Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Cell Cycle

• Publication date

  2015-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/15384101.2014.972901PMID 25659039PMCID PMC4353239
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection.

  2014cited by this paper
• Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells

  2014cited by this paper
• CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity.

  2014cited by this paper
• Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers

  2014cited by this paper
• RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

  2013cited by this paper
• The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression

  2013cited by this paper
• The predictive value of 53BP1 and BRCA1 mRNA expression in advanced non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy

  2013cited by this paper
• Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression.

  2013cited by this paper
• A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice.

  2013cited by this paper
• RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair*

  2013cited by this paper
• Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection

  2013cited by this paper
• Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.

  2012cited by this paper
• BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

  2012cited by this paper
• The proteasomal de‐ubiquitinating enzyme POH1 promotes the double‐strand DNA break response

  2012cited by this paper
• The F-box Protein FBXO44 Mediates BRCA1 Ubiquitination and Degradation*

  2012cited by this paper
• Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications.

  2011cited by this paper
• BRCA1 and its toolbox for the maintenance of genome integrity

  2010influential reference
• 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.

  2010cited by this paper
• The CHK2–BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

  2010cited by this paper
• The DNA damage response: making it safe to play with knives.

  2010cited by this paper
• Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

  2010cited by this paper
• CtIP-BRCA1 modulates the choice of DNA double-strand break repair pathway throughout the cell cycle

  2009influential reference
• Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair*S⃞

  2009cited by this paper
• Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer

  2008cited by this paper
• Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair*

  2008cited by this paper
• Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

  2008cited by this paper
• Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends.

  2008cited by this paper
• Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.

  2008cited by this paper
• BRCA1 is regulated by Chk2 in response to spindle damage.

  2008cited by this paper
• Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.

  2007influential reference
• Human CtIP promotes DNA end resection

  2007cited by this paper
• Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.

  2007cited by this paper
• Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex.

  2007cited by this paper
• BRCA1 promotes induction of ssDNA by ionizing radiation.

  2006influential reference
• ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

  2006cited by this paper
• Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

  2005cited by this paper
• The Role of the BRCA1 Tumor Suppressor in DNA Double-Strand Break Repair

  2005cited by this paper
• Uterus Hyperplasia and Increased Carcinogen-Induced Tumorigenesis in Mice Carrying a Targeted Mutation of the Chk2 Phosphorylation Site in Brca1

  2004cited by this paper
• The CDK regulates repair of double‐strand breaks by homologous recombination during the cell cycle

  2004cited by this paper
• DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

  2004cited by this paper
• DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

  2004cited by this paper
• Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

  2004influential reference
• Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

  2003cited by this paper
• Direct DNA binding by Brca1

  2001cited by this paper
• Involvement of Brca1 in S-Phase and G2-Phase Checkpoints after Ionizing Irradiation

  2001cited by this paper
• Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

  2001cited by this paper
• hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

  2000influential reference
• Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.

  1999cited by this paper
• Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.

  1999cited by this paper
• Association of BRCA1 with Rad51 in mitotic and meiotic cells.

  1997cited by this paper
• Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage.

  1997cited by this paper

• Defining homologous recombination deficiency status in pancreatic ductal adenocarcinoma: Clinical implications for evaluating response to platinum chemotherapy.

  2025cites this paper
• Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth

  2025cites this paper
• Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection

  2024cites this paper
• Targeting the Cdc2‐like kinase 2 for overcoming platinum resistance in ovarian cancer

  2024cites this paper
• Radiotherapy and radio‐sensitization in H3 K27M ‐mutated diffuse midline gliomas

  2023cites this paper
• Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice

  2022influential citation
• Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop

  2022cites this paper
• Modulation of BRCA1 mediated DNA damage repair by deregulated ER-α signaling in breast cancers.

  2022cites this paper
• Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies

  2021cites this paper
• Interaction of Wwox with Brca1 and associated complex proteins prevents premature resection at double-strand breaks and aberrant homologous recombination.

  2021cites this paper
• Functional Analysis Identifies Damaging CHEK2 Missense Variants Associated with Increased Cancer Risk

  2021cites this paper
• Cell cycle checkpoint control in response to dna damage by environmental stresses.

  2021influential citation
• USP39 promotes non-homologous end-joining repair by poly(ADP-ribose)-induced liquid demixing

  2021cites this paper
• BRCA1 Antibodies Matter

  2021cites this paper
• Genomic Features and Classification of Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma.

  2021cites this paper
• Inactivation of the Prolyl Isomerase Pin1 Sensitizes BRCA1-Proficient Breast Cancer to PARP Inhibition

  2020cites this paper
• Identification of regulatory crosstalks between RKIP and BRCA1 tumor suppressors in healthy tissues and cancer (breast and ovarian): Therapeutic implications

  2020cites this paper
• The F-Box-Like Protein FBL17 Is a Regulator of DNA-Damage Response and Colocalizes with RETINOBLASTOMA RELATED1 at DNA Lesion Sites1[OPEN]

  2020cites this paper
• Homologous recombination deficiency in breast cancer: Implications for risk, cancer development, and therapy

  2020cites this paper
• Fresh and ozonized black carbon promoted DNA damage and repair responses in A549 cells.

  2019cites this paper
• The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage

  2019cites this paper
• Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents

  2019cites this paper
• Mapping genetic interactions in cancer: a road to rational combination therapies

  2019cites this paper
• MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers

  2019cites this paper
• Mitotic and Meiotic Functions for the SUMOylation Pathway in the Caenorhabditis elegans Germline

  2018cites this paper
• Melanoma antigen‐D2 controls cell cycle progression and modulates the DNA damage response

  2018cites this paper
• The Roles of Cullin RING Ligases and the Anaphase Promoting Complex/Cyclosome in the Regulation of DNA Double Strand Break Repair

  2017cites this paper
• Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer

  2017cites this paper
• DNA-damage-induced degradation of EXO1 exonuclease limits DNA end resection to ensure accurate DNA repair

  2017influential citation
• Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway

  2016influential citation
• Skp2 is over-expressed in breast cancer and promotes breast cancer cell proliferation

  2016cites this paper
• Breast cancer predisposition gene brca1, pathogenic c61g mutation in mice: synthetic viability in DNA repair and tumour development

  2016influential citation
• Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development

  2016cites this paper
• Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.

  2016influential citation
• Hsp90: A New Player in DNA Repair?

  2015cites this paper
• Effects of Radiation Therapy on Breast Epithelial Cells in BRCA1/2 Mutation Carriers

  2015cites this paper