p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Cell

• Publication date

  2000-09-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0092-8674(00)00073-8PMID 11030628
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

  2000cited by this paper
• Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.

  2000cited by this paper
• A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

  2000cited by this paper
• A Role for the p38 Mitogen-activated Protein Kinase Pathway in the Transcriptional Activation of p53 on Genotoxic Stress by Chemotherapeutic Agents

  2000cited by this paper
• Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53.

  2000cited by this paper
• p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c‐independent apoptosis blocked by Bcl‐2

  1999cited by this paper
• Isolation and characterization of a novel TP53‐inducible gene, TP53TG3

  1999cited by this paper
• Phosphorylation of human p53 by p38 kinase coordinates N‐terminal phosphorylation and apoptosis in response to UV radiation

  1999cited by this paper
• Increased apoptosis induction by 121F mutant p53

  1999cited by this paper
• Identification of a Novel p53 Functional Domain That Is Necessary for Mediating Apoptosis*

  1998cited by this paper
• CSR, a scavenger receptor-like protein with a protective role against cellular damage causedby UV irradiation and oxidative stress.

  1998cited by this paper
• The complexity of p53 modulation: emerging patterns from divergent signals.

  1998cited by this paper
• The requirement for the p53 proline‐rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

  1998cited by this paper
• Characterization of Structural p53 Mutants Which Show Selective Defects in Apoptosis but Not Cell Cycle Arrest

  1998cited by this paper
• Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild‐type TP53 expression system

  1998cited by this paper
• Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53.

  1998cited by this paper
• Mitochondria and apoptosis.

  1998cited by this paper
• Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines.

  1998cited by this paper
• Signaling to p53: breaking the MDM2-p53 circuit.

  1998cited by this paper
• A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis

  1997cited by this paper
• A model for p53-induced apoptosis

  1997cited by this paper
• Cloning of P2XM, a novel human P2X receptor gene regulated by p53.

  1997cited by this paper
• The proto-oncogene Bcl-2 and its role in regulating apoptosis

  1997cited by this paper
• The proto-oncogene Bcl-2 and its role in regulating apoptosis

  1997cited by this paper
• DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2.

  1997cited by this paper
• Prediction of complete gene structures in human genomic DNA.

  1997cited by this paper
• DNA damage induces phosphorylation of the amino terminus of p53.

  1997cited by this paper
• Identification of a novel p53 functional domain that is necessary for efficient growth suppression.

  1996cited by this paper
• A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

  1996cited by this paper
• p53: puzzle and paradigm.

  1996cited by this paper
• Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis.

  1996cited by this paper
• Isolation of a novel GPI-anchored gene specifically regulated by p53; correlation between its expression and anti-cancer drug sensitivity.

  1996cited by this paper
• Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.

  1995cited by this paper
• Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

  1995cited by this paper
• Molecular events underlying schistosomiasis‐related bladder cancer

  1995cited by this paper
• Predicting internal exons by oligonucleotide composition and discriminant analysis of spliceable open reading frames.

  1994cited by this paper
• Relationship of p53 to the control of apoptotic cell death.

  1994cited by this paper
• p53 tagged sites from human genomic DNA.

  1994cited by this paper
• P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines.

  1993cited by this paper
• A knowledge base for predicting protein localization sites in eukaryotic cells

  1992cited by this paper
• p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features.

  1992cited by this paper
• Efficient selection for high-expression transfectants with a novel eukaryotic vector.

  1991cited by this paper
• Efficient selection for high-expression transfectants with a novel eukaryotic vector

  1991cited by this paper
• Suppression of human colorectal carcinoma cell growth by wild-type p53.

  1990cited by this paper
• Rapid and sensitive sequence comparison with FASTP and FASTA.

  1990cited by this paper
• Basic local alignment search tool.

  1990cited by this paper

• Pioneers: Glucose sensing and control of health-span and lifespan.

  2026cites this paper
• Pexophagy-driven redox imbalance promotes virus-induced ferroptosis.

