Coronary risk correlates with cerebral amyloid deposition.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Neurobiology of Aging

• Publication date

  2012-09-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.neurobiolaging.2011.10.002PMID 22078485PMCID PMC3371309
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cerebrovascular disease, β-amyloid, and cognition in aging.

  2012cited by this paper
• Linking lipids to Alzheimer's disease: cholesterol and beyond

  2011cited by this paper
• Linking lipids to Alzheimer's disease: cholesterol and beyond

  2011cited by this paper
• Contrast of the impact of multiple cardiovascular risk factors on the femoral and carotid intima-media thickness in asymptomatic young adults: the Bogalusa Heart Study.

  2011cited by this paper
• Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia.

  2011cited by this paper
• Comprehensive Evaluation of Coronary Artery Disease and Aortic Atherosclerosis in Acute Ischemic Stroke Patients: Usefulness Based on Framingham Risk Score and Stroke Subtype

  2011cited by this paper
• Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden.

  2010cited by this paper
• Contribution of vascular pathology to the clinical expression of dementia.

  2010cited by this paper
• Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease.

  2010cited by this paper
• Diabetes, related conditions, and dementia.

  2010influential reference
• Higher serum total cholesterol levels in late middle age are associated with glucose hypometabolism in brain regions affected by Alzheimer's disease and normal aging

  2010cited by this paper
• Linking cardiometabolic disorders to sporadic Alzheimer’s disease: a perspective on potential mechanisms and mediators

  2010influential reference
• The vascular contribution to Alzheimer's disease.

  2010influential reference
• Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of aging cohort

  2010cited by this paper
• Prevalence and Impact of Cerebrovascular Lesions in Alzheimer and Lewy Body Diseases

  2010influential reference
• Effects of Blood Pressure Changes on Alzheimer’s Disease

  2010cited by this paper
• Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later

  2009cited by this paper
• Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

  2009influential reference
• The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged.

  2009cited by this paper
• SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

  2009cited by this paper
• Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects.

  2009cited by this paper
• Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

  2009cited by this paper
• Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia

  2009cited by this paper
• Alzheimer's dementia by circulation disorders: when trees hide the forest

  2009cited by this paper
• Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP.

  2009cited by this paper
• The Nun Study.

  2008cited by this paper
• General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study

  2008cited by this paper
• Blood–brain barrier impairment in Alzheimer disease

  2007cited by this paper
• Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations?

  2007cited by this paper
• Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations?

  2007cited by this paper
• Imaging beta-amyloid burden in aging and dementia.

  2007cited by this paper
• Mixed brain pathologies account for most dementia cases in community-dwelling older persons

  2007cited by this paper
• Automated template-based PET region of interest analyses in the aging brain

  2007cited by this paper
• The Honolulu-Asia Aging Study

  2007cited by this paper
• Cerebral Ischemia and Alzheimer's Disease: The Expression of Amyloid-β and Apolipoprotein E in Human Hippocampus

  2007cited by this paper
• Circle of Willis atherosclerosis: association with Alzheimer’s disease, neuritic plaques and neurofibrillary tangles

  2006cited by this paper
• Cholesterol as a risk factor for Alzheimer's disease – epidemiological evidence

  2006cited by this paper
• Atherosclerosis and AD

  2005cited by this paper
• High total cholesterol levels in late life associated with a reduced risk of dementia

  2005cited by this paper
• Measures of brain morphology and infarction in the framingham heart study: establishing what is normal.

  2005cited by this paper
• Carotid Intima-Media Thickness, Plaques, and Framingham Risk Score as Independent Determinants of Stroke Risk

  2005cited by this paper
• Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B

  2005cited by this paper
• Midlife cardiovascular risk factors and risk of dementia in late life

  2005cited by this paper
• ALS and military service

  2005cited by this paper
• Aggregation of vascular risk factors and risk of incident Alzheimer disease

  2005cited by this paper
• Atherosclerosis and AD : Analysis of data from the US national Alzheimer's coordinating center. Author's reply

  2005cited by this paper
• Vascular factors in dementia: an overview.

  2004cited by this paper
• Convergence of atherosclerosis and alzheimer's disease: Cholesterol, inflammation, and misfolded proteins.

