Regionally reduced brain volume, altered serotonin neurochemistry, and abnormal behavior in mice null for the circadian rhythm output gene Magel2

No abstract is available for this paper.

• Publication year

  2009

• Venue

  American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

• Publication date

  2009-12-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ajmg.b.30934PMID 19199291
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• High Throughput Microimaging of the Mouse Brain

  2010influential reference
• Loss of Magel2, a Candidate Gene for Features of Prader-Willi Syndrome, Impairs Reproductive Function in Mice

  2009influential reference
• Genes and structural brain imaging in schizophrenia

  2008cited by this paper
• Follicle stimulating and leutinizing hormones, estradiol and testosterone in Prader–Willi syndrome

  2008cited by this paper
• Pituitary height and neuroradiological alterations in patients with Prader-Labhart-Willi syndrome

  2008cited by this paper
• The phenomenology and diagnosis of psychiatric illness in people with Prader–Willi syndrome

  2008cited by this paper
• Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster

  2008cited by this paper
• SnoRNA Snord116 (Pwcr1/MBII-85) Deletion Causes Growth Deficiency and Hyperphagia in Mice

  2008cited by this paper
• Loss of the Prader‐Willi syndrome protein necdin causes defective migration, axonal outgrowth, and survival of embryonic sympathetic neurons

  2008cited by this paper
• Automated deformation analysis in the YAC128 Huntington disease mouse model

  2008cited by this paper
• Pituitary abnormalities in Prader–Willi syndrome and early onset morbid obesity

  2008cited by this paper
• Cortical thickness measured from MRI in the YAC128 mouse model of Huntington's disease

  2008cited by this paper
• Behavioral phenotyping strategies for mutant mice.

  2008cited by this paper
• High resolution three-dimensional brain atlas using an average magnetic resonance image of 40 adult C57Bl/6J mice

  2008cited by this paper
• Beta N‐acetylglucosaminyltransferase V (Mgat5) deficiency reduces the depression‐like phenotype in mice

  2008cited by this paper
• Neuroanatomy of autism.

  2008cited by this paper
• Inactivation of the mouse Magel2 gene results in growth abnormalities similar to Prader-Willi syndrome.

  2007influential reference
• Genome-wide atlas of gene expression in the adult mouse brain

  2007cited by this paper
• Intracranial abnormalities detected by three‐dimensional magnetic resonance imaging in Prader–Willi syndrome

  2007cited by this paper
• Analyzing grooming microstructure in neurobehavioral experiments

  2007cited by this paper
• Mouse behavioral mutants have neuroimaging abnormalities

  2007influential reference
• What's Wrong With My Mouse?

  2007cited by this paper
• Deletion of the MBII-85 snoRNA Gene Cluster in Mice Results in Postnatal Growth Retardation

  2007cited by this paper
• Neonatal serotonin depletion alters behavioral responses to spatial change and novelty.

  2007cited by this paper
• Neuroscience: Obsessed with grooming

  2007cited by this paper
• Behavioral phenotypes of Disc1 missense mutations in mice.

  2007cited by this paper
• Sexual dimorphism revealed in the structure of the mouse brain using three-dimensional magnetic resonance imaging

  2007cited by this paper
• The course and outcome of psychiatric illness in people with Prader-Willi syndrome: implications for management and treatment.

  2007cited by this paper
• The imprinted gene Magel2 regulates normal circadian output

  2007influential reference
• Brain Developmental Abnormalities in Prader-Willi Syndrome Detected by Diffusion Tensor Imaging

  2006cited by this paper
• Statistical diffusion tensor histology reveals regional dysmyelination effects in the shiverer mouse mutant

  2006cited by this paper
• Serotonin reciprocally regulates melanocortin neurons to modulate food intake.

  2006cited by this paper
• Mapping brain maturation.

  2006cited by this paper
• Anatomical phenotyping in the brain and skull of a mutant mouse by magnetic resonance imaging and computed tomography.

