Pharmacokinetic‐pharmacodynamic relationships of methadone infusions in patients with cancer pain

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Clinical pharmacology and therapy

• Publication date

  1990-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/clpt.1990.77PMID 2188771
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Estimation of methadone clearance: application in the management of cancer pain

  1988cited by this paper
• Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation.

  1987cited by this paper
• Analgesic drug therapy in cancer pain: principles and practice.

  1987cited by this paper
• Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain

  1987cited by this paper
• Goodman and Gilman's The Pharmacological Basis of Therapeutics

  1986cited by this paper
• The mu, kappa and delta properties of various opioid agonists.

  1986cited by this paper
• Pain Measurement in Man. Neurophysiological Correlates of Pain.

  1986cited by this paper
• EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil.

  1985cited by this paper
• Clinical pharmacology of opioid analgesics.

  1984cited by this paper
• Postoperative Pain Control with Methadone: Influence of Supplementary Methadone Doses and Blood Concentration—Response Relationships

  1984cited by this paper
• Methadone induced physical dependence in the rat.

  1984cited by this paper
• Pharmacodynamics and Pharmacokinetics of Methadone during the Perioperative Period

  1982cited by this paper
• Prediction of Drug Concentrations on Multiple Dosing Using the Principle of Superposition

  1982cited by this paper
• PATTERNS OF NARCOTIC DRUG USE IN A CANCER PAIN CLINIC *

  1981cited by this paper
• The method of separate exponentials: A simple aid to devising intravenous drug‐loading regimens

  1981cited by this paper
• Understanding the Dose-Effect Relationship

  1981cited by this paper
• Simultaneous pharmacokinetic and pharmacodynamic modeling

  1981cited by this paper
• Methadone: radioimmunoassay and pharmacokinetics in the rat.

  1981cited by this paper
• Relationship Between Blood Meperidine Concentrations and Analgesic Response: A Preliminary Report

  1980cited by this paper
• Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine.

  1980cited by this paper
• CLINICAL MEASUREMENT OF PAIN

  1979cited by this paper
• DISPOSITION OF NARCOTICS AND NARCOTIC ANTAGONISTS *

  1976cited by this paper
• The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

  1976cited by this paper
• Disposition of methadone in man after a single oral dose

  1972cited by this paper
• A dinical eomparison of the analgesie effects of methadone and morphine administered intramuseularly, and oforally and parenterally administered methadone

  1967cited by this paper

• Population Pharmacokinetics to Support Intravenous and Enteral Methadone Dosing in Children

  2025cites this paper
• The IMPOWR Network Divided or Single Exposure Study (DOSE) Protocol: A Randomized Controlled Comparison of Once Versus Split Dosing of Methadone for the Treatment of Comorbid Chronic Pain and Opioid Use Disorder

  2024cites this paper
• Methadone and Enhanced Recovery After Surgery: Concepts and Protocols.

  2024cites this paper
• Use of physiologically‐based pharmacokinetic modeling to inform dosing of the opioid analgesics fentanyl and methadone in children with obesity

  2022cites this paper
• Pharmacological Diversity in Opioid Analgesics: Lessons From Clinically Useful Drugs

  2021cites this paper
• Pharmacokinetics and Pharmacodynamics in the Pediatric Population

  2021cites this paper
• Practicalities of Total Intravenous Anesthesia and Target-controlled Infusion in Children.

  2019cites this paper
• Pharmacogenetics of opioid analgesics in dogs

  2018cites this paper
• The Pharmacology of Intravenous Opioids

  2018cites this paper
• Growing Implications for Primary Care

  2016cites this paper
• Effect of intramuscular methadone on pharmacokinetic data and thermal and mechanical nociceptive thresholds in the cat

  2016cites this paper
• Metabolomics of methadone: clinical and forensic toxicological implications and variability of dose response

  2016cites this paper
• Revista Española de Geriatría y Gerontología

  2016cites this paper
• Development of hysteresis analysis as a model-independent approach to assess temporal dissociation in pharmacokinetics and pharmacodynamics

  2016cites this paper
• Gender differences in pharmacokinetics and pharmacodynamics of methadone substitution therapy

  2015cites this paper
• Methadone Recycling Sustains Drug Reservoir in Tissue

  2015cites this paper
• The pharmacokinetics of methadone and its metabolites in neonates, infants, and children

  2014cites this paper
• Potential Role and Challenges of Methadone in Cancer Pain Management

  2014cites this paper
• [Use of methadone in the elderly with cancer pain: a systematic review].

