Overview on Rodent Models of Alzheimer's Disease

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Current Protocols in Neuroscience

• Publication date

  2005-10-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1002/0471142301.ns0922s33PMID 18428631
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transgenic mice.

  2006cited by this paper
• A case for a non‐transgenic animal model of Alzheimer's disease

  2005cited by this paper
• Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for j 3-APP 751 ( Alz 50 / P-amyloid / jp-amyloid precursor / Down syndrome )

  2005cited by this paper
• Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

  2005cited by this paper
• Deciphering the molecular basis of memory failure in Alzheimer's disease.

  2004cited by this paper
• Minocycline protects basal forebrain cholinergic neurons from mu p75‐saporin immunotoxic lesioning

  2004cited by this paper
• Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction.

  2003cited by this paper
• Single intracerebroventricular administration of amyloid-beta (25-35) peptide induces impairment in short-term rather than long-term memory in rats.

  2003cited by this paper
• Amnesia induced by beta-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade.

  2003cited by this paper
• In Vitro Characterization of Conditions for Amyloid-β Peptide Oligomerization and Fibrillogenesis*

  2003cited by this paper
• Peptide vaccination.

  2002influential reference
• Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies.

  2002cited by this paper
• Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice

  2002cited by this paper
• Impaired eyeblink conditioning and decreased hippocampal volume in PDAPP V717F mice.

  2002cited by this paper
• Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in PDAPP mice.

  2002cited by this paper
• Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

  2002cited by this paper
• Behavioral impairment of APP(V717F) mice in fear conditioning: is it only cognition?

  2002cited by this paper
• The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

  2002cited by this paper
• Does my mouse have Alzheimer's disease?

  2002cited by this paper
• Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.

  2002cited by this paper
• Pharmacotherapy for Alzheimer's disease: progress and prospects.

  2002influential reference
• Microglial Activation and β-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice

  2002cited by this paper
• Amyloid β-peptide induces cholinergic dysfunction and cognitive deficits: a minireview

  2002cited by this paper
• Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

  2001cited by this paper
• Neurofibrillary Pathology in Transgenic Mice Overexpressing V717F β‐Amyloid Precursor Protein

  2001cited by this paper
• Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

  2001cited by this paper
• Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

  2001cited by this paper
• Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice.

  2001cited by this paper
• Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

  2001cited by this paper
• Selective Immunolesions of Cholinergic Neurons in Mice: Effects on Neuroanatomy, Neurochemistry, and Behavior

  2001cited by this paper
• Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease.

  2001cited by this paper
• A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.

  2001cited by this paper
• Comparative Analysis of Amyloid-β Chemical Structure and Amyloid Plaque Morphology of Transgenic Mouse and Alzheimer's Disease Brains*

  2001cited by this paper
• Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques

  2001cited by this paper
• Key Factors in Alzheimer's Disease: β‐amyloid Precursor Protein Processing, Metabolism and Intraneuronal Transport

  2001cited by this paper
• Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease

  2001cited by this paper
• Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice.

  2001cited by this paper
• Gene targeting: technical confounds and potential solutions in behavioral brain research.

  2001cited by this paper
• Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695*

  2001influential reference
• Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

  2001cited by this paper
• Cognitive and behavioral heterogeneity in Alzheimer's disease: seeking the neurobiological basis.

  2000cited by this paper
• Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease

  2000cited by this paper
• Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

  2000cited by this paper
• The β-Amyloid Precursor Protein and its Derivatives: From Biology to Learning and Memory Processes

  2000influential reference
• Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

  2000cited by this paper
• A learning de ® cit related to age and b-amyloid plaques in a mouse model of Alzheimer ' s disease

  2000cited by this paper
• Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

  2000cited by this paper
• Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice.

  2000influential reference
• A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.

  2000cited by this paper
• In vivo synaptic transmission in young and aged amyloid precursor protein transgenic mice.

  2000cited by this paper
• Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.

  2000cited by this paper
• Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

  2000cited by this paper
• Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

  2000cited by this paper
• The role of acetylcholine in cortical synaptic plasticity.

  2000cited by this paper
• A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

  2000cited by this paper
• The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins.

  2000cited by this paper
• The neuropsychology of preclinical Alzheimer's disease and mild cognitive impairment.

  2000cited by this paper
• Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain*

  1999influential reference
• Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.

  1999cited by this paper
• Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo.

  1999cited by this paper
• Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice.

  1999cited by this paper
• Attention and executive deficits in Alzheimer's disease. A critical review.

  1999cited by this paper
• Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease.

  1999cited by this paper
• Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein.

  1999cited by this paper
• Long-term memory in Alzheimer's disease.

  1999cited by this paper
• Protective effects of idebenone and α‐tocopherol on β‐amyloid‐(1–42)‐induced learning and memory deficits in rats: implication of oxidative stress in β‐amyloid‐induced neurotoxicity in vivo

  1999cited by this paper
• Behavioral Changes in Transgenic Mice Expressing Both Amyloid Precursor Protein and Presenilin-1 Mutations: Lack of Association with Amyloid Deposits

  1999cited by this paper
• Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

  1999cited by this paper
• Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

  1999cited by this paper
• Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer’s Disease

  1999cited by this paper
• Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

  1999cited by this paper
• Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.

