Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  American Journal of Pathology

• Publication date

  2000-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0002-9440(10)64763-3PMID 10666388PMCID PMC1850035
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997influential reference
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995influential reference
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Overexpression and localization of cyclin D1 mRNA and antigen in esophageal cancer.

  1995cited by this paper
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  1994influential reference
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• Mammalian G1 cyclins.

  1993cited by this paper
• Amplification of cyclin genes in colorectal carcinomas.

  1993cited by this paper
• Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes.

  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1992cited by this paper
• Pathological studies of human gastric cancer.

  1982cited by this paper

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