The calcium-sensing receptor is silenced by genetic and epigenetic mechanisms in unfavorable neuroblastomas and its reactivation induces ERK1/2-dependent apoptosis.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Carcinogenesis

• Publication date

  2012-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/carcin/bgs338PMID 23108190
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA methylation screening identifies driver epigenetic events of cancer cell survival.

  2012cited by this paper
• CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression

  2011cited by this paper
• CD133 suppresses neuroblastoma cell differentiation via signal pathway modification

  2011cited by this paper
• CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells.

  2011cited by this paper
• Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis

  2011cited by this paper
• ERK and cell death: Mechanisms of ERK‐induced cell death – apoptosis, autophagy and senescence

  2010cited by this paper
• Recent advances in neuroblastoma.

  2010cited by this paper
• The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report.

  2009cited by this paper
• The calcium‐sensing receptor and parathyroid hormone‐related protein are expressed in differentiated, favorable neuroblastic tumors

  2009cited by this paper
• Monosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas.

  2009cited by this paper
• The role of the calcium-sensing receptor in the development and progression of cancer.

  2009cited by this paper
• Genome based cell population heterogeneity promotes tumorigenicity: The evolutionary mechanism of cancer

  2009cited by this paper
• Differential expression of genes mapping to recurrently abnormal chromosomal regions characterize neuroblastic tumours with distinct ploidy status

  2008cited by this paper
• Optimal primer design using the novel primer design program: MSPprimer provides accurate methylation analysis of the ATM promoter

  2007cited by this paper
• Methylation of CASP8, DCR2, and HIN-1 in Neuroblastoma Is Associated with Poor Outcome

  2007cited by this paper
• Loss of Heterozygosity of Chromosome 3 Detected with Single Nucleotide Polymorphisms Is Superior to Monosomy 3 for Predicting Metastasis in Uveal Melanoma

  2007cited by this paper
• Comprehensive analysis of tumoral DNA content reveals clonal ploidy heterogeneity as a marker with prognostic significance in locoregional neuroblastoma

  2007cited by this paper
• The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

  2007cited by this paper
• Keratoepithelin suppresses the progression of experimental human neuroblastomas.

  2006cited by this paper
• Extracellular calcium as a candidate mediator of prostate cancer skeletal metastasis.

  2006cited by this paper
• Oligonucleotide array‐based comparative genomic hybridization (aCGH) of 90 neuroblastomas reveals aberration patterns closely associated with relapse pattern and outcome

  2006cited by this paper
• CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas.

  2005cited by this paper
• High Affinity Interaction with Filamin A Protects against Calcium-sensing Receptor Degradation*

  2005cited by this paper
• EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma.

  2005cited by this paper
• Differential expression of the calcium sensing receptor and combined loss of chromosomes 1q and 11q in parathyroid carcinoma

  2004cited by this paper
• Characteristics of stem cells from human neuroblastoma cell lines and in tumors.

  2004cited by this paper
• Association of Epigenetic Inactivation of RASSF1A with Poor Outcome in Human Neuroblastoma

  2004cited by this paper
• Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma.

  2004cited by this paper
• cDNA Cloning and Functional Expression of a Ca2+-sensing Receptor with Truncated C-terminal Tail from the Mozambique Tilapia (Oreochromis mossambicus)*

  2004cited by this paper
• Extracellular calcium and calcium sensing receptor function in human colon carcinomas: promotion of E-cadherin expression and suppression of beta-catenin/TCF activation.

  2003cited by this paper
• Neuroblastoma: biological insights into a clinical enigma

  2003cited by this paper
• Human Calcium-sensing Receptor Gene

  2002cited by this paper
• Quantification of MYCN, DDX1, and NAG Gene Copy Number in Neuroblastoma Using a Real-Time Quantitative PCR Assay

  2002cited by this paper
• International neuroblastoma pathology classification for prognostic evaluation of patients with peripheral neuroblastic tumors

  2001cited by this paper
• Filamin-A Binds to the Carboxyl-terminal Tail of the Calcium-sensing Receptor, an Interaction That Participates in CaR-mediated Activation of Mitogen-activated Protein Kinase*

  2001cited by this paper
• Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism.

  2000cited by this paper
• Losses of chromosomes 1p and 3q are early genetic events in the development of sporadic pheochromocytomas.

  2000cited by this paper
• Gain of chromosome arm 17q and adverse outcome in patients with neuroblastoma.

  1999cited by this paper
• Role of ploidy, chromosome 1p, and Schwann cells in the maturation of neuroblastoma.

  1996cited by this paper
• A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism

  1995cited by this paper
• Human neuroblastoma I-type cells are malignant neural crest stem cells.

  1995cited by this paper
• Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid

  1993cited by this paper
• Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.

