Relation of Disease Pathogenesis and Risk Factors to Heart Failure With Preserved or Reduced Ejection Fraction: Insights From the Framingham Heart Study of the National Heart, Lung, and Blood Institute

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Circulation

• Publication date

  2009-06-23

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/CIRCULATIONAHA.108.815944PMID 19506115PMCID PMC2775498
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diastolic heart failure: a separate disease or selection bias?

  2007cited by this paper
• Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

  2007cited by this paper
• Associations of gender and etiology with outcomes in heart failure with systolic dysfunction: a pooled analysis of 5 randomized control trials.

  2007cited by this paper
• Outcome of heart failure with preserved ejection fraction in a population-based study.

  2006cited by this paper
• Trends in prevalence and outcome of heart failure with preserved ejection fraction.

  2006cited by this paper
• Applied Logistic Regression: Hosmer/Applied Logistic Regression

  2005cited by this paper
• Influence of Ejection Fraction on Cardiovascular Outcomes in a Broad Spectrum of Heart Failure Patients

  2005influential reference
• The death rate among hospitalized heart failure patients with normal and depressed left ventricular ejection fraction in the year following discharge: evolution over a 10-year period.

  2005cited by this paper
• Cross-sectional relations of electrocardiographic QRS duration to left ventricular dimensions: the Framingham Heart Study.

  2005cited by this paper
• Risk-treatment mismatch in the pharmacotherapy of heart failure.

  2005cited by this paper
• Heart failure with preserved left ventricular systolic function; epidemiology, clinical characteristics, and prognosis.

  2004cited by this paper
• Predicting mortality among patients hospitalized for heart failure: derivation and validation of a clinical model.

  2003cited by this paper
• Gender, age, and heart failure with preserved left ventricular systolic function.

  2003influential reference
• Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.

  2003influential reference
• The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.

  2003cited by this paper
• Outcome of Congestive Heart Failure in Elderly Persons: Influence of Left Ventricular Systolic Function: The Cardiovascular Health Study

  2002cited by this paper
• Incremental changes in QRS duration in serial ECGs over time identify high risk elderly patients with heart failure

  2002influential reference
• Left ventricular diastolic dysfunction as a predictor of the first diagnosed nonvalvular atrial fibrillation in 840 elderly men and women.

  2002cited by this paper
• Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort.

  1999cited by this paper
• Clinical determinants of mortality in patients with angiographically diagnosed ischemic or nonischemic cardiomyopathy.

  1997cited by this paper
• Spectrum and outcome of congestive heart failure in a hospitalized population.

  1993influential reference
• Survival After the Onset of Congestive Heart Failure in Framingham Heart Study Subjects

  1993cited by this paper
• Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.

  1991cited by this paper
• Clinical determinants of mortality in chronic congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy.

  1987cited by this paper
• An investigation of coronary heart disease in families. The Framingham offspring study.

  1979cited by this paper
• The natural history of congestive heart failure: the Framingham study.

  1971cited by this paper
• AN APPROACH TO LONGITUDINAL STUDIES IN A COMMUNITY: THE FRAMINGHAM STUDY

  1963cited by this paper

• Prognostic value of human serum alpha-klotho concentrations in patients with heart failure with reduced ejection fraction.

  2026cites this paper
• Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective

  2025cites this paper
• Intravenous Ferric Carboxymaltose in Ischemic Versus Non-Ischemic Heart Failure and Iron Deficiency: Insights From FAIR-HF2.

  2025cites this paper
• Peroxiredoxin‐4, a marker of systemic oxidative stress, is associated with incident heart failure

  2025cites this paper
• The role of estrogen in the sex difference for the risk factors of heart failure with preserved ejection fraction

  2025cites this paper
• Longitudinal changes in circulating cyclic guanosine monophosphate in women over the menopause transition compared to men: the Coronary Artery Risk Development in Young Adults (CARDIA) study

  2025cites this paper
• Evaluation of Medical Biomarkers in Machine Learning Models for Classification of Heart Failure with Preserved and Reduced Ejection Fraction

  2025cites this paper
• Association of Systemic Thromboxane Generation With Risk of Developing Heart Failure.

