BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Cancer Research

• Publication date

  1996-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 8764100
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Growth retardation and tumour inhibition by BRCA1

  1996cited by this paper
• BRCA1 is secreted and exhibits properties of a granin

  1996cited by this paper
• Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

  1996cited by this paper
• Location of BRCA1 in Human Breast and Ovarian Cancer Cells

  1996cited by this paper
• Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.

  1995cited by this paper
• A somatic BRCA1 mutation in an ovarian tumour

  1995cited by this paper
• Hormone-dependent regulation of BRCA1 in human breast cancer cells.

  1995cited by this paper
• A human BRCA1 gene knockout

  1995cited by this paper
• Aberrant Subcellular Localization of BRCA1 in Breast Cancer

  1995cited by this paper
• Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression

  1995cited by this paper
• Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families.

  1995cited by this paper
• Somatic mutations in the BRCA1 gene in sporadic ovarian tumours

  1995cited by this paper
• The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

  1995cited by this paper
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

  1994cited by this paper
• BRCA1 mutations in primary breast and ovarian carcinomas.

  1994cited by this paper
• The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing

  1994cited by this paper
• Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation.

  1989cited by this paper

• Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers.

  2025cites this paper
• Analysis of a high-dimensional free boundary problem on tumor growth with time-dependent nutrient supply and inhibitor action

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• Survival Outcomes Associated with the Location of BRCA Mutations in Ovarian Cancer: A Systematic Review and Meta-Analysis

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• The Role of Osteoprotegerin in Breast Cancer: Genetic Variations, Tumorigenic Pathways, and Therapeutic Potential

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• EGFR and Hippo signaling pathways are involved in organophosphate esters–induced proliferation and migration of triple-negative breast cancer cells

  2024cites this paper
• Linear stability analysis for the free boundary problem modeling tumor growth with angiogenesis in the presence of inhibitors

  2023cites this paper
• BRCA1 the Versatile Defender: Molecular to Environmental Perspectives

  2023cites this paper
• A transcription‐independent mechanism determines rapid periodic fluctuations of BRCA1 expression

  2023cites this paper
• BRCA-Mutated Pancreatic Cancer: From Discovery to Novel Treatment Paradigms

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• BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies

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• BRCA1 deficiency in triple-negative breast cancer: Protein stability as a basis for therapy.

  2022cites this paper
• Linear stability analysis for a free boundary problem modeling tumor growth in the presence of high-molecular mass drugs

  2022cites this paper
• BRCA1 and DNA damage response

  2022cites this paper
• The fellowship of the RING: BRCA1, its partner BARD1 and their liaison in DNA repair and cancer.

  2021cites this paper
• Absence of Germline BRCA1 c.68_69delAG and c.5266dupC Mutations among Hormone Receptor-negative Breast Cancer Patients: A First Impression at a Tertiary Cancer-care Facility in Tanzania

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• Advanced Approaches to Breast Cancer Classification and Diagnosis

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• Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis.

  2021cites this paper
• DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

  2020cites this paper
• Identification of regulatory crosstalks between RKIP and BRCA1 tumor suppressors in healthy tissues and cancer (breast and ovarian): Therapeutic implications

  2020cites this paper
• Characterizing BRCA1 Variants Using Multiplex Functional Assays

  2019cites this paper
• Breast Cancer in African Populations

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• Risk Haplotypes Uniquely Associated with Radioiodine-Refractory Thyroid Cancer Patients of High African Ancestry

  2019cites this paper
• Western Analysis of Breast Cancer 1 Protein (BRCA1).

