Use of N,O-bis-Fmoc-D-Tyr-ONSu for introduction of an oxidative iodination site into cholecystokinin family peptides.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  International journal of peptide & protein research

• Publication date

  2009-01-12

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1111/J.1399-3011.1988.TB00899.XPMID 3410633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Establishment of a new short, protease-resistant, affinity labeling reagent for the cholecystokinin receptor.

  1987cited by this paper
• Analysis of the carbohydrate composition of the pancreatic plasmalemmal glycoprotein affinity labeled by short probes for the cholecystokinin receptor.

  1987cited by this paper
• Affinity labeling of a novel cholecystokinin-binding protein in rat pancreatic plasmalemma using new short probes for the receptor.

  1987cited by this paper
• Preparation and characterization of a new cholecystokinin receptor probe that can be oxidatively radioiodinated.

  1986cited by this paper
• Pancreatic CCK receptors: characterization of covalently labeled subunits.

  1984cited by this paper
• Use of the heterobifunctional cross-linker m-maleimidobenzoyl N-hydroxysuccinimide ester to affinity label cholecystokinin binding proteins on rat pancreatic plasma membranes.

  1984cited by this paper
• Analysis of cholecystokinin-binding proteins using endo-beta-N- acetylglucosaminidase F

  1984cited by this paper
• Identification and localization of cholecystokinin-binding sites on rat pancreatic plasma membranes and acinar cells: a biochemical and autoradiographic study

  1983cited by this paper
• Characterization of cholecystokinin receptor subunits on pancreatic plasma membranes.

  1983cited by this paper
• Interactions of COOH-terminal fragments of cholecystokinin with receptors on dispersed acini from guinea pig pancreas.

  1982cited by this paper
• Specific photoaffinity crosslinking of [125I]cholecystokinin to pancreatic plasma membranes. Evidence for a disulfide-linked Mr 76 000 peptide in cholecystokinin receptors.

  1982cited by this paper
• Preparation of an N-acetyl-octapeptide of cholecystokinin. The role of N-acetylation in protecting the octapeptide from degradation by smooth muscle tissues.

  1982cited by this paper
• Structural requirements for action of cholecystokinin on enzyme secretion from pancreatic acini.

  1982cited by this paper
• Preparation and characterization of a probe for the cholecystokinin octapeptide receptor, N alpha (125I-desaminotyrosyl)CCK-8, and its interactions with pancreatic acini.

  1981cited by this paper
• [Cholecystokinin-pancreozymin synthesis. Synthesis of [28-threonine,31-norleucine]- and [28-threonine,31-leucine]cholecystokinin-pancreozymin-(25-33)-nonapeptide].

  1981cited by this paper
• Characterization of cholecystokinin receptors on rat pancreatic membranes.

  1981cited by this paper
• Binding of cholecystokinin to high affinity receptors on isolated rat pancreatic acini.

  1980cited by this paper
• Interaction of cholecystokinin with specific membrane receptors on pancreatic acinar cells.

  1980cited by this paper
• Cholecystokinin-pancreozymin

  1970cited by this paper
• Solid Phase Peptide Synthesis. II. The Synthesis of Bradykinin

  1964cited by this paper

• Cholesterol residence time drives regulation of the G protein-coupled cholecystokinin receptor.

  2025cites this paper
• Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling

  2024cites this paper
• Impact of secretin receptor homo-dimerization on natural ligand binding

  2024cites this paper
• Cholecystokinin receptors in GtoPdb v.2023.1 Cholecystokinin receptors in GtoPdb v.2023.1

  2023cites this paper
• Mechanism of Action and Structure–Activity Relationships of Tetracyclic Small Molecules Acting as Universal Positive Allosteric Modulators of the Cholecystokinin Receptor

  2023cites this paper
• Secretin Amino-Terminal Structure-Activity Relationships and Complementary Mutagenesis at the Site of Docking to the Secretin Receptor

  2022cites this paper
• Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

  2021cites this paper
• Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol

  2021cites this paper
• Rational development of a high-affinity secretin receptor antagonist.