  1984cited by this paper
• Evaluation of survival data and two new rank order statistics arising in its consideration.

  1966cited by this paper
• Nonparametric Estimation from Incomplete Observations

  1958cited by this paper

• Calcium sensing receptor expression is downregulated in gastroenteropancreatic neuroendocrine tumours via epigenetic mechanisms

  2024cites this paper
• Molecular regulation of calcium‐sensing receptor (CaSR)‐mediated signaling

  2024cites this paper
• Epigenetic Dysregulation in MYCN-Amplified Neuroblastoma

  2023cites this paper
• Pan-cancer analysis reveals the prognostic gene CASR suppresses tumor progression and epithelial-mesenchymal transition in renal clear cell carcinoma.

  2023cites this paper
• AC-265347 Inhibits Neuroblastoma Tumor Growth by Induction of Differentiation without Causing Hypocalcemia

  2022cites this paper
• Role of the calcium-sensing receptor (CaSR) in cancer metastasis to bone: Identifying a potential therapeutic target.

  2021cites this paper
• The calcium sensing receptor (CaSR) promotes Rab27B expression and activity to control secretion in breast cancer cells.

  2021cites this paper
• MYCN in Neuroblastoma: “Old Wine into New Wineskins”

  2021cites this paper
• The CaSR in Pathogenesis of Breast Cancer: A New Target for Early Stage Bone Metastases

  2020cites this paper
• International Union of Basic and Clinical Pharmacology. CVIII. Calcium-Sensing Receptor Nomenclature, Pharmacology, and Function

  2020cites this paper
• Calcium Sensing Receptor Inhibits Growth of Human Lung Adenocarcinoma Possibly via the GSK3β/Cyclin D1 Pathway

  2020cites this paper
• Proteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation

  2020cites this paper
• Biology of the extracellular calcium-sensing receptor

  2020cites this paper
• The Nervous System Relevance of the Calcium Sensing Receptor in Health and Disease

  2019influential citation
• Calcium-sensing receptor in physiology and in calcitropic and non-calcitropic diseases

  2019cites this paper
• Parathyroid hormone‐like hormone plays a dual role in neuroblastoma depending on PTH1R expression

  2019cites this paper
• DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome

  2019cites this paper
• In situ monitoring of PTHLH secretion in neuroblastoma cells cultured onto nanoporous membranes.

  2018cites this paper
• Molecular pathogenesis of parathyroid tumours.

  2018cites this paper
• Identification, characterization and HPLC quantification of formulation‐related impurities of honokiol, an antitumor natural drug candidate in clinical trials

  2018cites this paper
• Calcium-sensing receptor in colorectal inflammation and cancer: Current insights and future perspectives

  2018cites this paper
• The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases

  2018cites this paper
• The suppressive role of calcium sensing receptor in endometrial cancer

  2018cites this paper
• Alterations of DNA methylation in parathyroid tumors.

  2017cites this paper
• Tumor expression of calcium sensing receptor and colorectal cancer survival: Results from the nurses’ health study and health professionals follow‐up study

  2017cites this paper
• Genetic variants in the promoter region of the calcium‐sensing receptor gene are associated with its down‐regulation in neuroblastic tumors

  2017cites this paper
• Calcium-Sensing Receptor Gene: Regulation of Expression

  2016cites this paper
• Regulation of Differentiation by Calcium-Sensing Receptor in Normal and Tumoral Developing Nervous System

  2016cites this paper
• Cross Talk between the Calcium-Sensing Receptor and the Vitamin D System in Prevention of Cancer

  2016cites this paper
• The calcium-sensing receptor and the hallmarks of cancer.

  2016cites this paper
• The Calcium-Sensing Receptor in Health and Disease.

  2016cites this paper
• Cinacalcet inhibits neuroblastoma tumor growth and upregulates cancer-testis antigens

  2016cites this paper
• The Role of Intracellular Calcium for the Development and Treatment of Neuroblastoma

  2015cites this paper
• Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3

  2014cites this paper
• Parathyroid hormone-related protein overexpression protects goat mammary gland epithelial cells from calcium-sensing receptor activation-induced apoptosis

  2014cites this paper
• High calcium concentration in bones promotes bone metastasis in renal cell carcinomas expressing calcium-sensing receptor

  2014cites this paper
• Polymorphisms in the Calcium-Sensing Receptor Gene

  2013cites this paper
• Calcium sensing receptor signalling in physiology and cancer.

  2013cites this paper
• Polymorphisms in the Calcium-Sensing Receptor Gene Are Associated with Clinical Outcome of Neuroblastoma

  2013cites this paper
• The CASR gene: alternative splicing and transcriptional control, and calcium-sensing receptor (CaSR) protein: structure and ligand binding sites.

  2013cites this paper