Therapeutic Effects of l‐Carnitine and Propionyl‐l‐carnitine on Cardiovascular Diseases: A Review

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Annals of the New York Academy of Sciences

• Publication date

  2004-11-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1196/annals.1320.007PMID 15591005
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects ofl-carnitine loading on the aerobic and anaerobic performance of endurance athletes

  2006cited by this paper
• Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication.

  2001cited by this paper
• Study on propionyl-L-carnitine in chronic heart failure.

  1999cited by this paper
• European multicenter study on propionyl-L-carnitine in intermittent claudication.

  1999cited by this paper
• Serum from patients with severe heart failure downregulates eNOS and is proapoptotic: role of tumor necrosis factor-alpha.

  1999cited by this paper
• Tumor necrosis factor in CHF: a double facet cytokine.

  1998cited by this paper
• Acute and Chronic Effects of Propionyl-L-Carnitine on the Hemodynamics, Exercise Capacity, and Hormones in Patients with Congestive Heart Failure

  1998cited by this paper
• Skeletal muscle function at low work level as a model for daily activities in patients with chronic heart failure.

  1997cited by this paper
• Changes in Energy Metabolism of Calf Muscle in Patients with Intermittent Claudication Assessed by 31P Magnetic Resonance Spectroscopy: A Phase II Open Study

  1996cited by this paper
• Exercise limitation in chronic heart failure: central role of the periphery.

  1996cited by this paper
• Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial.

  1995cited by this paper
• Exercise intolerance in patients with chronic heart failure.

  1995cited by this paper
• Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure.

  1995cited by this paper
• Propionyl-L-carnitine in intermittent claudication: double-blind, placebo-controlled, dose titration, multicenter study.

  1995cited by this paper
• Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction.

  1994cited by this paper
• Propionyl-L-carnitine prevents myocardial mechanical alterations due to pressure overload in rats.

  1994cited by this paper
• Anaplerotic effect of propionyl carnitine in rat heart mitochondria.

  1994cited by this paper
• Propionyl-L-carnitine limits chronic ventricular dilation after myocardial infarction in rats.

  1993cited by this paper
• Factors contributing to the exercise limitation of heart failure.

  1993cited by this paper
• Beneficial Effect of Carnitine on Mechanical Recovery of Rat Hearts Reperfused After a Transient Period of Global Ischemia Is Accompanied by a Stimulation of Glucose Oxidation

  1993cited by this paper
• Current concepts in carnitine research

  1992cited by this paper
• Hemodynamic and Metabolic Activities of Propionyl‐L-Carnitine in Rats with Pressure‐Overload Cardiac Hypertrophy

  1992cited by this paper
• A Child With Valproic Acid-Associated Carnitine Deficiency and Carnitine-Responsive Cardiac Dysfunction

  1992cited by this paper
• Effect of propionyl-L-carnitine on experimental induced cardiomyopathy in rats.

  1992cited by this paper
• Controlled study on the therapeutic efficacy of propionyl-L-carnitine in patients with congestive heart failure.

  1992cited by this paper
• Short-term hemodynamic effects of intravenous propionyl-L-carnitine in anesthetized dogs

  1991cited by this paper
• Effect of propionyl-L-carnitine on mechanical function of isolated rabbit heart

  1991cited by this paper
• Hemodynamic study of intravenous propionyl-L-carnitine in patients with ischemic heart disease and normal left ventricular function

  1991cited by this paper
• Prolonged propionyl-L-carnitine pre-treatment of rabbit: biochemical, hemodynamic and electrophysiological effects on myocardium.

  1991cited by this paper
• Lack of correlation between the antiarrhythmic effect of l‐propionylcarnitine on reoxygenation‐induced arrhythmias and its electrophysiological properties

  1991cited by this paper
• Protection of the reperfused heart by L-propionylcarnitine.

  1991cited by this paper
• The therapeutic potential of carnitine in cardiovascular disorders.

  1991cited by this paper
• Elevated circulating levels of tumor necrosis factor in severe chronic heart failure.

  1990cited by this paper
• Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects.

  1990cited by this paper
• Valproate-induced hepatoxicity: protective effect of L-carnitine supplementation.

  1990cited by this paper
• Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure. Muscle blood flow is reduced with maintenance of arterial perfusion pressure.

  1989cited by this paper
• High doses of L-carnitine in acute myocardial infarction: metabolic and antiarrhythmic effects.