  2020cites this paper
• Structure and dynamics of the active Gs-coupled human secretin receptor

  2020cites this paper
• Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor

  2019cites this paper
• Cholecystokinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor*

  2016cites this paper
• Beneficial effects of β-sitosterol on type 1 cholecystokinin receptor dysfunction induced by elevated membrane cholesterol.

  2016cites this paper
• proteins with the class B secretin receptor Differential determinants for coupling of distinct G

  2016cites this paper
• Development of a Highly Selective Allosteric Antagonist Radioligand for the Type 1 Cholecystokinin Receptor and Elucidation of Its Molecular Basis of Binding

  2015cites this paper
• Elimination of a cholecystokinin receptor agonist 'trigger' in an effort to develop positive allosteric modulators without intrinsic agonist activity.

  2015cites this paper
• Use of Fluorescence Indicators in Receptor Ligands.

  2015cites this paper
• Impact of ursodeoxycholic acid on a CCK1R cholesterol-binding site may contribute to its positive effects in digestive function.

  2015cites this paper
• A Type 1 Cholecystokinin Receptor Mutant That Mimics the Dysfunction Observed for Wild Type Receptor in a High Cholesterol Environment*

  2014cites this paper
• Environment Wild Type Receptor in a High Cholesterol That Mimics the Dysfunction Observed for A Type 1 Cholecystokinin Receptor Mutant

  2014cites this paper
• A type 1 CCK receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment*

  2014cites this paper
• Insights into the impact of phenolic residue incorporation at each position along secretin for receptor binding and biological activity.

  2013influential citation
• Direct demonstration of unique mode of natural peptide binding to the type 2 cholecystokinin receptor using photoaffinity labeling.

  2013cites this paper
• The Concise Guide to Pharmacology 2013/14: G Protein-Coupled Receptors

  2013cites this paper
• Ligand-induced internalization of the type 1 cholecystokinin receptor independent of recognized signaling activity.

  2012cites this paper
• Site of action of a pentapeptide agonist at the glucagon-like peptide-1 receptor. Insight into a small molecule agonist-binding pocket.

  2012cites this paper
• Differential determinants for coupling of distinct G proteins with the class B secretin receptor.

  2012cites this paper
• Molecular Basis for Binding and Subtype Selectivity of 1,4-Benzodiazepine Antagonist Ligands of the Cholecystokinin Receptor*

  2012cites this paper
• Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping

  2012cites this paper
• Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular Modeling*

  2011cites this paper
• Importance of each residue within secretin for receptor binding and biological activity.

  2011cites this paper
• Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist.

  2011cites this paper
• Fluorescence Polarization Screening for Allosteric Small Molecule Ligands of the Cholecystokinin Receptor

  2011cites this paper
• Molecular Basis of Secretin Docking to Its Intact Receptor Using Multiple Photolabile Probes Distributed throughout the Pharmacophore*

  2011cites this paper
• Modulation of cell surface expression of nonactivated cholecystokinin receptors using bivalent ligand-induced internalization.

  2010cites this paper
• Spatial Approximations between Residues 6 and 12 in the Amino-terminal Region of Glucagon-like Peptide 1 and Its Receptor

  2010cites this paper
• Refinement of the pharmacophore of an agonist ligand of the secretin receptor using conformationally constrained cyclic hexapeptides.

  2010cites this paper
• Secretin Occupies a Single Protomer of the Homodimeric Secretin Receptor Complex

  2010cites this paper
• Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints.

  2010cites this paper
• Juxtamembranous Region of the Amino Terminus of the Family B G Protein-coupled Calcitonin Receptor Plays a Critical Role in Small-molecule Agonist Action*

  2009cites this paper
• Elucidation of the molecular basis of cholecystokinin Peptide docking to its receptor using site-specific intrinsic photoaffinity labeling and molecular modeling.

  2009cites this paper
• Solid phase synthesis of a fully active analogue of cholecystokinin using the acid-stable Boc-Phe (p-CH2) SO3H as a substitute for Boc-Tyr(SO3H) in CCK8.

  2009cites this paper
• Molecular Basis of Glucagon-like Peptide 1 Docking to Its Intact Receptor Studied with Carboxyl-terminal Photolabile Probes*

  2009cites this paper
• Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids.

