Modification of K+ channel–drug interactions by ancillary subunits

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Physiology

• Publication date

  2008-02-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1113/jphysiol.2007.139279PMID 18096604PMCID PMC2375646
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular driving forces determining potassium channel slow inactivation

  2007cited by this paper
• Probing the Cavity of the Slow Inactivated Conformation of Shaker Potassium Channels

  2007cited by this paper
• Mechanism of Action of the Antiarrhythmic Agent AZD7009

  2007cited by this paper
• State-dependent dissociation of HERG channel inhibitors

  2007cited by this paper
• Electrical remodeling in a canine model of ischemic cardiomyopathy.

  2007cited by this paper
• NADPH binding to beta-subunit regulates inactivation of voltage-gated K(+) channels.

  2007cited by this paper
• NADPH binding to β-subunit regulates inactivation of voltage-gated K+ channels

  2007cited by this paper
• Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle

  2006cited by this paper
• KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel.

  2006cited by this paper
• Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel

  2006influential reference
• The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1.

  2006cited by this paper
• Modulation of Voltage-dependent Shaker Family Potassium Channels by an Aldo-Keto Reductase*♦

  2006cited by this paper
• hERG potassium channels and cardiac arrhythmia

  2006cited by this paper
• KChIP2b modulates the affinity and use-dependent block of Kv4.3 by nifedipine.

  2006influential reference
• Structural characterization and pH-induced conformational transition of full-length KcsA.

  2006cited by this paper
• In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heart.

  2005cited by this paper
• A potassium channel, the M-channel, as a therapeutic target.

  2005cited by this paper
• Separation of P/C‐ and U‐type inactivation pathways in Kv1.5 potassium channels

  2005cited by this paper
• Blocking Characteristics of hERG, hNav1.5, and hKvLQT1/hminK after Administration of the Novel Anti‐Arrhythmic Compound AZD7009

  2005cited by this paper
• Structural Basis for Competition between Drug Binding and Kvβ1.3 Accessory Subunit-Induced N-Type Inactivation of Kv1.5 Channels

  2005cited by this paper
• Time- and voltage-dependent components of Kv4.3 inactivation.

  2005cited by this paper
• Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atrium.

  2005cited by this paper
• KCNQ1/KCNE1 channels during germ‐cell differentiation in the rat: Expression associated with testis pathologies

  2005influential reference
• Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K+ Channel

  2005cited by this paper
• Effect of beta-adrenoceptor blockers on human ether-a-go-go-related gene (HERG) potassium channels.

  2005cited by this paper
• Transient outward potassium current, ‘Ito’, phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms

  2005cited by this paper
• Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels

  2005cited by this paper
• Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane

  2005cited by this paper
• Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling

  2005cited by this paper
• Molecular basis of arrhythmias.

  2005cited by this paper
• Electrophysiological and molecular identification of hepatocellular volume-activated K+ channels.

  2005influential reference
• Inhibition of Kv4.3/KChIP2.2 Channels by Bupivacaine and Its Modulation by the Pore Mutation Kv4.3V401I

  2005influential reference
• Inhibition of Kv 4 . 3 / KChIP 2 . 2 Channels by Bupivacaine and Its Modulation by the Pore Mutation Kv 4 . 3 V 401 I

  2005cited by this paper
• MinK, MiRP1, and MiRP2 Diversify Kv3.1 and Kv3.2 Potassium Channel Gating*

  2004cited by this paper
• Interaction of Ropivacaine with Cloned Cardiac Kv4.3/KChIP2.2 Complexes

  2004cited by this paper
• The external TEA binding site and C-type inactivation in voltage-gated potassium channels.

  2004cited by this paper
• Regulation of Kv4.3 voltage‐dependent gating kinetics by KChIP2 isoforms

  2004cited by this paper
• Local anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A.

  2004cited by this paper
• Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges

  2004cited by this paper
• Molecular physiology and modulation of somatodendritic A-type potassium channels.

  2004cited by this paper
• Targeting K+ channels for cancer therapy.

  2004cited by this paper
• Pharmacology of cardiac potassium channels.

  2004cited by this paper
• Molecular Architecture of the KvAP Voltage-Dependent K+ Channel in a Lipid Bilayer

  2004cited by this paper
• KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain.

  2004cited by this paper
• Inactivation and recovery in Kv1.4 K+ channels: lipophilic interactions at the intracellular mouth of the pore

  2004influential reference
• The MinK-related peptides.

  2004influential reference
• KChIPs and Kv4 α Subunits as Integral Components of A-Type Potassium Channels in Mammalian Brain

  2004cited by this paper
• Structure and function of Kv4-family transient potassium channels.

  2004cited by this paper
• Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel.

  2004cited by this paper
• Functional properties of a brain-specific NH2-terminally spliced modulator of Kv4 channels.

