Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.

No abstract is available for this paper.

• Publication year

  1982

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/PNAS.79.1.175PMID 6798568PMCID PMC345685
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Antigen-presenting function of alveolar macrophages: uptake and presentation of Listeria monocytogenes.

  1981cited by this paper
• Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to T lymphocytes.

  1981cited by this paper
• Temporal changes of lysosome and phagosome pH during phagolysosome formation in macrophages: studies by fluorescence spectroscopy

  1981cited by this paper
• The regulatory role of macrophages in antigenic stimulation. Part Two: symbiotic relationship between lymphocytes and macrophages.

  1981cited by this paper
• H-2-restricted antigen binding by a hybridoma clone that produces antigen-specific helper factor.

  1981cited by this paper
• Chloroquine and ammonium ion inhibit receptor-mediated endocytosis of mannose-glycoconjugates by macrophages: apparent inhibition of receptor recycling.

  1980cited by this paper
• Regulation of the immune response--role of the macrophage.

  1980cited by this paper
• Antigen recognition by T cells and B cells: recognition of cross-reactivity between native and denatured forms of globular antigens.

  1980cited by this paper
• Ammonia inhibits phagosome–lysosome fusion in macrophages

  1980cited by this paper
• Control of proteolysis.

  1980cited by this paper
• Regulation of macrophage populations. I. Preferential induction of Ia-rich peritoneal exudates by immunologic stimuli.

  1980cited by this paper
• Is genetically related macrophage factor (GRF) a soluble immune response (Ir) gene product?

  1979cited by this paper
• Induction of cytocidal macrophages after in vitro interactions between Listeria-immune T cells and macrophages--role of H-2.

  1979cited by this paper
• The specific binding of Listeria monocytogenes-immune T lymphocytes to macrophages. I. Quantitation and role of H-2 gene products

  1979cited by this paper
• Macrophage-T cell interactions involving Listeria monocytogenes--role of the H-2 gene complex.

  1979cited by this paper
• Nature of T lymphocyte recognition of macrophage-associated antigens. II. Macrophage determination of guinea pig T cell responses to human fibrinopeptide B.

  1979cited by this paper
• Nature of T lymphocyte recognition of macrophage-associated antigens. I. Response of guinea pig T cells to human fibrinopeptide B.

  1979cited by this paper
• Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin.

  1979cited by this paper
• Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

  1978cited by this paper
• Antigen handling by guinea pig macrophages: further evidence for the sequestration of antigen relevant for activation of primed T lymphocytes.

  1977cited by this paper
• Immune responses against native and chemically modified albumins in mice. II. Effect of electric charge and conformation on the humoral antibody response and on helper T cell responses.

  1974cited by this paper
• Immunogenic properties of modified antigen E. I. Presence of specific determinants for T cells in denatured antigen and polypeptide chains.

  1974cited by this paper
• The release of antigen molecules from macrophages: characterization of the phenomena.

  1974cited by this paper
• Commentary. Lysosomotropic agents.

  1974cited by this paper
• FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES

  1973cited by this paper
• IMMUNE RESPONSES AGAINST NATIVE AND CHEMICALLY MODIFIED ALBUMINS IN MICE

  1972cited by this paper
• IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN

  1972cited by this paper
• Cellular and humoral immunity: a distinction in antigenic recognition.

  1972cited by this paper
• Studies on hypersensitivity. II. Delayed hypersensitivity to denatured proteins in guinea pigs.

  1959cited by this paper

• Evaluating large language models as a supplementary patient information resource on antimalarial use in systemic lupus erythematosus

  2025cites this paper
• Severe malaria enforces short-lived effector cell differentiation but does not prevent effective secondary responses by memory CD8 T cells

  2025cites this paper
• Thymic Eosinophils: What Are You Doing Here?

  2025cites this paper
• Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin

  2025cites this paper
• Inhibitory and Curative Effects and Mode of Action of Hydroxychloroquine on Botrytis cinerea of Tomato.

  2025cites this paper
• Pilot Trial of Hydroxychloroquine as Add-On Therapy in Patients With Membranous Nephropathy

  2024cites this paper
• Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly.

  2024cites this paper
• Effects of prolonged hydroxychloroquine use on the pancreatic tissue and expected ameliorative effect of lactoferrin in rats (biochemical, histological, and morphometric study).

  2024cites this paper
• Advancements on the impact of hydroxychloroquine in systemic lupus erythematosus

  2024cites this paper
• Inhibition of transient receptor potential vanilloid 3 channels by antimalarial hydroxychloroquine alleviates TRPV3-dependent dermatitis

  2024cites this paper
• Camellia sinensis polysaccharide attenuates inflammatory responses via the ROS-mediated pathway by endocytosis.

  2024cites this paper
• Current treatment of systemic lupus erythematosus: a clinician's perspective

  2023cites this paper
• The effects of hydroxychloroquine and its promising use in refractory obstetric antiphospholipid syndrome

  2023cites this paper
• Hydroxychloroquine - safety in pregnancy

  2022cites this paper
• Enhanced In Vitro Antiviral Activity of Hydroxychloroquine Ionic Liquids against SARS-CoV-2

  2022cites this paper
• DCs at the center of help: Origins and evolution of the three-cell-type hypothesis

  2022cites this paper
• Redox aspects of cytotoxicity and anti-neuroinflammatory profile of chloroquine and hydroxychloroquine in serum-starved BV-2 microglia.

