BRCA1 and its toolbox for the maintenance of genome integrity

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Nature reviews. Molecular cell biology

• Publication date

  2010-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrm2831PMID 20029420PMCID PMC3899800
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity.

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• MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.

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• Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair*S⃞

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• NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.

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• The Central Region of BRCA1 Binds Preferentially to Supercoiled DNA

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• The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

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• Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication.

  2009cited by this paper
• PALB2 is an integral component of the BRCA complex required for homologous recombination repair

  2009cited by this paper
• PALB2 links BRCA1 and BRCA2 in the DNA-damage response.

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• Common variations in BARD1 influence susceptibility to high-risk neuroblastoma

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• A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency.

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• The BRCA1‐dependent ubiquitin ligase, γ‐tubulin, and centrosomes

  2009cited by this paper
• CtIP-BRCA1 modulates the choice of DNA double-strand break repair pathway throughout the cell cycle

  2009cited by this paper
• MERIT40 facilitates BRCA1 localization and DNA damage repair.

  2009cited by this paper
• The DNA-damage response in human biology and disease

  2009cited by this paper
• Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair*

  2008cited by this paper
• E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

  2008cited by this paper
• DNA helicases Sgs1 and BLM promote DNA double-strand break resection.

  2008cited by this paper
• Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair

  2008cited by this paper
• Homologous recombination in DNA repair and DNA damage tolerance

  2008cited by this paper
• The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

  2008cited by this paper
• Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

  2008cited by this paper
• The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.

  2007cited by this paper
• BRCA2: a universal recombinase regulator

  2007cited by this paper
• Estrogen receptor alpha is a putative substrate for the BRCA1 ubiquitin ligase.

  2007cited by this paper
• A recurrent mutation in PALB2 in Finnish cancer families

  2007cited by this paper
• Human CtIP promotes DNA end resection

  2007cited by this paper
• Estrogen receptor α is a putative substrate for the BRCA1 ubiquitin ligase

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• Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

  2007cited by this paper
• Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.

  2007cited by this paper
• CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response

  2007cited by this paper
• RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.

  2007cited by this paper
• PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

  2007cited by this paper
• RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

  2007cited by this paper
• Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

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• Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

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• DNA Damage Response as an Anti-Cancer Barrier: Damage Threshold and the Concept of 'Conditional Haploinsufficiency'

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• BRCA1 Control of Steroid Receptor Ubiquitination

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• CCDC98 targets BRCA1 to DNA damage sites

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• A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.

  2007cited by this paper
• RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

  2007cited by this paper
• The FANCJ/MutLα interaction is required for correction of the cross‐link response in FA‐J cells

  2007cited by this paper
• Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

  2007cited by this paper
• Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response

  2007cited by this paper
• DNA damage checkpoints: from initiation to recovery or adaptation.

  2007cited by this paper
• E2–BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

  2007cited by this paper
• Fanconi anemia is associated with a defect in the BRCA2 partner PALB2

  2007cited by this paper
• Activation of BRCA1/BRCA2-Associated Helicase BACH1 Is Required for Timely Progression through S Phase

  2007cited by this paper
• Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

  2007cited by this paper
• Ubc13/Rnf8ユビキチンリガーゼはDNS損傷に反応してRap80/Abraxas/Brca1/Brca1/Brcc36複合体のフォーカス形成を制御する

  2007cited by this paper
• BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation.

  2006cited by this paper
• BRCA1 promotes induction of ssDNA by ionizing radiation.

  2006cited by this paper
• A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination.

  2006cited by this paper
• Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

  2006cited by this paper
• Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

  2006cited by this paper
• Substrates of the BRCA1-dependent ubiquitin ligase

  2006cited by this paper
• A conserved pathway to activate BRCA1‐dependent ubiquitylation at DNA damage sites

  2006cited by this paper
• BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP.

  2006cited by this paper
• Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.

  2006cited by this paper
• MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.

  2006cited by this paper
• Fanconi anemia (cross)linked to DNA repair.

  2005cited by this paper
• BRCA1 participates in DNA decatenation

  2005cited by this paper
• Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

  2005cited by this paper
• The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair

  2005cited by this paper
• MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.

  2005cited by this paper
• DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

  2005cited by this paper
• Human TopBP1 Ensures Genome Integrity during Normal S Phase

  2005cited by this paper
• The Fanconi Anemia/BRCA pathway: new faces in the crowd.

  2005cited by this paper
• DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

  2004cited by this paper
• BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number

  2004cited by this paper
• Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase*

  2004cited by this paper
• MDC1 is required for the intra-S-phase DNA damage checkpoint

  2003cited by this paper
• BARD1 Participates with BRCA1 in Homology-Directed Repair of Chromosome Breaks

  2003cited by this paper
• JAMM: A Metalloprotease-Like Zinc Site in the Proteasome and Signalosome

  2003cited by this paper
• A subset of ATM‐ and ATR‐dependent phosphorylation events requires the BRCA1 protein

  2003cited by this paper
• The BRCT Domain Is a Phospho-Protein Binding Domain

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• Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

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• Mediator of DNA Damage Checkpoint Protein 1 Regulates BRCA1 Localization and Phosphorylation in DNA Damage Checkpoint Control*

  2003cited by this paper
• H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.

  2003cited by this paper
• NFBD1/KIAA0170 Is a Chromatin-associated Protein Involved in DNA Damage Signaling Pathways*

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• BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

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• Enhancement of BRCA1 E3 Ubiquitin Ligase Activity through Direct Interaction with the BARD1 Protein*

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• Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

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  2003cited by this paper
• MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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• The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication

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• Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.

  2002cited by this paper
• Germline mutations of the BRCA1‐associated ring domain (BARD1) gene in breast and breast/ovarian families negative for BRCA1 and BRCA2 alterations

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• The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity.

  2002cited by this paper
• DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1

  2002cited by this paper
• BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

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• Genomic Instability in Mice Lacking Histone H2AX

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