Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Biological Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 17145753
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Urokinase receptor and integrin interactions.

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• Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis

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• C-terminal heparin-binding domain of fibronectin regulates integrin-mediated cell spreading but not the activation of mitogen-activated protein kinase.

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• Adenovirus-mediated antisense urokinase-type plasminogen activator receptor gene transfer reduces tumor cell invasion and metastasis in non-small cell lung cancer cell lines.

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• The role and regulation of urokinase‐type plasminogen activator receptor gene expression in cancer invasion and metastasis

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• Inhibition of colon cancer metastasis by a 3′‐ end antisense urokinase receptor mRNA in a nude mouse model

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• Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1.

  2001cited by this paper
• The plasminogen activation system in tumor growth, invasion, and metastasis

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• Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth.

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• Identification of a Urokinase Receptor-Integrin Interaction Site

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• Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling.

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• Significance of coexpression of urokinase-type plasminogen activator, and matrix metalloproteinase 3 (stromelysin) and 9 (gelatinase B) in colorectal carcinoma.

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• Syndecan-4 binding to the high affinity heparin-binding domain of fibronectin drives focal adhesion formation in fibroblasts.

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• Urokinase receptor: a molecular organizer in cellular communication.

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• Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype.

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• Urokinase-type plasminogen activator binding to its receptor stimulates tumor cell migration by enhancing integrin-mediated signal transduction.

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• Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13.

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• Activation of ProMMP‐9 by a Plasmin/MMP‐3 Cascade in a Tumor Cell Model: Regulation by Tissue Inhibitors of Metalloproteinases

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• Urokinase Plasminogen Activator and Gelatinases Are Associated with Membrane Vesicles Shed by Human HT1080 Fibrosarcoma Cells*

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• The urokinase‐type plasminogen activator system in cancer metastasis: A review

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• Regulation of Integrin Function by the Urokinase Receptor

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• Structural domains of heparan sulphate for specific recognition of the C-terminal heparin-binding domain of human plasma fibronectin (HEPII).

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