  2003cited by this paper
• N‐glycosylation‐dependent block is a novel mechanism for drug‐induced cardiac arrhythmia

  2003cited by this paper
• Mutant MiRP1 subunits modulate HERG K+ channel gating: a mechanism for pro‐arrhythmia in long QT syndrome type 6

  2003cited by this paper
• Effects of flecainide and quinidine on Kv4.2 currents: voltage dependence and role of S6 valines

  2003cited by this paper
• Kv channel subunits that contribute to voltage-gated K+ current in renal vascular smooth muscle

  2003cited by this paper
• Gating of Shaker-type Channels Requires the Flexibility of S6 Caused by Prolines*

  2003cited by this paper
• MinK-Related Peptide 2 Modulates Kv2.1 and Kv3.1 Potassium Channels in Mammalian Brain

  2003cited by this paper
• Regulation of N- and C-type inactivation of Kv1.4 by pHo and K+: evidence for transmembrane communication.

  2003cited by this paper
• C‐Type Inactivation Involves a Significant Decrease in the Intracellular Aqueous Pore Volume of Kv1.4 K+ Channels Expressed in Xenopus Oocytes

  2003influential reference
• Dihydropyridine Ca2+ channel antagonists and agonists block Kv4.2, Kv4.3 and Kv1.4 K+ channels expressed in HEK293 cells

  2003influential reference
• Molecular determinants of KCNQ1 channel block by a benzodiazepine.

  2003cited by this paper
• Differential modulation of Kv4 kinetics by KCHIP1 splice variants.

  2003cited by this paper
• A Fundamental Role for KChIPs in Determining the Molecular Properties and Trafficking of Kv4.2 Potassium Channels*

  2003cited by this paper
• Kv1.4 channel block by quinidine: evidence for a drug‐induced allosteric effect

  2003influential reference
• Heterogeneous expression of KChIP2 isoforms in the ferret heart

  2002cited by this paper
• A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?

  2002influential reference
• Remodelling inactivation gating of Kv4 channels by KChIP1, a small‐molecular‐weight calcium‐binding protein

  2002cited by this paper
• Elucidating KChiP effects on Kv4.3 inactivation and recovery kinetics with a minimal KChiP2 isoform

  2002cited by this paper
• Voltage Sensor Movements

  2002cited by this paper
• Potassium channels as anti-epileptic drug targets.

  2002cited by this paper
• KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current.

  2002cited by this paper
• The antihistamine fexofenadine does not affect IKr currents in a case report of drug‐induced cardiac arrhythmia

  2002cited by this paper
• A Single Transmembrane Site in the KCNE-encoded Proteins Controls the Specificity of KvLQT1 Channel Gating*

  2002cited by this paper
• Inhibitory effect of the class III antiarrhythmic drug nifekalant on HERG channels: mode of action.

  2002cited by this paper
• The open pore conformation of potassium channels

  2002cited by this paper
• Modulation of Kv4.3 current by accessory subunits

  2002cited by this paper
• Molecular basis of voltage-dependent potassium currents in porcine granulosa cells.

  2002influential reference
• Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels

  2002cited by this paper
• Assembly with the Kvbeta1.3 subunit modulates drug block of hKv1.5 channels.

  2002cited by this paper
• Computer Models of Ion Channels

  2002influential reference
• A kinetic study on the stereospecific inhibition of KCNQ1 and IKs by the chromanol 293B

  2001influential reference
• Conserved Kv4 N-terminal Domain Critical for Effects of Kv Channel-interacting Protein 2.2 on Channel Expression and Gating*

  2001cited by this paper
• Xe991 reveals differences in K(+) channels regulating chloride secretion in murine airway and colonic epithelium.

  2001cited by this paper
• Structure of the KcsA channel intracellular gate in the open state

  2001cited by this paper
• Molecular Interactions Between Two Long-QT Syndrome Gene Products, HERG and KCNE2, Rationalized by In Vitro and In Silico Analysis

  2001influential reference
• Differential expression of KvLQT1 and its regulator IsK in mouse epithelia.

  2001cited by this paper
• hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant.

  2001cited by this paper
• The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium.

  2001cited by this paper
• Two open states and rate‐limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channels

  2001cited by this paper
• Modulation of Voltage-Dependent K+ Channel Current in Vascular Smooth Muscle Cells from Rat Mesenteric Arteries

  2001cited by this paper
• A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia.

  2001cited by this paper
• MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis.

  2001cited by this paper
• Structural Determinants of KvLQT1 Control by the KCNE Family of Proteins*

  2001cited by this paper
• Inhibition of cardiac delayed rectifier K+ currents by an antisense oligodeoxynucleotide against IsK (minK) and over-expression of IsK mutant D77N in neonatal mouse hearts

  2001cited by this paper
• Open channel block of HERG K(+) channels by vesnarinone.

  2001cited by this paper
• Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs).

  2001cited by this paper
• Tight steric closure at the intracellular activation gate of a voltage-gated K(+) channel.