  1989cited by this paper
• Bicycle ergometer and echocardiographic study in healthy subjects and patients with angina pectoris after administration of L-carnitine: semiautomatic computerized analysis of M-mode tracing.

  1988cited by this paper
• Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over study.

  1988cited by this paper
• Valproic acid hepatic fatalities

  1987cited by this paper
• Substrate-induced alterations of high energy phosphate metabolism and contractile function in the perfused heart.

  1987cited by this paper
• Protection of the ischaemic myocardium by L-propionylcarnitine: effects on the recovery of cardiac output after ischaemia and reperfusion, carnitine transport, and fatty acid oxidation.

  1986cited by this paper
• Direct identification of propionylcarnitine in propionic acidaemia: Biochemical and clinical results of oral carnitine supplementation

  1986cited by this paper
• Symptoms limiting exercise in chronic heart failure.

  1986cited by this paper
• Effects of high doses of L-carnitine on myocardial lactate balance during pacing-induced ischemia in aging subjects

  1986cited by this paper
• L-carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia.

  1984cited by this paper
• Effects of L-carnitine on exercise tolerance in patients with stable angina pectoris.

  1984cited by this paper
• Exercise intolerance in patients with chronic heart failure: role of impaired nutritive flow to skeletal muscle.

  1984cited by this paper
• The metabolical effects of L-carnitine in angina pectoris.

  1984cited by this paper
• The surprising heart: a review of recent progress in cardiac electrophysiology.

  1984cited by this paper
• Urinary Excretion of l-Carnitine and Acylcarnitines by Patients with Disorders of Organic Acid Metabolism: Evidence for Secondary Insufficiency of l-Carnitine

  1984cited by this paper
• Medium-Chain Acyl-CoA Dehydrogenase Deficiency in Children with Non-Ketotic Hypoglycemia and Low Carnitine Levels

  1983cited by this paper
• Cardiac sarcoplasmic reticulum function in insulin- or carnitine-treated diabetic rats.

  1983cited by this paper
• Quantitative assessment of carnitine loss during hemodialysis and hemofiltration.

  1983cited by this paper
• Endocrine-metabolic effects of l-carnitine in patients on regular dialysis treatment.

  1983cited by this paper
• Favorable effects of L-carnitine treatment on hypertriglyceridemia in hemodialysis patients: decisive role of low levels of high-density lipoprotein-cholesterol.

  1983cited by this paper
• Kinetic modeling of hemodialysis, hemofiltration, and hemodiafiltration.

  1983cited by this paper
• Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients.

  1983cited by this paper
• Statistical evaluation of long-term L-carnitine therapy in hyperlipoproteinaemias

  1983cited by this paper
• LONG-TERM L-CARNITINE TREATMENT OF CHRONIC ANEMIA OF PATIENTS WITH END STAGE RENAL FAILURE

  1982cited by this paper
• L-carnitine for methylmalonicaciduria.

  1982cited by this paper
• BENEFICIAL EFFECTS OF L-CARNITINE IN POST-DIALYSIS SYNDROME

  1982cited by this paper
• Effect of carnitine on serum HDL-cholesterol: report of two cases.

  1982cited by this paper
• Metabolic and mechanical effects using L- and D-carnitine in working swine hearts.

  1982cited by this paper
• Myocardial carnitine deficiency in acute myocardial infarction.

  1982cited by this paper
• Myocardial carnitine deficiency in chronic heart failure.

  1982cited by this paper
• Carnitine deficiency and hyperammonemia associated with valproic acid therapy.

  1982cited by this paper
• Effects of L-carnitine on arrhythmias during hemodialysis.

  1981cited by this paper
• Effects of Carnitine Isomers on Fatty Acid Metabolism in Ischemic Swine Hearts

  1981cited by this paper
• CARNITINE IN HAEMODIALYSIS PATIENTS

  1980cited by this paper
• Improved pacing tolerance of the ischemic human myocardium after administration of carnitine.

  1979cited by this paper
• Le diagnostic de la communication interauriculaire basse

  1959cited by this paper

• Therapeutic potential of L-carnitine in coronary artery disease: a systematic review.

  2026cites this paper
• Association of plasma carnitine levels with bone mineral density and recent osteoporotic fracture

  2025cites this paper
• Decreased energy production and Ca2+ homeostasis imbalance induce myocardial hypertrophy in PDHA1-deficient human pluripotent stem cell derived cardiomyocytes.

