Expression of xenobiotic metabolizing enzymes in breast cancer

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Journal of Pathology

• Publication date

  1993-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/path.1711690312PMID 8492228
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cytochrome P450IA expression in adult and fetal human liver.

  1992cited by this paper
• Immunohistochemical demonstration of glutathione S‐transferases in primary human breast carcinomas

  1992cited by this paper
• Drug metabolism in carcinogenesis and cancer chemotherapy.

  1991cited by this paper
• Is aryl hydrocarbon hydroxylase activity a new prognostic indicator for breast cancer?

  1991cited by this paper
• Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes.

  1991cited by this paper
• Cytochrome P-450 metabolism of arachidonic acid.

  1991cited by this paper
• Expression of cytochrome P450IA in breast cancer.

  1991cited by this paper
• Expression of rat microsomal epoxide hydrolase gene during liver chemical carcinogenesis.

  1990cited by this paper
• The clinical relevance of multidrug resistance.

  1990cited by this paper
• Genetic heterogeneity of the human glutathione transferases: a complex of gene families.

  1990cited by this paper
• Glutathione transferase activity and isoenzyme composition in primary human breast cancers.

  1990cited by this paper
• Molecular genetics of the P-450 superfamily.

  1990cited by this paper
• Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue.

  1990cited by this paper
• Differences in adult and foetal human cytochrome P-450 forms recognized by monoclonal antibodies with specificity for the P450III family.

  1989cited by this paper
• Drug resistance: the clinical problem.

  1989cited by this paper
• Interaction of anticancer drugs with hepatic monooxygenase enzymes.

  1989cited by this paper
• Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines.

  1989cited by this paper
• Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.

  1988cited by this paper
• Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer.

  1988cited by this paper
• Epoxide-metabolizing enzymes in mammary gland and liver from BALB/c mice and effects of inducers on enzyme activity.

  1988cited by this paper
• Identification of an anionic form of glutathione transferase present in many human tumors and human tumor cell lines.

  1988cited by this paper
• The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450.

  1988cited by this paper
• Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis.

  1988cited by this paper
• Cytochrome P-450 localization in normal human adult and foetal liver by immunocytochemistry using a monoclonal antibody against human cytochrome P—450

  1987cited by this paper
• Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

  1986cited by this paper
• Regulation and expression of four cytochrome P-450 isoenzymes, NADPH-cytochrome P-450 reductase, the glutathione transferases B and C and microsomal epoxide hydrolase in preneoplastic and neoplastic lesions in rat liver.

  1985cited by this paper
• The assessment of histological differentiation in breast cancer.

  1985cited by this paper
• Cholesterol epoxide is a direct-acting mutagen.

  1984cited by this paper
• THE ASSESSMENT OF HISTOLOGICAL DIFFERENTIATION IN BREAST CANCER

  1984cited by this paper
• Molecular properties and biological functions of microsomal epoxide hydrase.

  1980cited by this paper

• High-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning.

  2025cites this paper
• Insights into the molecular and genetic role of obesity in breast cancer pathogenesis

  2025cites this paper
• The Role of CYP3A in Health and Disease

  2022cites this paper
• Ultra‐Fast Portable and Wearable Sensing Design for Continuous and Wide‐Spectrum Molecular Analysis and Diagnostics

  2022cites this paper
• Regulation of cardiovascular biology by microsomal epoxide hydrolase

  2021cites this paper
• The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease

  2020cites this paper
• Proteomic Analysis Reveals that EPHX1 Contributes to 5‐Fluorouracil Resistance in a Human Hepatocellular Carcinoma Cell Line

  2020cites this paper
• Tumorigenesis and Metabolism Disorder

  2019cites this paper
• Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes

  2019cites this paper
• Insilico Investigation of CYP 1 A 1 Mediated Pathway Contribution in Liver Hepatocellular Carcinoma : A Drug Discovery Approach

  2018cites this paper
• A Review on Some Proposed Targets and its Effective Molecules in Cancer Disease

  2016cites this paper
• Pathway-Structured Predictive Model for Cancer Survival Prediction: A Two-Stage Approach

  2016cites this paper
• Discovery of microarray-identified genes associated with ovarian cancer progression.

  2015cites this paper
• Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease.

  2015cites this paper
• Ellipticines as DNA-targeted chemotherapeutics.

  2014cites this paper
• Metabolism (Non-CYP Enzymes)

  2014cites this paper
• Emerging Targets in the Bioactivity of Ellipticines and Derivatives

  2013cites this paper
• Antiproliferative effect of the Ginkgo biloba extract is associated with the enhancement of cytochrome P450 1B1 expression in estrogen receptor-negative breast cancer cells.

