Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Human Molecular Genetics

• Publication date

  2001-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/HMG/10.11.1141PMID 11371507
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hereditary cancer: Two hits revisited

  2005cited by this paper
• The molecular basis for developmental disorders of the pituitary gland in man.

  2001cited by this paper
• Expression of the pituitary transcription factor Ptx-1, but not that of the trans-activating factor prop-1, is reduced in human corticotroph adenomas and is associated with decreased alpha-subunit secretion.

  2000cited by this paper
• MR imaging of the pituitary gland in children and young adults with congenital combined pituitary hormone deficiency associated with PROP1 mutations.

  2000cited by this paper
• Impaired adrenocorticotropin-adrenal axis in combined pituitary hormone deficiency caused by a two-base pair deletion (301-302delAG) in the prophet of Pit-1 gene.

  2000cited by this paper
• Functional significance of prop-1 gene expression in pituitary adenomas.

  2000cited by this paper
• Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary.

  2000cited by this paper
• The molecular basis for developmental disorders of the pituitary gland in man

  2000cited by this paper
• Reduced Pax2 gene dosage increases apoptosis and slows the progression of renal cystic disease.

  2000cited by this paper
• Prop-1 gene expression in human pituitary tumors.

  1999cited by this paper
• The pathology of pituitary tumors.

  1999cited by this paper
• The Ethics of Clinical Research

  1999cited by this paper
• Combinatorial codes in signaling and synergy: lessons from pituitary development.

  1999cited by this paper
• Transient dwarfism and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control of pituitary levels of GH, FSH and LH.

  1998cited by this paper
• Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice.

  1998cited by this paper
• The cytogenesis and pathogenesis of pituitary adenomas.

  1998cited by this paper
• The molecular genetics of growth hormone deficiency

  1998cited by this paper
• The PROP1 2-base pair deletion is a common cause of combined pituitary hormone deficiency.

  1998cited by this paper
• Mutations in PROP1 cause familial combined pituitary hormone deficiency

  1998cited by this paper
• Screening for Thyroid Disease: An Update

  1998cited by this paper
• Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg-->Cys at codon 120 (R120C).

  1998cited by this paper
• Clinical guideline, part 2. Screening for thyroid disease: an update. American College of Physicians.

  1998cited by this paper
• Pituitary-directed leukemia inhibitory factor transgene causes Cushing's syndrome: neuro-immune-endocrine modulation of pituitary development.

  1998cited by this paper
• Remodeling of hyperplastic pituitaries in hypothyroid α-subunit knockout mice after thyroxine and 17β-estradiol treatment: Role of apoptosis

  1998cited by this paper
• Simian virus 40 T antigen-induced gonadotroph adenomas: a model of human null cell adenomas.

  1998cited by this paper
• How many homeobox genes does it take to make a pituitary gland?

  1998cited by this paper
• Genetic basis of endocrine disease: pituitary tumor pathogenesis.

  1997cited by this paper
• Pituitary Tumor Pathogenesis1

  1997cited by this paper
• Modular regulation of muscle gene transcription: a mechanism for muscle cell diversity.

  1997cited by this paper
• Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology.

  1997cited by this paper
• Homeobox Genes in Embryogenesis and Pathogenesis

  1997cited by this paper
• Pituitary-directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function. A model for human pituitary Rathke's cysts.

  1997cited by this paper
• The Ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of Rpx transcription and initiation of lineage-specific cell proliferation.

  1996cited by this paper
• Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice.

  1996cited by this paper
• Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

  1996cited by this paper
• Transcription factor genes and the developing eye: a genetic perspective.

  1996cited by this paper
• Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion.

  1996cited by this paper
• Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo.

  1996cited by this paper
• Inherited disorders of the gonadotropin hormones.

  1996cited by this paper
• Luteinizing Hormone Deficiency and Female Infertility in Mice Lacking the Transcription Factor NGFI-A (Egr-1)

  1996cited by this paper
• The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney.

  1996cited by this paper
• The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations.

  1996cited by this paper
• Targeted ablation of cells in the pituitary primordia of transgenic mice.

  1996cited by this paper
• Inherited disorders of the gonadotropin hormones.