  2025cites this paper
• Evaluation of Sperm Parameters in Asthenozoospermic Men: A Comparative Study of Swim-Up and Layering Techniques with Lepidium meyenii (Maca), L-Carnitine, and Pentoxifylline

  2025cites this paper
• Effects of evolocumab combined with L-carnitine on prognosis of patients after emergency PCI.

  2025cites this paper
• Effects of L-carnitine supplementation on markers of exercise-induced muscle damage in healthy adults: A systematic review and meta-analysis of randomized controlled trials

  2025cites this paper
• A sequential nanotherapy potentiate anti-angiogenic therapy by disrupting lipid metabolism under metabolic stress

  2025cites this paper
• Comparison of short-term and long-term effects of peroral L-carnitine intake: clinical implications of elevated TMAO levels in cardiovascular complications

  2025cites this paper
• Therapeutic targets of L-carnitine against polycystic ovary syndrome and the underlying signaling mechanisms

  2025cites this paper
• Serum carnitine profile changes after open heart surgery in children with CHDs.

  2025cites this paper
• Physiological Adaptability of Yak in Extreme High-Altitude Habitat Using Serum Metabolite Analysis

  2024cites this paper
• Propionyl-l-carnitine mitigates ischemia-reperfusion injury in rat epigastric island flaps

  2024cites this paper
• Anaplerotic filling in heart failure: a review of mechanism and potential therapeutics

  2024cites this paper
• Microbiota but not immune modulation by a pro- and postbiotic was associated with the diet-additive interaction in broilers

  2024cites this paper
• Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism

  2024cites this paper
• An exploratory study of metabolomics in endogenous and cannabis-use-associated psychotic-like experiences in adolescence

  2024cites this paper
• Cord plasma metabolomic signatures of prenatal per- and polyfluoroalkyl substance (PFAS) exposures in the Boston Birth Cohort

  2024cites this paper
• ANALYSIS OF SCIENTIFIC RESEARCH ON CLINICAL APPLICATIONS OF L-CARNITINE IN PEDIATRIC PRACTICE

  2023cites this paper
• Protective Effect of L-carnitine against Cefquinome Sulfate Induced Testicular Damage and Oxidative Stress in Male Albino Rats

  2023cites this paper
• Evaluation of Acetic Acid‐Induced Chronic Gastric Ulcer Healing by Propionyl‐L‐Carnitine Administration

  2023cites this paper
• Metaphorical investigation of aqueous distillate of Cichorium intybus, Foeniculum vulgare and Solanum nigrum along with atorvastatin and orlistat in experimental rodent models of dyslipidaemia and obesity

  2023cites this paper
• Biomedical role of L-carnitine in several organ systems, cellular tissues, and COVID-19.

  2023cites this paper
• Effect of Protein Concentrate Withdrawal and Reducing the Crude Protein in Diets and Supporting Them with a Mixtures of Essential Amino Acids on some Physiological Traits of Laying Hens

  2023cites this paper
• Metabolic Approaches for the Treatment of Dilated Cardiomyopathy

  2023cites this paper
• Lipidomic analysis identifies long-chain acylcarnitine as a target for ischemic stroke

  2023cites this paper
• Berberis microphylla G. Forst Intake Reduces the Cardiovascular Disease Plasmatic Markers Associated with a High-Fat Diet in a Mice Model

  2023cites this paper
• SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer

  2023cites this paper
• Comparison of muscle metabolomics between two Chinese horse breeds

  2023cites this paper
• l-carnitine: Nutrition, pathology, and health benefits

  2022cites this paper
• An Integrative Approach to Heart Failure

  2022cites this paper
• Association of Systemic Trimethyllysine With Heart Failure With Preserved Ejection Fraction and Cardiovascular Events

  2022cites this paper
• Metabolomics-based safety evaluation of acute exposure to electronic cigarettes in mice.

  2022cites this paper
• Effect of Energy Drinks Consumption on Physical Performance Beneficial and Adverse Impact on Health

  2022cites this paper
• Plasma l-carnitine and risks of cardiovascular events and recurrent stroke after ischemic stroke: A nested case-control study.

  2022cites this paper
• VDAC2 as a novel target for heart failure: Ca2+ at the sarcomere, mitochondria and SR.