  2013cites this paper
• Biomedical Importance of Indoles

  2013cites this paper
• Complementary and Alternative Medicine: A Survey of Its Use in Pediatric Oncology

  2013cites this paper
• Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency.

  2011cites this paper
• Profiling the expression of cytochrome P450 in breast cancer

  2010cites this paper
• The comparison of cytotoxicity of the anticancer drugs doxorubicin and ellipticine to human neuroblastoma cells

  2008cites this paper
• CYP 2 C 9 Polymorphisms in Human Tumors

  2008cites this paper
• Transplacental Transfer of Monomethyl Phthalate and Mono(2-ethylhexyl) Phthalate in a Human Placenta Perfusion System

  2007cites this paper
• Tissue-specific induction of the carcinogen-inducible cytochrome P450 isoforms in the gastrointestinal tract.

  2007cites this paper
• Formulation Studies and Development of Novel Anticancer Prodrugs

  2007cites this paper
• Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development.

  2007cites this paper
• Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those found in vivo and generated from 12‐hydroxyellipticine and 13‐hydroxyellipticine

  2007cites this paper
• Differential Induction of Drug Metabolizing Enzymes and Drug Transporters by Tamoxifen: Molecular Mechanisms and Clinical Implications

  2006cites this paper
• Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma.

  2006cites this paper
• Pharmacogenetics and Regulation of Human Cytochrome P450 1B1: Implications in Hormone-Mediated Tumor Metabolism and a Novel Target for Therapeutic Intervention

  2006cites this paper
• Expression of xenobiotic and steroid hormone metabolizing enzymes in human breast carcinomas

  2006cites this paper
• Oxidation pattern of the anticancer drug ellipticine by hepatic microsomes - similarity between human and rat systems.

  2006cites this paper
• Drug metabolism and chemotherapy resistance

  2006cites this paper
• Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans

  2006cites this paper
• Cytochrome P450 and anticancer drugs.

  2006cites this paper
• CYP2C9 polymorphisms in human tumors.

  2006cites this paper
• Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine.

  2006cites this paper
• Immunohistochemical evaluation of cytochrome P450 (CYP) and p53 in breast cancer.

  2005cites this paper
• Profiling Cytochrome P450 Expression in Ovarian Cancer: Identification of Prognostic Markers

  2005cites this paper
• Profiling Cytochrome P 450 Expression in Ovarian Cancer : Identification of PrognosticMarkers

  2005cites this paper
• Polypeptide-A , in Human Breast Carcinoma Possible Target Gene , Organic Anion Transporting Expression of the Steroid and Xenobiotic Receptor and Its

  2005cites this paper
• Oxidation of an antitumor drug ellipticine by peroxidases.

  2005cites this paper
• Cytochrome P450 expression in rat gastric epithelium with intestinal metaplasia induced by high dietary NaCl levels.

  2005cites this paper
• Expression of cytochrome P450 in tumor tissues and its association with cancer development.

  2004cites this paper
• Expression of cytochrome P 450 3A enzymes in human lung: a combined RT-PCR and immunohistochemical analysis of normal tissue and lung tumours

  2004cites this paper
• CYP3A4, CYP2C9 and CYP2B6 expression and ifosfamide turnover in breast cancer tissue microsomes

  2004cites this paper
• The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, through Metabolism to 13-Hydroxyellipticine and Ellipticine N2-Oxide

  2004cites this paper
• Two distinct classes of CCAAT box elements that bind nuclear factor-Y/alpha-actinin-4: potential role in human CYP1A1 regulation.

  2004cites this paper
• Expression of CYP3A4 in human breast tumour and non-tumour tissues.

  2003cites this paper
• DNA adduct formation by the anticancer drug ellipticine in rats determined by 32P postlabeling

  2003cites this paper
• Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues.

  2003cites this paper
• Rat microsomes activating the anticancer drug ellipticine to species covalently binding to deoxyguanosine in DNA are a suitable model mimicking ellipticine bioactivation in humans.

  2003cites this paper
• Prognostic Significance of Glutathione S-Transferase-Pi in Invasive Breast Cancer

  2003cites this paper
• Decreased Hepatic Drug Metabolising Enzyme Activity in Rats with Nitrosamine-induced Tumours

  2002cites this paper
• Tumour cytochrome P450 and drug activation.

  2002cites this paper
• Covalent binding of the anticancer drug ellipticine to DNA in V79 cells transfected with human cytochrome P450 enzymes.

  2002cites this paper
• The Organochlorine Pesticide Residues and Antioxidant Enzyme Activities in Human Breast Tumors: Is There Any Association?

  2002influential citation
• A Genomic Approach to the Treatment of Breast Cancer

  2002cites this paper
• Polymorphisms in glutathione S-transferases (GSTM1 and GSTT1) and survival after treatment for breast cancer.

