Human N-acetylation of benzidine: role of NAT1 and NAT2.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Cancer Research

• Publication date

  1996-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 8752161
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Determination of benzidine, N-acetylbenzidine, and N,N'-diacetylbenzidine in human urine by capillary gas chromatography/negative ion chemical ionization mass spectrometry.

  1996cited by this paper
• The impact of interindividual variation in NAT2 activity on benzidine urinary metabolites and urothelial DNA adducts in exposed workers.

  1996cited by this paper
• N-acetylbenzidine and N,N'-diacetylbenzidine formation by rat and human liver slices exposed to benzidine.

  1995cited by this paper
• The role of acetylation in benzidine metabolism and DNA adduct formation in dog and rat liver.

  1995cited by this paper
• Role of aromatic amine acetyltransferases, NAT1 and NAT2, in carcinogen-DNA adduct formation in the human urinary bladder.

  1995cited by this paper
• Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions.

  1995cited by this paper
• A molecular epidemiological case-control study of lung cancer.

  1995cited by this paper
• Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue.

  1995cited by this paper
• Determination of human NAT2 acetylator genotype by restriction fragment-length polymorphism and allele-specific amplification.

  1995cited by this paper
• Nomenclature for N-acetyltransferases.

  1995cited by this paper
• Glucuronidation of N-acetylbenzidine by human liver.

  1994cited by this paper
• Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens

  1994cited by this paper
• A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China.

  1994cited by this paper
• Human liver glucuronidation of benzidine.

  1994cited by this paper
• Molecular genetics of human polymorphic N-acetyltransferase: enzymatic analysis of 15 recombinant wild-type, mutant, and chimeric NAT2 allozymes.

  1994cited by this paper
• Acetylator phenotype, aminobiphenyl-hemoglobin adduct levels, and bladder cancer risk in white, black, and Asian men in Los Angeles, California.

  1994cited by this paper
• N-acetylbenzidine-N'-glucuronidation by human, dog and rat liver.

  1993cited by this paper
• N-acetylation phenotype and genotype and risk of bladder cancer in benzidine-exposed workers.

  1993cited by this paper
• Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus.

  1993cited by this paper
• DNA adducts, mutations and cancer.

  1993cited by this paper
• Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases.

  1993cited by this paper
• Benzidine glucuronidation in dog liver.

  1993cited by this paper
• Salmonella typhimurium strains expressing human arylamine N-acetyltransferases: metabolism and mutagenic activation of aromatic amines.

  1992cited by this paper
• Role of N-glucuronidation in benzidine-induced bladder cancer in dog.

  1992cited by this paper
• Acetyl transferase-mediated metabolic activation of N-hydroxy-4-aminobiphenyl by human uroepithelial cells.

  1992cited by this paper
• Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2.

  1992cited by this paper
• Mortality and incidence of bladder cancer in benzidine-exposed workers in China.

  1992cited by this paper
• Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes.

  1991cited by this paper
• Molecular mechanism of slow acetylation of drugs and carcinogens in humans.

  1991cited by this paper
• Kinetics of acetyl CoA: arylamine N-acetyltransferase from rapid and slow acetylator human liver.

  1991cited by this paper
• Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver.

  1990cited by this paper
• Correlation between acetylator phenotypes and genotypes of polymorphic arylamine N-acetyltransferase in human liver.

  1990cited by this paper
• Acetylation phenotype, carcinogen-hemoglobin adducts, and cigarette smoking.

  1990cited by this paper
• Metabolism and disposition of benzidine in the dog.

  1990cited by this paper
• Kinetic characterization of acetylator genotype-dependent and -independent N-acetyltransferase isozymes in homozygous rapid and slow acetylator inbred hamster liver cytosol.

  1989cited by this paper
• N-acetyltransferase.

  1989cited by this paper
• Use of human peripheral blood lymphocytes to measure DNA binding capacity of chemical carcinogens.

  1988cited by this paper
• Acetylator genotype and arylamine-induced carcinogenesis.

  1988cited by this paper
• Acetyl coenzyme A-dependent metabolic activation of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl and several carcinogenic N-hydroxy arylamines in relation to tissue and species differences, other acyl donors, and arylhydroxamic acid-dependent acyltransferases.

  1986cited by this paper
• N-Acetyltransferase phenotypes in the urinary bladder carcinogenesis of a low-risk population.

  1985cited by this paper
• N-acetylation pharmacogenetics.

