The signal transduction cascade regulating the expression of the gap junction protein connexin43 by β‐adrenoceptors

No abstract is available for this paper.

• Publication year

  2009

• Venue

  British Journal of Pharmacology

• Publication date

  2009-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1476-5381.2009.00344.xPMID 19719782PMCID PMC2795252
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Subchronic alpha‐ and beta‐adrenergic regulation of cardiac gap junction protein expression

  2006influential reference
• Pharmacology of gap junctions. New pharmacological targets for treatment of arrhythmia, seizure and cancer?

  2005cited by this paper
• Cardiac oxidative stress in acute and chronic isoproterenol-infused rats.

  2005cited by this paper
• Chronic regulation of the expression of gap junction proteins connexin40, connexin43, and connexin45 in neonatal rat cardiomyocytes.

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• Gap junction remodeling and altered connexin43 expression in the failing human heart

  2004influential reference
• Transcription activator protein 1 mediates alpha- but not beta-adrenergic hypertrophic growth responses in adult cardiomyocytes.

  2004cited by this paper
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  2004cited by this paper
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  2002influential reference
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  2001cited by this paper
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  2001cited by this paper
• Altered connexin expression in human congestive heart failure.

  2001influential reference
• Activation and inactivation of cAMP-response element-mediated gene transcription in cardiac myocytes.

  2001cited by this paper
• Effects of chronic atrial fibrillation on gap junction distribution in human and rat atria.

  2001cited by this paper
• Increased JNK, AP-1 and NF-κB DNA binding activities in isoproterenol-induced cardiac remodeling

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  2000cited by this paper
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  1999influential reference
• Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene.

  1999cited by this paper
• Increased JNK, AP-1 and NF-kappa B DNA binding activities in isoproterenol-induced cardiac remodeling.

  1999cited by this paper
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  1999cited by this paper
• Regulation of Connexin-43 Gap Junctional Intercellular Communication by Mitogen-activated Protein Kinase*

  1998cited by this paper
• Rapid turnover of connexin43 in the adult rat heart.

  1998cited by this paper
• Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle.

  1998cited by this paper
• Altered patterns of cardiac intercellular junction distribution in hypertrophic cardiomyopathy.

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  1996influential reference
• Physiological role of phosphorylation of the cyclic AMP response element binding protein in rat cardiac nuclei

  1996cited by this paper
• Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes.

  1996cited by this paper
• β2‐Adrenoreceptors Stimulate c‐fos Transcription Through Multiple Cyclic AMP‐ and Ca2+‐Responsive Elements in Cerebellar Granular Neurons

  1995cited by this paper
• Beta-adrenergic stimulation of cFOS via protein kinase A is mediated by cAMP regulatory element binding protein (CREB)-dependent and tissue-specific CREB-independent mechanisms in corticotrope cells.

  1992cited by this paper
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  year unknowncited by this paper

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  2023cites this paper
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  2023cites this paper
• Analysis of the function and therapeutic strategy of connexin 43 from its subcellular localization.

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  2022cites this paper
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  2021cites this paper
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  2020cites this paper
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  2018cites this paper
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• [Left ventricular noncompaction: A clinical and morphological study].

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• A simulation study of cellular hypertrophy and connexin lateralization in cardiac tissue.

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