Clonotypic Dominance and Variable Gene Elements of Pathogenic Anti‐DNA Autoantibodies from a Single Patient with Lupus

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Scandinavian Journal of Immunology

• Publication date

  1994-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1365-3083.1994.tb03356.xPMID 8296159
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Somatic diversification in the heavy chain variable region genes expressed by human autoantibodies bearing a lupus-associated nephritogenic anti-DNA idiotype.

  1994cited by this paper
• Analysis of immunoglobulin variable region genes from human IgG anti‐DNA hybridomas

  1992cited by this paper
• Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice

  1992cited by this paper
• Development of Human Antibody Variable Genes in Systemic Autoimmunity

  1992cited by this paper
• Sequences of proteins of immunological interest

  1991cited by this paper
• Human immunoglobulin heavy-chain variable region genes: organization, polymorphism, and expression.

  1991cited by this paper
• Somatic mutations in the variable regions of a human IgG anti-double- stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus

  1991cited by this paper
• Molecular characteristics of antibodies bearing an anti-DNA-associated idiotype [published erratum appears in J Exp Med 1992 Jul 1;176(1):309]

  1991cited by this paper
• Molecular characteristics of antibodies bearing an anti-DNA-associated idiotype

  1991cited by this paper
• Many variable region genes are utilized in the antibody response of BALB/c mice to the influenza virus A/PR/8/34 hemagglutinin.

  1991cited by this paper
• Probing VH gene-family utilization in human peripheral B cells by in situ hybridization.

  1991cited by this paper
• Autoantibodies and autoantigens: a conserved system that may shape a primary immunoglobulin gene pool.

  1991cited by this paper
• Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life.

  1990cited by this paper
• V region sequences of an idiotypically connected family of pathogenic anti-DNA autoantibodies.

  1990cited by this paper
• Variable region primary structures of monoclonal anti-DNA autoantibodies from NZB/NZW F1 mice.

  1990cited by this paper
• Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation

  1990cited by this paper
• Clonotypes of anti-DNA antibodies expressing specific idiotypes in immune complexes of patients with active lupus nephritis.

  1990cited by this paper
• Idiotype-mediated intervention in systemic lupus erythematosus.

  1990cited by this paper
• The role of germline gene expression and somatic mutation in the generation of autoantibodies to DNA.

  1990cited by this paper
• Restriction fragment length polymorphism analysis of the VX locus in human lupus

  1989cited by this paper
• Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response

  1989cited by this paper
• Fidelity of DNA polymerases in DNA amplification.

  1989cited by this paper
• Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney.

  1989cited by this paper
• Diversity of Ig V gene segments found in anti-DNA autoantibodies from a single (NZB x NZW)F1 mouse.

  1989cited by this paper
• Restriction fragment length polymorphism analysis of the V kappa locus in human lupus.

  1989cited by this paper
• Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies [published erratum appears in J Exp Med 1990 Aug 1;172(2):669]

  1988cited by this paper
• Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase.

  1988cited by this paper
• The Dynamic Nature of the Antibody Repertoire

  1988cited by this paper
• Errors in the polymerase chain reaction.

  1988cited by this paper
• Origin and Diversification of Anti‐DNA Antibodies

  1988cited by this paper
• Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.

  1988cited by this paper
• Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits.

  1987cited by this paper
• Early restriction of the human antibody repertoire.

  1987cited by this paper
• The role of clonal selection and somatic mutation in autoimmunity

  1987cited by this paper
• Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.

  1987cited by this paper
• Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis

  1987cited by this paper
• Evolutionary and somatic selection of the antibody repertoire in the mouse.

  1987cited by this paper
• A gamma 3 hinge region probe: first specific human immunoglobulin subclass probe

  1986cited by this paper
• Expression of idiotype on the surface of human B cells producing anti-DNA antibody.

  1986cited by this paper
• A rapid ELISA for measurement of antibodies to nucleic acid antigens using UV-treated polystyrene microplates.

  1986cited by this paper
• Organization and evolution of variable region genes of the human immunoglobulin heavy chain.

  1986cited by this paper
• VH genes encoding the immune response to beta‐(1,6)‐galactan: somatic mutation in IgM molecules.

