Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Lancet. Infectious Diseases (Print)

• Publication date

  2017-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S1473-3099(17)30104-4PMID 28216244PMCID PMC6803168
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Protection against Plasmodium falciparum malaria by PfSPZ Vaccine.

  2017cited by this paper
• Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming

  2016cited by this paper
• Protection against malaria at 1 year and immune correlates following PfSPZ vaccination

  2016cited by this paper
• Combining one‐sample confidence procedures for inference in the two‐sample case

  2015cited by this paper
• Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines

  2015cited by this paper
• The march toward malaria vaccines.

  2015cited by this paper
• Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults

  2015cited by this paper
• The March Toward Malaria Vaccines.

  2015cited by this paper
• Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine

  2013cited by this paper
• Comparative cost models of a liquid nitrogen vapor phase (LNVP) cold chain-distributed cryopreserved malaria vaccine vs. a conventional vaccine.

  2013cited by this paper
• Protective CD8+ T lymphocytes in Primates Immunized with Malaria Sporozoites

  2012cited by this paper
• Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity

  2011cited by this paper
• Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria

  2010cited by this paper
• Exact and Asymptotic Weighted Logrank Tests for Interval Censored Data: The interval R package.

  2010cited by this paper
• Protection against a malaria challenge by sporozoite inoculation.

  2009cited by this paper
• Evaluation of RTS,S/AS02A and RTS,S/AS01B in Adults in a High Malaria Transmission Area

  2009cited by this paper
• Five year safety and immunogenicity of GlaxoSmithKline's candidate malaria vaccine RTS,S/AS02 following administration to semi-immune adult men living in a malaria-endemic region of The Gambia

  2009cited by this paper
• Chronic parasite infections cause immune changes that could affect successful vaccination.

  2008cited by this paper
• Shaping and reshaping CD8+ T-cell memory

  2008cited by this paper
• Year-to-year variation in the age-specific incidence of clinical malaria in two potential vaccine testing sites in Mali with different levels of malaria transmission intensity.

  2007cited by this paper
• World malaria report

  2005cited by this paper
• Community permission for medical research in developing countries.

  2005cited by this paper
• Does malaria suffer from lack of memory?

  2004cited by this paper
• Vaccines: Effector and memory T-cell differentiation: implications for vaccine development

  2002cited by this paper
• Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites.

  2002cited by this paper
• Effect of deworming on human T cell responses to mycobacterial antigens in helminth‐exposed individuals before and after bacille Calmette–Guérin (BCG) vaccination

  2001cited by this paper
• Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial.

  2001cited by this paper
• γ Interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites

  1987cited by this paper
• Use of attenuated sporozoites in the immunization of human volunteers against falciparum malaria.

  1979cited by this paper
• Immunization of man against sporozite-induced falciparum malaria

  1973cited by this paper

• The endemic dilemma: why whole sporozoite malaria vaccine efficacy falls in the field.

  2026cites this paper
• mRNA vaccination overcomes haemozoin-mediated impairment of whole-parasite malaria vaccines in mice.

  2026cites this paper
• A review of the genotoxic effects of antiparasitic drugs on parasites and their hosts.

  2025cites this paper
• Protective targets of PfSPZ vaccines identified from whole-genome sieve analysis of isolates from malaria vaccine efficacy trials in West Africa

  2025cites this paper
• Assessment of Health Status and Creation of a Registry of Potential Research Participants Aged 1.5 to 50 Years on Bioko Island, Equatorial Guinea

  2025cites this paper
• T follicular helper cell development during malaria.

  2025cites this paper
• Effectiveness of interventions to improve vaccine efficacy: a systematic review and meta-analysis

  2025cites this paper
• Safety, tolerability, and protective efficacy of a radiation-attenuated, whole sporozoite malaria vaccine in children in Gabon: a randomised, double-blind, placebo-controlled, phase 2 trial.

  2025cites this paper
• A Plasmodium LARC GAP provides preerythrocytic, stage and species transcending protection in mice

  2025cites this paper
• Complete attenuation of Plasmodium falciparum sporozoites by atovaquone–proguanil

  2025cites this paper
• Successful insertion and expression of a tetracycline transactivator in Anopheles stephensi associated with increased egg production and decreased hatching rate

  2025cites this paper
• Exposing the hidden: establishing immunity to Plasmodium liver stage infection.

  2025cites this paper
• First efficacy evidence for a multistage malaria vaccine targeting infection and transmission.

  2025cites this paper
• mRNA delivery of circumsporozoite protein epitope-based malaria vaccines induces protection in a mouse model

  2025cites this paper
• Successful insertion and expression of a tetracycline transactivator in Anopheles stephensi associated with increased egg production and decreased hatching rate

  2025cites this paper
• Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination.

