Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Immunity

• Publication date

  2007-07-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.IMMUNI.2007.05.021PMID 17658279PMCID PMC2062505
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CD8− DCs induce IL-12–independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS

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• Notch signalling: a simple pathway becomes complex

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• Notch Signaling Requires GATA-2 to Inhibit Myelopoiesis from Embryonic Stem Cells and Primary Hemopoietic Progenitors1

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• Generation of new Notch2 mutant alleles

  2006cited by this paper
• Notch1 augments NF-kappaB activity by facilitating its nuclear retention.

  2006cited by this paper
• Regulation of Th2 differentiation and Il4 locus accessibility.

  2006influential reference
• The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells.

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• Notch signaling: distinct ligands induce specific signals during lymphocyte development and maturation.

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• The nervous system and innate immunity: the neuropeptide connection.

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• Notch signaling is an important regulator of type 2 immunity

  2005cited by this paper
• RBPjκ-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells

  2005cited by this paper
• Regulation of GATA gene expression during vertebrate development.

  2005cited by this paper
• TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand

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• Opposing Roles for RelB and Bcl-3 in Regulation of T-Box Expressed in T Cells, GATA-3, and Th Effector Differentiation 1

  2005influential reference
• Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

  2005influential reference
• T Helper Cell Fate Specified by Kinase-Mediated Interaction of T-bet with GATA-3

  2005cited by this paper
• Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.

  2005cited by this paper
• Regulation of lymphoid development, differentiation, and function by the Notch pathway.

  2005influential reference
• GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells

  2004cited by this paper
• Notch1 expression on T cells is not required for CD4+ T helper differentiation

  2004cited by this paper
• Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.

  2004influential reference
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• Signaling pathways in Th2 development

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• Analysis of Notch1 Function by In Vitro T Cell Differentiation of Pax5 Mutant Lymphoid Progenitors1

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• Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling.

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• Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells

  2002cited by this paper
• Decision making in the immune system: The lineage decisions of helper T cells

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• Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression.

  2001cited by this paper
• Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection

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• A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation

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• Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile

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• A novel transcription factor, T-bet, directs Th1 lineage commitment.

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• Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

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• Stat6 Regulation of In Vivo IL-4 Responses1

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• A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology.

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• Deficient T cell fate specification in mice with an induced inactivation of Notch1.

  1999cited by this paper
• Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells.

  1999cited by this paper
• Notch signaling: cell fate control and signal integration in development.

  1999cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999influential reference
• Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism.

  1998cited by this paper
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• An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

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• Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives.

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  1996cited by this paper
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  1995cited by this paper
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