  2025cites this paper
• Obesity and Atrial Fibrillation: A Comprehensive Review

  2025cites this paper
• Underpinnings of Heart Failure With Preserved Ejection Fraction in Women - From Prevention to Improving Function. A Co-publication With the American Journal of Preventive Cardiology and the Journal of Cardiac Failure.

  2025cites this paper
• Characteristics of comparatively young heart failure with preserved ejection fraction: PurSuit–HFpEF registry

  2025influential citation
• Lipoprotein(a) and Heart Failure Among Black and White Participants in Atherosclerosis Risk in Communities Study, Framingham Offspring Study, and Multi‐Ethnic Study of Atherosclerosis: The Pooling Project

  2025cites this paper
• Underpinnings of heart failure with preserved ejection fraction in women - From prevention to improving function. A co-publication with the American Journal of Preventive Cardiology and the Journal of Cardiac Failure

  2025cites this paper
• Frontal Plane QRS – T Angle Is a Predictor of Ventricular Arrhythmia in Heart Failure With Preserved Ejection Fraction

  2025cites this paper
• Risk factors of mortality among heart failure patients in Jordan: the Jordanian Heart Failure Registry (JoHFR)

  2025cites this paper
• Autoimmune inflammation as a key risk factor for heart failure with preserved ejection fraction: the different types of inflammation driving to HFpEF

  2025cites this paper
• Renal Macro- and Microcirculatory Perturbations in Acute Kidney Injury and Chronic Kidney Disease Associated with Heart Failure and Cardiac Surgery.

  2025cites this paper
• Aging and metabolism in HFpEF: Pathophysiology and therapeutic implications.

  2025cites this paper
• Sex-related differences in heart failure patients: physiological mechanisms of cardiovascular ageing and evidence-based sex-specific medical therapies

  2025cites this paper
• Clinical Significance of Serum Total Testosterone Concentration in Japanese Elderly Women With Pre-Heart Failure With Preserved Ejection Fraction

  2025cites this paper
• Cardiovascular, Kidney, Liver, and Metabolic Interactions in Heart Failure: Breaking Down Silos

  2025cites this paper
• Cardiac TRPM7 Causes Diabetic Heart Failure With Preserved Ejection Fraction

  2025cites this paper
• Treatment Progress of Heart Failure with Preserved Ejection Fraction

  2025cites this paper
• Etiology of Heart Failure Across the Ejection Fraction Spectrum and Association With Prognosis.

  2025cites this paper
• Comparative Analysis of Heart Failure with Preserved Vs Reduced Ejection Fraction: Patient Characteristics, Outcomes, Mortality Prediction, and Machine Learning Model Development in the JoHFR

  2024cites this paper
• Penerapan Machine Learning untuk Mengetahui Kelangsungan Hidup Pasien Gagal Jantung (Kardiovaskular) Menggunakan Kreatinin Serum dan Fraksi Ejeksi

  2024cites this paper
• Contemporary treatment options in heart failure with preserved ejection fraction.

  2024cites this paper
• Subclinical impairment of the left atrium is associated with MRI-based lung volume but not with parameters from pulmonary function testing

  2024cites this paper
• Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction

  2024cites this paper
• A higher mortality in men compared to women with heart failure in primary care and ejection fraction equal to or more than 40%

  2024cites this paper
• Racial and Ethnic Disparities in Heart Failure with Preserved Ejection Fraction: Epidemiology, Diagnosis, Management and Outcomes

  2024cites this paper
• Ferric carboxymaltose for iron deficiency in patients with heart failure: a systematic review and meta-analysis

  2024cites this paper
• Characteristics of heart failure with a preserved ejection fraction in black South African patients

  2024cites this paper
• A comprehensive review of heart failure: Unraveling the etiology, decoding pathophysiological mechanisms, navigating diagnostic modalities, exploring pharmacological interventions, advocating lifestyle modifications, and charting the horizon of emerging therapies in the complex landscape of chronic

  2024influential citation
• Expert Opinion on Screening and Risk Stratification of Heart Diseases in Indian Women

  2024cites this paper
• Prognostic impact of prior LVEF in patients with heart failure with mildly reduced ejection fraction

  2024cites this paper
• Eligibility of sodium-glucose cotransporter-2 inhibitors in heart failure with preserved ejection fraction: Insights from the Colombian heart failure registry (RECOLFACA)

  2024cites this paper
• Clinical Characteristics and Rhythm Outcomes in Patients With Atrial Myopathy After Successful Catheter Ablation of Atrial Fibrillation.

