Adaptive evolution of genes underlying schizophrenia

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Proceedings of the Royal Society B: Biological Sciences

• Publication date

  2007-11-22

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1098/rspb.2007.0876PMID 17785269PMCID PMC2288689
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Replication of genetic association studies between markers at the Epsin 4 gene locus and schizophrenia in two Han Chinese samples.

  2007cited by this paper
• Role of DISC1 in neural development and schizophrenia.

  2007cited by this paper
• Genome-wide linkage scan of schizophrenia: a cross-isolate study.

  2007cited by this paper
• Widespread positive selection in synonymous sites of mammalian genes.

  2007cited by this paper
• Association of Neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish population

  2007cited by this paper
• Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use.

  2007cited by this paper
• LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia

  2007cited by this paper
• Extreme individual marker FST values do not imply population-specific selection in humans: the NRG1 example

  2007cited by this paper
• Localizing Recent Adaptive Evolution in the Human Genome

  2007cited by this paper
• MCPH1 is associated with risk for illness and cognitive ability in patients with schizophrenia

  2007cited by this paper
• Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia

  2007cited by this paper
• The association of the HOPA12bp polymorphism with schizophrenia in the NIMH genetics initiative for schizophrenia sample

  2007cited by this paper
• GABRB2 association with schizophrenia: commonalities and differences between ethnic groups and clinical subtypes.

  2007cited by this paper
• Brief Report Insight problem solving in individuals with high versus low schizotypy

  2007cited by this paper
• Positive Selection within the Schizophrenia-Associated GABAA Receptor β2 Gene

  2007cited by this paper
• Characterization of LRRTM and NGR gene families: Expression and functions

  2007cited by this paper
• Reconciling the mutation-selection balance model with the schizotypy-creativity connection

  2006cited by this paper
• Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best?

  2006cited by this paper
• Accelerated Evolution of Conserved Noncoding Sequences in Humans

  2006cited by this paper
• Meta-analysis of association between ApoE ε4 allele and schizophrenia

  2006cited by this paper
• A Map of Recent Positive Selection in the Human Genome

  2006influential reference
• Does negative symptom change relate to neurocognitive change in schizophrenia? Implications for targeted treatments.

  2006cited by this paper
• Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder

  2006cited by this paper
• Genomic insights into positive selection.

  2006cited by this paper
• Schizotypy and mental health amongst poets, visual artists, and mathematicians

  2006influential reference
• Identification of first candidate genes for creativity: a pilot study.

  2006cited by this paper
• Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinations

  2006cited by this paper
• Schizophrenia and cancer risk: can the CCR5-delta 32 chemokine receptor gene mutation play a role?

  2006cited by this paper
• The genetics and biology of DISC1--an emerging role in psychosis and cognition.

  2006cited by this paper
• Association between the CCR5 32-bp deletion allele and late onset of schizophrenia.

  2006cited by this paper
• Meta-analysis of association between ApoE epsilon4 allele and schizophrenia.

  2006cited by this paper
• Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.

  2006cited by this paper
• Convergent evidence that oligodendrocyte lineage transcription factor 2 (OLIG2) and interacting genes influence susceptibility to schizophrenia

  2006cited by this paper
• Association study of the dysbindin (DTNBP1) gene in schizophrenia from the Japanese population.

  2006cited by this paper
• Geographic Distribution

  2006cited by this paper
• A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms

  2006cited by this paper
• Positive Natural Selection in the Human Lineage

  2006cited by this paper
• Response to Comment on "Ongoing Adaptive Evolution of ASPM, a Brain Size Determinant in Homo sapiens" and "Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans"

  2006cited by this paper
• Psychosis: a costly by-product of social brain evolution in Homo sapiens.

  2006cited by this paper
• "A gene for...": the nature of gene action in psychiatric disorders.

  2006cited by this paper
• Gene regulation by hypoxia and the neurodevelopmental origin of schizophrenia.

  2006cited by this paper
• Family-based association study of Epsin 4 and Schizophrenia

  2006cited by this paper
• AHI1, a pivotal neurodevelopmental gene, and C6orf217 are associated with susceptibility to schizophrenia

  2006cited by this paper
• The NPAS3 gene--emerging evidence for a role in psychiatric illness.

  2006cited by this paper
• A polymorphism in the PDLIM5 gene associated with gene expression and schizophrenia.

  2006cited by this paper
• The role of the phosphatidylinositide 3-kinase-protein kinase B pathway in schizophrenia.

  2006cited by this paper
• Molecular genetic studies of schizophrenia

  2006influential reference
• FFAS03: a server for profile–profile sequence alignments

  2005cited by this paper
• Accelerated Evolution of the Pituitary Adenylate Cyclase-Activating Polypeptide Precursor Gene During Human Origin

  2005cited by this paper
• Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans

  2005cited by this paper
• Contrasting effects of natural selection on human and chimpanzee CC chemokine receptor 5.