  2025cites this paper
• mRNA vaccination overcomes hemozoin-mediated impairment of whole parasite vaccine efficacy for malaria

  2025cites this paper
• Efficacy of ProC6C-AlOH/Matrix-M against Plasmodium falciparum infection and mosquito transmission: a phase 2, randomised, controlled human malaria infection study.

  2025cites this paper
• IgM, IgG, and IgG Subclass Antibody Responses to Plasmodium falciparum Proteins in Naïve, Malaria-Vaccinated and Semi-Immune Volunteers after Controlled Human Malaria Infection

  2025cites this paper
• Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection

  2025cites this paper
• Safety and protective efficacy of PfSPZ Vaccine administered to HIV-negative and -positive Tanzanian adults

  2024cites this paper
• Cross-reactivity of rPvs48/45, a recombinant Plasmodium vivax protein, with sera from Plasmodium falciparum endemic areas of Africa

  2024cites this paper
• Protective efficacy and safety of radiation-attenuated and chemo-attenuated Plasmodium Falciparum sporozoite vaccines against controlled and natural malaria infection: a systematic review and meta-analysis of randomized controlled trials

  2024influential citation
• A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion

  2024cites this paper
• The effect of intensive praziquantel administration on vaccine-specific responses among schoolchildren in Ugandan schistosomiasis-endemic islands (POPVAC A): an open-label, randomised controlled trial

  2024cites this paper
• Malaria vaccine efficacy, safety, and community perception in Africa: a scoping review of recent empirical studies

  2024cites this paper
• Advances and Challenges for the Malaria Vaccine: A Review

  2024cites this paper
• PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adults

  2024cites this paper
• Safety and efficacy of PfSPZ Vaccine against malaria in healthy adults and women anticipating pregnancy in Mali: two randomised, double-blind, placebo-controlled, phase 1 and 2 trials.

  2024cites this paper
• B cells targeting parasites capture spatially linked antigens to secure T cell help

  2024cites this paper
• A systematic review on malaria and Tuberculosis (TB) vaccine challenges in sub-Saharan African clinical trials

  2024cites this paper
• Malaria vaccines: a new era of prevention and control

  2024cites this paper
• Previous Malaria Exposures and Immune Dysregulation: Developing Strategies To Improve Malaria Vaccine Efficacy in Young Children.

  2024cites this paper
• Ultra-low volume intradermal administration of radiation-attenuated sporozoites with the glycolipid adjuvant 7DW8-5 completely protects mice against malaria

  2024cites this paper
• A Micronemal Protein, Scot1, Is Essential for Apicoplast Biogenesis and Liver Stage Development in Plasmodium berghei.

  2024cites this paper
• Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine

  2024cites this paper
• Vaccines and monoclonal antibodies: new tools for malaria control

  2024cites this paper
• Biotechnological potential of actinomycetes in the 21st century: a brief review

  2024cites this paper
• Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2

  2024cites this paper
• Genotypic analysis of RTS,S/AS01E malaria vaccine efficacy against parasite infection as a function of dosage regimen and baseline malaria infection status in children aged 5–17 months in Ghana and Kenya: a longitudinal phase 2b randomised controlled trial

  2024cites this paper
• A conserved Plasmodium nuclear protein is critical for late liver stage development

  2024cites this paper
• Safety and Efficacy of Immunization with a Late-Liver-Stage Attenuated Malaria Parasite.

  2024cites this paper
• Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected

  2024cites this paper
• A Plasmodium late liver stage arresting GAP provides superior protection in mice

  2024cites this paper
• Whole-sporozoite malaria vaccines: where we are, where we are going

  2024cites this paper
• Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2 in mice

  2024cites this paper
• Malaria in Pregnancy, Current Challenges, and Emerging Prevention Strategies in a Warming Climate.

  2024cites this paper
• R21/Matrix-M™ malaria vaccine: a new tool to achieve WHO’s goal to eliminate malaria in 30 countries by 2030?

  2023cites this paper
• A CAF01-adjuvanted whole asexual blood-stage liposomal malaria vaccine induces a CD4+ T-cell-dependent strain-transcending protective immunity in rodent models

  2023cites this paper
• Chemically augmented malaria sporozoites display an altered immunogenic profile

  2023cites this paper
• Ultra-low volume intradermal administration of radiation-attenuated sporozoites with the glycolipid adjuvant 7DW8-5 completely protects mice against malaria

  2023cites this paper
• Baseline malaria infection status and RTS,S/AS01E malaria vaccine efficacy

  2023cites this paper
• A review of criteria strictness in "Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials".

