CCL5/CCR5 axis induces vascular endothelial growth factor-mediated tumor angiogenesis in human osteosarcoma microenvironment.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Carcinogenesis

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/carcin/bgu218PMID 25330803
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CTGF increases matrix metalloproteinases expression and subsequently promotes tumor metastasis in human osteosarcoma through down-regulating miR-519d

  2014cited by this paper
• The CCN Family Proteins: Modulators of Bone Development and Novel Targets in Bone-Associated Tumors

  2014cited by this paper
• Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells

  2014cited by this paper
• Inflammatory chemokines and metastasis—tracing the accessory

  2014influential reference
• RANTES / CCL 5-induced pro-angiogenic effects depend on CCR 1 , CCR 5 and glycosaminoglycans

  2013cited by this paper
• Butein Inhibits Angiogenesis of Human Endothelial Progenitor Cells via the Translation Dependent Signaling Pathway

  2013cited by this paper
• CCL5 and CCR5 Interaction Promotes Cell Motility in Human Osteosarcoma

  2012influential reference
• Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing.

  2012cited by this paper
• CCR5 antagonist blocks metastasis of basal breast cancer cells.

  2012cited by this paper
• Common musculoskeletal tumors of childhood and adolescence.

  2012cited by this paper
• Molecular mechanisms of chondrosarcoma metastasis

  2012cited by this paper
• RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans

  2012cited by this paper
• Tumor angiogenesis: molecular pathways and therapeutic targets

  2011cited by this paper
• PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC‐3 prostate cancer cells

  2011cited by this paper
• CCL5 Neutralization Restricts Cancer Growth and Potentiates the Targeting of PDGFRβ in Colorectal Carcinoma

  2011cited by this paper
• Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature

  2011cited by this paper
• Chemokines and chemokine receptors: new insights into cancer-related inflammation.

  2010influential reference
• Prostaglandin E2/EP1 Signaling Pathway Enhances Intercellular Adhesion Molecule 1 (ICAM-1) Expression and Cell Motility in Oral Cancer Cells*

  2010cited by this paper
• CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways.

  2009cited by this paper
• PKC-delta/c-Src-mediated EGF receptor transactivation regulates thrombin-induced COX-2 expression and PGE(2) production in rat vascular smooth muscle cells.

  2008cited by this paper
• Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis

  2008cited by this paper
• CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway.

  2007cited by this paper
• Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

  2007cited by this paper
• Protein kinase C‐δ regulates the stability of hypoxia‐inducible factor‐1α under hypoxia

  2007cited by this paper
• Hypoxia-inducible Factor 1α Is Regulated by the Mammalian Target of Rapamycin (mTOR) via an mTOR Signaling Motif*

  2007cited by this paper
• Protein kinase C-delta regulates the stability of hypoxia-inducible factor-1 alpha under hypoxia.

  2007cited by this paper
• Angiogenesis Assays in the Chick

  2007cited by this paper
• Protein kinase C and other diacylglycerol effectors in cancer

  2007cited by this paper
• Inflammation-associated immune suppression in cancer: the roles played by cytokines, chemokines and additional mediators.

  2006cited by this paper
• Expression of CCL5 (RANTES) and CCR5 in prostate cancer

  2006cited by this paper
• Contribution of bone marrow–derived endothelial cells to human tumor vasculature

  2005cited by this paper
• Phorbol 12-Myristate 13-Acetate Induces Epidermal Growth Factor Receptor Transactivation via Protein Kinase Cδ/c-Src Pathways in Glioblastoma Cells*

  2005cited by this paper
• Angiogenesis assays in the chick CAM.

  2005cited by this paper
• Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis.

  2005cited by this paper
• Friends or foes — bipolar effects of the tumour stroma in cancer

  2004cited by this paper
• Exploiting tumour hypoxia in cancer treatment

  2004cited by this paper
• A renaissance for SRC

  2004cited by this paper
• Inhibition of metastasis by inhibition of tumor-derived CCL5

  2004cited by this paper
• Vascular endothelial growth factor as a target for anticancer therapy.

  2004cited by this paper
• Protein Kinase Cδ Induces Src Kinase Activity via Activation of the Protein Tyrosine Phosphatase PTPα*

  2003cited by this paper
• Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha.

  2003cited by this paper
• Activated pp60c-Src Leads to Elevated Hypoxia-inducible Factor (HIF)-1α Expression under Normoxia*

  2002cited by this paper
• HIF-1 and tumor progression: pathophysiology and therapeutics.