  2006cited by this paper
• GH in the dwarf dopaminergic D2 receptor knockout mouse: somatotrope population, GH release, and responsiveness to GH-releasing factors and somatostatin.

  2006cited by this paper
• Imprinting defects on human chromosome 15

  2006cited by this paper
• Brain development and ADHD.

  2006cited by this paper
• Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death

  2006cited by this paper
• Digging and marble burying in mice: simple methods for in vivo identification of biological impacts

  2006influential reference
• Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth.

  2005cited by this paper
• A three-dimensional MRI atlas of the mouse brain with estimates of the average and variability.

  2005cited by this paper
• Serotonin alterations in anorexia and bulimia nervosa: new insights from imaging studies.

  2005cited by this paper
• Molecular breakpoint cloning and gene expression studies of a novel translocation t(4;15)(q27;q11.2) associated with Prader-Willi syndrome

  2005cited by this paper
• Guest editorial: update on enteric viruses.

  2005cited by this paper
• Developmental abnormalities of neuronal structure and function in prenatal mice lacking the prader-willi syndrome gene necdin.

  2005influential reference
• MR of the pituitary in patients with Prader-Willi syndrome: Size determination and imaging findings

  2005cited by this paper
• Structure, chromosomal localization, and expression of 12 genes of the MAGE family

  2005cited by this paper
• Effects of the rd1 Mutation and Host Strain on Hippocampal Learning in Mice

  2005cited by this paper
• A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin.

  2004cited by this paper
• A Comprehensive Team Approach to the Management of Patients with Prader-Willi Syndrome

  2004cited by this paper
• Necdin-related MAGE Proteins Differentially Interact with the E2F1 Transcription Factor and the p75 Neurotrophin Receptor*

  2004cited by this paper
• Neurobehavioral assessment in the information age

  2004cited by this paper
• Psychotic disorders in Prader–Willi syndrome

  2004cited by this paper
• On the delay-dependent involvement of the hippocampus in object recognition memory.

  2004cited by this paper
• Prader-Willi syndrome: advances in genetics, pathophysiology and treatment.

  2004cited by this paper
• Festina lente: Late-night thoughts on high-throughput screening of mouse behavior

  2004cited by this paper
• Prader-Willi syndrome transcripts are expressed in phenotypically significant regions of the developing mouse brain.

  2003cited by this paper
• The developmental role of serotonin: news from mouse molecular genetics

  2003cited by this paper
• Absence of Ndn, Encoding the Prader-Willi Syndrome-Deleted Gene necdin, Results in Congenital Deficiency of Central Respiratory Drive in Neonatal Mice

  2003cited by this paper
• The MAGE proteins: Emerging roles in cell cycle progression, apoptosis, and neurogenetic disease

  2002cited by this paper
• Suprachiasmatic nucleus organization

  2002cited by this paper
• Behavioral phenotypes in genetic syndromes: genetic clues to human behavior.

  2002cited by this paper
• Thresholding of Statistical Maps in Functional Neuroimaging Using the False Discovery Rate

  2002cited by this paper
• The p75 Neurotrophin Receptor Interacts with Multiple MAGE Proteins*

  2002cited by this paper
• Necdin is required for terminal differentiation and survival of primary dorsal root ganglion neurons.

  2002cited by this paper
• A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues

  2001cited by this paper
• The changing purpose of Prader-Willi syndrome clinical diagnostic criteria and proposed revised criteria.

  2001cited by this paper
• Analysis of amino acids and catecholamines, 5-hydroxytryptamine and their metabolites in brain areas in the rat using in vivo microdialysis.

  2001cited by this paper
• ‘Cerebrospinal fluid neuropeptide Y in Prader‐Willi syndrome’

  2001cited by this paper
• An overview of the MAGE gene family with the identification of all human members of the family.

  2001cited by this paper
• Expression and imprinting of MAGEL2 suggest a role in Prader-willi syndrome and the homologous murine imprinting phenotype.