  1996cited by this paper
• Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux

  1995cited by this paper
• Targeted disruption of the pituitary glycoprotein hormone alpha-subunit produces hypogonadal and hypothyroid mice.

  1995cited by this paper
• Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.

  1995cited by this paper
• Pax-2 controls multiple steps of urogenital development.

  1995cited by this paper
• Report of two cases

  1995cited by this paper
• The Ames dwarf gene is required for Pit-1 gene activation.

  1995cited by this paper
• In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development.

  1994cited by this paper
• A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.

  1994cited by this paper
• Enhancer-mediated high level expression of mouse pituitary glycoprotein hormone alpha-subunit transgene in thyrotropes, gonadotropes, and developing pituitary gland.

  1994cited by this paper
• Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus.

  1994cited by this paper
• A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

  1993cited by this paper
• Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities

  1993cited by this paper
• Gonadotropin secretion, synthesis, and gene expression in human growth hormone transgenic mice and in Ames dwarf mice.

  1993cited by this paper
• Intercellular communication within the rat anterior pituitary gland: V. Changes in cell‐to‐cell communications as a function of the timing of castration in male rats

  1993cited by this paper
• Leukemia inhibitory factor is expressed by the preimplantation uterus and selectively blocks primitive ectoderm formation in vitro.

  1992cited by this paper
• Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice.

  1990cited by this paper
• Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

  1990cited by this paper
• CELL PROLIFERATION IN THE ANTERIOR PITUITARY OF MICE DURING GROWTH

  1989cited by this paper
• Pituitary gonadotroph adenomas in old Sprague-Dawley rats.

  1985cited by this paper
• The effects of daily administration of single and multiple injections of gonadotropin-releasing hormone on pituitary and gonadal function in the hypogonadal (hpg) mouse.

  1983cited by this paper
• Symptomatic Rathke's cleft cysts. Report of two cases.

  1982cited by this paper
• Mechanisms of sex differentiation in animals and man

  1981cited by this paper
• Symptomatic Rathke's cleft cyst: Morphological study with light and electron microscopy and tissue culture

  1977cited by this paper
• The response of two types of dwarf mice to growth hormone, thyrotropin, and thyroxine.

  1965cited by this paper
• Principles of Anatomy and Physiology

  1911cited by this paper
• The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society Expression of the Pituitary Transcription Factor Ptx-1, But Not That of the Trans-Activating Factor Prop-1, Is Reduced in Human Corticotroph Ade

  year unknowncited by this paper
• Printed in U.S.A. Copyright © 1999 by The Endocrine Society Thyroid Hormone Is Essential for Pituitary

  year unknowncited by this paper
• The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 1999 by The Endocrine Society Characterization of Prophet of Pit-1 Gene Expression in Normal Pituitary and Pituitary Adenomas in Humans*

  year unknowncited by this paper

• Nucleoredoxin regulates WNT signaling during pituitary stem cell differentiation

  2025cites this paper
• Nucleoredoxin regulates WNT signaling during pituitary stem cell differentiation

  2025cites this paper
• The endocrine spectrum of Rathke cleft cysts

  2025cites this paper
• Triple sellar collision lesion: a unique case of pituitary adenoma, Rathke cleft cyst, and xanthogranuloma—case report and systematic review of the literature

  2025cites this paper
• Role of PROP1 in postnatal pituitary gland maturation.

  2025cites this paper
• Rathke’s cleft cyst: From history to molecular genetics

  2025influential citation
• Pituitary stem cell regulation by Zeb2 and BMP signaling.

  2023cites this paper
• Contribution of PROP1 in the pathogenesis of Cushing’s disease: A preliminary study

  2023cites this paper
• Pituitary Remodeling Throughout Life: Are Resident Stem Cells Involved?

  2021cites this paper
• Development of the Pituitary Gland.