  2014cites this paper
• Pharmacokinetic and pharmacodynamic modeling for acute and chronic pain drug assessment

  2014cites this paper
• Methadone in healthy goats - pharmacokinetics, behaviour and blood pressure.

  2013cites this paper
• Intravenous Use of Methadone: Efficacy and Safety

  2013cites this paper
• The pharmacokinetics of methadone in adolescents undergoing posterior spinal fusion

  2013cites this paper
• Pharmacokinetic-Pharmacodynamic Modeling of Mood and Withdrawal Symptoms in Relation to Plasma Concentrations of Methadone in Patients Undergoing Methadone Maintenance Treatment

  2012cites this paper
• Variability of Plasma Methadone Concentration in Opiate Dependent Receiving Methadone: A Personalised Approach Towards Optimizing Dose

  2012cites this paper
• Characterization of the antinociceptive effects of the individual isomers of methadone after acute and chronic administrations

  2011cites this paper
• Population Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Relationships of Methadone in a Sample of Iranian (Mazandarani) Opiate Users Undergoing Methadone Maintenance Treatment

  2011cites this paper
• Pain Assessment and Management

  2011cites this paper
• Clinical pharmacology of methadone in dogs.

  2010cites this paper
• A formal feasibility study of sublingual methadone for breakthrough cancer pain

  2010cites this paper
• Methadone Antinociception Is Dependent on Peripheral

  2009cites this paper
• Cooperative N-methyl-D-aspartate (NMDA) receptor antagonism and mu-opioid receptor agonism mediate the methadone inhibition of the spinal neuron pain-related hyperactivity in a rat model of neuropathic pain.

  2009cites this paper
• Methadone antinociception is dependent on peripheral opioid receptors.

  2009cites this paper
• Opioid-Induced Side Effects in Beta-arrestin2 adn G Protein-Coupled Receptor Kinase Knockout Mice

  2009cites this paper
• Interindividual Variability of Methadone Response

  2008cites this paper
• Simultaneous determination of ketamine, tramadol, methadone, and their metabolites in urine by gas chromatography-mass spectrometry.

  2008cites this paper
• Pediatric cancer pain

  2008cites this paper
• The Pharmacology of Opioids

  2008cites this paper
• Conversion from Parenteral to Oral Methadone

  2008cites this paper
• Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships

  2007cites this paper
• Methadone for cancer pain.

  2007cites this paper
• 15 Pharmacology of Opioids

  2007cites this paper
• Nurse case management program of chronic pain patients treated with methadone.

  2007cites this paper
• Pain and Pain Relief in Pediatric End-of-Life Care

  2006cites this paper
• Population Pharmacokinetic/Pharmacodynamic Modelling of the Analgesic Effects of Tramadol in Pediatrics

  2006cites this paper
• Medikamentöse Therapie von Tumorschmerzen

  2006cites this paper
• Pain in children who have life-limiting conditions.

  2006cites this paper
• The Acute Disposition of (R)- and (S)-Methadone in Brain and Lung of Sheep

  2005cites this paper
• Proceedings of the Symposium "Updates of the Clinical Pharmacology of Opioids with Special Attention to Long-Acting Drugs"

  2005cites this paper
• Pharmacokinetic-pharmacodynamic modeling of opioids.

  2005cites this paper
• Within- and between- subject variability in methadone pharmacokinetics and pharmacodynamics in methadone maintenance subjects.

  2005cites this paper
• Pain Control Options in Palliative Care

  2005cites this paper
• Characterization of the early pharmacodynamic profile of oral methadone for cancer-related breakthrough pain: a pilot study.

  2004cites this paper
• The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone.

  2004cites this paper
• Bioavailability and Pharmacokinetics of Intranasal Hydromorphone in Patients Experiencing Vasomotor Rhinitis

  2004cites this paper
• Methadone for cancer pain.