  2000influential reference
• NRAGE , A Novel MAGE Protein , Interacts with the p 75 Neurotrophin Receptor and Facilitates Nerve Growth Factor – Dependent Apoptosis and Shooter

  2000cited by this paper
• Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome.

  2000cited by this paper
• NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis.

  2000cited by this paper
• What's Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice

  2000cited by this paper
• Detecting structural changes in whole brain based on nonlinear deformations-application to schizophrenia research.

  1999cited by this paper
• A new family of mouse genes homologous to the human MAGE genes.

  1999cited by this paper
• The human MAGEL2 gene and its mouse homologue are paternally expressed and mapped to the Prader-Willi region.

  1999cited by this paper
• Cerebrospinal fluid monoamines in Prader-Willi syndrome.

  1998cited by this paper
• Suprachiasmatic nucleus organization.

  1998cited by this paper
• Is monoamine oxidase activity elevated in Prader-Willi syndrome?

  1998cited by this paper
• Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment

  1997influential reference
• Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes.

  1995cited by this paper
• Automatic 3D Intersubject Registration of MR Volumetric Data in Standardized Talairach Space

  1994cited by this paper
• A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells.

  1991cited by this paper

• Genomic Imprinting, Epigenetic Dysregulation, and Neuropsychiatric Mechanisms in Prader–Willi Syndrome: A Multi-Level Integrative Review

  2026influential citation
• Environmental enrichment normalizes metabolic function in the murine model of Prader-Willi syndrome Magel2-null mice.

  2025cites this paper
• The role of physical exercise on hippocampal volume in depressive symptoms: a systematic review and multi-level meta-analysis

  2025cites this paper
• Investigation of a mouse model of Prader-Willi Syndrome with combined disruption of Necdin and Magel2

  2025cites this paper
• Magel2 in hypothalamic POMC neurons influences the impact of stress on anxiety-like behavior and spatial learning associated with a food reward in male mice

  2025cites this paper
• Ablation of Magel2 in hypothalamic proopiomelanocortin neurons that innervate the medial amygdala influences the impact of stress on anxiety-like behavior in male mice

  2025influential citation
• MAGEL2 (patho‐)physiology and Schaaf–Yang syndrome

  2024cites this paper
• Disengagement of somatostatin neurons from lateral septum circuitry by oxytocin and vasopressin restores social-fear extinction and suppresses aggression outbursts in Prader-Willi syndrome model.

  2023cites this paper
• Hypomethylation of the dopamine transporter (DAT) gene promoter is associated with hyperphagia-related behavior in Prader-Willi syndrome: a case-control study.

  2023cites this paper
• The Metabolic Efficacy of a Cannabidiolic Acid (CBDA) Derivative in Treating Diet- and Genetic-Induced Obesity

  2022cites this paper
• Deleting Snord115 genes in mice remodels monoaminergic systems activity in the brain toward cortico-subcortical imbalances.

  2022cites this paper
• Adult Neurogenesis under Control of the Circadian System

  2022cites this paper
• Analysis of the hypothalamic oxytocin system and oxytocin receptor-expressing astrocytes in a mouse model of Prader-Willi syndrome

  2022cites this paper
• Preserved Sleep for the Same Level of Respiratory Disturbance in Children with Prader-Willi Syndrome

  2022cites this paper
• Hypothalamic AAV-BDNF gene therapy improves metabolic function and behavior in the Magel2-null mouse model of Prader-Willi syndrome

  2022cites this paper
• Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions

  2022cites this paper
• A Comprehensive Review of Genetically Engineered Mouse Models for Prader-Willi Syndrome Research

  2021cites this paper
• Ontogenesis of Hypothalamic Neurons in Mammals

  2021cites this paper
• Epigenetics in Prader-Willi Syndrome

  2021cites this paper
• Animal models for Prader-Willi syndrome.