  2020cites this paper
• Disorders of Hypothalamo‐Pituitary Axis

  2019cites this paper
• Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegaly

  2019cites this paper
• PITX2 Expression in Non-functional Pituitary Neuroendocrine Tumor with Cavernous Sinus Invasion

  2019cites this paper
• Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine System

  2019cites this paper
• The Stem Cell Connection of Pituitary Tumors

  2017cites this paper
• Cornea Foxc 1 and Foxc 2 in the Neural Crest Are Required for Ocular Anterior Segment Development

  2017cites this paper
• Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development

  2017cites this paper
• Genetic screening of regulatory regions of pituitary transcription factors in patients with idiopathic pituitary hormone deficiencies

  2017cites this paper
• Involvement of DNA methylation in regulating rat Prop1 gene expression during pituitary organogenesis

  2016cites this paper
• LMO 4 is an essential mediator of ErbB 2 / HER 2 / Neu-induced breast cancer cell cycle progression

  2016cites this paper
• AP-2β Is a Downstream Effector of PITX2 Required to Specify Endothelium and Establish Angiogenic Privilege During Corneal Development

  2016cites this paper
• Polymorphisms and genes associated with puberty in heifers.

  2016cites this paper
• PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells

  2016cites this paper
• All Hormone-Producing Cell Types of the Pituitary Intermediate and Anterior Lobes Derive From Prop1-Expressing Progenitors.

  2016cites this paper
• Chapter 5 – Development of the Pituitary∗

  2016cites this paper
• Mouse Models of Gonadotrope Development.

  2016cites this paper
• Animal models of pituitary neoplasia

  2016cites this paper
• Expression studies of neuronatin in prenatal and postnatal rat pituitary

  2015cites this paper
• Huge familial colloid cyst of the third ventricle: An extraordinary presentation

  2015cites this paper
• Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene

  2015cites this paper
• Recent advances in central congenital hypothyroidism

  2015cites this paper
• gene expression profiling Candidate genes for panhypopituitarism identified by

  2015cites this paper
• Deletion of OTX2 in neural ectoderm delays anterior pituitary development.

  2015cites this paper
• Pituitary stem cells: where do we stand?

  2014cites this paper
• Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification.

  2014cites this paper
• The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea

  2014cites this paper
• A novel loss-of-function mutation in Npr2 clarifies primary role in female reproduction and reveals a potential therapy for acromesomelic dysplasia, Maroteaux type.

  2013cites this paper
• Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies.

  2013cites this paper
• A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression.

  2013cites this paper
• The Genetic and Molecular Etiologies of Two Spontaneous Mouse Models of Skeletal Dysplasia and Infertility.

  2013cites this paper
• PROP1 overexpression in corticotrophinomas: evidence for the role of PROP1 in the maintenance of cells committed to corticotrophic differentiation

  2013cites this paper
• Identification and Analysis of Two Novel Sites of Rat GnRH Receptor Gene Promoter Activity: The Pineal Gland and Retina

  2012cites this paper
• Pituitary stem cells drop their mask.

  2012cites this paper
• Candidate genes for panhypopituitarism identified by gene expression profiling.

  2011cites this paper
• A novel modifier of hypothyroidism-induced hearing impairment in Pou1f1 dw dwarf mice

  2011cites this paper
• PROP1 and CTNNB1 expression in adamantinomatous craniopharyngiomas with or without β-catenin mutations

  2011cites this paper
• CHAPTER 8 – Pituitary Physiology and Diagnostic Evaluation

  2011cites this paper
• In Vivo Analysis of Human LHX3 Gene Regulation

  2011cites this paper
• Pitx2 is an upstream activator of extraocular myogenesis and survival.

  2011cites this paper
• A Modifier Gene Alleviates Hypothyroidism-Induced Hearing Impairment in Pou1f1dw Dwarf Mice

  2011cites this paper
• A Modi fi er Gene Alleviates Hypothyroidism-Induced Hearing Impairment in Pou 1 f 1 dw Dwarf Mice

  2011cites this paper
• Análise da expressão dos genes PROP1 e CTNNB1 em craniofaringiomas adamantinomatosos com e sem mutação somática no CTNNB1

  2010cites this paper
• Recent Developments in the Molecular Biology of Pituitary Tumors

  2010cites this paper
• Pituitary stem /progenitor cells: embryonic players in the adult gland?

  2010cites this paper
• Stem cells in the pituitary gland: A burgeoning field.

  2010cites this paper
• Molecular Genetics of Deafness: The Roles of MYO15 and Thyroid Hormone.

  2010cites this paper
• Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes.