  2024cites this paper
• Dissecting the heart failure phenotype through phenomics

  2024cites this paper
• Preload dependence in an animal model of mild heart failure with preserved ejection fraction (HFpEF)

  2024cites this paper
• Association of Cardiac MRI-derived Aortic Stiffness with Early Stages and Progression of Heart Failure with Preserved Ejection Fraction.

  2024cites this paper
• NT-proBNP in Heart Failure with Preserved Ejection Fraction: A Comprehensive Review

  2024cites this paper
• Biomarker for cardiorenal syndrome risk in patients with liver cirrhosis and type 2 diabetes in Saudi Arabia

  2024cites this paper
• AMPK and O-GlcNAcylation: interplay in cardiac pathologies and heart failure.

  2024cites this paper
• Association between ventricular arrhythmia (premature ventricular contractions burden and nonsustained ventricular tachycardia) and cardiovascular events in patients without structural heart disease

  2024cites this paper
• Efficacy of Sodium-Glucose 2 Transporter Inhibitors in Heart Failure With Preserved Ejection Fraction: A Narrative Review

  2024cites this paper
• Diagnostic and therapeutic challenges for PCPs regarding heart failure with preserved ejection fraction and obesity: results of an online internet-based survey

  2024cites this paper
• Prevalence and outcomes of heart failure phenotypes in patients with atrial fibrillation.

  2024cites this paper
• Coronary Revascularisation in Heart Failure with Reduced Ejection Fraction

  2024cites this paper
• Cardiac Left Ventricular miRNA-26a Is Downregulated in Ovariectomized Mice, Upregulated upon 17-Beta Estradiol Replacement, and Inversely Correlated with Collagen Type 1 Gene Expression

  2024cites this paper
• Myocardial Metabolic Reprogramming in HFpEF

  2023cites this paper
• A review of the impact, pathophysiology, and management of atrial fibrillation in patients with heart failure with preserved ejection fraction

  2023cites this paper
• Multimorbidity in Heart Failure: Leveraging Cluster Analysis to Guide Tailored Treatment Strategies

  2023cites this paper
• Association between allostatic load and adverse outcomes among older patients with heart failure with preserved ejection fraction

  2023cites this paper
• Echocardiographic Evaluation of Diastolic Function in Special Populations.

  2023cites this paper
• Sex-Specific Impairment of Cardiac Functional Reserve in HFpEF

  2023cites this paper
• Deep learning-based prognostic model using non-enhanced cardiac cine MRI for outcome prediction in patients with heart failure

  2023cites this paper
• A Machine Learning Approach Using Statistical Models for Early Detection of Cardiac Arrest in Newborn Babies in the Cardiac Intensive Care Unit

  2023cites this paper
• Sex differences in 123I-mIBG scintigraphy imaging techniques in patients with heart failure

  2023cites this paper
• Discovering Distinct Phenotypical Clusters in Heart Failure Across the Ejection Fraction Spectrum: a Systematic Review

  2023cites this paper
• Heart Failure with Preserved Left Ventricular Ejection Fraction: A Complex Conundrum Simply Not Limited to Diastolic Dysfunction

  2023cites this paper
• Ischemic Etiology in Advanced Heart Failure: Insight from the HELP-HF Registry.

  2023cites this paper
• MiR-155 regulates macrophage polarization and alleviates myocardial fibrosis through paracrine secretion of transforming growth factor-beta 1 in ischemic heart failure

  2023cites this paper
• Optimization of The Machine Learning Approach using Optuna in Heart Disease Prediction

  2023cites this paper
• A machine learning approach for risk factors analysis and survival prediction of Heart Failure patients

  2023cites this paper
• Cardiac contractility modulation: an effective treatment strategy for heart failure beyond reduced left ventricular ejection fraction?

  2023cites this paper
• Molecular Mechanisms and Therapeutic Implications of Endothelial Dysfunction in Patients with Heart Failure

  2023cites this paper
• Association between Cardiovascular Disease and Liver Disease, from a Clinically Pragmatic Perspective as a Cardiologist

  2023cites this paper
• Heart Failure and Multimorbidity in Asia

  2023cites this paper
• Sex differences in major adverse cardiovascular and cerebrovascular event risk among central retinal artery occlusion patients

  2023cites this paper
• 2023 ACC Expert Consensus Decision Pathway on Management of Heart Failure With Preserved Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee.

