The cdc2‐related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  EMBO Journal

• Publication date

  1993-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/j.1460-2075.1993.tb05981.xPMID 8393783PMCID PMC413578
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin‐dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

  1993cited by this paper
• Phosphorylation independent activation of human cyclin-dependent kinase 2 by cyclin A in vitro.

  1993cited by this paper
• Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.

  1993cited by this paper
• Control of the yeast cell cycle by the Cdc28 protein kinase.

  1993cited by this paper
• Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.

  1992cited by this paper
• Animal cell cycles and their control.

  1992cited by this paper
• p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15.

  1992cited by this paper
• Role of phosphorylation in p34cdc2 activation: identification of an activating kinase.

  1992cited by this paper
• Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.

  1992cited by this paper
• Isolation and characterization of goldfish cdk2, a cognate variant of the cell cycle regulator cdc2.

  1992cited by this paper
• Activation of human cyclin-dependent kinases in vitro.

  1992cited by this paper
• Cell cycle regulation of vertebrate p34cdc2 activity: identification of Thr161 as an essential in vivo phosphorylation site.

  1992cited by this paper
• A dominant negative allele of p34cdc2 shows altered phosphoamino acid content and sequesters p56cdc13 cyclin

  1992cited by this paper
• Sister chromatid separation in frog egg extracts requires DNA topoisomerase II activity during anaphase

  1992cited by this paper
• Association of human cyclin E with a periodic G1-S phase protein kinase.

  1992cited by this paper
• Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits.

  1992cited by this paper
• Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

  1992cited by this paper
• A family of human cdc2‐related protein kinases.

  1992cited by this paper
• Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.

  1992cited by this paper
• cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2.

  1992cited by this paper
• Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

  1992cited by this paper
• Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.

  1992cited by this paper
• Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

  1991cited by this paper
• Cyclin A and the retinoblastoma gene product complex with a common transcription factor

  1991cited by this paper
• Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

  1991cited by this paper
• Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase

  1991cited by this paper
• Cyclins and their partners during Xenopus oocyte maturation.

  1991cited by this paper
• Population explosion in the cyclin family.

  1991cited by this paper
• Purification of his-tagged proteins in non-denaturing conditions suggests a convenient method for protein interaction studies.

  1991cited by this paper
• Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2.

  1991cited by this paper
• cDNA cloning of a novel cdc2+/CDC28‐related protein kinase from rice

  1991cited by this paper
• Cloning and characterization of Xenopus cdc2, a component of MPF.

  1991cited by this paper
• Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

  1991cited by this paper
• cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2.

  1991cited by this paper
• Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation.

  1991cited by this paper
• Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.

  1991cited by this paper
• cdc2 phosphorylation is required for its interaction with cyclin.

  1991cited by this paper
• A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.

  1991cited by this paper
• The cdc25 protein contains an intrinsic phosphatase activity.

  1991cited by this paper
• Determination of phosphoamino acid composition by acid hydrolysis of protein blotted to Immobilon.

  1991cited by this paper
• Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.

  1991cited by this paper
• p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast.

  1991cited by this paper
• Cyclin is a component of maturation-promoting factor from Xenopus.

  1990cited by this paper
• p40MO15, a cdc2‐related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes.

  1990cited by this paper
• The A‐ and B‐type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2‐M transition.

  1990cited by this paper
• Cyclin activation of p34cdc2.

  1990cited by this paper
• Universal control mechanism regulating onset of M-phase

  1990cited by this paper
• MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B.

  1989cited by this paper
• Activation of human CDC2 protein as a histone H1 kinase is associated with complex formation with the p62 subunit.

  1989cited by this paper
• Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2.

  1989cited by this paper
• Biochemical characterization of the p34cdc2 protein kinase component of purified maturation-promoting factor from Xenopus eggs.

  1989cited by this paper
• The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

  1988cited by this paper
• Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+.

  1988cited by this paper
• The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis.

  1988cited by this paper
• Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

  1987cited by this paper
• Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog.

