Meta-analysis of genome-wide association studies of anxiety disorders

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Molecular Psychiatry

• Publication date

  2016-10-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1038/mp.2016.11PMID 26857599
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation.

  2015cited by this paper
• Meta-analysis of genome-wide association studies of anxiety disorders

  2015cited by this paper
• Genome-Wide Association Study in Obsessive-Compulsive Disorder: Results from the OCGAS

  2014cited by this paper
• Cystinuria: current diagnosis and management.

  2014cited by this paper
• Genome-Wide and Gene-Based Association Studies of Anxiety Disorders in European and African American Samples

  2014cited by this paper
• Research review: Polygenic methods and their application to psychiatric traits.

  2014influential reference
• LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

  2014cited by this paper
• Cohort Profile Update: The TRacking Adolescents’ Individual Lives Survey (TRAILS)

  2014cited by this paper
• Genome-wide association study implicates a novel RNA gene, the lincRNA AC068718.1, as a risk factor for post-traumatic stress disorder in women.

  2013cited by this paper
• [The lifetime prevalence of mental disorders in north-eastern Germany. What is the influence of earlier mental morbidity on survey participation and prevalence estimates? Results from the SHIP-study].

  2013cited by this paper
• Power in GWAS: lifting the curse of the clinical cut-off

  2013cited by this paper
• Performance of Polygenic Scores for Predicting Phobic Anxiety

  2013cited by this paper
• Genome-wide association study of obsessive-compulsive disorder

  2013cited by this paper
• Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

  2013cited by this paper
• Genome-wide Association Study Identifies New Susceptibility Loci for Posttraumatic Stress Disorder

  2013cited by this paper
• A genome-wide association study of posttraumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus

  2012cited by this paper
• Five years of GWAS discovery.

  2012cited by this paper
• Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

  2012cited by this paper
• Meta-analysis of genome-wide association studies for panic disorder in the Japanese population

  2012cited by this paper
• GCTA: a tool for genome-wide complex trait analysis.

  2011influential reference
• Is obsessive–compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective

  2011cited by this paper
• GATES: a rapid and powerful gene-based association test using extended Simes procedure.

  2011cited by this paper
• TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies

  2011cited by this paper
• Genetic risk profiles for depression and anxiety in adult and elderly cohorts

  2010cited by this paper
• A Knowledge-Based Weighting Framework to Boost the Power of Genome-Wide Association Studies

  2010cited by this paper
• Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin.

  2010cited by this paper
• METAL: fast and efficient meta-analysis of genomewide association scans

  2010influential reference
• Research domain criteria (RDoC): toward a new classification framework for research on mental disorders.

  2010cited by this paper
• MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

  2010cited by this paper
• The Internet-based MGS2 control sample: self report of mental illness.

  2010cited by this paper
• Anxiety disorder

  2010cited by this paper
• The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors

  2009cited by this paper
• Genetics of anxiety disorders: the complex road from DSM to DNA

  2009influential reference
• Comparing apples and oranges: equating the power of case‐control and quantitative trait association studies

  2009cited by this paper
• Common disorders are quantitative traits

  2009cited by this paper
• Multi-system disorder syndromes associated with cystinuria type I.

  2008cited by this paper
• The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods

  2008cited by this paper
• The Rotterdam Study: objectives and design update

  2007cited by this paper
• Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia, agoraphobia, and animal phobia.

  2007cited by this paper
• Reference List

  2006cited by this paper
• Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism

  2006cited by this paper
• PREPL: a putative novel oligopeptidase propelled into the limelight

  2006cited by this paper
• Netherlands Twin Register: From Twins to Twin Families

  2006cited by this paper
• The co-morbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies

  2005influential reference
• Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.

  2005cited by this paper
• The structure of genetic and environmental risk factors for anxiety disorders in men and women.

  2005cited by this paper
• The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women.

  2003cited by this paper
• False discoveries and models for gene discovery.

  2003cited by this paper
• Statistical significance for genomewide studies

  2003cited by this paper
• Netherlands Twin Register: A Focus on Longitudinal Research

  2002cited by this paper
• A review and meta-analysis of the genetic epidemiology of anxiety disorders.