  2019cites this paper
• The BARD1 BRCT Domain in Tumor Suppression and Genome Stability

  2018cites this paper
• Five zinc finger protein 350 single nucleotide polymorphisms and the risks of breast cancer: a meta-analysis

  2017cites this paper
• Achieving selectivity in space and time with DNA double-strand-break response and repair: molecular stages and scaffolds come with strings attached

  2017cites this paper
• A label-free electrochemical DNA sensor to identify breast cancer susceptibility

  2017cites this paper
• Síndrome de cáncer de mama y ovario hereditario: Estudio in vitro de variantes BRCA1 y BRCA2 de significado biológico desconocido y búsqueda de nuevos genes responsables de este síndrome

  2016cites this paper
• Breast cancer predisposition gene brca1, pathogenic c61g mutation in mice: synthetic viability in DNA repair and tumour development

  2016cites this paper
• ARTD1 regulates cyclin E expression and consequently cell-cycle re-entry and G1/S progression in T24 bladder carcinoma cells

  2016cites this paper
• Inherited Breast Cancer

  2016cites this paper
• Identifying long-range control elements of the BRCA1 promoter

  2015cites this paper
• DNA double-strand break formation and signalling in response to transcription-blocking topoisomerase I complexes

  2015cites this paper
• BRCA1, BRCA2, HER2 and RAD51 gene polymorphisms in breast cancer patients of Bangladesh

  2015cites this paper
• Protein phosphatase 1 and its complexes in carcinogenesis.

  2014cites this paper
• Targeting tumor suppressor networks for cancer therapeutics.

  2014cites this paper
• The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers.

  2014cites this paper
• Hormone responsive breast cancer and BRCA1 mutation: mechanism, regulation and iron-mediated effects.

  2014cites this paper
• The role of the BARD1 BRCT domains in the DNA damage response

  2014influential citation
• DNA Methylierung ausgewählter BRCA- und Fanconi Anämie-Gene beim familiären Mammakarzinom

  2014cites this paper
• The BRCA1 Variant p.Ser36Tyr Abrogates BRCA1 Protein Function and Potentially Confers a Moderate Risk of Breast Cancer

  2014cites this paper
• Insulin-like growth factor receptor-1 (IGF-IR) as a target for prostate cancer therapy

  2014cites this paper
• The K898E germline variant in the PP1-binding motif of BRCA1 causes defects in DNA Repair

  2014cites this paper
• Detection of BRCA1 and 2 Genes Mutations Among Women with Breast Cancer Attending Radio and Isotope Center in Khartoum, Sudan

  2014cites this paper
• Regularized Rare Variant Enrichment Analysis for Case‐Control Exome Sequencing Data

  2014cites this paper
• Management of Hereditary Ovarian–Breast Cancer

  2014cites this paper
• A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.

  2013cites this paper
• Differences in 53BP1 and BRCA1 regulation between cycling and non-cycling cells

  2013cites this paper
• GENETIC STUDIES TO DIAGNOSE AND ESTABLISH ADEQUATE TREATMENT STRATEGIES FOR ESOPHAGEAL CANCER

  2013cites this paper
• Selection of a Non-Phosphorylated Peptide Inhibitor of BRCA1’s (BRCT)2 Domain

  2013cites this paper
• BRCA1-Ku80 Protein Interaction Enhances End-joining Fidelity of Chromosomal Double-strand Breaks in the G1 Phase of the Cell Cycle*

  2013cites this paper
• BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

  2013cites this paper
• The role of ubiquitination and deubiquitination in the regulation of BRCA1 function during genotoxic stress

  2013cites this paper
• Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle

  2013cites this paper
• A Genome-Wide Study of Homologous Recombination in Mammalian Cells Identifies RBMX, a Novel Component of the DNA Damage Response

  2013cites this paper
• Effect of the novel Moroccan BRCA1 and BRCA2 frameshift mutations

  2013cites this paper
• Identification, Exploitation and Manipulation of BRCA1-Dependent DNA Double-Strand Break and Interstrand Crosslink Repair in Breast and Ovarian Cancer Therapy

  2012cites this paper
• BRCA1 and Its Network of Interacting Partners

  2012cites this paper
• Activation of the BRCA1/Chk1/p53/p21(Cip1/Waf1) pathway by nitric oxide and cell cycle arrest in human neuroblastoma NB69 cells.

