miR-124 regulates cell apoptosis and autophagy in dopaminergic neurons and protects them by regulating AMPK/mTOR pathway in Parkinson's disease.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  American journal of translational research

• Publication date

  2016-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 27347320PMCID PMC4891425
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Parkinson's disease: A review

  2018cited by this paper
• MiR‐124 Regulates Apoptosis and Autophagy Process in MPTP Model of Parkinson's Disease by Targeting to Bim

  2016influential reference
• Medial temporal regional argyrophilic grain as a possible important factor affecting dementia in Parkinson's disease

  2015cited by this paper
• Downregulation of miR-124 in MPTP-treated mouse model of Parkinson's disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 pathway proteins.

  2014cited by this paper
• Increasing the Efficiency of Parkinson's Disease Treatment Using a poly(lactic-co-glycolic acid) (PLGA) Based L-DOPA Delivery System

  2014cited by this paper
• Mitogen-activated protein kinases and protein phosphatase 5 mediate glucocorticoid-induced cytotoxicity in pancreatic islets and β-cells.

  2014cited by this paper
• The brain-enriched microRNA miR-124 in plasma predicts neurological outcome after cardiac arrest

  2014cited by this paper
• LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons

  2014cited by this paper
• Inhibition of AMPK/Autophagy Potentiates Parthenolide‐Induced Apoptosis in Human Breast Cancer Cells

  2014cited by this paper
• Neuroplasticity, axonal guidance and micro‐RNA genes are associated with morphine self‐administration behavior

  2013cited by this paper
• Probenecid potentiates MPTP/MPP+ toxicity by interference with cellular energy metabolism

  2013cited by this paper
• Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells

  2013cited by this paper
• MicroRNAs and neurodegeneration: role and impact.

  2013cited by this paper
• Loss of Brain-enriched miR-124 MicroRNA Enhances Stem-like Traits and Invasiveness of Glioma Cells*

  2012cited by this paper
• Heparin Cofactor II, a Serine Protease Inhibitor, Promotes Angiogenesis via Activation of the AMP-activated Protein Kinase-Endothelial Nitric-oxide Synthase Signaling Pathway

  2012cited by this paper
• MicroRNA regulation of autophagy.

  2012cited by this paper
• MiR-204 regulates cardiomyocyte autophagy induced by ischemia-reperfusion through LC3-II

  2011cited by this paper
• Enhanced Autophagy from Chronic Toxicity of Iron and Mutant A53T α-Synuclein

  2011cited by this paper
• The Beclin 1 network regulates autophagy and apoptosis

  2011cited by this paper
• Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway

  2011cited by this paper
• AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

  2011cited by this paper
• The pro-differentiating role of miR-124: Indicating the road to become a neuron

  2010cited by this paper
• MicroRNAs and deregulated gene expression networks in neurodegeneration.

  2010cited by this paper
• MiR-124 regulates early neurogenesis in the optic vesicle and forebrain, targeting NeuroD1

  2010cited by this paper
• miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1.

  2009cited by this paper
• MicroRNAs: Target Recognition and Regulatory Functions

  2009cited by this paper
• Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases

  2009cited by this paper
• Repression of α-synuclein expression and toxicity by microRNA-7

  2009cited by this paper
• Progressive loss of dopaminergic neurons in the ventral midbrain of adult mice heterozygote for Engrailed1: a new genetic model for Parkinson's disease?

  2008cited by this paper
• MicroRNAs in neurodegeneration.

  2008cited by this paper
• Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells.

  2008cited by this paper
• Resveratrol stimulates AMP kinase activity in neurons

  2007cited by this paper
• AMPK Mediates Autophagy during Myocardial Ischemia In Vivo

  2007cited by this paper
• The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development.

  2007cited by this paper
• A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons

  2007cited by this paper
• Fluorescent biomembrane probe for ratiometric detection of apoptosis.

  2007cited by this paper
• Detecting protein–protein interactions by far western blotting

  2007cited by this paper
• Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

  2003cited by this paper
• Apoptotic molecules and MPTP-induced cell death.

  2002cited by this paper
• Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease.

  2002cited by this paper
• Ascorbic acid prevents 3,4‐methylenedioxymethamphetamine (MDMA)‐induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5‐HT

  2001cited by this paper
• Resistance to induced apoptosis in the human neuroblastoma cell line SK-N-SH in relation to neuronal differentiation. Role of Bcl-2 protein family.

  2001cited by this paper
• Apoptosis, Glial Cells and Parkinson’s Disease

  2001cited by this paper
• Dopamine Transporter Is Required for In Vivo MPTP Neurotoxicity: Evidence from Mice Lacking the Transporter

  1997cited by this paper
• Morphologic and cytochemical properties of a clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

  1978cited by this paper
• Establishment and characterization of human neuroblastoma cell lines.

