ZapA, the IgA‐degrading metalloprotease of Proteus mirabilis, is a virulence factor expressed specifically in swarmer cells

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Molecular Microbiology

• Publication date

  1999-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1365-2958.1999.01401.xPMID 10361285
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii

  2007cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001influential reference
• Characterization of Rhizobium leguminosarum Exopolysaccharide Glycanases That Are Secreted via a Type I Exporter and Have a Novel Heptapeptide Repeat Motif

  1998cited by this paper
• Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

  1997cited by this paper
• Proteus mirabilis ambient-temperature fimbriae: cloning and nucleotide sequence of the aft gene cluster

  1996cited by this paper
• Protein secretion by heterologous bacterial ABC‐transporters: the C‐terminus secretion signal of the secreted protein confers high recognition specificity

  1996cited by this paper
• Requirement for FlhA in flagella assembly and swarm‐cell differentiation by Proteus mirabilis

  1995cited by this paper
• Molecular cloning of Proteus mirabilis uroepithelial cell adherence (uca) genes

  1995cited by this paper
• The three genes lipB, lipC, and lipD involved in the extracellular secretion of the Serratia marcescens lipase which lacks an N-terminal signal peptide

  1995cited by this paper
• Proteus mirabilis amino acid deaminase: cloning, nucleotide sequence, and characterization of aad

  1995cited by this paper
• Molecular analysis of a metalloprotease from Proteus mirabilis

  1995influential reference
• Nucleotide sequences of two fimbrial major subunit genes, pmpA and ucaA, from canine-uropathogenic Proteus mirabilis strains.

  1995cited by this paper
• Cloning of the Serratia marcescens hasF gene encoding the Has ABC exporter outer membrane component: a TolC analogue

  1995cited by this paper
• Expression of multiple flagellin-encoding genes of Proteus mirabilis

  1994influential reference
• Secretion of the Serratia marcescens HasA protein by an ABC transporter

  1994influential reference
• Crystal structure of the 50 kDa metallo protease from Serratia marcescens.

  1994cited by this paper
• The role of swarm cell differentiation and multicellular migration in the uropathogenicity of Proteus mirabilis.

  1994cited by this paper
• Genetic organization and complete sequence of the Proteus mirabilis pmf fimbrial operon.

  1994cited by this paper
• Proteus mirabilis MR/P fimbriae: molecular cloning, expression, and nucleotide sequence of the major fimbrial subunit gene

  1993cited by this paper
• Cloning and characterization of the Actinobacillus pleuropneumoniae-RTX-toxin III (ApxIII) gene

  1993cited by this paper
• Three‐dimensional structure of the alkaline protease of Pseudomonas aeruginosa: a two‐domain protein with a calcium binding parallel beta roll motif.

  1993influential reference
• Identification of protein coding regions by database similarity search

  1993cited by this paper
• Contribution of Proteus mirabilis urease to persistence, urolithiasis, and acute pyelonephritis in a mouse model of ascending urinary tract infection

  1993influential reference
• The cleavage of immunoglobulin G in vitro and in vivo by a proteinase secreted by the urinary tract pathogen Proteus mirabilis.

  1993influential reference
• A superfamily of ATPases with diverse functions containing either classical or deviant ATP-binding motif.

  1993cited by this paper
• Identification of two components of the Serratia marcescens metalloprotease transporter: protease SM secretion in Escherichia coli is TolC dependent

  1993cited by this paper
• ABC transporters: bacterial exporters

  1993cited by this paper
• ABC transporters: from microorganisms to man.

  1992cited by this paper
• Cloning, nucleotide sequence and characterization of the gene encoding the Erwinia chrysanthemi B374 PrtA metalloprotease: a third metalloprotease secreted via a C-terminal secretion signal

  1992cited by this paper
• Co‐ordinate expression of virulence genes during swarm‐cell differentiation and population migration of Proteus mirabilis

  1992cited by this paper
• Ability of Proteus mirabilis to invade human urothelial cells is coupled to motility and swarming differentiation

  1992cited by this paper
• Sequence of a cluster of genes controlling synthesis and secretion of alkaline protease in Pseudomonas aeruginosa: relationships to other secretory pathways.

  1992cited by this paper
• Proteinases of Proteus spp.: purification, properties, and detection in urine of infected patients

  1992cited by this paper
• The production and activity in vivo of Proteus mirabilis IgA protease in infections of the urinary tract.

  1991cited by this paper
• The Actinobacillus pleuropneumoniae hemolysin determinant: unlinked appCA and appBD loci flanked by pseudogenes

  1991cited by this paper
• Transposon mutagenesis in Proteus mirabilis

  1991cited by this paper
• Production of Immunoglobulin A Protease by Streptococcus pneumoniae from Animals

  1991influential reference
• Genetic systems in Haemophilus influenzae.