  2002cited by this paper
• Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

  2001cited by this paper
• Involvement of chemokine receptors in breast cancer metastasis

  2001cited by this paper
• Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cervical cancer.

  2001cited by this paper
• Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.

  2001cited by this paper
• Angiogenesis in cancer and other diseases

  2000cited by this paper
• Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma.

  1999cited by this paper
• Common musculoskeletal tumors of childhood and adolescence.

  1999cited by this paper
• Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

  1997cited by this paper
• Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

  1996cited by this paper
• Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES

  1990cited by this paper

• CCR-CCL axes as key upstream influencers of pancreatic ductal adenocarcinoma: CCR2–CCL2, CCR5–CCL5, CCR4–CCL17/22, CCR6–CCL20, CCR7–CCL19/21

  2026cites this paper
• Pipelines for lymphocyte homeostasis maintenance during cancer immunotherapy

  2025cites this paper
• Screening and identification Hub genes associated with immune cell infiltration and critical biomarkers in osteosarcoma.

  2025cites this paper
• The Laws of Attraction: Chemokines as Critical Mediators in Cancer Progression and Immunotherapy Response in Bladder Cancer

  2024cites this paper
• Development and experimental verification of novel angiogenesis related prognostic model and immune infiltration characterization in osteosarcoma

  2024cites this paper
• CCL5 promotes the epithelial-mesenchymal transition of circulating tumor cells in renal cancer

  2024cites this paper
• Targeting PADI2 as a potential therapeutic strategy against metastasis in oral cancer via suppressing EMT-mediated migration and invasion and CCL3/5-induced angiogenesis

  2024cites this paper
• Surface Markers and Chemokines/Cytokines of Tumor-Associated Macrophages in Osteosarcoma and Other Carcinoma Microenviornments—Contradictions and Comparisons

  2024cites this paper
• Innate Immune Cells in Melanoma: Implications for Immunotherapy

  2024cites this paper
• Redirecting B7-H3.CAR T Cells to Chemokines Expressed in Osteosarcoma Enhances Homing and Antitumor Activity in Preclinical Models

  2024cites this paper
• Senescence induces miR‐409 to down‐regulate CCL5 and impairs angiogenesis in endothelial progenitor cells

  2024cites this paper
• Human platelet lysate-cultured adipose-derived stem cell sheets promote angiogenesis and accelerate wound healing via CCL5 modulation

  2024cites this paper
• Association of VEGFA and CCL4L2 polymorphisms with hand-foot skin reaction and survival of regorafenib in Japanese patients with colorectal cancer

  2024influential citation
• Hypoxia inducible factor-1ɑ as a potential therapeutic target for osteosarcoma metastasis

  2024cites this paper
• Exploring the Impact of Exosomal Cargos on Osteosarcoma Progression: Insights into Therapeutic Potential

  2024cites this paper
• CCR5 and CCL5 gene expression in colorectal cancer: comprehensive profiling and clinical value

  2024cites this paper
• Inhibition of Slit3/Robo1 signaling alleviates osteoarthritis in mice by reducing abnormal H-type vessel formation in subchondral bone

  2024cites this paper
• Advancing osteosarcoma 3D modeling in vitro for novel tumor microenvironment-targeted therapies development.

  2024cites this paper
• Immune signatures of checkpoint inhibitor-induced autoimmunity - a focus on neurotoxicity.

  2023cites this paper
• CCL5 promotes the proliferation and metastasis of bladder cancer via the JAK2/STAT3 signaling pathway

  2023cites this paper
• Roles of Tumor-Associated Macrophages in Tumor Environment and Strategies for Targeting Therapy

  2023cites this paper
• The Role and Therapeutic Targeting of CCR5 in Breast Cancer

  2023cites this paper
• Vascular Immune Evasion of Mesenchymal Glioblastoma Is Mediated by Interaction and Regulation of VE-Cadherin on PD-L1

  2023influential citation
• C-C motif chemokine ligand 5 (CCL5): a potential biomarker and immunotherapy target for osteosarcoma.

  2023cites this paper
• Promise and Challenges of T Cell Immunotherapy for Osteosarcoma

  2023cites this paper
• Liver immunopathogenesis in fatal cases of dengue in children: detection of viral antigen, cytokine profile and inflammatory mediators

  2023cites this paper
• Comprehensive analysis of angiogenesis pattern and related immune landscape for individual treatment in osteosarcoma

  2023cites this paper
• TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages

  2023influential citation
• The regulatory network of the chemokine CCL5 in colorectal cancer

  2023cites this paper
• The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications

  2023cites this paper
• Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression

  2023cites this paper
• Current Trends in Vascular Biomarkers for Systemic Sclerosis: A Narrative Review

  2023cites this paper
• Senescent cells and SASP in cancer microenvironment: New approaches in cancer therapy.