  1999cited by this paper
• The cholinergic hypothesis of Alzheimer’s disease: a review of progress

  1999cited by this paper
• Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests.

  1999cited by this paper
• Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.

  1999cited by this paper
• Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F beta-amyloid precursor protein.

  1999cited by this paper
• Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

  1998cited by this paper
• The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease

  1998cited by this paper
• The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.

  1998cited by this paper
• Mutant genes in familial Alzheimer's disease and transgenic models.

  1998cited by this paper
• Mutant Presenilin 2 Transgenic Mouse: Effect on an Age‐Dependent Increase of Amyloid β‐Protein 42 in the Brain

  1998cited by this paper
• Tau in Alzheimer's disease.

  1998cited by this paper
• Mémoires et démences

  1998cited by this paper
• induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation

  1998cited by this paper
• Abnormalities of neural circuitry in Alzheimer's disease

  1998cited by this paper
• [Apolipoprotein E and Alzheimer's disease].

  1998cited by this paper
• Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

  1997influential reference
• Cognitive functions of cortical acetylcholine: toward a unifying hypothesis.

  1997cited by this paper
• Amyloid, the presenilins and Alzheimer's disease.

  1997influential reference
• Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

  1997cited by this paper
• Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.

  1997influential reference
• Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies

  1997cited by this paper
• Present imperfect: a critical review of animal models of the mnemonic impairments in Alzheimer's disease.

  1997cited by this paper
• Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

  1997cited by this paper
• The Pathogenesis of Senile Plaques

  1997cited by this paper
• A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice.

  1997cited by this paper
• Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice.

  1997cited by this paper
• Assessing Patterns of Agitation in Alzheimer's Disease Patients with the Cohen‐Mansfield Agitation Inventory

  1997cited by this paper
• The cholinergic system in Alzheimer's disease.

  1997cited by this paper
• Normal and pathological Tau proteins as factors for microtubule assembly.

  1997cited by this paper

• Alzheimer's disease and epilepsy: Research hotspots for comorbidity in the era of global aging.

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• Transgenic Mouse Models for the Study of Neurodegenerative Diseases.

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• Neuronal Calcium Imaging, Excitability, and Plasticity Changes in the Aldh2–/– Mouse Model of Sporadic Alzheimer’s Disease

  2020cites this paper
• The Erythrocytic Hypothesis of Brain Energy Crisis in Sporadic Alzheimer Disease: Possible Consequences and Supporting Evidence

  2020cites this paper
• Overview of Transgenic Mouse Models for Alzheimer's Disease

  2019cites this paper
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  2018cites this paper
• Ontogenetic and Phylogenetic Approaches for Studying the Mechanisms of Cognitive Dysfunctions

  2018cites this paper
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• Lupeol Isolated from Betula alnoides Ameliorates Amyloid Beta Induced Neuronal Damage via Targeting VariousPathological Events and Alteration in Neurotransmitter Levels in Ratâs Brain

  2017cites this paper
• Acquisition and reversal of visual discrimination learning in APPSwDI/Nos2-/- (CVN) mice.

  2017cites this paper
• Why therapies for Alzheimer's disease do not work: Do we have consensus over the path to follow?

  2016cites this paper
• Post-mortem analysis of neuroinflammatory changes in human Alzheimer’s disease

  2015cites this paper
• The Benefits of Exercise on Structural and Functional Plasticity in the Rodent Hippocampus of Different Disease Models

  2015cites this paper
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  2015cites this paper
• Evidence for early identification of Alzheimer's disease

  2012cites this paper
• Overview of Mouse Models for Psychiatric and Neurologic Disorders

  2012cites this paper
• Alzheimer's Disease and Frontotemporal Dementia

  2011cites this paper
• Knock-down of protein L-isoaspartyl O-methyltransferase increases β-amyloid production by decreasing ADAM10 and ADAM17 levels

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• PIB binding in aged primate brain: enrichment of high-affinity sites in humans with Alzheimer's disease.

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• Neurovascular function in Alzheimer's disease patients and experimental models

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• Aβ Infusion and Related Models of Alzheimer Dementia

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• Gold Standard Animal Models

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• Selecting a mouse model of Alzheimer's disease.

  2010cites this paper
• In Vitro and In Vivo Activation of Astrocytes by Amyloid-β is Potentiated by Pro-Oxidant Agents

  2010cites this paper
• Transgenic animal models of neurodegeneration based on human genetic studies

  2010cites this paper
• Intranasal Delivery of Human β-Amyloid Peptide in Rats: Effective Brain Targeting

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• The neuroprotective effects of Nokyongdaebo-tang(Lurongdabutang) treatment in pathological Alzheimer's disease model of neural tissues

  2009cites this paper
• Distribution and progression of amyloid-beta deposits in the amygdala of the aged macaque monkey, and parallels with zinc distribution.

  2009cites this paper
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