  2005cited by this paper
• Phenotype of schizophrenia: a review and formulation

  2005cited by this paper
• A case-control study of the relationship between the metabotropic glutamate receptor 3 gene and schizophrenia in the Chinese population.

  2005cited by this paper
• Evidence for a common biological basis of the absorption trait, hallucinogen effects, and positive symptoms: Epistasis between 5‐HT2a and COMT polymorphisms

  2005cited by this paper
• Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia

  2005cited by this paper
• Evaluation of an improved branch-site likelihood method for detecting positive selection at the molecular level.

  2005influential reference
• AVPR1a and SLC6A4 Gene Polymorphisms Are Associated with Creative Dance Performance

  2005cited by this paper
• Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?

  2005cited by this paper
• Natural selection on protein-coding genes in the human genome

  2005cited by this paper
• Schizophrenia as one extreme of a sexually selected fitness indicator.

  2004cited by this paper
• Abnormal cerebellar development and axonal decussation due to mutations in AHI1 in Joubert syndrome

  2004cited by this paper
• Schizophrenia-an evolutionary enigma?

  2004cited by this paper
• Polymorphisms in the Serotonin Transporter and Monoamine Oxidase A Genes and Their Relationship to Personality Traits Measured by the Temperament and Character Inventory and NEO Five-Factor Inventory in Healthy Volunteers

  2004cited by this paper
• Reconstructing the evolutionary history of microcephalin, a gene controlling human brain size.

  2004cited by this paper
• Accelerated evolution of nervous system genes in the origin of Homo sapiens.

  2004cited by this paper
• Meat‐Adaptive Genes and the Evolution of Slower Aging in Humans

  2004cited by this paper
• Molecular evolution of microcephalin, a gene determining human brain size.

  2004cited by this paper
• The PANTHER database of protein families, subfamilies, functions and pathways

  2004cited by this paper
• The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus.

  2004cited by this paper
• Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.

  2004cited by this paper
• Positive selection in MAOA gene is human exclusive: determination of the putative amino acid change selected in the human lineage

  2004cited by this paper
• Association of the HOPA12bp allele with a large X‐chromosome haplotype and positive symptom schizophrenia

  2004cited by this paper
• Patterns of linkage disequilibrium in the MHC region on human chromosome 6p

  2004cited by this paper
• Creativity & Madness Revisited from Current Psychological Perspectives

  2004cited by this paper
• Dopamine D4 receptor gene (DRD4) variants and schizophrenia: meta-analyses.

  2003cited by this paper
• DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.

  2003cited by this paper
• Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia families.

  2003cited by this paper
• Serotonin Transporter Gene Polymorphism and Schizoid Personality Traits in Patients with Psychosis and Psychiatrically Well Subjects

  2003influential reference
• Association between a promoter variant in the monoamine oxidase A gene and schizophrenia.

  2003cited by this paper
• Schizotypal personality traits in nonpsychotic relatives are associated with positive symptoms in psychotic probands.

  2003cited by this paper
• Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species

  2003cited by this paper
• A strong signature of balancing selection in the 5′ cis-regulatory region of CCR5

  2002cited by this paper
• Evidence for positive selection and population structure at the human MAO-A gene

  2002cited by this paper
• Schizotypal dimensions in normals and schizophrenic patients: a comparison with other clinical samples.

  2002cited by this paper
• Accelerated protein evolution and origins of human-specific features: Foxp2 as an example.

  2002cited by this paper
• Ethnic heterogeneity in allele variation in the DRD4 gene in schizophrenia.

  2002cited by this paper
• Molecular evolution of FOXP2, a gene involved in speech and language

  2002cited by this paper
• Selective sweeps in the human genome: a starting point for identifying genetic differences between modern humans and chimpanzees.

  2002cited by this paper
• The Geographic Distribution of Monoamine Oxidase Haplotypes Supports a Bottleneck During the Dispersion of Modern Humans from Africa

  2001cited by this paper
• Population-based association analyses of the HOPA12bp polymorphism for schizophrenia and hypothyroidism.

  2001cited by this paper
• Strong Imagination: Madness, Creativity and Human Nature

  2001influential reference
• Schizophrenia and HLA: a review.

  2001cited by this paper
• Evidence of positive selection acting at the human dopamine receptor D4 gene locus

  2001cited by this paper
• Investigation of a candidate gene for schizophrenia on Xq13 previously associated with mental retardation and hypothyroidism.

  2000cited by this paper
• Molecular heterosis: a review.

  2000cited by this paper
• Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism.

  2000cited by this paper
• Gene regulation by hypoxia

  2000cited by this paper
• Schizophrenia as a consequence of brain evolution.

