HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Aging Cell

• Publication date

  2010-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1474-9726.2010.00600.xPMID 20569235PMCID PMC2941558
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

  2009influential reference
• Protection of C. elegans from Anoxia by HYL-2 Ceramide Synthase

  2009influential reference
• Genetic architecture of quantitative traits in mice, flies, and humans.

  2009cited by this paper
• Diabetes and apoptosis: lipotoxicity

  2009cited by this paper
• A standard procedure for creating a frailty index

  2008cited by this paper
• Genetic analysis of hyl-1, the C. elegans homolog of LAG1/LASS1

  2008cited by this paper
• More chores for TOR: de novo ceramide synthesis.

  2008cited by this paper
• Functionally significant insulin-like growth factor I receptor mutations in centenarians

  2008cited by this paper
• Evidence that the gene encoding insulin degrading enzyme influences human lifespan.

  2008cited by this paper
• FOXO3A genotype is strongly associated with human longevity

  2008cited by this paper
• Cumulative deficits and physiological indices as predictors of mortality and long life.

  2008cited by this paper
• Disentangling the roles of disability and morbidity in survival to exceptional old age.

  2008cited by this paper
• Exact sample size needed to detect dependence in 2 x 2 x 2 tables.

  2007influential reference
• Buffering Mechanisms in Aging: A Systems Approach Toward Uncovering the Genetic Component of Aging

  2007cited by this paper
• Frailty in relation to the accumulation of deficits.

  2007cited by this paper
• Prediction of Protein-protein Interactions on the Basis of Evolutionary Conservation of Protein Functions

  2007cited by this paper
• Exact Sample Size Needed to Detect Dependence in 2 × 2 × 2 Tables

  2007influential reference
• Site‐specific genetic divergence in parallel hybrid zones suggests nonallopatric evolution of reproductive barriers

  2006cited by this paper
• Test for interaction between two unlinked loci.

  2006cited by this paper
• Interactions between noncontiguous haplotypes in the adiponectin gene ACDC are associated with plasma adiponectin.

  2006cited by this paper
• Exact sample sizes needed to detect dependence in 2 x 3 tables.

  2006cited by this paper
• The quest for genetic determinants of human longevity: challenges and insights

  2006influential reference
• Inference of human geographic origins using Alu insertion polymorphisms.

  2005influential reference
• Arlequin (version 3.0): An integrated software package for population genetics data analysis

  2005cited by this paper
• The plasticity of aging: insights from long-lived mutants.

  2005cited by this paper
• Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 in Human Head and Neck Squamous Cell Carcinomas*

  2004cited by this paper
• FAST‐TRACK: Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis)

  2004cited by this paper
• Biologically active sphingolipids in cancer pathogenesis and treatment

  2004cited by this paper
• Suppressor analysis points to the subtle role of the LAG1 ceramide synthase gene in determining yeast longevity.

  2004cited by this paper
• Genetics, statistics and human disease: analytical retooling for complexity.

  2004cited by this paper
• Meta-Analysis: Apolipoprotein E Genotypes and Risk for Coronary Heart Disease

  2004cited by this paper
• Human population genetic structure and inference of group membership.

  2003influential reference
• Ceramide Enhances Cholesterol Efflux to Apolipoprotein A-I by Increasing the Cell Surface Presence of ATP-binding Cassette Transporter A1*

  2003cited by this paper
• Morbidity profiles of centenarians: survivors, delayers, and escapers.

  2003cited by this paper
• The genetics of aging.

  2003cited by this paper
• Genetic variation among world populations: inferences from 100 Alu insertion polymorphisms.

  2003influential reference
• Human Homologues of LAG1 Reconstitute Acyl-CoA-dependent Ceramide Synthesis in Yeast*

  2003cited by this paper
• An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity.

  2002cited by this paper
• The Structure of Haplotype Blocks in the Human Genome

  2002influential reference
• LAG1 puts the focus on ceramide signaling.

  2002cited by this paper
• Recent advances in human gene-longevity association studies.

  2001cited by this paper
• Inference of population structure using multilocus genotype data.

  2000influential reference
• Apolipoprotein E: far more than a lipid transport protein.

  2000cited by this paper
• The accuracy of statistical methods for estimation of haplotype frequencies: an example from the CD4 locus.

  2000cited by this paper
• The p66shc adaptor protein controls oxidative stress response and life span in mammals

  1999cited by this paper
• Redox regulation of c-Ha-ras and osteopontin signaling in vascular smooth muscle cells: implications in chemical atherogenesis.

  1999cited by this paper
• Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene

  1998cited by this paper
• Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene.

  1998cited by this paper
• The genetics of aging.

  1997cited by this paper
• Longevity, Genes, and Aging

  1996cited by this paper
• Longevity, Genes, and Aging

  1996cited by this paper
• Divergent roles of RAS1 and RAS2 in yeast longevity.

  1994cited by this paper
• Cloning and characterization of LAG1, a longevity-assurance gene in yeast.

  1994cited by this paper
• Genetic associations with human longevity at the APOE and ACE loci

  1994cited by this paper
• Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

  1993cited by this paper
• Prolongation of the yeast life span by the v‐Ha‐RAS oncogene

  1990cited by this paper

• Association of Clinical Severity in Autism Spectrum Disorder with Biomolecules Involved in Lipid Metabolism, Inflammation and miRNAs.

  2026cites this paper
• Associations of APOE Genetic Isoforms with Longevity and Risk of Mortality in Human Populations

  2025cites this paper
• Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells

  2024cites this paper
• Healthy aging among centenarians and near-centenarians: Findings from the Georgia Centenarian Study.