  2001influential reference
• A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents

  2001cited by this paper
• MinK-Related Peptide 1 Associates With Kv4.2 and Modulates Its Gating Function: Potential Role as &bgr; Subunit of Cardiac Transient Outward Channel?

  2001cited by this paper
• Coupling of Voltage-dependent Potassium Channel Inactivation and Oxidoreductase Active Site of Kvβ Subunits*

  2001cited by this paper
• Immunohistochemical study on the distribution of six members of the Kv1 channel subunits in the rat cerebellum.

  2001cited by this paper

• Inhibition of Cardiac Kv4.3/KChIP2 Channels by Sulfonylurea Drug Gliquidone

  2023cites this paper
• Effect of Channel Assembly (KCNQ1 or KCNQ1 + KCNE1) on the Response of Zebrafish IKs Current to IKs Inhibitors and Activators

  2022cites this paper
• Pharmacological Approaches for the Modulation of the Potassium Channel KV4.x and KChIPs

  2021cites this paper
• Effect of channel assembly (KCNQ1 or KCNQ1 + KCNE1) on the response of zebrafish IKs to IKs inhibitors and activators

  2021cites this paper
• Regulación de canales Kv4 por subunidades beta accesorias

  2017cites this paper
• Hormones and sex differences: changes in cardiac electrophysiology with pregnancy.

  2016cites this paper
• KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

  2016cites this paper
• AMIGO-Kv 2 . 1 Potassium Channel Complex : Identification and Association with Schizophrenia-Related Phenotypes

  2015cites this paper
• Potassium Channels and Signal Transduction Pathways in Neurons

  2015cites this paper
• Functional Expression Profile of Voltage-Gated K+ Channel Subunits in Rat Small Mesenteric Arteries

  2015cites this paper
• Block of Kv4.3 potassium channel by trifluoperazine independent of CaMKII.

  2014cites this paper
• Sex differences in the mechanisms underlying long QT syndrome.

  2014cites this paper
• K(V)7 potassium channels: a new therapeutic target in smooth muscle disorders.

  2014cites this paper
• Insight into the modulation of Shaw2 Kv channels by general anesthetics: structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR.

  2013cites this paper
• Effect of mosapride on Kv4.3 potassium channels expressed in CHO cells

  2013cites this paper
• Macromolecular Interactions in West Nile Virus RNA-TIAR Protein Complexes and of Membrane Associated Kv Channel Peptides

  2013cites this paper
• Signal function of potassium channels (cid:150) clinical aspects

  2012cites this paper
• Characterizing Human Ion Channels in Induced Pluripotent Stem Cell–Derived Neurons

  2012cites this paper
• Interaction of the S6 proline hinge with N-type and C-type inactivation in Kv1.4 channels.

  2012cites this paper
• Cytoplasmic Domains and Voltage-Dependent Potassium Channel Gating

  2012cites this paper
• Strong Activation of ether-à-go-go-Related Gene 1 K+ Channel Isoforms by NS1643 in Human Embryonic Kidney 293 and Chinese Hamster Ovary Cells

  2011cites this paper
• Inhibition of Kv4.3 by genistein via a tyrosine phosphorylation-independent mechanism.

  2011cites this paper
• Sex specific association of potassium channel subunits

  2011cites this paper
• A model of the interaction between N-type and C-type inactivation in Kv1.4 channels.

  2011cites this paper
• K(V)4.3 N-terminal deletion mutant Δ2-39: effects on inactivation and recovery characteristics in both the absence and presence of KChIP2b.

  2011cites this paper
• (1,3-bis-(2-hydroxy-5-trifluoromethylphenyl)-urea) in HEK-293 and CHO cells

  2011cites this paper
• KV4.3 N-terminal deletion mutant D2-39

  2011cites this paper
• Effects of lobeline, a nicotinic receptor ligand, on the cloned Kv1.5

  2010cites this paper
• Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2

  2010cites this paper
• Pharmacology of cardiac potassium channels.

  2010cites this paper
• Signal function of potassium channels--clinical aspects.

  2010cites this paper
• Amino Acid Substitutions and Ancillary Subunits Alter the Affinity of Heteropoda venatoria Toxin 2 for Kv 4

  2009cites this paper
• Kv4 Channels Underlie the Subthreshold-Operating A-type K+-current in Nociceptive Dorsal Root Ganglion Neurons

  2009cites this paper
• S3b Amino Acid Substitutions and Ancillary Subunits Alter the Affinity of Heteropoda venatoria Toxin 2 for Kv4.3

  2009cites this paper
• The dipeptidyl-aminopeptidase-like protein 6 is an integral voltage sensor-interacting β-subunit of neuronal KV4.2 channels

  2009cites this paper
• Structure, Function, and Modification of the Voltage Sensor in Voltage-Gated Ion Channels

  2008cites this paper
• MOLPHARM-AR-2023-000787R Inhibition of cardiac Kv4.3/KChIP2 channels by a sulfonylurea drug gliquidone

  year unknowncites this paper