The secretory leukocyte protease inhibitor is a type 1 insulin-like growth factor receptor-regulated protein that protects against liver metastasis by attenuating the host proinflammatory response.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cancer Research

• Publication date

  2006-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-05-2638PMID 16540655
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of the host proinflammatory response to tumor cells during the initial stages of liver metastasis.

  2005influential reference
• Smoldering and polarized inflammation in the initiation and promotion of malignant disease.

  2005cited by this paper
• Tumor necrosis factor-alpha in the pathogenesis and treatment of cancer.

  2004cited by this paper
• Tumor necrosis factor-α in the pathogenesis and treatment of cancer

  2004cited by this paper
• Dual Regulation of MMP-2 Expression by the Type 1 Insulin-like Growth Factor Receptor

  2004cited by this paper
• Loss of Tumorigenicity and Metastatic Potential in Carcinoma Cells Expressing the Extracellular Domain of the Type 1 Insulin-Like Growth Factor Receptor

  2004cited by this paper
• Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression.

  2004cited by this paper
• Adenoviral Gene Delivery of Elafin and Secretory Leukocyte Protease Inhibitor Attenuates NF-κB-Dependent Inflammatory Responses of Human Endothelial Cells and Macrophages to Atherogenic Stimuli1

  2004cited by this paper
• Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression

  2004cited by this paper
• Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling

  2003cited by this paper
• Murine Macrophages Produce Secretory Leukocyte Protease Inhibitor During Clearance of Apoptotic Cells: Implications for Resolution of the Inflammatory Response 1

  2003cited by this paper
• Secretory leukocyte protease inhibitor promotes the tumorigenic and metastatic potential of cancer cells

  2003cited by this paper
• Tumour necrosis factor α: a potential target for the therapy of solid tumours

  2003cited by this paper
• Neuroprotective effects of IGF-I against TNFalpha-induced neuronal damage in HIV-associated dementia.

  2003cited by this paper
• Tumour necrosis factor alpha: a potential target for the therapy of solid tumours.

  2003cited by this paper
• Type 1 Insulin-like Growth Factor Receptor (IGF-IR) Signaling Inhibits Apoptosis Signal-regulating Kinase 1 (ASK1)*

  2003cited by this paper
• TRAIL and apoptosis induction by TNF-family death receptors

  2003cited by this paper
• Influence of TNFA on the formation of liver metastases in a syngenic mouse model

  2003cited by this paper
• Tumor necrosis factor or tumor promoting factor?

  2002cited by this paper
• Tumour necrosis factor-α mediates tumour promotion via a PKCα- and AP-1-dependent pathway

  2002cited by this paper
• Essential roles of tumor necrosis factor receptor p55 in liver metastasis of intrasplenic administration of colon 26 cells.

  2002cited by this paper
• Tumour necrosis factor-alpha mediates tumour promotion via a PKC alpha- and AP-1-dependent pathway.

  2002cited by this paper
• Effects of insulin-like growth factors I and II on tumour-necrosis-factor-alpha-induced apoptosis in early murine embryos.

  2002cited by this paper
• Regulation of B16F1 melanoma cell metastasis by inducible functions of the hepatic microvasculature.

  2002cited by this paper
• Inhibition of hepatic endothelial E-selectin expression by C-raf antisense oligonucleotides blocks colorectal carcinoma liver metastasis.

  2002cited by this paper
• Cooperative Regulation of the Invasive and Metastatic Phenotypes by Different Domains of the Type I Insulin-like Growth Factor Receptor β Subunit*

  2001cited by this paper
• Tumor cell interactions with the microvasculature: a rate-limiting step in metastasis.

  2001cited by this paper
• Insulin-like Growth Factor-I Stimulates Dephosphorylation of IκB through the Serine Phosphatase Calcineurin (Protein Phosphatase 2B)*

  2000cited by this paper
• Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

  1999cited by this paper
• Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.

  1999cited by this paper
• Inhibition of neutrophil cathepsin G by oxidized mucus proteinase inhibitor. Effect of heparin.

  1999cited by this paper
• Secretory leukocyte protease inhibitor in mice regulates local and remote organ inflammatory injury induced by hepatic ischemia/reperfusion.

  1999cited by this paper
• Inhibition of NF-κB Activation and Augmentation of IκBβ by Secretory Leukocyte Protease Inhibitor during Lung Inflammation

  1999cited by this paper
• Inhibition of NF-kappaB activation and augmentation of IkappaBbeta by secretory leukocyte protease inhibitor during lung inflammation.

  1999cited by this paper
• Understanding the Pathogenesis of Inflammation Using Rodent Models: Identification of a Transcription Factor (NFkappaB) Necessary for Development of Inflammatory Injury.

  1999cited by this paper
• Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor.

  1998cited by this paper
• Lipopolysaccharide-Related Stimuli Induce Expression of the Secretory Leukocyte Protease Inhibitor, a Macrophage-Derived Lipopolysaccharide Inhibitor

  1998cited by this paper
• Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis

  1997cited by this paper
• Liver endothelial E‐selectin mediates carcinoma cell adhesion and promotes liver metastasis

  1997cited by this paper
• Secretory leukocyte protease inhibitor suppresses the production of monocyte prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinases.