  1998cited by this paper
• Recent origin of HLA-DRB1 alleles and implications for human evolution

  1998cited by this paper
• Schizophrenia: The illness that made us human

  1998influential reference

• Why do mood disturbances often occur in early postpartum? An integrative neurobiological and evolutionary perspective.

  2025cites this paper
• Identifying Shared Determinants Underpinning Depression, Schizophrenia and Dementia: A Scoping Review

  2025cites this paper
• Understanding the Emergence of Schizophrenia in the Light of Human Evolution: New Perspectives in Genetics

  2025cites this paper
• Addressing technical pitfalls in pursuit of molecular factors that mediate immunoglobulin gene regulation

  2024cites this paper
• Asian-European differentiation of schizophrenia-associated genes driven by admixture and natural selection

  2024cites this paper
• Free Imagination

  2024cites this paper
• The cliff edge model of the evolution of schizophrenia: mathematical, epidemiological, and genetic evidence.

  2024cites this paper
• Depression: an adaptive disease?

  2023cites this paper
• Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy

  2023cites this paper
• The evolutionary origin of psychosis

  2023cites this paper
• Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution

  2023cites this paper
• Evolutionarily recent retrotransposons contribute to schizophrenia

  2023cites this paper
• The adaptive evolution of cancer driver genes

  2023cites this paper
• Evolutionarily recent retrotransposons contribute to schizophrenia

  2023cites this paper
• Evolution and dysfunction of human cognitive and social traits: A transcriptional regulation perspective

  2022cites this paper
• Investigation of the functional vesicular monoamine transporter 1 (VMAT1/SLC18A1) Thr136Ile gene variant in bipolar disorder

  2022cites this paper
• Novel open reading frames in human accelerated regions and transposable elements reveal new leads to understand schizophrenia and bipolar disorder

  2021cites this paper
• The shared genetic architecture of schizophrenia, bipolar disorder and lifespan

  2020cites this paper
• The evolution of the human brain and disease susceptibility.

  2020cites this paper
• Anomalies in language as a biomarker for schizophrenia.

  2020cites this paper
• Molecular Genetics

  2020cites this paper
• Creativity and Bipolar Disorder: A Shared Genetic Vulnerability.

  2020cites this paper
• A method for genome-wide genealogy estimation for thousands of samples

  2019cites this paper
• 48AN EVOLUTIONARY EPIGENETICS APPROACH TO SCHIZOPHRENIA

  2019cites this paper
• Psychoses et créativité : une histoire de vulnérabilité ?

  2019cites this paper
• Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia.

  2019cites this paper
• No Evidence for Widespread Positive Selection Signatures in Common Risk Alleles Associated with Schizophrenia.

  2019cites this paper
• Commentary on: “Host-parasite interaction associated with major mental illness”. Why we need integrative explanations based on evolutionary theory

  2019cites this paper
• How evolutionary psychiatry can advance psychopharmacology


  2019cites this paper
• Antagonistic Pleiotropy in Human Disease

  2019cites this paper
• Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore.

  2019cites this paper
• Genetics of human brain evolution.

  2019cites this paper
• A biocultural approach to psychiatric illnesses

  2019cites this paper
• Evolutionary Perspectives on Genetic and Environmental Risk Factors for Psychiatric Disorders.

  2018cites this paper
• Recently evolved human-specific methylated regions are enriched in 1 schizophrenia signals 2 3 4

  2018cites this paper
• Large-scale whole-genome sequencing of three diverse Asian populations in Singapore

  2018cites this paper
• Surprising conservation of schizophrenia risk genes in lower organisms reflects their essential function and the evolution of genetic liability.

  2018cites this paper
• Positive and balancing selection on SLC18A1 gene associated with psychiatric disorders and human‐unique personality traits

  2018cites this paper
• Genetic Basis of Auditory Verbal Hallucinations in Schizophrenia

  2018cites this paper
• A red queen model of personality

  2018cites this paper
• Recently evolved human-specific methylated regions are enriched in schizophrenia signals

  2018cites this paper
• Analysis of differentially methylated regions in primates and non-primates provides support for the evolutionary hypothesis of schizophrenia

  2018cites this paper
• Evolution of Large Brain and Body Size in Mammals

  2017cites this paper
• Functions of Neuropilins in Wiring the Nervous System and Their Role in Neurological Disorders

  2017cites this paper
• Human-specific methylated regions are enriched in schizophrenia

  2017cites this paper
• The adaptive brain in mental health: overcoming inherited risk factors

  2017cites this paper
• Evidence of a Conserved Molecular Response to Selection for Increased Brain Size in Primates

  2017cites this paper
• O nieuzasadnionych wnioskach etycznych z psychiatrii ewolucyjnej

  2017cites this paper
• Polygenic selection underlies evolution of human brain structure and behavioral traits

  2017cites this paper
• Ancestral resurrection of anthropoid estrogen receptor β demonstrates functional consequences of positive selection.