  1976cited by this paper
• 6-Hydroxy-dopamine induced degeneration of central monoamine neurons.

  1968cited by this paper

• Regulation of Apoptotic Pathways by MicroRNAs: A Therapeutic Strategy for Alzheimer’s Disease

  2025cites this paper
• Mitochondrial microRNAs: Key Drivers in Unraveling Neurodegenerative Diseases

  2025cites this paper
• Harnessing miRNAs: A Novel Approach to Diagnosis and Treatment of Tuberculosis

  2025cites this paper
• LncRNA MCF2L-AS1 inhibits neuronal damage induced by 1-methyl-4-phenylpyridinium (MPP+) via regulating miR-28-5p

  2025cites this paper
• Integrative assessment of RNA sequencing and in silico analysis to pinpoint mRNAs, lncRNAs, and circRNAs interactions with miRNAs underlying arsenic-induced neurotoxicity

  2025cites this paper
• The autophagy–lysosome pathway: a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

  2024cites this paper
• Non-coding RNAs as therapeutic targets in Parkinson's Disease: A focus on dopamine.

  2024cites this paper
• Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis

  2024influential citation
• Parkinson’s Disease and MicroRNAs: A Duel Between Inhibition and Stimulation of Apoptosis in Neuronal Cells

  2024cites this paper
• Phillyrin alleviates high glucose-induced oxidative stress and inflammation in HBZY-1 cells through inhibition of the PI3K/Akt signaling pathway.

  2024cites this paper
• The Potential of Targeting Autophagy-Related Non-coding RNAs in the Treatment of Alzheimer’s and Parkinson’s Diseases

  2024cites this paper
• MicroRNA-124-3p Modulates Alpha-Synuclein Expression Levels in a Paraquat-Induced in vivo Model for Parkinson’s Disease

  2024cites this paper
• A Glance at Biogenesis and Functionality of MicroRNAs and Their Role in the Neuropathogenesis of Parkinson's Disease

  2023cites this paper
• Understanding the Roles and Regulation of Mitochondrial microRNAs (MitomiRs) in Neurodegenerative Diseases: Current Status and Advances.

  2023cites this paper
• Autophagy-regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review)

  2023cites this paper
• Promising biomarkers and therapeutic targets for the management of Parkinson's disease: recent advancements and contemporary research

  2023cites this paper
• Repressor Element-1 Binding Transcription Factor (REST) as a Possible Epigenetic Regulator of Neurodegeneration and MicroRNA-Based Therapeutic Strategies

  2023cites this paper
• The Potential Role of MicroRNA‐124‐3p in Growth, Development, and Reproduction of Schistosoma japonicum

  2022cites this paper
• Regulatory effects of lncRNAs and miRNAs on the crosstalk between autophagy and EMT in cancer: a new era for cancer treatment

  2022cites this paper
• microRNAs associated with the pathogenesis and their role in regulating various signaling pathways during Mycobacterium tuberculosis infection

  2022cites this paper
• The Improvement of Porcine In Vitro Embryo Development through Regulating Autophagy by miRNA-143 Inhibition

  2022cites this paper
• Chronic AMPK Activation Reduces the Expression and Alters Distribution of Synaptic Proteins in Neuronal SH-SY5Y Cells

  2022cites this paper
• Neuronal microRNAs safeguard ER Ca2+ homeostasis and attenuate the unfolded protein response upon stress

  2022cites this paper
• MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson’s disease

  2022cites this paper
• MALAT1 lncRNA and Parkinson’s Disease: The role in the Pathophysiology and Significance for Diagnostic and Therapeutic Approaches

  2022cites this paper
• Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases

  2022cites this paper
• Sporadic Alzheimer’s Disease- and Neurotoxicity-Related microRNAs Affecting Key Events of Tau-Driven Adverse Outcome Pathway Toward Memory Loss

  2022cites this paper
• MicroRNA Dysregulation in Parkinson’s Disease: A Narrative Review

  2021cites this paper
• Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway

  2021cites this paper
• MiR-124-3p attenuates brain microvascular endothelial cell injury in vitro by promoting autophagy.

  2021cites this paper
• Micro-RNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy.

  2021cites this paper
• Comprehensive Perspectives on Experimental Models for Parkinson’s Disease

  2021cites this paper
• Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson’s disease

  2021cites this paper
• Emerging Roles of Non-Coding RNA in Neuronal Function and Dysfunction

  2021cites this paper
• Muscles in Winter: The Epigenetics of Metabolic Arrest

  2021cites this paper
• MicroRNA-124 ameliorates autophagic dysregulation in glaucoma via regulation of P2X7-mediated Akt/mTOR signaling

  2021cites this paper
• Exercise-Induced Autophagy and Parkinson’s Disease

  2021cites this paper
• Autophagy and apoptosis cascade: which is more prominent in neuronal death?