  1985cited by this paper
• Hepatic N-oxidation, acetyl-transfer and DNA-binding of the acetylated metabolites of the carcinogen, benzidine.

  1985cited by this paper
• Disposition of the aromatic amine, benzidine, in the rat: characterization of mutagenic urinary and biliary metabolites.

  1984cited by this paper
• Binding of N-acetylbenzidine and N,N'-diacetylbenzidine to hepatic DNA of rat and hamster in vivo and in vitro.

  1984cited by this paper
• Metabolism of the human carcinogen, benzidine, in the isolated perfused rat liver.

  1983cited by this paper
• Role of N-acetyltransferase phenotypes in bladder carcinogenesis: a pharmacogenetic epidemiological approach to bladder cancer.

  1982cited by this paper
• Covalent binding of benzidine and N-acetylbenzidine to DNA at the C-8 atom of deoxyguanosine in vivo and in vitro.

  1982cited by this paper
• N-Acetyltransferase phenotype and risk in urinary bladder cancer: approaches in molecular epidemiology. Preliminary results in Sweden and Denmark

  1979cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper
• Hepatic microsomal N-glucuronidation and nucleic acid binding of N-hydroxy arylamines in relation to urinary bladder carcinogenesis.

  1977cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Benzidine exposure as a cause of bladder tumors.

  1973cited by this paper
• Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

  1970cited by this paper
• The mechanism of isoniazid acetylation by human N-acetyltransferase.

  1968cited by this paper
• N-acetylation of drugs: isolation and properties of an N-acetyltransferase from rabbit liver.

  1967cited by this paper
• Tumours Of The Urinary Bladder in Workmen Engaged in the Manufacture and Use Of Certain Dyestuff Intermediates In The British Chemical Industry. Part I. The Role Of Aniline, Benzidine, Alpha-Naphthylamine, And Beta-Naphthylamine

  1954cited by this paper

• Pharmacogenomic heterogeneity of N-acetyltransferase 2: a comprehensive analysis of real world data in Indian tuberculosis patients and from literature and database review

  2025cites this paper
• Suspect and non-target screening of contaminants of emerging concern in Norwegian biogas digestates

  2025cites this paper
• Effects of dose and human N-acetyltransferase 1 genetic polymorphism in benzidine metabolism and genotoxicity

  2023cites this paper
• 560G>A (rs4986782) (R187Q) Single Nucleotide Polymorphism in Arylamine N-Acetyltransferase 1 Increases Affinity for the Aromatic Amine Carcinogens 4-Aminobiphenyl and N-Hydroxy-4-Aminobiphenyl: Implications for Cancer Risk Assessment

  2022cites this paper
• Human N-Acetyltransferase 1 and 2 Differ in Affinity Towards Acetyl-Coenzyme A Cofactor and N-Hydroxy-Arylamine Carcinogens

  2022cites this paper
• NAT1 genetic variation increases asthma risk in children with secondhand smoke exposure

  2019cites this paper
• Role of the human N-acetyltransferase 2 genetic polymorphism in metabolism and genotoxicity of 4, 4′-methylenedianiline

  2019cites this paper
• Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80

  2018cites this paper
• Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review.

  2018cites this paper
• Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens

  2017cites this paper
• Comparison of in vitro test systems using bacterial and mammalian cells for genotoxicity assessment within the “health-related indication value (HRIV) concept

  2017cites this paper
• Pharmacogenomics and Laboratory Medicine

  2016cites this paper
• Human arylamine n-acetyltransferase 1: pursuit of an endogenous role

  2015cites this paper
• Rapid and intermediate N-acetylators are less susceptible to oxidative damage among 4,4'-methylenebis(2-chloroaniline) (MBOCA)-exposed workers.

  2013cites this paper
• Aromatic Nitro and Amino Compounds

  2012cites this paper
• Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct.

  2012cites this paper
• Arylamine N-Acetyltransferase 1: A Novel Drug Target in Cancer Development

  2012cites this paper
• Etude du polymorphisme génétique de la N-Acétyltransférase de type 2 dans la population sénégalaise : prévention de la toxicité et de l’échec thérapeutique de l’isoniazide dans la prise en charge de la tuberculose

  2012cites this paper
• Détermination du polymorphisme d’acétylation de la N-acétyltransférase 2 dans la population sénégalaise par utilisation du test à la caféine

  2012cites this paper
• Cyanamide-mediated Inhibition of N-acetyltransferase 1.