  2004cited by this paper
• Relation of plasma lipids to Alzheimer disease and vascular dementia.

  2004cited by this paper
• Meta-Analysis: Apolipoprotein E Genotypes and Risk for Coronary Heart Disease

  2004cited by this paper
• Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer’s Disease

  2003cited by this paper
• Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.

  2003cited by this paper
• Risk Factors for Progression of Atherosclerosis Measured at Multiple Sites in the Arterial Tree: The Rotterdam Study

  2003cited by this paper
• Low blood pressure and risk of dementia in the Kungsholmen project: a 6-year follow-up study.

  2003cited by this paper
• Apolipoprotein E 4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease

  2002cited by this paper
• Faculty Opinions recommendation of Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease.

  2002cited by this paper
• Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study.

  2002cited by this paper
• Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain

  2002cited by this paper
• Improved common carotid elasticity and intima-media thickness measurements from computer analysis of sequential ultrasound frames.

  2001cited by this paper
• The Role of Risk Factors in the Development of Atherosclerosis

  2001cited by this paper
• Accuracy of clinical criteria for AD in the Honolulu–Asia Aging Study, a population-based study

  2001cited by this paper
• Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales

  2001cited by this paper
• Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).

  2001cited by this paper
• Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS☆

  2000cited by this paper
• Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study.

  2000cited by this paper
• Midlife blood pressure and dementia: the Honolulu-Asia aging study.

  2000cited by this paper
• The Blood‐Brain Barrier and Cerebrovascular Pathology in Alzheimer's Disease

  1999influential reference
• Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study.

  1998cited by this paper
• Prediction of coronary heart disease using risk factor categories.

  1998cited by this paper
• Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the Cardiovascular Health Study.

  1998cited by this paper
• Brain Infarction and the Clinical Expression of Alzheimer Disease-Reply

  1997cited by this paper
• Brain infarction and the clinical expression of Alzheimer disease.

  1997cited by this paper
• Brain infarction and the clinical expression of Alzheimer disease.

  1997cited by this paper
• Brain infarction and the clinical expression of Alzheimer disease. The Nun Study.

  1997cited by this paper
• 15-year longitudinal study of blood pressure and dementia.

  1996cited by this paper
• Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data

  1996cited by this paper
• The association between midlife blood pressure levels and late-life cognitive function. The Honolulu-Asia Aging Study.

  1995cited by this paper
• Genetic basis of familial dyslipidemia and hypertension: 15-year results from Utah.

  1993cited by this paper
• The Clinical Dementia Rating (CDR)

  1993cited by this paper
• Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease.

  1990cited by this paper
• Apo E 2 phenotypes in type II diabetics with and without insulin therapy

  1988cited by this paper
• Autopsy Studies in Atherosclerosis

  1959cited by this paper
• Autopsy Studies in Atherosclerosis: III. Distribution and Severity of Atherosclerosis in the Presence of Obesity, Hypertension, Nephrosclerosis, and Rheumatic Heart Disease

  1959cited by this paper
• Autopsy Studies in Atherosclerosis: I. Distribution and Severity of Atherosclerosis in Patients Dying without Morphologic Evidence of Atherosclerotic Catastrophe

  1959cited by this paper

• Associations of early-onset coronary heart disease and genetic susceptibility with incident dementia and white matter hyperintensity: A prospective cohort study

  2025cites this paper
• Preoperative blood-brain barrier disruption increased risk of postoperative cognitive decline after coronary artery bypass grafting: a prospective cohort study

  2025cites this paper
• Associations of ischemic heart disease with brain glymphatic MRI indices and risk of Alzheimer's disease

  2025cites this paper
• Statin is associated with higher cortical thickness in early Alzheimer's disease.

  2025cites this paper
• Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospective observational study

  2025cites this paper
• The association of glucose metabolism measures and diabetes status with Alzheimer's disease biomarkers of amyloid and tau: a systematic review and meta-analysis.

  2024cites this paper
• The complex pathway between amyloid β and cognition: implications for therapy.