  2023cites this paper
• Advancements in the Diagnosis of Hepatocellular Carcinoma

  2023cites this paper
• Assessment of the RANTES Level Correlation and Selected Inflammatory and Pro-Angiogenic Molecules Evaluation of Their Influence on CRC Clinical Features: A Preliminary Observational Study

  2022influential citation
• Anti-angiogenic Drug Resistance: Roles and Targeting of Non-coding RNAs (microRNAs and long non-coding RNAs).

  2022cites this paper
• A promising research direction for colorectal cancer immunotherapy: The regulatory mechanism of CCL5 in colorectal cancer

  2022cites this paper
• LAP+CD4+T cells regulate the anti-tumor role of CIK cells in colorectal cancer through IL-10 and TGF-β.

  2022cites this paper
• An overview of resistance to chemotherapy in osteosarcoma and future perspectives

  2022cites this paper
• Co-Targeting Tumor Angiogenesis and Immunosuppressive Tumor Microenvironment: A Perspective in Ethnopharmacology

  2022cites this paper
• UTP Regulates the Cardioprotective Action of Transplanted Stem Cells Derived From Mouse Cardiac Adipose Tissue

  2022cites this paper
• Targeted Molecular Imaging Probes Based on Magnetic Resonance Imaging for Hepatocellular Carcinoma Diagnosis and Treatment

  2022cites this paper
• Integration of chemokine signaling with non-coding RNAs in tumor microenvironment and heterogeneity in different cancers.

  2022cites this paper
• Immunopathology of Renal Tissue in Fatal Cases of Dengue in Children

  2022cites this paper
• CAR T targets and microenvironmental barriers of osteosarcoma.

  2022cites this paper
• Potential Molecular Cross Talk Among CCR5 Pathway Predicts Regorafenib Responsiveness in Metastatic Colorectal Cancer Patients

  2021cites this paper
• The Roles of SDF-1/CXCR4, MCP-1/CCR2 and CCL5/CCR5 Chemokine Pathway in Hypertrophic Scarring

  2021cites this paper
• LRH1 Acts as an Oncogenic Driver in Human Osteosarcoma and Pan-Cancer

  2021cites this paper
• Identification of Potential Novel Prognosis-Related Genes Through Transcriptome Sequencing, Bioinformatics Analysis, and Clinical Validation in Acute Myeloid Leukemia

  2021cites this paper
• Bi-directional nanosystem breaking tumor microenvironment and vessels induced negative Möbius ring.

  2021cites this paper
• Tumor-Associated Macrophages and Their Functional Transformation in the Hypoxic Tumor Microenvironment

  2021cites this paper
• CCL5/CCR5 axis in human diseases and related treatments

  2021cites this paper
• S1P Increases VEGF Production in Osteoblasts and Facilitates Endothelial Progenitor Cell Angiogenesis by Inhibiting miR-16-5p Expression via the c-Src/FAK Signaling Pathway in Rheumatoid Arthritis

  2021cites this paper
• Depiction of the genomic and genetic landscape identifies CCL5 as a protective factor in colorectal neuroendocrine carcinoma

  2021cites this paper
• Effect of rose extract treatment on soluble CCR5 and CXCR4 secretion by the endothelial cells in vitro

  2021cites this paper
• C‐C chemokine hepatocellular carcinoma motif ligand 5‐deficiency promotes hepatocellular carcinoma progression by affecting B cell recruitment

  2021cites this paper
• Senescent cells in cancer therapy: why and how to remove them.

  2021cites this paper
• The CCL5/CCR5 Axis in Cancer Progression

  2020cites this paper
• Identification of a six‐gene prognostic signature for oral squamous cell carcinoma

  2020cites this paper
• Soya-cerebroside inhibits VEGF-facilitated angiogenesis in endothelial progenitor cells

  2020cites this paper
• Circulating cytokines and outcome in metastatic colorectal cancer patients treated with regorafenib

  2020cites this paper
• The Emerging Role of Myeloid-Derived Suppressor Cells in the Glioma Immune Suppressive Microenvironment

  2020cites this paper
• Hypoxic Cancer-Secreted Exosomal miR-182-5p Promotes Glioblastoma Angiogenesis by Targeting Kruppel-like Factor 2 and 4

  2020cites this paper
• Understanding the Differentiation, Expansion, Recruitment and Suppressive Activities of Myeloid-Derived Suppressor Cells in Cancers

  2020cites this paper
• Visfatin Increases VEGF-Dependent Angiogenesis of Endothelial Progenitor Cells during Osteoarthritis Progression

  2020cites this paper
• The hypoxic tumour microenvironment: A safe haven for immunosuppressive cells and a therapeutic barrier to overcome.