  1987cited by this paper
• Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe

  1986cited by this paper
• KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28.

  1986cited by this paper

• Cyclin-dependent protein kinases and cell cycle regulation in biology and disease

  2025cites this paper
• Structural basis of Cdk7 activation by dual T-loop phosphorylation

  2024cites this paper
• Structural basis of Cdk7 activation by dual T-loop phosphorylation

  2024cites this paper
• CDC6 as a Key Inhibitory Regulator of CDK1 Activation Dynamics and the Timing of Mitotic Entry and Progression

  2023cites this paper
• Two target gene activation pathways for orphan ERR nuclear receptors

  2023cites this paper
• Structural polymorphism of the PH domain in TFIIH

  2023cites this paper
• Unveiling the noncanonical activation mechanism of CDKs: insights from recent structural studies

  2023cites this paper
• A ROS-dependent mechanism to drive progression through S phase

  2022cites this paper
• Functional characterization of the human Cdk10/Cyclin Q complex

  2022cites this paper
• A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase

  2022cites this paper
• Dynamic structures of intrinsically disordered proteins related to the general transcription factor TFIIH, nucleosomes, and histone chaperones

  2022cites this paper
• Cell cycle-dependent binding between Cyclin B1 and Cdk1 revealed by time-resolved fluorescence correlation spectroscopy

  2022cites this paper
• Cell Cycle Proteins as Key Regulators of Postmitotic Cell Death

  2019cites this paper
• Biochemical characterization of mammalian Cdk2-Speedy/Ringo

  2018cites this paper
• MAT1 correlates with molecular subtypes and predicts poor survival in breast cancer.

  2018cites this paper
• Analyzing the G 2 / M Checkpoint 51 51

  2017influential citation
• The Malaria Parasite Cyclin H Homolog PfCyc1 Is Required for Efficient Cytokinesis in Blood-Stage Plasmodium falciparum

  2017influential citation
• Derivation of the human cell cycle transcriptional signature

  2017cites this paper
• Nucleotide Excision Repair and Transcriptional Regulation: TFIIH and Beyond.

  2016cites this paper
• Regulation of the Embryonic Cell Cycle During Mammalian Preimplantation Development.

  2016cites this paper
• Symbiont Dependent Host Reproduction In The Marine Bryozoan, Bugula neritina

  2016cites this paper
• Neuronal cell cycle: the neuron itself and its circumstances

  2015cites this paper
• Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors

  2015cites this paper
• Role of cell cycle regulatory molecules in retinoic acid‐ and vitamin D3‐induced differentiation of acute myeloid leukaemia cells

  2014cites this paper
• The Role of a Cyclin D2 Splice Variant in the Regulation of the Cell Cycle: Connecting Cell Cycle to Cancer Biology

  2014cites this paper
• The G 2 / M DNA damage checkpoint inhibits mitosis through Tyr 15 phosphorylation of p 34 cdc 2 in Aspergillus nidulans

  2013cites this paper
• Dual phosphorylation of the T-loop in cdk 7 : its role in controlling cyclin H binding and CAK activity with two further subunits to form CAK ( cdk-activating

  2013cites this paper
• cerevisiae.for start in Saccharomyces not required for exit from mitosis but may be Dephosphorylation of threonine 169 of Cdc28 is

  2013cites this paper
• Characterization of the Plasmodium falciparum replication licensing factor

  2012cites this paper
• The interplay between MYCN and the DNA damage response : modulation of MYCN expression, its interactions with components of the DNA damage response and cellular responses to N-myc following genotoxic stress

  2012cites this paper
• TFIIH: when transcription met DNA repair

  2012cites this paper
• Expression of Spy1 protein in human Non-Hodgkin’s Lymphomas is correlated with phosphorylation of p27Kip1 on Thr187 and cell proliferation

  2012cites this paper
• Cyclins and cell cycle control in cancer and disease.