  2001influential reference
• Molecular Psychiatry

  1998cited by this paper
• The Comorbidity of Anxiety and Depression

  1997cited by this paper
• Cardiovascular risk factors

  1988cited by this paper
• Genetic covariation between neuroticism and the symptoms of anxiety and depression

  1984cited by this paper

• Impact of Glucagon-like Peptide-1 Receptor Agonists on Mental Illness: Evidence from a Mendelian Randomization Study

  2025cites this paper
• Causal influences of migraine on neuropsychiatric disorders: A 2-sample Mendelian randomization study

  2025cites this paper
• Genetic and Epigenetic Foundations of Childhood Internalizing and Externalizing Problems and their Co-occurrence

  2025cites this paper
• Adolescent Peer Victimization Through a Trauma Lens: Heightened Startle Response, Increased Pupil Dilation, Elevated Cortisol, and Reduced Heart Rate Variability in Young Adulthood

  2025cites this paper
• Fat-brain axis indicated by mutual impacts between body fat and brain phenotypes

  2025cites this paper
• Polygenic Risk Scores for Pediatric Obsessive-Compulsive Symptoms and their Mediating Effect in Clinically Diagnosed Samples of Obsessive-Compulsive Disorder, Attention-Deficit/Hyperactivity Disorder, Anxiety, Depression, Autism and Tourette syndrome

  2025influential citation
• Computer reconstruction of gene networks controlling anxiety levels in humans and laboratory mice

  2025cites this paper
• Dysregulated Gene Expression: A Candidate Mechanism for Anxiety Disorders

  2025cites this paper
• Associations between rosacea, anxiety, and depression: a bidirectional two-sample Mendelian randomization study

  2025cites this paper
• Hyperactivity and Differential Gene Expression in lbx1a(−/−) Zebrafish Larvae

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• Transdiagnostic Polygenic Risk Models for Psychopathology and Comorbidity: Cross-Ancestry Analysis in the All of Us Research Program

  2025cites this paper
• Adolescent peer victimization and subsequent cognitive-affective biases in threat attention, reactivity, and interpretation

  2025cites this paper
• The Genetic Association Between Prescription Pain Medication Use and the Risk for Fibromyalgia: A Bidirectional and Multivariable Mendelian Randomization Analysis

  2025cites this paper
• Genetic association between sleep quality, insomnia, and psychological distress: a systematic review and meta-analysis.

  2025cites this paper
• Contributions of Genetic Liability and the COVID-19 Pandemic to Rising Psychopathology Among Youth in the United States

  2025cites this paper
• Patterns of Shared Genetic Risk Between Chronic Pain, Psychopathologies, and Neuroticism

  2025cites this paper
• Onsite vasovagal reactions with and without loss of consciousness are distinct outcomes with different risk factors

  2025cites this paper
• Dynamics of clinical and neurophysiological manifestations of generalized anxiety disorder after right median nerve TENS depending on different current modalities.

  2025cites this paper
• Clinical features and genetic mechanisms of anxiety, fear, and avoidance: A comprehensive review of five anxiety disorders

  2025cites this paper
• Large-scale composite hypothesis testing procedure for omics data analyses

  2025cites this paper
• Machine learning-driven polygenic risk scores for bipolar disorder, depression, and panic disorder

  2024influential citation
• Cross-EHR validation of antidepressant response algorithm and links with genetics of psychiatric traits

  2024cites this paper
• Causal associations between chronic viral hepatitis and psychiatric disorders: a Mendelian randomization study

  2024cites this paper
• Cardiovascular health (“Life’s Essential 8”), risk of depression and anxiety: a prospective cohort study

  2024cites this paper
• A Multivariate Genome-Wide Association Study Reveals Neural Correlates and Common Biological Mechanisms of Psychopathology Spectra

  2024influential citation
• Blood metabolites, neurocognition and psychiatric disorders: a Mendelian randomization analysis to investigate causal pathways

  2024cites this paper
• The causal relationship of female infertility and psychiatric disorders in the European population: a bidirectional two-sample Mendelian randomization study

  2024cites this paper
• Causal relationships between atopic dermatitis and psychiatric disorders: a bidirectional two-sample Mendelian randomization study

  2024cites this paper
• Mendelian randomization analysis does not reveal a causal influence between keratoconus and three major mental disorders

  2024cites this paper
• The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores

  2024cites this paper
• Cardiovascular Disease, Genetic Susceptibility, and Risk of Psychiatric Disorders and Suicide Attempt: A Community‐Based Matched Cohort Study Based on the UK Biobank

  2024cites this paper
• Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization study

  2024cites this paper
• The Influence of Genetic and Environmental Factors on Anxiety among Chinese Adolescents: A Twin Study

  2024cites this paper
• Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology

  2024cites this paper
• A genome-wide gene-environmental interaction study identified novel loci for the relationship between ambient air pollution exposure and depression, anxiety.