  2021cites this paper
• The N-terminal domain of the Schaaf–Yang syndrome protein MAGEL2 likely has a role in RNA metabolism

  2021cites this paper
• Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model

  2020cites this paper
• Developmental disabilities, autism, and schizophrenia at a single locus

  2020cites this paper
• Sertraline as a treatment option for temper outbursts in Prader–Willi syndrome

  2020cites this paper
• Disentangling ingestive behavior-related phenotypes in Prader-Willi syndrome: integrating information from nonclinical studies and clinical trials to better understand the pathophysiology of hyperphagia and obesity.

  2020cites this paper
• Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome

  2020cites this paper
• Complex Economic Behavior Patterns Are Constructed from Finite, Genetically Controlled Modules of Behavior

  2019cites this paper
• New subtypes of allele-specific epigenetic effects: implications for brain development, function and disease.

  2019cites this paper
• Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome.

  2019cites this paper
• Baby food and bedtime: Evidence for opposite phenotypes from different genetic and epigenetic alterations in Prader-Willi and Angelman syndromes

  2019cites this paper
• Neuronal differentiation defects in induced pluripotent stem cells derived from a Prader-Willi syndrome patient.

  2019cites this paper
• Preclinical Testing in Translational Animal Models of Prader-Willi Syndrome: Overview and Gap Analysis

  2019cites this paper
• Ectopic expression of Snord115 in choroid plexus interferes with editing but not splicing of 5-Ht2c receptor pre-mRNA in mice

  2019cites this paper
• Prader–Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition

  2019cites this paper
• Chronic diazoxide treatment decreases fat mass and improves endurance capacity in an obese mouse model of Prader-Willi syndrome.

  2018cites this paper
• Machine Learning Reveals Modules of Economic Behavior from Foraging Mice

  2018cites this paper
• Territorial Behavior and Social Stability in the Mouse Require Correct Expression of Imprinted Cdkn1c

  2018cites this paper
• Magel2 Modulates Bone Remodeling and Mass in Prader‐Willi Syndrome by Affecting Oleoyl Serine Levels and Activity

  2018cites this paper
• A Comprehensive Guide to the MAGE Family of Ubiquitin Ligases.

  2017cites this paper
• Regulation of USP7: A High Incidence of E3 Complexes.

  2017cites this paper
• In vivo microscopic voxel-based morphometry with a brain template to characterize strain-specific structures in the mouse brain

  2017cites this paper
• Magel2 knockout mice manifest altered social phenotypes and a deficit in preference for social novelty

  2017cites this paper
• The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways

  2017cites this paper
• Box C/D small nucleolar RNA genes and the Prader‐Willi syndrome: a complex interplay

  2017cites this paper
• Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice

  2017cites this paper
• What Gene Mutations Affect Serotonin in Mice?

  2017cites this paper
• Autism spectrum disorder: neuropathology and animal models

  2017cites this paper
• Zebrafish Models of Prader-Willi Syndrome: Fast Track to Pharmacotherapeutics.

  2016cites this paper
• Magel2‐null mice are hyper‐responsive to setmelanotide, a melanocortin 4 receptor agonist

  2016cites this paper
• Prader-Willi Syndrome and Schaaf-Yang Syndrome: Neurodevelopmental Diseases Intersecting at the MAGEL2 Gene

  2016cites this paper
• Dopamine pathway imbalance in mice lacking Magel2, a Prader-Willi syndrome candidate gene.

  2016cites this paper
• Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader–Willi syndrome

  2016cites this paper
• Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite

  2016cites this paper
• Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits.

  2016cites this paper
• Zebrafish Models of Prader-Willi Syndrome: Fast Track to Pharmacotherapeutics

  2016cites this paper
• Muscle dysfunction caused by loss of Magel2 in a mouse model of Prader-Willi and Schaaf-Yang syndromes.

  2016cites this paper
• Sodium azide-induced degenerative changes in the dorsolateral prefrontal cortex of rats: attenuatingmechanisms of kolaviron

  2016cites this paper
• Progressive postnatal decline in leptin sensitivity of arcuate hypothalamic neurons in the Magel2-null mouse model of Prader-Willi syndrome.