  2023cites this paper
• Different heart failure phenotypes of valvular heart disease: the role of mitochondrial dysfunction

  2023cites this paper
• Prediction of left ventricular ejection fraction changes in heart failure patients using machine learning and electronic health records: a multi-site study

  2023cites this paper
• Blood pressure per the 2017 ACC/AHA and 2018 ESC/ESH guidelines and heart failure risk: the Suita Study

  2023cites this paper
• Educational inequalities in heart failure mortality and the cycles of the internal armed conflict in Colombia: An observational panel study of ecological data, 1999–2017

  2023cites this paper
• Towards clinical application of GlycA and GlycB for early detection of inflammation associated with (pre)diabetes and cardiovascular disease: recent evidence and updates

  2023cites this paper
• Supra-Normal Left Ventricular Function.

  2023cites this paper
• Exercise intolerance in heart failure with preserved ejection fraction: Causes, consequences and the journey towards a cure

  2023cites this paper
• Fibroblast Growth Factor 23 and Risk of Heart Failure Subtype: The CRIC (Chronic Renal Insufficiency Cohort) Study

  2023cites this paper
• Carbohydrate antigen 125 and risk of heart failure readmissions in patients with heart failure and preserved ejection fraction

  2022cites this paper
• Prevalence and clinical outcome of main echocardiographic and hemodynamic heart failure phenotypes in a population of hospitalized patients 70 years old and older

  2022cites this paper
• Impact of Outpatient Diuretic Infusion Therapy on Healthcare Cost and Readmissions

  2022cites this paper
• Atrial Fibrillation In Heart Failure With Preserved Ejection Fraction

  2022cites this paper
• Characteristics and long‐term prognosis of patients with reduced, mid‐range, and preserved ejection fraction: A systemic review and meta‐analysis

  2022cites this paper
• Transcatheter Implantation of Interatrial Shunt Devices to Lower Left Atrial Pressure in Heart Failure

  2022cites this paper
• New factors in heart failure pathophysiology: Immunity cells release of extracellular vesicles

  2022cites this paper
• Treatment response in recent‐onset heart failure with reduced ejection fraction: non‐ischaemic vs. ischaemic aetiology

  2022cites this paper
• Sex related differences in the characteristics and outcomes of heart failure: A sub analysis of heart failure disease management study

  2022cites this paper
• SGLT-2 inhibice užitečným nástrojem v léčbě srdečního selhání se sníženou i zachovalou ejekční frakcí

  2022cites this paper
• Device-based percutaneous treatments to decompress the left atrium in heart failure with preserved ejection fraction

  2022cites this paper
• Sleep Apnea and Physical Movement During Sleep, But Not Sleep Duration, Are Independently Associated With Progression of Left Ventricular Diastolic Dysfunction: Prospective Hyogo Sleep Cardio‐Autonomic Atherosclerosis Cohort Study

  2022cites this paper
• Aetiology of chronic heart failure in patients from a super‐aged society: the KUNIUMI registry chronic cohort

  2022cites this paper
• Epidemiology and Clinical Features of Heart Failure with Preserved Ejection Fraction

  2022cites this paper
• Associations of body mass index with mortality in heart failure with preserved ejection fraction patients with ischemic versus non-ischemic etiology

  2022cites this paper
• Coronary Artery Disease and Heart Failure With Preserved Ejection Fraction: The ARIC Study

  2022cites this paper
• SGLT-2 inhibition a useful tool in the treatment of heart failure with reduced and preserved ejection fraction.

  2022cites this paper
• RRCC_A_380136 63..71

  2022cites this paper
• Endothelial cell-specific mineralocorticoid receptor activation promotes diastolic dysfunction in diet induced obese male mice.

  2022cites this paper
• Understanding How Heart Metabolic Derangement Shows Differential Stage Specificity for Heart Failure with Preserved and Reduced Ejection Fraction

  2022cites this paper
• Atrial fibrillation in heart failure patients: An update on renin–angiotensin–aldosterone system pathway blockade as a therapeutic and prevention target

  2022cites this paper