  2024cites this paper
• Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder

  2024cites this paper
• Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder

  2024cites this paper
• Positive and negative affect, related mental health traits, and cognitive performance: shared genetic architecture and potential causality

  2024cites this paper
• Assessing the causal relationship between psychiatric disorders and obstructive sleep apnea: a bidirectional Mendelian randomization

  2024cites this paper
• Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis

  2024cites this paper
• Gene Discovery and Biological Insights into Anxiety Disorders from a Multi-Ancestry Genome-wide Association Study of >1.2 Million Participants

  2024influential citation
• Exploring the genetic and socioeconomic interplay between ADHD and anxiety disorders using Mendelian randomization

  2024cites this paper
• Bi-directional two-sample Mendelian randomization identifies causal association of depression with temporomandibular disorders.

  2024cites this paper
• Causal influences of neuropsychiatric disorders on Alzheimer’s disease

  2024cites this paper
• Evaluation of the Observational Associations and Shared Genetics Between Glaucoma With Depression and Anxiety

  2024cites this paper
• A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan.

  2023cites this paper
• Prioritizing genes associated with brain disorders by leveraging enhancer-promoter interactions in diverse neural cells and tissues

  2023cites this paper
• Treatment Resistance in Schizophrenia Is Associated with Attention Deficit/Hyperactivity Disorder and Gut Microbiota: A Genetic Correlation and Mendelian Randomization Study

  2023cites this paper
• Adverse Childhood Events, Mood and Anxiety Disorders, and Substance Dependence: Gene X Environment Effects and Moderated Mediation

  2023cites this paper
• Genetic liability to major psychiatric disorders contributes to multi-faceted quality of life outcomes in children and adults

  2023cites this paper
• Polygenic scores for psychiatric disorders in a diverse postmortem brain tissue cohort

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• Causal atlas between inflammatory bowel disease and mental disorders: a bi-directional 2-sample Mendelian randomization study

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• Shared genetic basis informs the roles of polyunsaturated fatty acids in brain disorders

  2023influential citation
• Mapping microRNA expression quantitative trait loci in the prenatal human brain implicates miR-1908-5p expression in bipolar disorder and other brain-related traits

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• The interactions between host genome and gut microbiome increase the risk of psychiatric disorders: Mendelian randomization and biological annotation

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• The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis

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• Multivariate patterns between brain network properties, polygenic scores, phenotypes, and environment in preadolescents

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• The association between polygenic risk scores for mental disorders and social cognition: A scoping review.

  2023cites this paper
• Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH)

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• Genetic Determinants of the Association between Osteoarthritis and Psychiatric Disorders

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• Cross-continental environmental and genome-wide association study on children and adolescent anxiety and depression

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• Treatment Course Comparison Between Anxiety-Related Disorders in Adult Outpatients

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• The impact of poverty on mental illness: Emerging evidence of a causal relationship

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• Effect of 25-hydroxyvitamin D levels on the internalising dimension as a transdiagnostic risk factor: Mendelian randomisation study

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• Genetic associations among internalizing and externalizing traits with polysubstance use among young adults

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• Assessment of Bidirectional Relationships between Mental Illness and Rheumatoid Arthritis: A Two-Sample Mendelian Randomization Study

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• Understanding the relationship between loneliness, substance use traits and psychiatric disorders: A genetically informed approach

  2023cites this paper
• Genetic relationships between chronic pain, psychopathologies, and neuroticism.

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• The overlapping genetic architecture of psychiatric disorders and cortical brain structure

  2023cites this paper
• Causal effects of diabetic retinopathy on depression, anxiety and bipolar disorder in the European population: a Mendelian randomization study

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• The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits

  2022cites this paper
• A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan.

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• Brain Structural Mapping of Multi-factorial Aging Mechanism Using 35,035 UK Biobank Subjects

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• Psychiatric disorders and Type 2 diabetes mellitus: A bidirectional Mendelian randomization

  2022cites this paper
• Linkage Disequilibrium Score Statistic Regression for Identifying Novel Trait Associations

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• Systematic review of genome-wide association studies of anxiety disorders and neuroticism

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• Testing Human Anxiety Associations of Genes Previously Implicated by Mouse Anxiety Models

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• Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts

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• Testing the causal relationships of physical activity and sedentary behaviour with mental health and substance use disorders: a Mendelian randomisation study

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• Genomic Structural Equation Modeling Reveals Latent Phenotypes in the Human Cortex with Distinct Genetic Architecture

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