  2025cites this paper
• Dissecting cross‐lineage tumourigenesis under p53 inactivation through single‐cell multi‐omics and spatial transcriptomics

  2025cites this paper
• The DNA-PKcs/JNK/p53 pathway underlies changes in cell fate decision toward death during DNA replication catastrophe

  2025cites this paper
• RCC1 knockdown sensitizes drug-resistant colorectal cancer to 5-fluorouracil or doxorubicin by impairing DNA repair

  2025cites this paper
• Renal transcriptome-wide analyses in association with kidney black carbon load

  2025cites this paper
• Biology and pharmacological inhibition of homeodomain-interacting protein kinases

  2025cites this paper
• SNCA inhibits breast cancer progression through TP53AIP1–p53-mediated mitochondrial apoptosis and suppression of cancer stemness

  2025cites this paper
• p53-inducible lncRNA LOC644656 causes genotoxic stress-induced stem cell maldifferentiation and cancer chemoresistance

  2025cites this paper
• The Long Non-Coding RNA NR3C2-8:1 Promotes p53-Mediated Apoptosis through the miR-129-5p/USP10 Axis in Amyotrophic Lateral Sclerosis

  2024cites this paper
• Multi-Omic Data Integration Suggests Putative Microbial Drivers of Aetiopathogenesis in Mycosis Fungoides

  2024cites this paper
• Determinants of p53 DNA binding, gene regulation, and cell fate decisions

  2024cites this paper
• TP53AIP1 induce autophagy via the AKT/mTOR signaling pathway in the breast cancer cells

  2024cites this paper
• Understanding the complexity of p53 in a new era of tumor suppression.

  2024cites this paper
• High iASPP (PPP1R13L) expression is an independent predictor of adverse clinical outcome in acute myeloid leukemia (AML)

  2024cites this paper
• PTMD 2.0: an updated database of disease-associated post-translational modifications

  2024cites this paper
• Temporal regulation of gene expression through integration of p53 dynamics and modifications

  2024cites this paper
• An intestinal Sir2-HSF1-ATGL1 pathway regulates lipolysis in C. elegans

  2024cites this paper
• Multiomic Data Integration Reveals Microbial Drivers of Aetiopathogenesis in Mycosis Fungoides

  2024cites this paper
• Mieap forms membrane-less organelles involved in cardiolipin metabolism

  2024cites this paper
• The Neem Limonoid Nimbolide Modulates Key Components of the DNA Damage Response Signalling in Cellular and Animal Models of Oral Squamous Cell Carcinoma.

  2024cites this paper
• Splicing DNA Damage Adaptations for the Management of Cancer Cells.

  2024cites this paper
• Exploring Candidate Gene Studies and Alexithymia: A Systematic Review

  2024cites this paper
• Navigating the complexity of p53-DNA binding: implications for cancer therapy

  2024cites this paper
• Oestradiol and osteoclast differentiation: Effects on p53 and mitochondrial metabolism

  2024cites this paper
• Magnetospirillum magneticum triggers apoptotic pathways in human breast cancer cells

  2023cites this paper
• Molecular Aspects of Hypoxic Stress Effects in Chronic Ethanol Exposure of Neuronal Cells

  2023cites this paper
• Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies

  2023cites this paper
• Identification of a mitochondrial targeting sequence in cathepsin D and its localization in mitochondria

  2023cites this paper
• Kinases control of Regulated Cell Death Revealing Druggable Targets for Parkinson's disease.

  2023cites this paper
• Mechanisms of UV-induced human lymphocyte apoptosis

  2023influential citation
• Phosphorylation and specific DNA improved the incorporation ability of p53 into functional condensates.

  2023cites this paper
• Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

  2023cites this paper
• Protein crotonylation: An emerging regulator in DNA damage response.

