The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  European Journal of Biochemistry

• Publication date

  2000-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1046/J.1432-1327.2000.01536.XPMID 10951191
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999influential reference
• The solution structure of uperin 3.6, an antibiotic peptide from the granular dorsal glands of the Australian toadlet, Uperoleia mjobergii.

  1999cited by this paper
• Alamethicin helices in a bilayer and in solution: molecular dynamics simulations.

  1999cited by this paper
• Synthesis and characterization of bactericidal oligopeptides designed on the basis of an insect anti-bacterial peptide.

  1999cited by this paper
• Host Defence Antibacterial Peptides from Skin Secretions of Australian Amphibians. The Relationship Between Structure and Activity

  1999cited by this paper
• Magainins as paradigm for the mode of action of pore forming polypeptides.

  1998cited by this paper
• The solution structure and activity of caerin 1.1, an antimicrobial peptide from the Australian green tree frog, Litoria splendida.

  1997cited by this paper
• Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin

  1997cited by this paper
• Floating stereospecific assignment revisited: Application to an 18 kDa protein and comparison with J-coupling data

  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• MOLMOL: a program for display and analysis of macromolecular structures.

  1996cited by this paper
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  1996cited by this paper
• 1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects

  1995cited by this paper
• Membrane thinning caused by magainin 2.

  1995cited by this paper
• Molecular basis for prokaryotic specificity of magainin-induced lysis.

  1995cited by this paper
• Molecular recognition between membrane-spanning polypeptides.

  1995cited by this paper
• Larger scale multipin peptide synthesis.

  1995cited by this paper
• Mechanisms for the modulation of membrane bilayer properties by amphipathic helical peptides

  1995cited by this paper
• The program XEASY for computer-supported NMR spectral analysis of biological macromolecules

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.

  1995cited by this paper
• Amphibian skin: a promising resource for antimicrobial peptides.

  1995cited by this paper
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  1994cited by this paper
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• Folding of peptide fragments comprising the complete sequence of proteins. Models for initiation of protein folding. I. Myohemerythrin.

  1992cited by this paper
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  1992cited by this paper
• Effect of trifluoroethanol on protein secondary structure: an NMR and CD study using a synthetic actin peptide.

  1992cited by this paper
• The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy.

  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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• Relationship between nuclear magnetic resonance chemical shift and protein secondary structure.

  1991cited by this paper
• The relationship between chemical shift and secondary structure in proteins

  1990cited by this paper
• Peptides from frog skin.

  1990cited by this paper
• Differentiation-dependent expression of phosphatidylserine in mammalian plasma membranes: quantitative assessment of outer-leaflet lipid by prothrombinase complex formation.

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  1979cited by this paper
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  1977cited by this paper

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