  2004cites this paper
• Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

  2004cites this paper
• Treating opioid dependence: Growing implications for primary care

  2004cites this paper
• QTc interval prolongation associated with intravenous methadone

  2003cites this paper
• Bradycardia Associated with Intravenous Methadone Administered for Sedation in a Patient with Acute Respiratory Distress Syndrome

  2002cites this paper
• Interindividual Variability of the Clinical Pharmacokinetics of Methadone

  2002cites this paper
• Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of baclofen in mice

  2002cites this paper
• Clinical Use of Methadone

  2002cites this paper
• Reduced tolerance to the anti‐hyperalgesic effect of methadone in comparison to morphine in a rat model of mononeuropathy

  2002influential citation
• Differential antinociception by morphine and methadone in two sub-strains of Sprague-Dawley rats and its potentiation by dextromethorphan.

  2002cites this paper
• Palliative care and the child with cancer.

  2002cites this paper
• Pain measurement tools and methods in clinical research in palliative care: recommendations of an Expert Working Group of the European Association of Palliative Care.

  2002cites this paper
• Pain management in cancer rehabilitation.

  2001cites this paper
• Effets analgésiques des morphiniques et systèmes opioïdergiques dans les douleurs chroniques: confrontation des données cliniques et des données expérimentales chez l’animal

  2001cites this paper
• Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration

  2001cites this paper
• Comparison of Five Experimental Pain Tests to Measure Analgesic Effects of Alfentanil

  2001cites this paper
• Cancer pain management in children

  2001cites this paper
• Metabolism of Methadone andlevo-α-Acetylmethadol (LAAM) by Human Intestinal Cytochrome P450 3A4 (CYP3A4): Potential Contribution of Intestinal Metabolism to Presystemic Clearance and Bioactivation

  2001cites this paper
• Proceedings of an expert workshop on the induction and stabilisation of patients onto methadone

  2000cites this paper
• Neuronal inhibitory effects of methadone are predominantly opioid receptor mediated in the rat spinal cord in vivo

  2000cites this paper
• Alpha 1-acid glycoprotein (AAG) and serum protein binding of methadone in heroin addicts with abstinence syndrome.

  2000cites this paper
• Pharmacokinetic and Pharmacodynamic Action of Etodolac in Patients after Oral Surgery

  1999cites this paper
• Steady‐state pharmacokinetics and pharmacodynamics in methadone maintenance patients: Comparison of those who do and do not experience withdrawal and concentration‐effect relationships

  1999cites this paper
• Use of Methadone in Treating Chronic Noncancer Pain

  1999cites this paper
• The management of pain in terminally ill cancer patients with difficulty swallowing

  1999cites this paper
• Use of morphine in nonmalignant joint pain: the Limoges recommendations. The French Society for Rheumatology.

  1999cites this paper
• Methadone: a review of its pharmacokinetic/pharmacodynamic properties.

  1999cites this paper
• Alterations in methadone metabolism during late pregnancy.

  1999cites this paper
• Opioid tolerance: the clinical perspective.

  1998cites this paper
• Human variability and noncancer risk assessment--an analysis of the default uncertainty factor.

  1998cites this paper
• Antiretroviral Therapy and Medical Management of Pediatric HIV Infection

  1998cites this paper
• Integrated pharmacokinetics and pharmacodynamics of the novel calcium sensitizer levosimendan as assessed by systolic time intervals.

  1998cites this paper
• Monitoring of opioid therapy in advanced cancer pain patients.

  1997cites this paper
• An update on the clinical use of methadone for cancer pain

  1997cites this paper
• Pharmacokinetics and Pharmacodynamics of Sedatives and Analgesics in the Treatment of Agitated Critically Ill Patients

  1997cites this paper
• [Treatment of pain in oncology].

  1997cites this paper
• Pharmacokinetic-pharmacodynamic relationships for analgesics.

  1997cites this paper
• Concentration-effect relationship after intravenous hydromorphone administration: Use of an effect compartment model and system analysis to minimize hysteresis of effects

  1997cites this paper
• Clinical experience with oral methadone administration in the treatment of pain in 196 advanced cancer patients.

  1996cites this paper
• Morphine and morphine-6-glucuronide plasma concentrations and effect in cancer pain.

  1996cites this paper
• Intractable Pain in Children with Terminal Cancer

  1996cites this paper
• Alfentanil Dose-Response Relationships for Relief of Postoperative Pain

  1996cites this paper
• Opioid analgesic drugs in the elderly.

  1996cites this paper
• Rectal methadone in cancer patients with pain. A preliminary clinical and pharmacokinetic study.

  1995cites this paper
• Relationship between pharmacokinetics and the analgesic effect of ketorolac in the rat.

  1995cites this paper