  2023cites this paper
• A molecular mechanism for the “digital” response of p53 to stress

  2023cites this paper
• Characteristic Mutational Damages in Gastric and Colorectal Adenocarcinomas

  2023cites this paper
• Expanding Roles of the E2F-RB-p53 Pathway in Tumor Suppression

  2023cites this paper
• Coordination of MAPK and p53 dynamics in the cellular responses to DNA damage and oxidative stress

  2022cites this paper
• A deuterohemin peptide protects cerebral ischemia-reperfusion injury by preventing oxidative stress in vitro and in vivo.

  2022cites this paper
• The role of p53 in liver fibrosis

  2022cites this paper
• Dynamic structures of intrinsically disordered proteins related to the general transcription factor TFIIH, nucleosomes, and histone chaperones

  2022cites this paper
• Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia

  2022cites this paper
• Running title: EEF1AKMT3/MAP2K7/TP53 axis in gastric cancerThe EEF1AKMT3/MAP2K7/TP53 axis suppresses tumor invasiveness and metastasis in gastric cancer.

  2022cites this paper
• Recent advances in the molecular basis of chemotherapy resistance and potential application of epigenetic therapeutics in chemorefractory renal cell carcinoma.

  2022cites this paper
• A new insight into cell biological and biochemical changes through aging.

  2022cites this paper
• Appraising the Phytochemical and Therapeutic Perspectives of Bryonia laciniosa: A Literature Metasynthesis.

  2022cites this paper
• Chimeric HDAC and the cytoskeleton inhibitor broxbam as a novel therapeutic strategy for liver cancer

  2022cites this paper
• HIPK2 in cancer biology and therapy: Recent findings and future perspectives.

  2022cites this paper
• On the intrinsic disorder status of the major players in programmed cell death pathways [version 1; peer review: 2 approved]

  2022cites this paper
• Regulation of HIF-1α and p53 in stress responses in the subterranean rodents Lasiopodomys mandarinus and Lasiopodomys brandtii (Rodentia: Cricetidae)

  2021cites this paper
• Tenacissoside G synergistically potentiates inhibitory effects of 5-fluorouracil to human colorectal cancer.

  2021cites this paper
• Indole-3-carbinol inhibits the proliferation of colorectal carcinoma LoVo cells through activation of the apoptotic signaling pathway

  2021cites this paper
• Germline mutations in apoptosis pathway genes in ovarian cancer; the functional role of a TP53I3 (PIG3) variant in ROS production and DNA repair

  2021cites this paper
• Role of FOXO protein's abnormal activation through PI3K/AKT pathway in platinum resistance of ovarian cancer

  2021cites this paper
• Cell Lysis Directed by SulA in Response to DNA Damage in Escherichia coli

  2021cites this paper
• Exogenous bacterial DnaK increases protein kinases activity in human cancer cell lines

  2021cites this paper
• DAZAP2 acts as specifier of the p53 response to DNA damage

  2021cites this paper
• Male obesity impacts DNA methylation reprogramming in sperm

  2021cites this paper
• Anti-aging mechanisms of melatonin and regulatory effects of melatonin in radiation-induced premature senescence

  2021cites this paper
• Temporal gene regulation by p53 is associated with the rotational setting of its binding sites in nucleosomes

  2021cites this paper
• The Combination of AHCC and ETAS Decreases Migration of Colorectal Cancer Cells, and Reduces the Expression of LGR5 and Notch1 Genes in Cancer Stem Cells: A Novel Potential Approach for Integrative Medicine

  2021cites this paper
• Protective Effect of 20(R)-Ginsenoside Rg3 Against Cisplatin-Induced Renal Toxicity via PI3K/AKT and NF-[Formula: see text]B Signaling Pathways Based on the Premise of Ensuring Anticancer Effect.