  2021cites this paper
• Evaluation role of miR-124 in neurodegenerative diseases: literature review and in silico analysis

  2021cites this paper
• Therapeutic potential of PGC-1α in age-related macular degeneration (AMD) – the involvement of mitochondrial quality control, autophagy, and antioxidant response

  2021cites this paper
• Downregulation of lncRNA MEG3 is involved in Parkinson’s disease

  2021cites this paper
• MicroRNA-mediated inhibition of AMPK coordinates tissue-specific downregulation of skeletal muscle metabolism in hypoxic naked mole-rats.

  2021cites this paper
• Multifaceted Regulation of MicroRNA Biogenesis: Essential Roles and Functional Integration in Neuronal and Glial Development

  2021cites this paper
• circSAMD 4 A participates in the apoptosis and autophagy of dopaminergic neurons via the miR ‐ 29 c ‐ 3 p ‐ mediated AMPK / mTOR pathway in Parkinson ' s disease

  2021cites this paper
• circSAMD4A participates in the apoptosis and autophagy of dopaminergic neurons via the miR-29c-3p-mediated AMPK/mTOR pathway in Parkinson's disease

  2021cites this paper
• Inhibition of Long Non-Coding RNA KCNQ1OT1 Attenuates Neuroinflammation and Neuronal Apoptosis Through Regulating NLRP3 Expression via Sponging miR-30e-3p

  2021cites this paper
• AMPK‐regulated miRNA‐210‐3p is activated during ischaemic neuronal injury and modulates PI3K‐p70S6K signalling

  2021cites this paper
• Long non-coding RNA NEAT1 mediates MPTP/MPP+-induced apoptosis via regulating the miR-124/KLF4 axis in Parkinson’s disease

  2020cites this paper
• MiR-124 and the Underlying Therapeutic Promise of Neurodegenerative Disorders

  2020cites this paper
• Emerging molecular functions of microRNA-124: Cancer pathology and therapeutic implications.

  2020cites this paper
• Cell-free miRNAs in Parkinson's disease: potential biomarkers that provide new insights into disease pathogenesis.

  2020cites this paper
• Neuronal microRNAs modulate TREK two-pore domain K+ channel expression and current density

  2020cites this paper
• Disruption of intracellular signaling

  2020cites this paper
• MiR-124 involvement of apoptosis, immunity and regulator of diseases

  2020cites this paper
• Chronic Regulation of miR-124-3p in the Perilesional Cortex after Experimental and Human TBI

  2020cites this paper
• Molecular Regulation in Dopaminergic Neuron Development. Cues to Unveil Molecular Pathogenesis and Pharmacological Targets of Neurodegeneration

  2020cites this paper
• Noncoding RNAs and Midbrain DA Neurons: Novel Molecular Mechanisms and Therapeutic Targets in Health and Disease

  2020cites this paper
• Structural characterization and hypoglycemic effect of green alga Ulva lactuca oligosaccharide by regulating microRNAs in Caenorhabditis elegans

  2020cites this paper
• A hypothesis-generating scoping review of miRs identified in both multiple sclerosis and dementia, their protein targets, and miR signaling pathways.

  2020cites this paper
• Neuroprotective effects of hydro-alcoholic extract of Eclipta alba against 1-methyl-4-phenylpyridinium-induced in vitro and in vivo models of Parkinson’s disease

  2020cites this paper
• Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia

  2020cites this paper
• Competing Endogenous RNA Networks as Biomarkers in Neurodegenerative Diseases

  2020cites this paper
• The long-non-coding RNA NEAT1 is a novel target for Alzheimer’s disease progression via miR-124/BACE1 axis

  2019cites this paper
• miR-124 upregulates astrocytic glutamate transporter-1 via the Akt and mTOR signaling pathway post ischemic stroke.

  2019cites this paper
• Metformin accelerates myelin recovery and ameliorates behavioral deficits in the animal model of multiple sclerosis via adjustment of AMPK/Nrf2/mTOR signaling and maintenance of endogenous oligodendrogenesis during brain self-repairing period

  2019cites this paper
• The Potential Role of MicroRNA-124 in Cerebral Ischemia Injury

  2019influential citation
• Circulating Brain‐Enriched MicroRNAs for Detection and Discrimination of Idiopathic and Genetic Parkinson's Disease

  2019cites this paper
• miR-124 and Parkinson's disease: a biomarker with therapeutic potential.

