SCIENCE@home

Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission.

C. B. Beard,J. Carter,S. Keely,Laurence Huang,N. Pieniązek,I. Moura,J. Roberts,A. Hightower,Michelle S. Bens,A. Freeman,Sherline H. Lee,J. Stringer,J. Duchin,C. Rio,D. Rimland,R. Baughman,D. Levy,V. Dietz,P. Simon,T. Navin

Published 2000 in Emerging Infectious Diseases

ABSTRACT

To study transmission patterns of Pneumocystis carinii pneumonia (PCP) in persons with AIDS, we evaluated P. carinii isolates from patients in five U.S. cities for variation at two independent genetic loci, the mitochondrial large subunit rRNA and dihydropteroate synthase. Fourteen unique multilocus genotypes were observed in 191 isolates that were examined at both loci. Mixed infections, accounting for 17.8% of cases, were associated with primary PCP. Genotype frequency distribution patterns varied by patients' place of diagnosis but not by place of birth. Genetic variation at the two loci suggests three probable characteristics of transmission: that most cases of PCP do not result from infections acquired early in life, that infections are actively acquired from a relatively common source (humans or the environment), and that humans, while not necessarily involved in direct infection of other humans, are nevertheless important in the transmission cycle of P. carinii f. sp. hominis.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-50 of 50 references · Page 1 of 1

CITED BY

Showing 1-100 of 260 citing papers · Page 1 of 3

123
Next