  2022cites this paper
• Propionyl-L-Carnitine-Delivering Wound Dressings for the Treatment of Diabetic Wounds: An In Vitro and In Vivo Study

  2022cites this paper
• Role of cellular retinol‐binding protein, type 1 and retinoid homeostasis in the adult mouse heart: A multi‐omic approach

  2022cites this paper
• Hydroxytyrosol Benefits Boar Semen Quality via Improving Gut Microbiota and Blood Metabolome

  2022cites this paper
• Aus der Klinik für Augenheilkunde der Medizinischen Fakultät Charité – Universitätsmedizin Berlin DISSERTATION Influence of L-carnitine on transient receptor potential vanilloid 1 (TRPV1) activity in human corneal keratocytes

  2022cites this paper
• Lipid metabolism part II

  2021cites this paper
• The Effect of L- Carnitine on Cardiac Output in Patient with Chronic Kidney Disease on Regular Hemodialysis

  2021cites this paper
• Lipid metabolism part I

  2021cites this paper
• QT Prolongation in Dialysis Patients: An Epidemiological Study with a Focus on Malnutrition

  2021cites this paper
• Metabolic Signature of Arrhythmogenic Cardiomyopathy

  2021cites this paper
• L-carnitine: Searching for New Therapeutic Strategy for Sepsis Management.

  2021cites this paper
• APPLICATION OF "L-BIOCOMPLEX" IN CHRONIC HEART FAILURE TREATMENT IN PATIENTS WITH METABOLIC SYNDROME

  2021cites this paper
• The effect of l-carnitine supplementation on insulin resistance, sex hormone-binding globulin and lipid profile in overweight/obese women with polycystic ovary syndrome: a randomized clinical trial

  2021cites this paper
• Metabolic Impairment in Coronary Artery Disease: Elevated Serum Acylcarnitines Under the Spotlights

  2021cites this paper
• Effect of different doses of L-carnitine on fertility of the male reproductive system of albino rats

  2020cites this paper
• L-Carnitine; to fuel or not to fuel the failing heart?

  2020cites this paper
• карнітину в регуляції енергетичного обміну й перебігу серцево-судинних

  2020cites this paper
• A Pilot Study on the Effects of l-Carnitine and Trimethylamine-N-Oxide on Platelet Mitochondrial DNA Methylation and CVD Biomarkers in Aged Women

  2020cites this paper
• Variability in Nutritional Profile and Textural Properties of Differe nt Cuts of Lamb Meat from Subei Gansu

  2020cites this paper
• Carnitine promotes recovery from oxidative stress and extends lifespan in C. elegans

  2020cites this paper
• Effects of l-Carnitine Supplementation in Patients Receiving Hemodialysis or Peritoneal Dialysis

  2020cites this paper
• Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis.

  2020cites this paper
• Preventive Role of L-Carnitine and Balanced Diet in Alzheimer’s Disease

  2020cites this paper
• Microbiome-Metabolome Signature of Acute Kidney Injury

  2020cites this paper
• Effect of Vitamins and Dietary Supplements on Cardiovascular Health

  2020cites this paper
• Increased risk of sudden death in untreated primary carnitine deficiency

  2020cites this paper
• Energy drinks: health effects and consumer safety

  2019cites this paper
• Peripheral blood metabolite profiles associated with new onset atrial fibrillation

  2019cites this paper
• Effect of L-carnitine on Troponin, IL-6 and HS–CRP levels after Coronary Artery Bypass Graft Surgery

  2019cites this paper
• Metabolic profiling reveals that salidroside antagonizes hypoxic injury via modulating energy and lipid metabolism in cardiomyocytes.

  2019cites this paper
• Role of L-carnitine and Green tea in prevention of Tilmicosin induced cardiotoxicity in Healthy Dogs: An experimental study

  2019cites this paper
• Scientific Papers and Patents on Substances with Unproven Effects.