  2015cites this paper
• Imaging mouse models of neurodegeneration using multi-parametric MRI

  2015cites this paper
• USP 7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and IsMutated in aHumanNeurodevelopmental Disorder Graphical

  2015cites this paper
• Neuroanatomical Phenotypes Are Consistent With Autism‐Like Behavioral Phenotypes in the 15q11‐13 Duplication Mouse Model

  2015influential citation
• USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder.

  2015cites this paper
• MAGEL2 and Oxytocin-Implications in Prader-Willi Syndrome and Beyond.

  2015cites this paper
• How Could Circadian Clock Genes influence Short Duration Timing

  2015cites this paper
• Promoter characterization and functional association with placenta of porcine MAGEL2.

  2014influential citation
• Development of leptin responses in the Magel2-null mouse model of Prader-Willi syndrome

  2014cites this paper
• Drosophila Mage, a component of Smc5/6 DNA response complex, confers resistance to caffeine and genotoxic stress and plays a role in the cell cycle and cell survival

  2014cites this paper
• H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment.

  2014cites this paper
• Magel2 Is Required for Leptin-Mediated Depolarization of POMC Neurons in the Hypothalamic Arcuate Nucleus in Mice

  2013cites this paper
• Mouse models of Prader-Willi Syndrome: a systematic review.

  2013cites this paper
• Epigenetics and Maternal Brain Evolution

  2013cites this paper
• An orphan genetic obesity syndrome no more

  2013cites this paper
• An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy.

  2013cites this paper
• Behavioural and cognitive profiles of mouse models for Prader-Willi syndrome.

  2013cites this paper
• Leptin signaling defects in a mouse model of Prader-Willi syndrome

  2013influential citation
• Recommendations for the investigation of animal models of Prader–Willi syndrome

  2013cites this paper
• Mapping registration sensitivity in MR mouse brain images

  2013cites this paper
• 3-Dimensional Imaging Modalities for Phenotyping Genetically Engineered Mice

  2012cites this paper
• Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus.

  2012cites this paper
• Genetic diseases: congenital central hypoventilation, Rett, and Prader-Willi syndromes.

  2012cites this paper
• Preparation of fixed mouse brains for MRI

  2012cites this paper
• Deformation-based brain morphometry in rats

  2012cites this paper
• HFE GENE VARIANTS AND DYSREGULATION OF CHOLESTEROL AND IRON METABOLISM IN ALZHEIMER DISEASE AND CANCER

  2012cites this paper
• The Neurogenetics of Energy Balance

  2012cites this paper
• Maze training in mice induces MRI-detectable brain shape changes specific to the type of learning

  2011cites this paper
• Impaired hypothalamic regulation of endocrine function and delayed counterregulatory response to hypoglycemia in Magel2-null mice.

  2011cites this paper
• Genomic Imprinting Effects on Brain and Behavior: Future Directions

  2011cites this paper
• Imprinting analysis of porcine MAGEL2 gene in two fetal stages and association analysis with carcass traits

  2011cites this paper
• Genomic imprinting and mammalian reproduction.

  2011cites this paper
• Placental protection of the fetal brain during short-term food deprivation

  2011cites this paper
• How could clock gene variants contribute to the causes of autism

  2011cites this paper
• Epigenetics and brain evolution.

  2011cites this paper
• The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index.

  2010cites this paper
• Lack of Association Between MAGEL2 and Schizophrenia and Mood Disorders in the Japanese Population

  2010influential citation
• A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene.

  2010cites this paper
• Loss of Necdin impairs myosin activation and delays cell polarization

  2010cites this paper
• Parent-of-origin and trans-generational germline influences on behavioral development: the interacting roles of mothers, fathers, and grandparents.

  2010cites this paper
• Distinct Transcriptomes Define Rostral and Caudal Serotonin Neurons

  2010cites this paper
• NEUROENDOCRINE CONTROL OF BODY ENERGY HOMEOSTASIS

  year unknowncites this paper