  2012cites this paper
• N-Acetyltransferase 2 genotype, exfoliated urothelial cells and benzidine exposure.

  2012cites this paper
• Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines.

  2011cites this paper
• Phase I and II enzyme polymorphisms as risk factors for Barrett's esophagus and esophageal adenocarcinoma: a systematic review and meta-analysis.

  2009cites this paper
• Skin metabolism of aminophenols: human keratinocytes as a suitable in vitro model to qualitatively predict the dermal transformation of 4-amino-2-hydroxytoluene in vivo.

  2009cites this paper
• Electrochemical genotoxicity screening for arylamines bioactivated by N-acetyltransferase.

  2008cites this paper
• Phase II enzyme genotypes and their toxicologically relevant phenotypes.

  2008cites this paper
• Regulation of arylamine N-acetyltransferases.

  2008cites this paper
• Evidence that 4‐aminobiphenyl, benzidine, and benzidine congeners produce genotoxicity through reactive oxygen species

  2007influential citation
• N‐Acetyltransferases and the susceptibility to benzidine‐induced bladder carcinogenesis

  2007cites this paper
• Precision-cut tissue slices as a tool to predict metabolism of novel drugs

  2007cites this paper
• Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: meta-analysis, historical refinements of the hypothesis, and lessons learned.

  2007cites this paper
• Review of the Salmonella typhimurium mutagenicity of benzidine, benzidine analogues, and benzidine-based dyes.

  2006cites this paper
• 4,4′-Methylenedianiline-Induced Hepatotoxicity Is Modified by N-Acetyltransferase 2 (NAT2) Acetylator Polymorphism in the Rat

  2006cites this paper
• N-Acetyltransferase and sulfotransferase activity in human prostate: potential for carcinogen activation

  2006cites this paper
• Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1

  2006cites this paper
• The genetic and environmental factors involved in benzidine metabolism and bladder carcinogenesis in exposed workers.

  2006influential citation
• NAT2 slow acetylation and bladder cancer in workers exposed to benzidine

  2006influential citation
• N-Acetyltransferase-1 gene polymorphisms and correlation between genotype and its activity in a central Chinese Han population.

  2006cites this paper
• Arylamine N-Acetyltransferases: What We Learn from Genes and Genomes

  2005cites this paper
• Hemoglobin adducts in workers exposed to benzidine and azo dyes.

  2005cites this paper
• A simple, bead-based approach for multi-SNP molecular haplotyping.

  2005cites this paper
• Analysis of the involvement of human N-acetyltransferase 1 in the genotoxic activation of bladder carcinogenic arylamines using a SOS/umu assay system.

  2004cites this paper
• Distribution of N-acetyltransferase Type 1 (NAT1) genotypes and alleles in a Turkish population

  2004cites this paper
• Polymorphism in the N-acetyltransferase 1 alleles NAT1*10 and NAT1*14A and cytological gradings of exfoliated urothelial cells in benzidine-exposed Chinese workers: discussion of ethnic differences

  2004influential citation
• Characterization of the serotoninergic system in the C57BL/6 mouse skin.

  2003cites this paper
• Transformation and activation of benzidine by oxidants of the inflammatory response.

  2003cites this paper
• IFN-γ sensitization of prostate cancer cells to Fas-mediated death: A gene therapy approach

  2003cites this paper
• Metabolism of N-acetylbenzidine and initiation of bladder cancer.

  2002cites this paper
• Arylamine N-acetyltransferases and drug response.

  2002cites this paper
• N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk.

  2002cites this paper
• Urothelial cell DNA adducts in rubber workers †

  2002cites this paper
• Effect of nucleotide substitutions in N-acetyltransferase-1 on N-acetylation (deactivation) and O-acetylation (activation) of arylamine carcinogens: implications for cancer predisposition.

  2002cites this paper
• Biomonitoring of arylamines and nitroarenes

  2002cites this paper
• Pharmacogenetics of the arylamine N-acetyltransferases

  2002cites this paper
• T Cell Responses to Paraphenylenediamine and to Its Metabolites Mono- and Diacetyl-Paraphenylenediamine

  2001cites this paper
• Toxicological profile for benzidine

  2001cites this paper
• Association of NAT 1 and NAT 2 Polymorphisms to Urinary Bladder Cancer : Significantly Reduced Risk in Subjects with NAT 1 * 10 1

  2001cites this paper
• Biomarkers in risk assessment: validity and validation

  2001cites this paper
• Aktivität der N-Acetyltransferase NAT1 und NAT2 in menschlichen Geweben

  2001cites this paper
• Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1.