  2019cites this paper
• ОСОБЛИВОСТІ ПЕРЕБІГУ ГОСТРОГО КОРОНАРНОГО СИНДРОМУ, ЗУМОВЛЕНОГО ФЕНОМЕНОМ “SLOW-FLOW” (ОГЛЯД ЛІТЕРАТУРИ ТА ОПИС КЛІНІЧНОГО ВИПАДКУ)

  2019cites this paper
• Scientific Papers and Patents on Substances with Unproven Effects. Part 2

  2019cites this paper
• Quality Formation Mechanism of Stiff Silkworm, Bombyx batryticatus Using UPLC-Q-TOF-MS-Based Metabolomics

  2019cites this paper
• EFFECT OF COMBINED ORAL FERROTHERAPY WITH L-CARNITINE ON EXERCISE TOLERANCE OF PATIENTS WITH CHRONIC HEART FAILURE WITH REDUCED EJECTION FRACTION OF LEFT VENTRICLE WITH CONCOMITANT IRON DEFICIENCY ANEMIA

  2019cites this paper
• DNA damage induced by alloisoleucine and other metabolites in maple syrup urine disease and protective effect of l-carnitine.

  2019cites this paper
• The Relationship Between The Use of L-Carnitine Supplements and The Male Sub-Infertility

  2019cites this paper
• An Overview of the Dietary Ingredient Carnitine

  2019cites this paper
• AAV9-TAZ Gene Replacement Ameliorates Cardiac TMT Proteomic Profiles in a Mouse Model of Barth Syndrome

  2019cites this paper
• The metabolic time line of pancreatic cancer: Opportunities to improve early detection of adenocarcinoma.

  2019cites this paper
• The effect of L-carnitine on cardiac injury in an experimental aortic ischemia-reperfusion injury model

  2018cites this paper
• L-Carnitine and Potential Protective Effects Against Ischemia-Reperfusion Injury in Noncardiac Organs: From Experimental Data to Potential Clinical Applications

  2018cites this paper
• L-Carnitine: An Antioxidant Remedy for the Survival of Cardiomyocytes under Hyperglycemic Condition

  2018cites this paper
• L-carnitine on myocardial function after coronary artery bypass grafting.

  2018cites this paper
• Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases.

  2018cites this paper
• Effect of Tivorel on the level of matrix metalloproteinases-2 and 9, galectin-3, final glycation products and functional state of the endothelium in patients with postinfarction chronic heart failure with preserved ejection fraction

  2018cites this paper
• Chapter 25 – Heart Failure

  2018cites this paper
• Effect of L-carnitine on diabetes-induced changes of skeletal muscles in rats

  2018cites this paper
• Effect of L-Carnitine Supplementation on Apelin and Apelin Receptor (Apj) Expression in Cardiac Muscle of Obese Diabetic Rats

  2018cites this paper
• Meat Proteins as a Potential Source of Bioactive Ingredients for Food and Pharmaceutical Use

  2018cites this paper
• Meat Proteins as a Potential Source of Bioactive Ingredients for Food and Pharmaceutical Use

  2018cites this paper
• 7 Metabolic Modulators to Treat Cardiac Arrhythmias Induced by Ischemia and Reperfusion Moslem Najafi and

  2018influential citation
• l-Carnitine Supplementation in Recovery after Exercise

  2018cites this paper
• L-Carnitine and extendin-4 improve outcomes following moderate brain contusion injury

  2018cites this paper
• Experimental extraction of L-Carnitine from oyster mushroom with supercritical carbon dioxide and methanol as co-solvent: Modeling and optimization

  2018cites this paper
• Efficacy and Safety of L-Carnitine Treatment for Chronic Heart Failure: A Meta-Analysis of Randomized Controlled Trials

  2017cites this paper
• Intravenous Carnitine Administration in Addition to Parenteral Nutrition With Lipid Emulsion May Decrease the Inflammatory Reaction in Postoperative Surgical Patients

  2017cites this paper
• Propionyl-CoA carboxylase - A review.

  2017cites this paper
• Meat and Health

  2017cites this paper
• Integrated Approach to Heart Failure

  2017cites this paper
• L-carnitine reduces susceptibility to bupivacaine-induced cardiotoxicity: an experimental study in rats

  2017cites this paper
• The Protective Effect of L-carnitine against Gamma Irradiation- Induced Cardiotoxicity in Male Albino Rats.

  2017cites this paper
• Phospholipids and L-Carnitine Screening in Children with Congenital Heart Diseases Undergoing Surgical Correction

  2017cites this paper
• L-Name Hipertansif Ratlarda Ace İnhibitörü ile Birlikte L-Karnitin ve Co-enzim Q10 Verilmesinin Total Oksidan ve Antioksidan Düzeyleri Üzerine Etkileri

  2017cites this paper
• The role and place of cardioprotection with modern infusion solutions in the perioperative period

  2017cites this paper