  2001cites this paper
• Immunolocalisation of cytochrome P-450 3A enzymes in human breast carcinoma: relationship with tumour differentiation and steroid receptors.

  2001cites this paper
• The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue

  2001cites this paper
• Microsomal epoxide hydrolase expression as a predictor of tamoxifen response in primary breast cancer: a retrospective exploratory study with long-term follow-up.

  2001cites this paper
• Distribution of Microsomal Epoxide Hydrolase in Humans: An Immunohistochemical Study in Normal Tissues, and Benign and Malignant Tumours

  2001influential citation
• Assessment of the involvement of CYP3A in the vitro metabolism of a new modulator of MDR in cancer chemotherapy, OC144-193, by human liver microsomes

  2001cites this paper
• Genetic polymorphism at the glutathione S‐tranferase (GST) P1 locus is a breast cancer risk modifier

  2001cites this paper
• Primary breast tumor levels of suspected molecular determinants of cellular sensitivity to cyclophosphamide, ifosfamide, and certain other anticancer agents as predictors of paired metastatic tumor levels of these determinants

  2001cites this paper
• The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts.

  2001cites this paper
• Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol.

  2000cites this paper
• Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent

  2000cites this paper
• Nuclear morphometry and glutathione S-transferase pi expression in breast cancer.

  2000cites this paper
• Metabolism and Pharmacokinetics of Oxazaphosphorines

  2000cites this paper
• Detoxication of vinca alkaloids by human P450 CYP3A4-mediated metabolism: implications for the development of drug resistance.

  2000cites this paper
• Monitoring the expression profiles of doxorubicin-induced and doxorubicin-resistant cancer cells by cDNA microarray.

  2000cites this paper
• The role of cytochrome P450 in tumour development and progression and its potential in therapy

  2000cites this paper
• Rat cytochromes P450 (CYP) specifically contribute to the reductive bioactivation of AQ4N, an alkylaminoanthraquinone-di-N-oxide anticancer prodrug.

  1999cites this paper
• Investigation of the major human hepatic cytochrome P450 involved in 4-hydroxylation and N -dechloroethylation of trofosfamide

  1999cites this paper
• Immunohistochemical study of cytochrome P450 2C and 3A in human non-neoplastic and neoplastic tissues

  1999cites this paper
• MGMT- and P450 3A-inhibitors do not sensitize glioblastoma cell cultures against nitrosoureas.

  1999cites this paper
• P450-expression in brain tumors.

  1999cites this paper
• Glutathione S-transferase M1 null genotype: lack of association with tumour characteristics and survival in advanced breast cancer

  1999cites this paper
• Cytochrome P450 CYP3A in human renal cell cancer

  1999cites this paper
• Merits and limitations of recombinant models for the study of human P450-mediated drug metabolism and toxicity: an intralaboratory comparison.

  1999cites this paper
• Smoking as a Risk Factor for Breast Cancer

  1999cites this paper
• Divergent mechanisms for loss of Ah-responsiveness in benzo[a]pyrene- and adriamycinR-resistant MCF-7 cells.

  1999cites this paper
• Antitumour prodrug development using cytochrome P450 (CYP) mediated activation.

  1999cites this paper
• Enhanced expression of cytochrome P450 in stomach cancer.

  1998cites this paper
• Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity.

  1998cites this paper
• Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug.

  1998cites this paper
• Enzymology of tirapazamine metabolism: a review.

  1998cites this paper
• In vivo detection of ifosfamide by 31P-MRS in rat tumours: increased uptake and cytotoxicity induced by carbogen breathing in GH3 prolactinomas.

  1997cites this paper
• Multienzyme-mediated stable and transient multidrug resistance and collateral sensitivity induced by xenobiotics

  1997cites this paper
• Relation of glutathione S-transferase alpha and mu isoforms to response to therapy in human breast cancer.

  1997cites this paper
• Relation of glutathione S-transferase α and μ isoforms to response to therapy in human breast cancer

  1997cites this paper
• Cellular levels of class 1 and class 3 aldehyde dehydrogenases and certain other drug-metabolizing enzymes in human breast malignancies.

  1997cites this paper
• Glutathione S-transferase class mu deletion polymorphism and breast cancer: results from prevalent versus incident cases.

  1997cites this paper
• Synovial sarcoma: immunohistochemical expression of P-glycoprotein and glutathione S transferase-pi and clinical drug resistance.

  1997cites this paper
• Alcohol and Breast Cancer: Interactions Between Alcohol and Other Risk Factors

  1996cites this paper
• Immunohistochemical assessment of human microsomal epoxide hydrolase in primary and secondary liver neoplasm: a quantitative approach.

  1996cites this paper