  2012cites this paper
• CDK7 and CCNH Are Components of CDK-Activating Kinase and Are Required for Meiotic Progression of Pig Oocytes1

  2011cites this paper
• Implication de la voie ERK3/4-MK5 dans la phase G2/M du cycle cellulaire

  2011cites this paper
• Established and novel Cdk/cyclin complexes regulating the cell cycle and development.

  2011cites this paper
• Role of Protein Kinase C-iota in Neuroblastoma and the Effect of ICA-1, a Novel Protein Kinase C-iota Inhibitor on the Proliferation and Apoptosis of Neuroblastoma Cells

  2011cites this paper
• Promotion of apoptosis in cancer cells by selective purine-derived pharmacological CDK inhibitors: one outcome, many mechanisms.

  2011cites this paper
• Regulatory pathways coordinating cell cycle progression in early Xenopus development.

  2011cites this paper
• MPF and the Control of Meiotic Divisions: Old Problems, New Concepts

  2010cites this paper
• Functional Analysis of the Cdk7·Cyclin H·Mat1 Complex in Mouse Embryonic Stem Cells and Embryos

  2010cites this paper
• Analysis of recombinant phosphoprotein complexes with complementary mass spectrometry approaches.

  2010cites this paper
• Identification and functional characterisation of novel APC/C interacting proteins

  2010cites this paper
• An ATM and ATR dependent checkpoint inactivates spindle assembly by targeting CEP63

  2010cites this paper
• Mechanisms of G2 Phase Arrest in DNA Damage-Induced Checkpoint Response

  2010cites this paper
• Exposure to Interferon γ Decreases Levels and Activity of Key Cell Cycle Proteins Resulting in Severe Growth Arrest of the Human Non-Transformed Cell Line, WISH

  2010cites this paper
• Proteome analysis reveals new mechanisms of Bcl11b-loss driven apoptosis.

  2010cites this paper
• Cell Cycle Control in Pancreatic Cancer Pathogenesis

  2010cites this paper
• S-phase lengthening induced by p16INK4a overexpression in malignant cells with wild-type pRb and p53

  2010cites this paper
• Upstream Factors Regulating Maturation/M-Phase Promoting Factor Activity During Oocyte Maturation

  2010cites this paper
• Peptide aptamers in label-free protein detection: 2. Chemical optimization and detection of distinct protein isoforms.

  2009cites this paper
• Novel potent pharmacological cyclin-dependent kinase inhibitors.

  2009cites this paper
• Phospho-p70S6K and cdc2/cdk1 as therapeutic targets for diffuse large B-cell lymphoma

  2009cites this paper
• Synthesis and evaluation of functionalized isoindigos as antiproliferative agents.

  2009cites this paper
• Selective Cyclin‐Dependent Kinase Inhibitors Discriminating between Cell Cycle and Transcriptional Kinases

  2009cites this paper
• A phosphorylation-independent role for the yeast cyclin-dependent kinase activating kinase Cak1.

  2009cites this paper
• Improved enrichment strategies for phosphorylated peptides on titanium dioxide using methyl esterification and pH gradient elution.

  2008cites this paper
• Fertilization differently affects the levels of cyclin B1 and M-phase promoting factor activity in maturing and metaphase II mouse oocytes.

  2008cites this paper
• Differential regulation of the cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1) by phosphorylation directed by the cyclin encoded by Murine Herpesvirus 68.

  2008cites this paper
• Cyclin E and SV40 Small t Antigen Cooperate to Bypass Quiescence and Contribute to Transformation by Activating CDK2 in Human Fibroblasts*

  2008cites this paper
• De la progestérone à l'activation du MPF dans l'ovocyte de Xénope: Quels rôles pour H-Ras et la kinase Myt1?

  2007cites this paper
• Spy1 Enhances Phosphorylation and Degradation of the Cell Cycle Inhibitor p27

  2007cites this paper
• Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population.

  2007influential citation
• Autocatalytic Phosphorylation of CDK2 at the Activating Thr160

  2007cites this paper
• Recognition of Cdk2 by Cdk7

  2007cites this paper
• Specialized roles of the two mitotic cyclins in somatic cells: cyclin A as an activator of M phase-promoting factor.