  2023cites this paper
• Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS‐HD study

  2023cites this paper
• Predicting positron emission tomography brain amyloid positivity using interpretable machine learning models with wearable sensor data and lifestyle factors

  2023cites this paper
• Association Between Onset Age of Coronary Heart Disease and Incident Dementia: A Prospective Cohort Study

  2023cites this paper
• Cognitive impairment and outcomes in older adults with non-ST-elevation acute coronary syndrome

  2023cites this paper
• Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study

  2022cites this paper
• Long-term low-dose acetylsalicylic use shows protective potential for the development of both vascular dementia and Alzheimer’s disease in patients with coronary heart disease but not in other individuals from the general population: results from two large cohort studies

  2022cites this paper
• Quadratic relationship between systolic blood pressure and white matter lesions in individuals with hypertension

  2022cites this paper
• Long-term low-dose acetylsalicylic use shows protective potential for the development of both vascular dementia and Alzheimer’s disease in patients with coronary heart disease but not in other individuals from the general population: results from two large cohort studies

  2021cites this paper
• Tau Pathologies Mediate the Associations of Vascular Risk Burden with Cognitive Impairments in Non-demented Elders: The CABLE Study

  2021cites this paper
• Prevalence and Family-Related Factors Associated With Suicidal Ideation, Suicide Attempts, and Self-injury in Children Aged 9 to 10 Years.

  2020cites this paper
• Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life Evidence From a British Birth Cohort

  2020cites this paper
• Pancreatic Angiopathy Associated With Islet Amyloid and Type 2 Diabetes Mellitus

  2020cites this paper
• Association of Low Systolic Blood Pressure with Postmortem Amyloid-β and Tau

  2020cites this paper
• Association of Vascular Risk Factors With β-Amyloid Peptide and Tau Burdens in Cognitively Unimpaired Individuals and Its Interaction With Vascular Medication Use

  2020cites this paper
• Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life

  2019cites this paper
• Genetic risk for coronary heart disease alters the influence of Alzheimer's genetic risk on mild cognitive impairment.

  2019cites this paper
• The influence of life course vascular risk on brain pathologies and cognition in later life - a neuroimaging study of the British 1946 birth cohort

  2019cites this paper
• Risk factors for development of neurocognitive disorders

  2019influential citation
• Cognitive Decline Before and After Incident Coronary Events.

  2019cites this paper
• Title: Genetic risk for coronary heart disease alters the influence of Alzheimer’s genetic risk on mild cognitive impairment Running Title: Polygenic risk score interaction effects on MCI

  2019cites this paper
• Modifiable cardiovascular risk and cognitive function: findings from the Maine Syracuse Longitudinal Study

  2019cites this paper
• Midlife Atherosclerosis and Development of Alzheimer or Vascular Dementia

  2019cites this paper
• Low-Density Lipoprotein Particle Size Subfractions and Cerebral Amyloidosis

  2019cites this paper
• Mid‐life and late‐life vascular risk factor burden and neuropathology in old age

  2019cites this paper
• Vascular Burden Score Impacts Cognition Independent of Amyloid PET and MRI Measures of Alzheimer’s Disease and Vascular Brain Injury

  2019cites this paper
• The Dose-Dependent Effects of Vascular Risk Factors on Dynamic Compensatory Neural Processes in Mild Cognitive Impairment

  2018cites this paper
• Genetic risk for coronary heart disease alters the influence of Alzheimer’s genetic risk on mild cognitive impairment

  2018cites this paper
• Age-related hearing loss and neurocognitive function: Normal and pathological processes in cognitive ageing

  2018cites this paper
• Do Cardiometabolic Risk Factors Influence Amyloid, Tau, and Neuronal Function in APOE4 Carriers and Non-Carriers in Alzheimer’s Disease Trajectory?

  2018cites this paper
• Reply: Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance.

  2017cites this paper
• Associations between amyloid β and white matter hyperintensities: A systematic review

  2017cites this paper
• Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance: The Young Finns Study.

  2017cites this paper
• Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition

  2017cites this paper
• Modeling the Relationships Among Late-Life Body Mass Index, Cerebrovascular Disease, and Alzheimer’s Disease Neuropathology in an Autopsy Sample of 1,421 Subjects from the National Alzheimer’s Coordinating Center Data Set

  2017cites this paper
• Cerebral Amyloid Burden and Hoehn and Yahr Stage 3 Scoring in Parkinson Disease

  2017cites this paper
• Clinical Tools to Detect and Predict Individuals at Risk of Alzheimer’s

  2016cites this paper
• Impact of lifestyle dimensions on brain pathology and cognition.

