paper
• Clinical Utility of Epigenetic Changes in Pancreatic Adenocarcinoma

  2021cites this paper
• The role of SOX family transcription factors in gastric cancer.

  2021cites this paper
• BMI-1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor

  2020cites this paper
• SOX9 promotes tumor progression through the axis BMI1-p21CIP

  2020cites this paper
• Prognostic Significance of ALDH1, Bmi1, and OCT4 Expression in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma

  2020cites this paper
• LncSNHG3/miR-139-5p/BMI1 axis regulates proliferation, migration, and invasion in hepatocellular carcinoma

  2019cites this paper
• A 6-gene risk score system constructed for predicting the clinical prognosis of pancreatic adenocarcinoma patients

  2019cites this paper
• Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer

  2019cites this paper
• Association between RNF2+P-AKT expression in pretreatment biopsy specimens, and poor survival following radiotherapy in patients with esophageal squamous cell carcinoma

  2019cites this paper
• Combination chemotherapy of valproic acid (VPA) and gemcitabine regulates STAT3/Bmi1 pathway to differentially potentiate the motility of pancreatic cancer cells

  2019cites this paper
• Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma

  2019cites this paper
• MicroRNA-203 Induces Apoptosis by Targeting Bmi-1 in YD-38 Oral Cancer Cells

  2018cites this paper
• Clinicopathological significance of Bmi-1 overexpression in esophageal cancer: a meta-analysis.

  2018cites this paper
• ShRNA‐mediated BMI‐1 gene silencing inhibits gastrointestinal stromal tumor cell telomerase activity and enhances apoptosis

  2018cites this paper
• The mechanism of BMI1 in regulating cancer stemness maintenance, metastasis, chemo- and radiation resistance

  2018cites this paper
• Circulating Bmi-1 mRNA as a diagnostic and prognostic biomarker for non-small cell lung cancer

  2017cites this paper
• MicroRNA-452 suppresses pancreatic cancer migration and invasion by directly targeting B-cell-specific Moloney murine leukemia virus insertion site 1.

  2017cites this paper
• COMMD7 functions as molecular target in pancreatic ductal adenocarcinoma

  2017cites this paper
• Evènements moléculaires spécifiques au cours des adénocarcinomes pulmonaires lépidiques humains et animaux

  2017cites this paper
• A Nanoparticle Carrier for Co-Delivery of Gemcitabine and Small Interfering RNA in Pancreatic Cancer Therapy.

  2016cites this paper
• Bmi1 combines with oncogenic KRAS to induce malignant transformation of human pancreatic duct cells in vitro

  2016cites this paper
• Polycomb complex protein BMI-1 promotes invasion and metastasis of pancreatic cancer stem cells by activating PI3K/AKT signaling, an ex vivo, in vitro, and in vivo study

  2016cites this paper
• Context-dependent actions of Polycomb repressors in cancer

  2016cites this paper
• Bmi-1 regulates stem cell-like properties of gastric cancer cells via modulating miRNAs

  2016cites this paper
• The relationship between the expression of USP22, BMI1, and EZH2 in hepatocellular carcinoma and their impacts on prognosis

  2016cites this paper
• NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia

  2016cites this paper
• miR‐376c inhibits cervical cancer cell proliferation and invasion by targeting BMI1

  2016cites this paper
• Radiosensitization of esophageal carcinoma cells by the silencing of BMI-1.

  2016cites this paper
• Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts

  2016cites this paper
• miR-203 inhibits cell growth and regulates G1/S transition by targeting Bmi-1 in myeloma cells.

  2016cites this paper
• Bmi 1 is required for the initiation of pancreatic cancer through an Ink 4 a-independent mechanism

  2015cites this paper
• Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism.

  2015cites this paper
• BMI-1, a promising therapeutic target for human cancer.

  2015cites this paper
• miR-15a inhibits cell proliferation and epithelial to mesenchymal transition in pancreatic ductal adenocarcinoma by down-regulating Bmi-1 expression.

  2014cites this paper
• ShRNA-mediated Bmi-1 silencing sensitizes multiple myeloma cells to bortezomib.

  2014cites this paper
• MicroRNA-183 is involved in cell proliferation, survival and poor prognosis in pancreatic ductal adenocarcinoma by regulating Bmi-1.

  2014cites this paper
• The role of maintenance proteins in the preservation of epithelial cell identity during mammary gland remodeling and breast cancer initiation

  2014cites this paper
• MicroRNA-135a Inhibits Cell Proliferation by Targeting Bmi1 in Pancreatic Ductal Adenocarcinoma

  2014cites this paper
• EZH2 Is Associated with Malignant Behavior in Pancreatic IPMN via p27Kip1 Downregulation

  2014cites this paper
• Expression patterns of microRNA-218 and its potential functions by targeting CIP2A and BMI1 genes in melanoma

  2014cites this paper
• miR-200b suppresses cell proliferation, migration and enhances chemosensitivity in prostate cancer by regulating Bmi-1.

  2014cites this paper
• Novel therapeutic targets for pancreatic cancer.

  2014cites this paper
• Computational analyses reveal a prognostic impact of TULP3 as a transcriptional master regulator in pancreatic ductal adenocarcinoma.