  2007influential citation
• Inhibition of normal lymphocyte proliferation by Indirubin-3′-monoxime: A multifactorial process

  2007cites this paper
• Regulation of Cell Cycle Progression and Cellular Survival in Primary Rat Hepatocytes

  2007cites this paper
• TFIIH controls developmentally‐regulated cell cycle progression as a holocomplex

  2007cites this paper
• Potential roles for autophosphorylation, kinase activity, and abundance of a CDK-activating kinase (Ee;CDKF;1) during growth in leafy spurge

  2007cites this paper
• Cell cycle control of embryonic stem cells

  2007cites this paper
• Induction of mitotic cell death and cell cycle arrest by spindle disruption and premature entry into mitosis after DNA damage

  2007cites this paper
• Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics

  2006cites this paper
• Cell growth-stimulating effect

  2006cites this paper
• Identification of an effector protein and gain-of-function mutants that activate Pfmrk, a malarial cyclin-dependent protein kinase.

  2006cites this paper
• Advances in the studies of cyclin dependent kinase-activating kinase (CAK)

  2006cites this paper
• Familial Cancer Syndromes Checkpoint Function in Cells from Individuals with 2 Defective G Updated

  2006cites this paper
• Defective G 2 Checkpoint Function in Cells from Individuals with Familial Cancer Syndromes 1

  2006cites this paper
• Diverse phosphoregulatory mechanisms controlling cyclin-dependent kinase-activating kinases in Arabidopsis.

  2006cites this paper
• Control of the G2/M transition

  2006cites this paper
• CAK—Cyclin-Dependent Activating Kinase: A Key Kinase in Cell Cycle Control and a Target for Drugs?

  2005cites this paper
• Getting in and out of mitosis with Polo-like kinase-1

  2005cites this paper
• Role of CDK/cyclin complexes in transcription and RNA splicing.

  2005cites this paper
• The Medicago CDKC;1-CYCLINT;1 kinase complex phosphorylates the carboxy-terminal domain of RNA polymerase II and promotes transcription.

  2005cites this paper
• Using Xenopus Egg Extracts toModify Recombinant Proteins

  2005cites this paper
• The Plk3-Cdc25 circuit

  2005cites this paper
• Studies on the regulation of mitotic transition by cyclin B1/Cdk1.

  2005cites this paper
• Cell Cycle-dependent Inhibition of p 34 cdc 2 Synthesis by Transforming Growth Factor in Cycling Epithelial Cells 1

  2005cites this paper
• Nutrition and Cancer Fisetin Inhibits the Activities of Cyclin-Dependent Kinases Leading to Cell Cycle Arrest in HT-29 Human Colon Cancer Cells 1

  2005cites this paper
• Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells.

  2005cites this paper
• Three forms of cyclin B transcripts in the ovary of the kuruma prawn Marsupenaeus japonicus: their molecular characterizations and expression profiles during oogenesis.

  2005cites this paper
• Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts.

  2005cites this paper
• CDK-Activating Kinases

  2005cites this paper
• Secrets of a double agent: CDK7 in cell-cycle control and transcription

  2005cites this paper
• Cell-cycle-dependent subcellular localization of cyclin B1, phosphorylated cyclin B1 and p34cdc2 during oocyte meiotic maturation and fertilization in mouse

  2005cites this paper
• Identification and Comparative Analysis of Multiple Mammalian Speedy/Ringo Proteins

  2005cites this paper
• Characterization of actin stress fibers: involvement of PDZ-LIM adapter proteins and the novel Clik1 kinase

  2004influential citation
• Strategies to isolate evolutionarily conserved cell cycle regulatory genes.

  2004cites this paper
• Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II.

  2004cites this paper
• controle de la transition meiose I/meiose II et role de DOC1R au cours de l'arret CSF lors de la maturation meiotique chez la souris

  2004cites this paper