  2010cites this paper
• Regulación del ciclo celular y el desarrollo de tumores in vivo por inhibidores INK4 y Cip/Kip

  2010cites this paper
• Morphogenesis of the Hypothalamus and Hypophysis

  2010cites this paper
• Adult pituitary progenitors/stem cells: from in vitro characterization to in vivo function

  2010cites this paper
• An Animal Model of Combined Pituitary Hormone Deficiency Disease

  2010cites this paper
• Association weight matrix for the genetic dissection of puberty in beef cattle

  2010influential citation
• Pathology, Pathogenesis and Therapy of Growth Hormone (GH)-producing Pituitary Adenomas: Technical Advances in Histochemistry and Their Contribution

  2009cites this paper
• LMO4 is an essential mediator of ErbB2/HER2/Neu-induced breast cancer cell cycle progression

  2009cites this paper
• Genetic regulation of pituitary gland development in human and mouse.

  2009cites this paper
• Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches.

  2009cites this paper
• Genetics, Gene Expression and Bioinformatics of the Pituitary Gland

  2009cites this paper
• Pituitary Progenitor Cells Tracked Down by Side Population Dissection

  2009cites this paper
• A GRFa2/Prop1/Stem (GPS) Cell Niche in the Pituitary

  2009cites this paper
• Hepatic Steatosis in Iranian Patients with Chronic Hepatitis C

  2008cites this paper
• Pituitary Changes in Prop1 Transgenic Mice: Hormone Producing Tumors and Signet-ring Type Gonadotropes

  2008influential citation
• Pitx2 deletion in pituitary gonadotropes is compatible with gonadal development, puberty, and fertility

  2008cites this paper
• Homeodomain transcription factor Hesx1/Rpx occupies Prop-1 activation sites in porcine follicle stimulating hormone (FSH) beta subunit promoter.

  2007cites this paper
• Comparative genomics reveals functional transcriptional control sequences in the Prop1 gene

  2007cites this paper
• Dietary thyroid hormone replacement ameliorates hearing deficits in hypothyroid mice

  2007cites this paper
• Hes1 is required for pituitary growth and melanotrope specification.

  2007cites this paper
• Noggin regulates Bmp4 activity during pituitary induction.

  2007cites this paper
• Hypothalamic and pituitary development: novel insights into the aetiology.

  2007cites this paper
• Molecular physiology of pituitary development: signaling and transcriptional networks.

  2007cites this paper
• HESX1 expression in human normal pituitaries and pituitary adenomas.

  2006cites this paper
• A case of trisomy 12 mosaicism with pituitary malformation and polycystic ovary syndrome.

  2006cites this paper
• Persistent expression of Notch2 delays gonadotrope differentiation.

  2006cites this paper
• The role of transcription factors implicated in anterior pituitary development in the aetiology of congenital hypopituitarism

  2006cites this paper
• Cell proliferation and vascularization in mouse models of pituitary hormone deficiency.

  2006cites this paper
• FOXL2 in the pituitary: molecular, genetic, and developmental analysis.

  2006cites this paper
• High level expression of Prop-1 gene in gonadotropic cell lines.

  2006cites this paper
• Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty.

  2006influential citation
• Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis.

  2006cites this paper
• Current molecular understanding of Axenfeld–Rieger syndrome

  2005cites this paper
• Genetics of pituitary adenomas: current theories and future implications.

  2005cites this paper
• Differentiation of Mouse Embryonic Stem Cells Into Gonadotrope-like Cells In Vitro

  2005cites this paper
• Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development.

  2005cites this paper
• Anterior Pituitary Hormones

  2005cites this paper
• Molecular and Histological Studies of Pituitary Tumorigenesis Using Experimental Animal Models

  2005cites this paper
• A familial form of congenital hypopituitarism due to a PROP1 mutation in a large kindred: phenotypic and in vitro functional studies.

  2004cites this paper
• WNT5A signaling affects pituitary gland shape.

  2004cites this paper
• Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression.

  2004cites this paper
• Pituitary transcription factor Prop-1 stimulates porcine follicle-stimulating hormone beta subunit gene expression.

  2004cites this paper
• Molecular Pathogenesis of Genetic and Inherited Diseases PITX2 Gain-of-Function in Rieger Syndrome Eye Model

  2004cites this paper
• Conserved amino acid sequences confer nuclear localization upon the Prophet of Pit-1 pituitary transcription factor protein.

  2004cites this paper