  2023cites this paper
• Immunological factors linked to geographical variation in vaccine responses

  2023influential citation
• Sporozoite immunization: innovative translational science to support the fight against malaria

  2023influential citation
• Safety and Immunogenicity of Radiation-Attenuated PfSPZ Vaccine in Equatoguinean Infants, Children, and Adults

  2023cites this paper
• mRNA vaccines: a new opportunity for malaria, tuberculosis and HIV

  2023cites this paper
• Malaria vaccines: the 60-year journey of hope and final success—lessons learned and future prospects

  2023cites this paper
• IL-10-producing Th1 cells possess a distinct molecular signature in malaria

  2023cites this paper
• Malaria Genomics, Vaccine Development, and Microbiome

  2023cites this paper
• Malaria Vaccines: From the Past towards the mRNA Vaccine Era

  2023cites this paper
• Immunogenicity, Efficacy, and Safety of a Novel Synthetic Microparticle Pre-Erythrocytic Malaria Vaccine in Multiple Host Species

  2023cites this paper
• Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine

  2023cites this paper
• Malaria in pregnancy: adverse pregnancy outcomes and the future of prevention

  2023cites this paper
• Malaria Vaccines: Progress to Date

  2023influential citation
• Germinal center activity and B cell maturation are associated with protective antibody responses against Plasmodium pre-erythrocytic infection

  2022cites this paper
• Controlled Human Infection Models To Accelerate Vaccine Development

  2022cites this paper
• Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy

  2022cites this paper
• PfSPZ-CVac malaria vaccine demonstrates safety among malaria-experienced adults: A randomized, controlled phase 1 trial

  2022cites this paper
• Aging and Microbiome in the Modulation of Vaccine Efficacy

  2022cites this paper
• Misconceptions Related to COVID 19 Vaccines Among the Jordanian Population: Myth and Public Health

  2022cites this paper
• Norovirus-VLPs expressing pre-erythrocytic malaria antigens induce functional immunity against sporozoite infection.

  2022cites this paper
• Plasmodium falciparum 7G8 challenge provides conservative prediction of efficacy of PfNF54-based PfSPZ Vaccine in Africa

  2022cites this paper
• Mosquirix™ RTS, S/AS01 Vaccine Development, Immunogenicity, and Efficacy

  2022cites this paper
• Recent malaria does not substantially impact COVID-19 antibody response or rates of symptomatic illness in communities with high malaria and COVID-19 transmission in Mali, West Africa

  2022cites this paper
• Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria

  2022cites this paper
• Controlled Human Malaria Infection Studies in Africa—Past, Present, and Future

  2022influential citation
• Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model

  2022cites this paper
• A conserved Plasmodium protein that localizes to liver stage nuclei is critical for late liver stage development

  2022cites this paper
• Cryopreserved Sporozoites with and without the Glycolipid Adjuvant 7DW8-5 Protect in Prime-and-Trap Malaria Vaccination.

  2022cites this paper
• A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum

  2022cites this paper
• RTS,S: the first malaria vaccine

  2022cites this paper
• A randomized controlled trial showing safety and efficacy of a whole sporozoite vaccine against endemic malaria

  2022cites this paper
• Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver

  2022cites this paper
• Current approaches to malaria vaccines.

  2022cites this paper
• In vitro production of infectious Plasmodium falciparum sporozoites

  2022cites this paper
• Towards identification and development of alternative vaccines against pregnancy-associated malaria based on naturally acquired immunity

  2022cites this paper
• Chemically Enhanced Immunogenicity of Bacteria by Supramolecular Functionalization with an Adjuvant

  2022cites this paper
• Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy

  2022cites this paper
• The impact of Loa loa microfilaraemia on research subject retention during a whole sporozoite malaria vaccine trial in Equatorial Guinea

  2022cites this paper
• Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge

  2022cites this paper
• Malaria vaccine approaches leveraging technologies optimized in the COVID-19 era

  2022cites this paper
• Immunoprofiling Identifies Functional B and T Cell Subsets Induced by an Attenuated Whole Parasite Malaria Vaccine as Correlates of Sterile Immunity

  2022cites this paper
• Multi-Dose Priming Regimens of PfSPZ Vaccine: Safety and Efficacy against Controlled Human Malaria Infection in Equatoguinean Adults

  2022cites this paper
• Five decades of clinical assessment of whole-sporozoite malaria vaccines

  2022cites this paper
• Longitudinal immune profiling after radiation-attenuated sporozoite vaccination reveals coordinated immune processes correlated with malaria protection

  2022cites this paper
• Efficient infection of non-human primates with purified, cryopreserved Plasmodium knowlesi sporozoites

  2022cites this paper
• Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model

  2022cites this paper
• A PfSPZ vaccine immunization regimen equally protective against homologous and heterologous controlled human malaria infection

  2022cites this paper
• Immunological profiles associated with distinct parasitemic states in volunteers undergoing malaria challenge in Gabon

  2022cites this paper