  2012cites this paper
• Deregulation of BRCA1 Leads to Impaired Spatiotemporal Dynamics of γ-H2AX and DNA Damage Responses in Huntington’s Disease

  2012cites this paper
• DNA repair genes BRCA1 and DNA-PKcs have great potential in radiation therapy

  2012cites this paper
• The WSTF-ISWI Chromatin Remodeling Complex Transiently Associates with the Human Inactive X Chromosome during Late S-Phase Prior to BRCA1 and γ-H2AX

  2012cites this paper
• Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

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• A guide for functional analysis of BRCA1 variants of uncertain significance

  2012cites this paper
• Determinants of cell cycle progression in human mammary epithelial MCF12 cells

  2012cites this paper
• Seventeen years after BRCA1: what is the BRCA mutation status of the breast cancer patients in Africa? – a systematic review

  2012cites this paper
• Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells

  2012cites this paper
• JOÃO DANIEL AMARAL FIGUEIREDO THE EFFECT OF ANTICANCER DRUGS PRODIGININES IN PP1 IN MELANOMA O EFEITO DAS DROGAS ANTICANCERIGENAS PRODIGININAS NA PP-1 EM MELANOMA

  2011cites this paper
• A Conditional Mouse Model for Measuring the Frequency of Homologous Recombination Events In Vivo in the Absence of Essential Genes

  2011cites this paper
• Regulation of the BRCA1 gene by an SRC3/53BP1 complex

  2011cites this paper
• Molecular biomarkers associated with mutant BRCAl breast cancer patients

  2011cites this paper
• Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice

  2011cites this paper
• The Role of BRCA1 Domains and Motifs in Tumor Suppression

  2011cites this paper
• The interaction of CtIP with DNA damage response proteins

  2010influential citation
• Turnover of BRCA 1 Involves in Radiation-Induced Apoptosis

  2010cites this paper
• HERC 2 Is an E 3 Ligase That Targets BRCA 1 for Degradation

  2010cites this paper
• BRCA1 Forms a Functional Complex with γ-H2AX as a Late Response to Genotoxic Stress

  2010cites this paper
• Genetics and Breast Cancer Risk

  2010cites this paper
• Transcriptional Regulation of the Base Excision Repair Pathway by BRCA1*

  2010cites this paper
• Turnover of BRCA1 Involves in Radiation-Induced Apoptosis

  2010cites this paper
• BRCA1 as a Therapeutic Target in Sporadic Epithelial Ovarian Cancer

  2010cites this paper
• HERC2 is an E3 ligase that targets BRCA1 for degradation.

  2010cites this paper
• Identification and Characterization of Novel Kinases that Regulate BRCA1 Expression and Function

  2010cites this paper
• Hereditary ovarian cancers: from BRCA mutations to clinical management. A modern appraisal

  2010cites this paper
• BRCA1 and BRCA2: Role in the DNA Damage Response, Cancer Formation and Treatment

  2009cites this paper
• Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex.

  2009cites this paper
• BRCA1/2 genetic background-based therapeutic tailoring of human ovarian cancer: hope or reality?

  2009influential citation
• Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors

  2009cites this paper
• Behind the wheel and under the hood: functions of cyclin-dependent kinases in response to DNA damage.

  2009cites this paper
• Differential Expressions of BRCA 1 and BRCA 2 in Infantile Gynecomastia

  2009cites this paper
• Early target genes of CALM/AF10 as revealed by gene expression profiling

  2008cites this paper
• BRCA1 is regulated by Chk2 in response to spindle damage.

  2008cites this paper
• BRCA1 5083del19 Mutant Allele Selectively Up-Regulates Periostin Expression In vitro and In vivo

  2008cites this paper
• BRCA1: a new genomic marker for non-small-cell lung cancer.

  2008cites this paper
• BRCA 15083 del 19 Mutant Allele Selectively UpRegulates Periostin Expression In vitro and In vivo

  2008cites this paper
• A PP1-binding motif present in BRCA1 plays a role in its DNA repair function

  2008cites this paper
• Decreased BRCA1 Confers Tamoxifen Resistance in Breast Cancer Cells by Altering Estrogen Receptor-Coregulator Interactions

  2008cites this paper
• Potentiality of phosphorylation of BRCA1 at Ser 1524 to activate p21 in response to X-ray irradiation

  2008cites this paper
• Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brcal, Brca2,

  2007cites this paper
• Ubiquitination and proteasome-mediated degradation of BRCA1 and BARD1 during steroidogenesis in human ovarian granulosa cells.

  2007cites this paper