  1991influential reference
• Characterization, localization and transmembrane organization of the three proteins PrtD, PrtE and PrtF necessary for protease secretion by the Gram‐negative bacterium Erwinia chrysanthemi

  1991cited by this paper
• Nucleotide sequence of the leukotoxin gene from Actinobacillus actinomycetemcomitans: homology to the alpha-hemolysin/leukotoxin gene family

  1990cited by this paper
• A proteolytic enzyme secreted by Proteus mirabilis degrades immunoglobulins of the immunoglobulin A1 (IgA1), IgA2, and IgG isotypes

  1990influential reference
• TolC, an Escherichia coli outer membrane protein required for hemolysin secretion.

  1990cited by this paper
• Protease secretion by Erwinia chrysanthemi: the specific secretion functions are analogous to those of Escherichia coli alpha‐haemolysin.

  1990cited by this paper
• The P-loop--a common motif in ATP- and GTP-binding proteins.

  1990cited by this paper
• The HpmA hemolysin is more common than HlyA among Proteus isolates

  1990cited by this paper
• Protein secretion in gram-negative bacteria. The extracellular metalloprotease B from Erwinia chrysanthemi contains a C-terminal secretion signal analogous to that of Escherichia coli alpha-hemolysin.

  1990cited by this paper
• Basic local alignment search tool.

  1990cited by this paper
• Cytotoxic activity of the Proteus hemolysin HpmA

  1990cited by this paper
• Short protocols in molecular biology : a compendium of methods from Current protocols in molecular biology

  1989cited by this paper
• Molecular cloning : a laboratory manual. Cold Spring Harbor, NY

  1989influential reference
• Cleavage of immunoglobulin G (IgG) and IgA around the hinge region by proteases from Serratia marcescens

  1988cited by this paper
• Proteus mirabilis urease: genetic organization, regulation, and expression of structural genes

  1988cited by this paper
• A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR

  1988cited by this paper
• Nucleotide sequence of the leukotoxin genes of Pasteurella haemolytica A1

  1987cited by this paper
• Cholera toxin transcriptional activator toxR is a transmembrane DNA binding protein.

  1987cited by this paper
• Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease

  1987cited by this paper
• A twenty-five year review of laboratory-acquired human infections at the National Animal Disease Center.

  1987cited by this paper
• Urease-positive bacteriuria and obstruction of long-term urinary catheters

  1987cited by this paper
• Uropathogenicity in rats and mice of Providencia stuartii from long-term catheterized patients.

  1987cited by this paper
• A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria

  1986cited by this paper
• Opacity genes in Neisseria gonorrhoeae: control of phase and antigenic variation.

  1986cited by this paper
• Domainal evolution of a prokaryotic DNA repair protein and its relationship to active-transport proteins

  1986cited by this paper
• Nucleotide sequence of an Escherichia coli chromosomal hemolysin

  1985cited by this paper
• Phosphate‐binding sequences in nucleotide‐binding proteins

  1985cited by this paper
• A comprehensive set of sequence analysis programs for the VAX

  1984cited by this paper
• The IgA1 proteases of pathogenic bacteria.

  1983cited by this paper
• OCCURRENCE AND NATURE OF BACTERIAL IgA PROTEASES *

  1983cited by this paper
• Proteus morgani is less frequently associated with urinary tract infections than Proteus mirabilis--an explanation.

  1983influential reference
• Distantly related sequences in the alpha‐ and beta‐subunits of ATP synthase, myosin, kinases and other ATP‐requiring enzymes and a common nucleotide binding fold.

  1982cited by this paper
• [Extracellular toxins of Pseudomonas aeruginosa. II. Effect of two proteases on human immunoglobulins IgG, IgA and secretory IgA (author's transl)].

  1981cited by this paper
• Attachment of Proteus mirabilis to human urinary sediment epithelial cells in vitro is different from that of Escherichia coli

  1980influential reference
• Pathogenic Species of the Genus Haemophilus and Streptococcus pneumoniae Produce Immunoglobulin A1 Protease

  1979influential reference
• Immunoglobulin A1 protease production by Haemophilus influenzae and Streptococcus pneumoniae

  1979cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper
• Neisseria gonorrhoeae and neisseria meningitidis: extracellular enzyme cleaves human immunoglobulin A

  1975cited by this paper
• L.D.L. AND TOTAL CHOLESTEROL IN CORD-BLOOD SCREENING FOR FAMILIAL HYPERCHOLESTEROLÆMIA

  1975cited by this paper
• Experiments in molecular genetics

  1972influential reference
• Site of infection in acute urinary-tract infection in general practice.

  1971influential reference
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970influential reference

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  2019cites this paper
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