  2019cites this paper
• Erythropoietin as a Modulator of Pathology in a Toxicant Mouse Model of Parkinson’s Disease

  2019cites this paper
• Tanshinone IIA alleviates oxidative damage after spinal cord injury in vitro and in vivo through up‐regulating miR‐124

  2019cites this paper
• Profiling circular RNA in methamphetamine-treated primary cortical neurons identified novel circRNAs related to methamphetamine addiction.

  2019cites this paper
• MicroRNA-124 Enhances Dopamine Receptor Expression and Neuronal Proliferation in Mouse Models of Parkinson’s Disease via the Hedgehog Signaling Pathway by Targeting EDN2

  2019cites this paper
• Corticosterone induces neurotoxicity in PC12 cells via disrupting autophagy flux mediated by AMPK/mTOR signaling

  2019cites this paper
• Increases in miR-124-3p in Microglial Exosomes Confer Neuroprotective Effects by Targeting FIP200-Mediated Neuronal Autophagy Following Traumatic Brain Injury

  2019cites this paper
• microRNA‐124 attenuates isoflurane‐induced neurological deficits in neonatal rats via binding to EGR1

  2019cites this paper
• The regulation of survival and differentiation of neural stem cells by miR-124 via modulating PAX3.

  2018cites this paper
• Mitochondria, lysosomes, and dysfunction: their meaning in neurodegeneration

  2018cites this paper
• Interplay between mitochondrial dysfunction and epigenetic alterations in environmental linked Parkinson's Disease

  2018cites this paper
• MicroRNA-128 Protects Dopamine Neurons from Apoptosis and Upregulates the Expression of Excitatory Amino Acid Transporter 4 in Parkinson’s Disease by Binding to AXIN1

  2018cites this paper
• miR‑124 targets retinoid X receptor α to reduce growth of TSC2‑deficient lymphangioleiomyomatosis.

  2018cites this paper
• By Targeting Atg7 MicroRNA-143 Mediates Oxidative Stress-Induced Autophagy of c-Kit+ Mouse Cardiac Progenitor Cells

  2018cites this paper
• Regulation of MicroRNAs-Mediated Autophagic Flux: A New Regulatory Avenue for Neurodegenerative Diseases With Focus on Prion Diseases

  2018cites this paper
• Increased miR‐124‐3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons

  2018cites this paper
• miR-124 promotes proliferation and neural differentiation of neural stem cells through targeting DACT1 and activating Wnt/β-catenin pathways

  2018cites this paper
• Increased frequency of AMP‐activated protein kinase‐positive spinal motor neurons after sciatic nerve injury in a mouse model

  2018cites this paper
• MALAT1 modulates the autophagy of retinoblastoma cell through miR‐124‐mediated stx17 regulation

  2018cites this paper
• miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1

  2017cites this paper
• NutrimiRAging: Micromanaging Nutrient Sensing Pathways through Nutrition to Promote Healthy Aging

  2017cites this paper
• MicroRNA-100 suppresses human osteosarcoma cell proliferation and chemo-resistance via ZNRF2

  2017cites this paper
• Crosstalk between MicroRNAs and Autophagy in Adult Neurogenesis: Implications for Neurodegenerative Disorders

  2017cites this paper
• MicroRNA: Basic concepts and implications for regeneration and repair of neurodegenerative diseases

  2017cites this paper
• Tongxinluo exerts protective effects via anti‐apoptotic and pro‐autophagic mechanisms by activating AMPK pathway in infarcted rat hearts

  2017cites this paper
• miR-124-3p attenuates MPP+-induced neuronal injury by targeting STAT3 in SH-SY5Y cells

  2017cites this paper
• miR-124 downregulates BACE 1 and alters autophagy in APP/PS1 transgenic mice.

  2017cites this paper
• Role of Bcl-2 and Bax in parotid gland atrophy.

  2017cites this paper
• Lithium Chloride Facilitates Autophagy Following Spinal Cord Injury via ERK-dependent Pathway

  2017cites this paper
• cPKCγ‐mediated down‐regulation of UCHL1 alleviates ischaemic neuronal injuries by decreasing autophagy via ERK‐mTOR pathway

  2017cites this paper
• MicroRNA-181a Regulates Apoptosis and Autophagy Process in Parkinson’s Disease by Inhibiting p38 Mitogen-Activated Protein Kinase (MAPK)/c-Jun N-Terminal Kinases (JNK) Signaling Pathways

  2017cites this paper
• A molecular window into Parkinson’s disease

  2017cites this paper
• Role of the AMPK pathway in promoting autophagic flux via modulating mitochondrial dynamics in neurodegenerative diseases: Insight into prion diseases.

  2017cites this paper