  2016cites this paper
• The association between pulse pressure change and cognition in late life: Age and where you start matters

  2016cites this paper
• Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition

  2016cites this paper
• Association Between Serum Triglycerides and Cerebral Amyloidosis in Cognitively Normal Elderly.

  2016cites this paper
• The effect of vascular risk factors in dementia of the Alzheimer's type

  2016cites this paper
• Normal Aging of the Brain

  2015cites this paper
• Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy‐confirmed Alzheimer's disease

  2015cites this paper
• Clinical and imaging features of mixed Alzheimer and vascular pathologies

  2015cites this paper
• White matter lesion load is associated with resting state functional MRI activity and amyloid pet but not FDG in mild cognitive impairment and early alzheimer's disease patients

  2015cites this paper
• Impaired Aβ clearance: a potential link between atherosclerosis and Alzheimer’s disease

  2015cites this paper
• Statins and brain integrity in older adults: Secondary analysis of the Health ABC study

  2015cites this paper
• Imaging Vascular Disease and Amyloid in the Aging Brain: Implications for Treatment.

  2015cites this paper
• A major role for cardiovascular burden in age-related cognitive decline

  2015cites this paper
• The link between cardiovascular risk, Alzheimer's disease, and mild cognitive impairment: support from recent functional neuroimaging studies.

  2014cites this paper
• Abnormal levels of brain metabolites may mediate cognitive impairment in stroke-free patients with cerebrovascular risk factors.

  2014cites this paper
• Hypertension and Inflammation in Alzheimer's Disease: Close Partners in Disease Development and Progression!

  2014cites this paper
• Vascular risk and Aβ interact to reduce cortical thickness in AD vulnerable brain regions

  2014cites this paper
• Associations between serum cholesterol levels and cerebral amyloidosis.

  2014cites this paper
• Early Adult to Midlife Cardiovascular Risk Factors and Cognitive Function

  2014cites this paper
• Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment.

  2014cites this paper
• Coronary artery disease and plasma apolipoprotein E4 in mild cognitive impairment

  2014cites this paper
• Advances in MRI biomarkers for the diagnosis of Alzheimer's disease.

  2014cites this paper
• Interactive effects of vascular risk burden and advanced age on cerebral blood flow

  2014cites this paper
• White Matter Hyperintensities as Early and Independent Predictors of Alzheimer's Disease Risk

  2014cites this paper
• The relationship between regional brain volumes and the extent of coronary artery disease in mild cognitive impairment

  2014cites this paper
• Cortical thickness mediates the effect of β-amyloid on episodic memory

  2014cites this paper
• Risk Factors for -Amyloid Deposition in Healthy Aging Vascular and Genetic Effects

  2013influential citation
• The aging brain and cognition: contribution of vascular injury and aβ to mild cognitive dysfunction.

  2013cites this paper
• Vascular Risk and FDDNP-PET Influence Cognitive Performance

  2013cites this paper
• Associations between White Matter Hyperintensities and β Amyloid on Integrity of Projection, Association, and Limbic Fiber Tracts Measured with Diffusion Tensor MRI

  2013cites this paper
• The Women's Healthy Ageing Project: Fertile ground for investigation of healthy participants ‘at risk’ for dementia

  2013influential citation
• Longitudinal Effects of Cognitive Reserve and Vascular Risks in Aging and Dementia By Yen Yu Lo A dissertation submitted in partial satisfaction of the Requirements for the degree of Doctor of Philosophy

  2012cites this paper
• Vascular burden and Alzheimer disease pathologic progression

  2012cites this paper
• Longitudinal Effects of Cognitive Reserve and Vascular Risks in Aging and Dementia

  2012cites this paper
• Cerebrovascular disease, β-amyloid, and cognition in aging.

  2012cites this paper
• Associations Among Vascular Risk Factors, Carotid Atherosclerosis, and Cortical Volume and Thickness in Older Adults

  2012cites this paper
• Alzheimer’s Disease and Habitual Exercise: Relationship Mediated and Fostered by Vascular Risk Profiles?

  2012cites this paper
• Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance The Finns

  year unknowncites this paper