  2009cites this paper
• Effects of pH and temperature on photoaffinity labeling of Family B G protein-coupled receptors.

  2009cites this paper
• Spatial Approximation between Secretin Residue Five and the Third Extracellular Loop of Its Receptor Provides New Insight into the Molecular Basis of Natural Agonist Binding

  2008influential citation
• Insights into the structural basis of endogenous agonist activation of family B G protein-coupled receptors.

  2008cites this paper
• Exploration of the Endogenous Agonist Mechanism for Activation of Secretin and VPAC1 Receptors Using Synthetic Glycosylated Peptides

  2008cites this paper
• Molecular Approximations between Residues 21 and 23 of Secretin and Its Receptor: Development of a Model for Peptide Docking with the Amino Terminus of the Secretin Receptor

  2007cites this paper
• Fluorescence Resonance Energy Transfer Analysis of Secretin Docking to Its Receptor

  2007cites this paper
• Mapping the architecture of secretin receptors with intramolecular fluorescence resonance energy transfer using acousto-optic tunable filter-based spectral imaging.

  2007cites this paper
• Role of lysine187 within the second extracellular loop of the type A cholecystokinin receptor in agonist-induced activation. Use of complementary charge-reversal mutagenesis to define a functionally important interdomain interaction.

  2007cites this paper
• Novel benzodiazepine photoaffinity probe stereoselectively labels a site deep within the membrane-spanning domain of the cholecystokinin receptor.

  2006cites this paper
• Possible Endogenous Agonist Mechanism for the Activation of Secretin Family G Protein-Coupled Receptors

  2006cites this paper
• Secretin receptor oligomers form intracellularly during maturation through receptor core domains.

  2006cites this paper
• Fluorescent Indicators Distributed throughout the Pharmacophore of Cholecystokinin Provide Insights into Distinct Modes of Binding and Activation of Type A and B Cholecystokinin Receptors*

  2006cites this paper
• Transmembrane segment peptides can disrupt cholecystokinin receptor oligomerization without affecting receptor function.

  2006cites this paper
• Differential spatial approximation between secretin and its receptor residues in active and inactive conformations demonstrated by photoaffinity labeling.

  2006cites this paper
• Demonstration of a Specific Site of Covalent Labeling of the Human Motilin Receptor Using a Biologically Active Photolabile Motilin Analog

  2005cites this paper
• Distinct Molecular Mechanisms for Agonist Peptide Binding to Types A and B Cholecystokinin Receptors Demonstrated Using Fluorescence Spectroscopy*

  2005cites this paper
• Insights into Interactions between the α-Helical Region of the Salmon Calcitonin Antagonists and the Human Calcitonin Receptor using Photoaffinity Labeling*

  2005cites this paper
• Insights into the structure and molecular basis of ligand docking to the G protein-coupled secretin receptor using charge-modified amino-terminal agonist probes.

  2005cites this paper
• Differential docking of high-affinity peptide ligands to type A and B cholecystokinin receptors demonstrated by photoaffinity labeling.

  2005cites this paper
• Paired Cysteine Mutagenesis to Establish the Pattern of Disulfide Bonds in the Functional Intact Secretin Receptor*

  2005cites this paper
• Differential Spatial Approximation between Cholecystokinin Residue 30 and Receptor Residues in Active and Inactive Conformations

  2005influential citation
• Fmoc-based synthesis of peptide alpha-thioesters using an aryl hydrazine support.

  2004cites this paper
• Molecular Approximation between a Residue in the Amino-terminal Region of Calcitonin and the Third Extracellular Loop of the Class B G Protein-coupled Calcitonin Receptor*

  2004cites this paper
• Spatial Approximation between the Amino Terminus of a Peptide Agonist and the Top of the Sixth Transmembrane Segment of the Secretin Receptor*

  2004cites this paper
• Key Differences in Molecular Complexes of the Cholecystokinin Receptor with Structurally Related Peptide Agonist, Partial Agonist, and Antagonist

  2004cites this paper
• Importance of the Amino Terminus in Secretin Family G Protein-coupled Receptors

  2004cites this paper
• Spatial Approximation between Two Residues in the Mid-region of Secretin and the Amino Terminus of Its Receptor

  2003cites this paper
• Development of a biologically active secretin analogue incorporating a radioiodinatable photolabile p-(4-hydroxybenzoyl)phenylalanine in position 10.