  1997cited by this paper
• Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide.

  1997cited by this paper
• Antibacterial activity of antileukoprotease

  1996cited by this paper
• Role of adhesion molecules and platelets in TNF-induced adhesion of tumor cells to endothelial cells: implications for experimental metastasis.

  1995cited by this paper
• Role of tumor necrosis factor alpha in innate resistance to mouse pulmonary infection with Pseudomonas aeruginosa

  1995cited by this paper
• Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor.

  1995cited by this paper
• Promotion of experimental liver metastasis by tumor necrosis factor

  1995cited by this paper
• Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro.

  1995cited by this paper
• Paracrine growth stimulation by hepatocyte-derived insulin-like growth factor-1: a regulatory mechanism for carcinoma cells metastatic to the liver.

  1994cited by this paper
• Expression of the secretory leukoprotease inhibitor gene in epithelial cells.

  1991cited by this paper
• Cells secreting tumour necrosis factor show enhanced metastasis in nude mice.

  1990cited by this paper
• The complex effects of recombinant tumour necrosis factor-alpha (rhTNF-alpha) in human ovarian cancer xenograft models.

  1990cited by this paper
• Heterogeneity of hematopoietic cells immortalized by v-myc/v-raf recombinant retrovirus infection of bone marrow or fetal liver.

  1989cited by this paper
• Tissue distribution of antileukoprotease and lysozyme in humans.

  1989cited by this paper
• Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

  1987cited by this paper
• Characterization of two highly metastatic variants of Lewis lung carcinoma with different organ specificities.

  1986cited by this paper

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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
• Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts.

  2015cites this paper
• Crosstalk between the TNF and IGF pathways enhances NF-κB activation and signaling in cancer cells.

  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Stimuli-induced Organ-specific Injury Enhancement of Organotropic Metastasis in a Spatiotemporal Regulation

  2013cites this paper
• The multifaceted role of the microenvironment in liver metastasis: biology and clinical implications.

  2013cites this paper
• Anti‐tumor effect of SLPI on mammary but not colon tumor growth

  2013cites this paper
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  2013cites this paper
• Current Knowledge on Pancreatic Cancer

  2012cites this paper
• Anti-Tumor Effects of the Peptide TMTP1-GG-D(KLAKLAK)2 on Highly Metastatic Cancers

  2012influential citation
• An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells

  2012cites this paper
• Metastatic cells can escape the proapoptotic effects of TNF-α through increased autocrine IL-6/STAT3 signaling.

  2012cites this paper
• KSHV Induction of Angiogenic and Lymphangiogenic Phenotypes

  2012cites this paper
• The Tumor Microenvironment at Different Stages of Hepatic Metastasis

  2011cites this paper
• Role of nogo - a in the intact central nervous system: an in vivo and in vitro approach.

  2011cites this paper
• Immunotherapy with SLPI over-expressing mammary tumor cells decreases tumor growth

  2011cites this paper
• Breast cancer cell-derived cytokines, macrophages and cell adhesion: implications for metastasis.

  2011cites this paper
• Secretory leukocyte protease inhibitor (SLPI) expression and tumor invasion in oral squamous cell carcinoma.

  2011cites this paper
• Type IV collagen-initiated signals provide survival and growth cues required for liver metastasis

  2011cites this paper
• Role of the IGF-Axis in Liver Metastasis: Experimental and Clinical Evidence

  2011cites this paper
• Role of Inflammation in the Early Stages of Liver Metastasis

  2011cites this paper
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  2010cites this paper
• Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis.

  2010cites this paper
• Highly sensitivity adhesion molecules detection in hereditary haemochromatosis patients reveals altered expression

  2010cites this paper
• Role of the Host Inflammatory Response in Colon Carcinoma Initiation, Progression and Liver Metastasis

  2010cites this paper
• The role of Interleukin-6 in nervous regeneration and functional recovery in organotypic hippocampal slice cultures

  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
• Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium

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• Identification of new genes associated with breast cancer progression by gene expression analysis of predefined sets of neoplastic tissues

  2008cites this paper
• TMTP1, a Novel Tumor-Homing Peptide Specifically Targeting Metastasis

  2008cites this paper
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  2008cites this paper
• Neutralization of the membrane protein Nogo‐A enhances growth and reactive sprouting in established organotypic hippocampal slice cultures

  2008cites this paper
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  2008cites this paper
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• The Prometastatic Microenvironment of the Liver

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• Perfis de expressão de genes relacionados a metástases em uma coorte de pacientes adultos e pediátricos portadores de neoplasias do córtex da supra-renal

  2008cites this paper
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  2008cites this paper
• Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels

  2008cites this paper
• Metabolism , and Physical Functioning Insulin Treatment in Cancer Cachexia : Effects on Survival , Updated

  2007cites this paper
• The host inflammatory response promotes liver metastasis by increasing tumor cell arrest and extravasation.

  2007cites this paper
• Insulin Treatment in Cancer Cachexia: Effects on Survival, Metabolism, and Physical Functioning

  2007cites this paper
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  2007cites this paper
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  2006cites this paper