  2017cites this paper
• Can we co-produce reality, normality, and a world that has meaning for all?

  2017cites this paper
• Re-examining rumination: An investigation into the relative contributions of reflective and brooding ruminative processes to problem solving

  2017cites this paper
• Positive Traits in the Bipolar Spectrum: The Space between Madness and Genius

  2016cites this paper
• Biological mechanisms underlying evolutionary origins of psychotic and mood disorders.

  2016cites this paper
• Modern Trends in Pharmacopsychiatry

  2016cites this paper
• Evolution and Mental Health

  2016cites this paper
• Using Evolutionary Theory to Guide Mental Health Research

  2016cites this paper
• Molecular Signatures of Natural Selection for Polymorphic Genes of the Human Dopaminergic and Serotonergic Systems: A Review

  2016cites this paper
• Closing Human Evolution: Life in the Ultimate Age

  2015cites this paper
• Genetic association of ACSM1 variation with schizophrenia and major depressive disorder in the Han Chinese population

  2015cites this paper
• The Evolutionary Biology of Human Neurodevelopment

  2015cites this paper
• Evolutionary Psychology and Mental Health

  2015cites this paper
• Diametrical diseases reflect evolutionary-genetic tradeoffs

  2015cites this paper
• Third Movement. The Ultimate Optimism: Finitics

  2015cites this paper
• Cumulative role of rare and common putative functional genetic variants at NPAS3 in schizophrenia susceptibility

  2015cites this paper
• Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function.

  2015cites this paper
• Genomic and network patterns of schizophrenia genetic variation in human evolutionary accelerated regions.

  2015cites this paper
• A matrilineal genetic legacy from the last glacial maximum confers susceptibility to schizophrenia in Han Chinese.

  2014cites this paper
• A Dual Comparative Approach: Integrating Lines of Evidence from Human Evolutionary Neuroanatomy and Neurodevelopmental Disorders

  2014cites this paper
• 4. Approche évolutionniste de l’anxiété

  2014cites this paper
• Decoding the Molecular Evolution of Human Cognition Using Comparative Genomics

  2014cites this paper
• The Duality of Schizotypy: Is it Both Dimensional and Categorical?

  2014cites this paper
• Candidate gene associations with mood disorder, cognitive vulnerability, and fronto-limbic volumes

  2014cites this paper
• Allelic differences between Europeans and Chinese for CREB

  2014cites this paper
• Mitochondrial dysfunction in schizophrenia: an evolutionary perspective

  2014cites this paper
• The evolutionary biology of human neurodevelopment : evo-neuro-devo comes of age

  2014cites this paper
• Evolutionary conservation in genes underlying human psychiatric disorders

  2014cites this paper
• Investigation of putative regulatory loci relevant to the pathogenesis of psychiatric illness

  2013cites this paper
• Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway

  2013cites this paper
• Disease consequences of human adaptation

  2013cites this paper
• The evolutionary paradox and the missing heritability of schizophrenia

  2013cites this paper
• Why we essentialize mental disorders.

  2013cites this paper
• Reconsideration of animal models of schizophrenia and other psychiatric disorders with evolutionary perspective.

  2013cites this paper
• Nonhuman primate models in the genomic era: a paradigm shift.

  2013cites this paper
• Paving the way for new research strategies in mental disorders. First part: the recurring crisis of psychiatry.

  2013cites this paper
• Connecting signaling pathways underlying communication to ASD vulnerability.

  2013cites this paper
• Candidate Genes Involved in the Expression of Psychotic Symptoms: A Focus on Hallucinations

  2013cites this paper
• From PPROM to caul: The evolution of membrane rupture in mammals

  2013cites this paper
• Hacia nuevas estrategias de investigación en los trastornos mentales. Primera Parte: La crisis recurrente de la psiquiatría

  2013cites this paper
• Neuroarcheologia musicale: musica come protolinguaggio

  2013cites this paper
• Altered cortical calbindin-immunoreactive interneuron populations associated with schizophrenia

  2013cites this paper
• Investigation of genetic variation contributing to antipsychotic treatment response in a South African first episode schizophrenia cohort.

  2013cites this paper
• The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)

  2012cites this paper
• Smith, Chris. "Neuroscience and History." In: "Environment, Culture, and the

  2012cites this paper
• Contribution bioinformatique à l' analyse du transcriptome humain

  2012cites this paper
• Evolution of psychological diversity in anthropoids

  2012cites this paper
• Can we vaccinate against depression?

  2012cites this paper
• Applied & translational genomics

  2012cites this paper
• Possible genetic and epigenetic links between human inner speech, schizophrenia and altruism.

  2012cites this paper
• Paradox of schizophrenia genetics: is a paradigm shift occurring?

  2012cites this paper