  2020cites this paper
• Chemokines and Bone.

  2020cites this paper
• Increased DEF6 expression is correlated with metastasis and poor prognosis in human osteosarcoma

  2020cites this paper
• Macrophages provide a transient muscle stem cell niche via NAMPT secretion

  2020cites this paper
• Genome-wide analysis revisits incipient sympatric and allopatric speciation in a beetle

  2020cites this paper
• Transition between canonical to non-canonical Wnt signaling during interactions between mesenchymal stem cells and osteosarcomas

  2020cites this paper
• Bone Microenvironment and Osteosarcoma Metastasis

  2020cites this paper
• The effect of CCL5 on the immune cells infiltration and the prognosis of patients with kidney renal clear cell carcinoma

  2020cites this paper
• CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands

  2020cites this paper
• Development of a novel immune-related genes prognostic signature for osteosarcoma

  2020cites this paper
• Chemokine Ligand 5 to Predict Optimal Cytoreduction in Ovarian Cancer

  2020cites this paper
• Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning

  2020cites this paper
• Single-cell RNA-sequencing analyses identify heterogeneity of CD8+ T cell subpopulations and novel therapy targets in melanoma

  2020influential citation
• CA9 is an important molecular marker for the prognosis of osteosarcoma patients

  2020cites this paper
• Cytokine CCL5 and Receptor CCR5 Axis in Glioblastoma Multiforme

  2019cites this paper
• Retracted Article: Exosomal miR-25-3p derived from hypoxia tumor mediates IL-6 secretion and stimulates cell viability and migration in breast cancer

  2019cites this paper
• Plumbagin suppresses endothelial progenitor cell-related angiogenesis in vitro and in vivo

  2019cites this paper
• Metabolic and functional reprogramming of myeloid-derived suppressor cells and their therapeutic control in glioblastoma

  2019cites this paper
• Variable chemokine expression in porcine trophoblasts and endometrium during the peri-implantation period.

  2019cites this paper
• Angiotensin II and aldosterone activate retinal microglia.

  2019cites this paper
• Melatonin attenuates TNF‐α and IL‐1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis

  2019cites this paper
• Angiogenesis Process in Osteosarcoma: An Updated Perspective of Pathophysiology and Therapeutics.

  2019cites this paper
• Resistin facilitates VEGF-A-dependent angiogenesis by inhibiting miR-16-5p in human chondrosarcoma cells

  2019cites this paper
• Role of CCL5 and CCR5 gene polymorphisms in epidermal growth factor receptor signalling blockade in metastatic colorectal cancer: analysis of the FIRE-3 trial.

  2019cites this paper
• Role of CCL5 and CCR5 gene polymorphisms in EGFR signaling blockade in Metastatic Colorectal Cancer: Analysis of the FIRE-3 trial

  2019cites this paper
• Sphingosine-1-phosphate promotes PDGF-dependent endothelial progenitor cell angiogenesis in human chondrosarcoma cells

  2019cites this paper
• MicroRNA-330-5p promotes the development of osteosarcoma by regulating SPRY2.

  2019cites this paper
• Broad‐spectrum chemokine inhibition blocks inflammation‐induced angiogenesis, but preserves ischemia‐driven angiogenesis

  2019cites this paper
• Glucocerebroside reduces endothelial progenitor cell-induced angiogenesis

  2019cites this paper
• TGF-β1 enhances FOXO3 expression in human synovial fibroblasts by inhibiting miR-92a through AMPK and p38 pathways

  2019cites this paper
• Chemokine Pathway Can Be the Potential Therapeutic Target for Hypertrophic Scar

  2019cites this paper
• Velvet Antler compounds targeting major cell signaling pathways in osteosarcoma - a new insight into mediating the process of invasion and metastasis in OS

  2019cites this paper
• MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5

  2019cites this paper
• Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTOR-dependent pathways in human endothelial progenitor cells.

  2019cites this paper
• To Explore the Mechanism of the GRM4 Gene in Osteosarcoma by RNA Sequencing and Bioinformatics Approach

  2018cites this paper