  2021cites this paper
• Comparative Analysis of the Antitumor Activity of Cis- and Trans-Resveratrol in Human Cancer Cells with Different p53 Status

  2021cites this paper
• EphB4 as a Novel Target for the EGFR-Independent Suppressive Effects of Osimertinib on Cell Cycle Progression in Non-Small Cell Lung Cancer

  2021cites this paper
• Cell Death and Survival Pathways Involving ATM Protein Kinase

  2021cites this paper
• Dying to Survive—The p53 Paradox

  2021cites this paper
• Role of Dietary Antioxidants in p53-Mediated Cancer Chemoprevention and Tumor Suppression

  2021influential citation
• The Program Cell Death (Apoptosis) and the Therapy of Cancer

  2021cites this paper
• Elucidation of dibenzo[a,l]pyrene and its metabolites as a mammary carcinogen: A comprehensive review

  2021cites this paper
• Pemetrexed Disodium Heptahydrate Induces Apoptosis and Cell-cycle Arrest in Non-small-cell Lung Cancer Carrying an EGFR Exon 19 Deletion

  2021cites this paper
• Encountering the Survival Strategies Using Various Nano Assemblages

  2021cites this paper
• The p53 status in rheumatoid arthritis with focus on fibroblast-like synoviocytes

  2021cites this paper
• Cisplatin Activates the Growth Inhibitory Signaling Pathways by Enhancing the Production of Reactive Oxygen Species in Non-small Cell Lung Cancer Carrying an EGFR Exon 19 Deletion.

  2021cites this paper
• Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies

  2021cites this paper
• MicroRNAs and the DNA damage response: How is cell fate determined?

  2021cites this paper
• Photoprotective Properties of Vitamin D and Lumisterol Hydroxyderivatives

  2020cites this paper
• Ubiquitin–proteasome system-targeted therapy for uveal melanoma: what is the evidence?

  2020cites this paper
• Oncogenic miRNAs and target therapies in colorectal cancer.

  2020cites this paper
• 6,8‐Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53

  2020cites this paper
• Caffeic acid phenethyl ester induces apoptosis in colorectal cancer cells via inhibition of survivin

  2020cites this paper
• A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding

  2020cites this paper
• Retraction Retracted: Apoptosis and Molecular Targeting Therapy in Cancer

  2020cites this paper
• Ubiquitin–proteasome system-targeted therapy for uveal melanoma: what is the evidence?

  2020cites this paper
• Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy

  2020cites this paper
• Crotonylation at serine 46 impairs p53 activity.

  2020cites this paper
• PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP.

  2020cites this paper
• Mitophagy and DNA Damage Signaling in Human Aging.

  2020cites this paper
• Induction of cell cycle arrest and apoptosis by tomentosin in hepatocellular carcinoma HepG2 and Huh7 cells

  2020cites this paper
• Arginine deimimase expressed in vivo activates the mitochondrial apoptosis pathway through inhibiting cytosolic ferritin and inducing chromotin autophagy

  2020cites this paper
• Modulation of p53 N-terminal transactivation domain 2 conformation ensemble and kinetics by phosphorylation

  2020cites this paper
• AMPK Activity Contributes to G2 Arrest and DNA Damage Decrease via p53/p21 Pathways in Oxidatively Damaged Mouse Zygotes

  2020cites this paper
• De Novo Deletion 17p (del17p) in an Adult T-Cell Prolymphocytic Leukemia as a Rare Presentation

  2019cites this paper
• Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions.

  2019cites this paper
• Overexpression of Tumor Protein p53-regulated Apoptosis-inducing Protein 1 Regulates Proliferation and Apoptosis of Breast Cancer Cells through the PI3K/Akt Pathway

  2019cites this paper
• Cell-type and stimulus-dependent activation of p53 pathway in response to cytotoxic chemotherapeutics

  2019cites this paper
• Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer

  2019cites this paper
• The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death

  2019cites this paper
• DNA Damage Stress: Cui Prodest?

  2019cites this paper
• Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment.

  2019cites this paper
• Near-Comprehensive Resequencing of Cancer-Associated Genes in Surgically Resected Metastatic Liver Tumors of Gastric Cancer.

  2019cites this paper