  1984cited by this paper
• Rearranged immunoglobulin heavy chain variable region (VH) pseudogene that deletes the second complementarity-determining region.

  1984cited by this paper
• Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

  1984cited by this paper
• Antibodies to native DNA and serum complement (C3) levels. Application to diagnosis and classification of systemic lupus erythematosus.

  1983cited by this paper
• A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

  1983cited by this paper
• The relationship of renal histopathological lesions to immunoglobulin classes and complement fixation of anti-native DNA antibodies in systemic lupus erythematosus.

  1983cited by this paper
• The 1982 revised criteria for the classification of systemic lupus erythematosus.

  1982cited by this paper
• Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes

  1981cited by this paper
• A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody.

  1981cited by this paper
• IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

  1981cited by this paper
• Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region.

  1981cited by this paper
• Relationship of renal histopathology in SLE nephritis to immunoglobulin class of anti-DNA.

  1980cited by this paper
• Single step separation of human T and B cells using AET treated srbc rosettes.

  1976cited by this paper
• PATHOGENESIS OF IMMUNE COMPLEX GLOMERULONEPHRITIS OF NEW ZEALAND MICE

  1971cited by this paper
• IMMUNOLOGICAL STUDIES CONCERNING THE NEPHRITIS OF SYSTEMIC LUPUS ERYTHEMATOSUS

  1967cited by this paper

• Oxygen free radical modified DNA: Implications in the etiopathogenesis of Systemic lupus erythematosus

  2009influential citation
• Homology-directed recombination in IgH variable region genes from human neonates, infants and adults: implications for junctional diversity.

  2007cites this paper
• Sensitization with Xenogeneic Tissues Alters the Heavy Chain Repertoire of Human Anti-Gal&agr;1–3Gal Antibodies

  2005cites this paper
• Superantigens and Autoantigens May Be Involved in the Pathogenesis of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

  2001cites this paper
• B cell tolerance to self in systemic autoimmunity.

  2001cites this paper
• The Anti-DNA Response in Lupus

  1999cites this paper
• Structural basis of the gp120 superantigen-binding site on human immunoglobulins.

  1998cites this paper
• Immunoglobulins Superantigen-Binding Site on Human Structural Basis of the gp 120

  1998cites this paper
• The structure of human lupus anti-DNA antibodies.

  1997cites this paper
• Characterization of a germline Vk gene encoding cationic anti-DNA antibody and role of receptor editing for development of the autoantibody in patients with systemic lupus erythematosus.

  1996cites this paper
• VH gene‐family representation in peripheral activated B cells from systemic lupus erythematosus (SLE) patients

  1996cites this paper
• DNA methylation: a potential pathway to abnormal autoreactive lupus B cells.

  1996cites this paper
• Molecular characterization of human monoclonal antibodies specific for several HIV proteins: analysis of the VH3 family expression.

  1995cites this paper
• Establishment and structural analysis of human mAb to the E2 component of the 2-oxoglutarate dehydrogenase complex generated from a patient with primary biliary cirrhosis.

  1995cites this paper
• Human Pathogenic Autoantibodies and Their Escape from Deletion a

  1995cites this paper
• Native DNA fragments photocrosslinked to psoralen binds to anti-B and anti-Z DNA antibodies.

  1995cites this paper
• Structural restriction in the heavy chain CDR3 of human rheumatoid factors.

  1995cites this paper
• Analysis of variable region genes encoding anti-Sm and anti-cardiolipin antibodies from a systemic lupus erythematosus patient.

  1995cites this paper
• Structure-Function Relationships of Anti-DNA Antibodies

  1995cites this paper
• Immunoglobulin gene sequence analysis of anti-cardiolipin and anti-cardiolipin idiotype (H3) human monoclonal antibodies.

  1995cites this paper
• Immunoglobulin variable region gene segments in human autoantibodies

  1995cites this paper
• Human autoantibodies and their genes

  1994cites this paper
• Trigger mechanisms of autoantibody production.

  1994cites this paper
• Synthetic Autoantigens of Immunoglobulins and T-Cell Receptors: Their Recognition in Aging, Infection, and Autoimmunity

  1994cites this paper
• Human lupus anti‐DNA autoantibodies undergo essentially primary V kappa gene rearrangements.

  1994cites this paper