  2002cites this paper
• Differential Determinants for Peptide and Non-peptidyl Ligand Binding to the Motilin Receptor

  2002cites this paper
• Environment and Mobility of a Series of Fluorescent Reporters at the Amino Terminus of Structurally Related Peptide Agonists and Antagonists Bound to the Cholecystokinin Receptor*

  2002cites this paper
• Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus.

  2002cites this paper
• Refinement of the conformation of a critical region of charge-charge interaction between cholecystokinin and its receptor.

  2002cites this paper
• Refinement of the Structure of the Ligand-occupied Cholecystokinin Receptor Using a Photolabile Amino-terminal Probe*

  2001cites this paper
• Identification of Peptide Ligand-binding Domains within the Human Motilin Receptor Using Photoaffinity Labeling*

  2001cites this paper
• Identification of Two Pairs of Spatially Approximated Residues within the Carboxyl Terminus of Secretin and Its Receptor*

  2000cites this paper
• Identification of an Interaction between Residue 6 of the Natural Peptide Ligand and a Distinct Residue within the Amino-terminal Tail of the Secretin Receptor*

  1999cites this paper
• A peptide agonist acts by occupation of a monomeric G protein-coupled receptor: dual sites of covalent attachment to domains near TM1 and TM7 of the same molecule make biologically significant domain-swapped dimerization unlikely.

  1999cites this paper
• ACELL Mar. 45/3

  1999cites this paper
• Regulation of lateral mobility and cellular trafficking of the CCK receptor by a partial agonist.

  1999cites this paper
• Structurally Related Peptide Agonist, Partial Agonist, and Antagonist Occupy a Similar Binding Pocket within the Cholecystokinin Receptor

  1999cites this paper
• Regulation of lateral mobility and cellular trafficking of the CCK receptor by a partial agonist.

  1999influential citation
• Demonstration of a Direct Interaction between Residue 22 in the Carboxyl-terminal Half of Secretin and the Amino-terminal Tail of the Secretin Receptor Using Photoaffinity Labeling*

  1999cites this paper
• Identification of a domain in the carboxy terminus of CCK receptor that affects its intracellular trafficking.

  1998cites this paper
• Direct Identification of a Second Distinct Site of Contact between Cholecystokinin and Its Receptor*

  1998cites this paper
• Characterization of Cholecystokinin (CCK) Receptors

  1998cites this paper
• Identification of a domain in the carboxy terminus of CCK receptor that affects its intracellular trafficking.

  1998cites this paper
• Cellular handling of unoccupied and agonist-stimulated cholecystokinin receptor determined by immunolocalization.

  1997cites this paper
• Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor.

  1997cites this paper
• Roles of cholecystokinin receptor phosphorylation in agonist-stimulated desensitization of pancreatic acinar cells and receptor-bearing Chinese hamster ovary cholecystokinin receptor cells.

  1997cites this paper
• Quantitative dynamic multicompartmental analysis of cholecystokinin receptor movement in a living cell using dual fluorophores and reconstruction of confocal images.

  1997cites this paper
• Direct Identification of a Distinct Site of Interaction between the Carboxyl-terminal Residue of Cholecystokinin and the Type A Cholecystokinin Receptor Using Photoaffinity Labeling*

  1997cites this paper
• Differences in partial agonist action at cholecystokinin receptors of mouse and rat are dependent on parameters extrinsic to receptor structure: molecular cloning, expression and functional characterization of the mouse type A cholecystokinin receptor.

  1997cites this paper
• Cholecystokinin‐Induced Desensitization, Receptor Phosphorylation, and Internalization in the CHP212 Neuroblastoma Cell Line

  1997cites this paper
• Role of Receptor Phosphorylation in Desensitization and Internalization of the Secretin Receptor*

  1996cites this paper
• Relationship Between Native and Recombinant Cholecystokinin Receptors: Role of Differential Glycosylation

  1996cites this paper