Glia instruct developmental neuronal remodeling through TGF-βsignaling

We found that glia secrete myoglianin, a TGF-β ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

• Publication year

  2011

• Venue

  Nature Neuroscience

• Publication date

  2011-06-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nn.2833PMID 21685919PMCID 3337551
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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