  2024cites this paper
• Mulberry polyphenol extracts attenuated senescence through inhibition of Ras/ERK via promoting Ras degradation in VSMC

  2022cites this paper
• Molecular inhibition of RAS signalling to target ageing and age-related health

  2022cites this paper
• Signatures of adaptive evolution in platyrrhine primate genomes

  2021cites this paper
• Feature selection algorithms enhance the accuracy of frailty indexes as measures of biological age.

  2021cites this paper
• Lipid metabolism and lipid signals in aging and longevity.

  2021cites this paper
• Signaling pathways and effectors of aging.

  2021cites this paper
• Genetic and regulatory architecture of Alzheimer's disease in the APOE region

  2020cites this paper
• Achyranthes bidentata extract protects chondrocytes functions through suppressing glycolysis and apoptosis via MAPK/AKT signaling axis.

  2020cites this paper
• Cocaine attenuates acid sphingomyelinase activity during establishment of addiction‐related behavior—A translational study in rats and monkeys

  2020cites this paper
• Searching for the longevity gene. Where are we heading?

  2019cites this paper
• APOE region molecular signatures of Alzheimer's disease across races/ethnicities.

  2019cites this paper
• Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms

  2019cites this paper
• Updated Genes, Lifestyles, and their Interactions for Human Longevity

  2019cites this paper
• G Genes that Delay Aging

  2019cites this paper
• Independent associations of TOMM40 and APOE variants with body mass index

  2018cites this paper
• Apolipoprotein E region molecular signatures of Alzheimer's disease

  2018cites this paper
• Strong impact of natural-selection–free heterogeneity in genetics of age-related phenotypes

  2018cites this paper
• Signal Transduction Pathways in Ageing.

  2018cites this paper
• Electronically ascertained extended pedigrees in breast cancer genetic counseling

  2018cites this paper
• Metabolic and Genetic Markers of Biological Age

  2017cites this paper
• Sphingolipids and their metabolism in physiology and disease

  2017cites this paper
• TECPR2 a positive regulator of autophagy is implicated in healthy brain ageing

  2017cites this paper
• Circadian Dysregulation and Melatonin Rhythm Suppression in the Context of Aging

  2017cites this paper
• The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age

  2017cites this paper
• Aging and the Biological Clock

  2017cites this paper
• Ras signaling in aging and metabolic regulation

  2017cites this paper
• Male sex and poverty predict abrupt health decline: Deficit accumulation patterns and trajectories in the KORA-Age cohort study.

  2017cites this paper
• Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE

  2017cites this paper
• Single nucleotide polymorphisms linked to mitochondrial uncoupling protein genes UCP2 and UCP3 affect mitochondrial metabolism and healthy aging in female nonagenarians

  2016cites this paper
• Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency

  2016cites this paper
• The enigma of ceramide synthase regulation in mammalian cells.

  2016cites this paper
• The circadian system as an organizer of metabolism.

  2016cites this paper
• Programmed Cell Death Genes Are Linked to Elevated Creatine Kinase Levels in Unhealthy Male Nonagenarians

  2016cites this paper
• The CD27+ memory B cells display changes in the gene expression pattern in elderly individuals

  2015cites this paper
• Age , gender , and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E 4 allele on lifespan

  2015cites this paper
• Mechanism of regulation of ‘chromosome kissing’ induced by Fob1 and its physiological significance

  2015cites this paper
• Quantitative measures of healthy aging and biological age

  2015cites this paper
• Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants

  2015cites this paper
• Non-coding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival

  2015cites this paper
• The aging clock and circadian control of metabolism and genome stability

  2015cites this paper
• APOE ϵ4, rated life experiences, and affect among centenarians

  2014cites this paper
• Biology of Aging and Implications for Heart Failure Therapy and Prevention

  2014cites this paper
• Aging Integromics: Module-Based Markers of Heart Aging from Multi-omics Data

  2014cites this paper
• Who are the Okinawans? Ancestry, genome diversity, and implications for the genetic study of human longevity from a geographically isolated population.

  2014cites this paper
• The aging biological clock in Neurospora crassa

  2014cites this paper
• An elevation of resting metabolic rate with declining health in nonagenarians may be associated with decreased muscle mass and function in women and men, respectively.

  2014cites this paper
• Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan

  2014cites this paper
• Sphingolipids and lifespan regulation.

  2014cites this paper
• Chemical regulation of mid- and late-life longevities in Drosophila.

  2013cites this paper
• Protein, lipid, and hematological biomarkers in centenarians: definitions, interpretation and relationships with health.

  2012cites this paper
• Association of healthy aging with parental longevity

  2012cites this paper
• Age-Specific Variation in Immune Response in Drosophila melanogaster Has a Genetic Basis

  2012cites this paper
• 1. Theoretical Perspectives

  2012cites this paper
• Prevention of heart failure in the elderly: when, where and how to begin?

  2012cites this paper
• 20 Adult Development and Aging

  2012cites this paper
• Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity

  2012influential citation
• Centenarian Studies: Important Contributors to Our Understanding of the Aging Process and Longevity

  2011cites this paper
• Large common deletions associate with mortality at old age.

  2011cites this paper
• A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

  2011cites this paper
• Parental longevity and diabetes risk in the Diabetes Prevention Program.

  2011cites this paper
• Insulin-like growth factor 1 receptor polymorphism rs2229765 and circulating interleukin-6 level affect male longevity in a population-based prospective study (Treviso Longeva− TRELONG)

  2011cites this paper
• APOE haplotypes are associated with human longevity in a Central Italy population: evidence for epistasis with HP 1/2 polymorphism.

  2011cites this paper
• Predicting Successful Aging in a Population-Based Sample of Georgia Centenarians

  2010cites this paper
• Theoretical Perspectives A Biopsychosocial Approach to Positive Aging

  year unknowncites this paper