  2014cites this paper
• MicroRNA‐320a inhibits cell proliferation, migration and invasion by targeting BMI‐1 in nasopharyngeal carcinoma

  2014cites this paper
• Plasma Bmi1 mRNA as a potential prognostic biomarker for distant metastasis in colorectal cancer patients.

  2014cites this paper
• Prognostic role of high Bmi-1 expression in Asian and Caucasian patients with solid tumors: a meta-analysis.

  2014cites this paper
• Epigenetics and pancreatic cancer: pathophysiology and novel treatment aspects.

  2014cites this paper
• Bmi-1 regulates epithelial-to-mesenchymal transition to promote migration and invasion of breast cancer cells.

  2014cites this paper
• Title Plasma Bmil mRNA as a potential prognostic biomarker for distant metastasis in colorectal cancer patients

  2014cites this paper
• Plasma Bmi 1 mRNA as a potential prognostic biomarker for distant metastasis in colorectal cancer patients

  2014cites this paper
• Epigenetic Alterations in Pancreatic Cancer

  2013cites this paper
• Deciphering the Mechanisms of Tumorigenesis in Human Pancreatic Ductal Epithelial Cells

  2013cites this paper
• The roles of FOXM1 in pancreatic stem cells and carcinogenesis

  2013cites this paper
• Bmi1 Enhances Tumorigenicity and Cancer Stem Cell Function in Pancreatic Adenocarcinoma

  2013cites this paper
• Biomarkers for predicting future metastasis of human gastrointestinal tumors

  2013cites this paper
• The Components of Drosophila Histone Chaperone dCAF-1 Are Required for the Cell Death Phenotype Associated with rbf1 Mutation

  2013cites this paper
• HPV16 E7 Protein and hTERT Proteins Defective for Telomere Maintenance Cooperate to Immortalize Human Keratinocytes

  2013cites this paper
• Role of B lymphoma Mo-MLV insertion region 1 in the oncogenic behavior of retinoblastomas

  2013cites this paper
• Silencing Bmi-1 expression by RNA interference suppresses the growth of laryngeal carcinoma cells.

  2013cites this paper
• Knockdown BMI1 expression inhibits proliferation and invasion in human bladder cancer T24 cells

  2013cites this paper
• Development and Application of a Novel Method to Detect Mammalian Protein-protein Interactions

  2013cites this paper
• Combined aberrant expression of Bmi1 and EZH2 is predictive of poor prognosis in glioma patients.

  2013cites this paper
• Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)‑2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway.

  2013cites this paper
• Caveolin-1 is related to invasion, survival, and poor prognosis in hepatocellular cancer

  2012cites this paper
• Bmi-1 Promotes the Chemoresistance, Invasion and Tumorigenesis of Pancreatic Cancer Cells

  2012cites this paper
• The identification of cellular genes altered by hTERT and HPV-16 E6 in the immortalization of human keratinocytes

  2012cites this paper
• Neuroblastoma: Role of MYCN/Bmi1 Pathway in Neuroblastoma

  2012cites this paper
• The expression and oncogenic effects of the embryonic stem cell marker SALL4 in ALK-positive anaplastic large cell lymphoma.

  2012cites this paper
• Integration of DNA Copy Number Alterations and Transcriptional Expression Analysis in Human Gastric Cancer

  2012influential citation
• The clinicopathological significance of Bmi-1 expression in pathogenesis and progression of gastric carcinomas.

  2012influential citation
• Overexpression of BMI‐1 correlates with drug resistance in B‐cell lymphoma cells through the stabilization of survivin expression

  2012cites this paper
• Bmi-1 siRNA inhibited ovarian cancer cell line growth and decreased telomerase activity

  2012cites this paper
• Cancer Stem Cell Marker Bmi-1 Expression is Associated with Basal-like Phenotype and Poor Survival in Breast Cancer

  2012cites this paper
• Pancreatic cancer stem cells: regulatory networks in the tumor microenvironment and targeted therapy

  2012cites this paper
• Detection of circulating Bmi‐1 mRNA in plasma and its potential diagnostic and prognostic value for uterine cervical cancer

  2012cites this paper
• BMI1 promotes the progression of laryngeal squamous cell carcinoma.

  2011cites this paper
• BMI1 as a novel target for drug discovery in cancer

  2011cites this paper
• BMI 1 promotes the progression of laryngeal squamous cell carcinoma

  2011cites this paper
• Investigating the role of Bmi-1 in liver growth and function

  2011cites this paper
• Polycomb and the Emerging Epigenetics of Pancreatic Cancer

  2011cites this paper
• THE MECHANISM OF TUMORIGENESIS IN THE IMMORTALIZED HUMAN PANCREATIC CELL LINES: CELL CULTURE MODELS OF HUMAN PANCREATIC CANCER

  2011cites this paper
• Cancer Stem-Like Cells Enriched in Panc-1 Spheres Possess Increased Migration Ability and Resistance to Gemcitabine

  2011cites this paper
• Co-Expression of Host and Viral MicroRNAs in Porcine Dendritic Cells Infected by the Pseudorabies Virus

  2011cites this paper
• Can BMI-1 be a biomarker of poor prognosis?

  2010cites this paper
• Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells

  2010cites this paper