  2001cites this paper
• Association of NAT1 and NAT2 polymorphisms to urinary bladder cancer: significantly reduced risk in subjects with NAT1*10.

  2001cites this paper
• N-acetyltransferase 2 phenotype but not NAT1*10 genotype affects aminobiphenyl-hemoglobin adduct levels.

  2000cites this paper
• Molecular Genetics and Epidemiology of the NAT 1 and NAT 2 Acetylation Polymorphisms 1

  2000cites this paper
• Potential use of radiolabeled glucuronide prodrugs with auger and/or alpha emitters in combined chemo- and radio-therapy of cancer.

  2000cites this paper
• Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells.

  2000cites this paper
• Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid.

  2000cites this paper
• Placental arylamine N-acetyltransferase type 1: potential contributory source of urinary folate catabolite p-acetamidobenzoylglutamate during pregnancy.

  2000cites this paper
• N-Acetylation of paraphenylenediamine in human skin and keratinocytes.

  2000cites this paper
• Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.

  2000cites this paper
• Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos.

  2000cites this paper
• A pilot study investigating the role of NAT1 and NAT2 polymorphisms in gastric adenocarcinoma

  2000cites this paper
• Sulfinamide formation following peroxidatic metabolism of N-acetylbenzidine.

  2000cites this paper
• Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.

  1999cites this paper
• Human bladder cancer: epidemiological, pathological and mechanistic aspects.

  1999cites this paper
• Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer.

  1999cites this paper
• Identification of N-acetyltransferase 2 genotypes by continuous monitoring of fluorogenic hybridization probes.

  1999cites this paper
• Purification and characterization of an arylamine N-acetyltransferase from Lactobacillus acidophilus.

  1999cites this paper
• Role of arylamine N-acetyltransferase 1 and 2 (NAT1 and NAT2) genotypes in susceptibility to oral/pharyngeal and laryngeal cancers.

  1999cites this paper
• A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma.

  1998cites this paper
• Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations.

  1998cites this paper
• A pilot study testing the association between N-acetyltransferases 1 and 2 and risk of oral squamous cell carcinoma in Japanese people.

  1998cites this paper
• The Characteristics of Arylamine N-Acetyltransferase in Pseudomonas aeruginosa

  1998cites this paper
• N'-(3'-monophospho-deoxyguanosin-8-yl)-N-acetylbenzidine formation by peroxidative metabolism.

  1998cites this paper
• N-glucuronidation of benzidine and its metabolites. Role in bladder cancer.

  1998cites this paper
• Genetic susceptibility to environmental and occupational cancers

  1997influential citation
• The effect of vitamin C on N-acetyltransferase activity in Klebsiella pneumoniae.

  1997cites this paper
• Genetic susceptibility to environmental and occupational

  1997cites this paper
• The Effect of Vitamin C N-Acetyltransferase Activity in pneumoniae

  1997cites this paper
• Urinary mutagenicity as a biomarker in workers exposed to benzidine: correlation with urinary metabolites and urothelial DNA adducts.

  1997cites this paper
• The role of carcinogen-metabolizing enzyme polymorphisms in cancer susceptibility.

  1997cites this paper
• Identification of a novel allele at the human NAT1 acetyltransferase locus.

  1997cites this paper
• Cloning, sequencing, and recombinant expression of NAT1, NAT2, and NAT3 derived from the C3H/HeJ (rapid) and A/HeJ (slow) acetylator inbred mouse: functional characterization of the activation and deactivation of aromatic amine carcinogens.

  1997cites this paper
• 2-Aminofluorene-DNA adduct levels in tumor-target and nontarget organs of rapid and slow acetylator Syrian hamsters congenic at the NAT2 locus.

  1996cites this paper
• JPET EARLY-CAREER MINIREVIEW INITIATIVE — MINIREVIEW Mini-review: Human N-acetyltransferase genetic polymorphisms in susceptibility to aromatic amine and alkylaniline genotoxicity

  year unknowncites this paper
• Benzidine 1. Exposure Data Benzidine and Benzidine-based Dyes – Chemical and Physical Data

  year unknowncites this paper