  2022cites this paper
• The human cathelicidin peptide LL-37 inhibits pancreatic cancer growth by suppressing autophagy and reprogramming of the tumor immune microenvironment

  2022cites this paper
• Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy

  2021cites this paper
• The clinical characteristics and treatment approaches of COVID-19: a concise review

  2021cites this paper
• An intracellular enzyme-responsive polymeric prodrug with synergistic effect of chemotherapy and two-photon photodynamic therapy

  2021cites this paper
• Enhancing Antigen Presentation and Inducing Antigen-Specific Immune Tolerance with Amphiphilic Peptides

  2021cites this paper
• Antimalarial-induced retinal toxicity

  2021cites this paper
• Antimalarial drugs—are they beneficial in rheumatic and viral diseases?—considerations in COVID-19 pandemic

  2021cites this paper
• Chloroquine and Hydroxychloroquine Interact Differently with ACE2 Domains Reported to Bind with the Coronavirus Spike Protein: Mediation by ACE2 Polymorphism

  2021cites this paper
• Bioenergetics of Islet Preparations in a Pilot Clinical Trial of Peri-Transplant Hydroxychloroquine for Autologous Islet Transplantation

  2021cites this paper
• Know thy immune self and non‐self: Proteomics informs on the expanse of self and non‐self, and how and where they arise

  2021cites this paper
• ANTIMALÁRICOS: INDICACIONES, TOXICIDAD Y PERSPECTIVA EN EL 2020

  2020cites this paper
• Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 In Vitro and SARS-CoV In Vivo

  2020cites this paper
• Hydroxychloroquine and Azithromycin to Treat Patients With COVID‐19: Both Friends and Foes?

  2020cites this paper
• FDA approved drugs with broad anti-coronaviral activity inhibit SARS-CoV-2 in vitro

  2020cites this paper
• Hydroxychloroquine in COVID-19 Patients: Pros and Cons

  2020cites this paper
• Hydroxychloroquine (HCQ) reverses anti-PD-1 immune murine checkpoint blockade: TCF1 as a marker in humans for COVID-19 and HCQ therapy

  2020cites this paper
• Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

  2020cites this paper
• Autophagy as an emerging target for COVID-19: lessons from an old friend, chloroquine

  2020cites this paper
• Hydroxychloroquine in rheumatic autoimmune disorders and beyond

  2020cites this paper
• Role of autophagy in the pathogenesis of rheumatoid arthritis: Latest evidence and therapeutic approaches.

  2020cites this paper
• Broad anti-coronaviral activity of FDA approved drugs against 1 SARS-CoV-2 in vitro and SARS-CoV in vivo 2

  2020cites this paper
• SARS-CoV-2 in vitro and SARS-CoV in vivo

  2020cites this paper
• Obsessive-Compulsive Behavior Isn't Necessarily a Bad Thing.

  2020cites this paper
• Hydroxychloroquine inhibits trained immunity - implications for COVID-19

  2020cites this paper
• Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of MHC class II molecules and expression of invariant chain

  2020cites this paper
• COVID-19: Immunology and treatment options

  2020cites this paper
• A REVIEW ON HYDROXYCHLOROQUINE AND ITS SIGNIFICANCE

  2020cites this paper
• Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons

  2020cites this paper
• Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine

  2020cites this paper
• Update on treatment and preventive interventions against COVID-19: an overview of potential pharmacological agents and vaccines

  2020cites this paper
• Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy

  2020cites this paper
• The role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases.

  2020cites this paper
• Management of Cutaneous Lupus Erythematosus

  2019cites this paper
• Juvenile-onset systemic lupus erythematosus: Update on clinical presentation, pathophysiology and treatment options.

  2019cites this paper
• A Tribute to John Mendelsohn: A Pioneer in Targeted Cancer Therapy.

  2019cites this paper
• Epstein-Barr Virus-Positive Mucocutaneous Ulcer Mimicking Peri-Implantitis in a Patient With Systemic Lupus Erythematosus.

  2019cites this paper
• Lysosomes as a therapeutic target

  2019cites this paper
• Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation

  2018cites this paper
• A series of terpyridine derivatives for aggregation-induced emission, two-photon absorption and mitochondrial targeting

  2018cites this paper
• A new insight into effects of a clinically proved combination of methotrexate and hydroxychloroquine

  2018cites this paper
• Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review

  2018cites this paper
• The role of the mitochondria and the endoplasmic reticulum contact sites in the development of the immune responses

  2018cites this paper
• An in vitro test system for compounds that modulate human inflammatory macrophage polarization

  2018cites this paper
• Treatment of preeclampsia with hydroxychloroquine: a review

  2018cites this paper
• Paradoxical Effect of Chloroquine Treatment in Enhancing Chikungunya Virus Infection

  2018cites this paper
• Novel function of hydroxychloroquine: Down regulation of T follicular helper cells in collagen-induced arthritis.

  2018cites this paper
• Autophagy and Rheumatoid Arthritis: Current Knowledges and Future Perspectives

  2018cites this paper
• Discovery of circulating DMARD response biomarkers in rheumatoid arthritis

  2018cites this paper
• Neuropsychiatric clinical manifestations in elderly patients treated with hydroxychloroquine: a review article

  2018cites this paper
• Diseases with Underlining Internal Conditions

  2017cites this paper
• Mild acidic-enhanced mitochondrial-targeting by a neutral thiophene based terpyridine molecule with large two-photon action cross-section

  2017cites this paper
• New insights into the pathogenesis of IgA nephropathy

  2017cites this paper
• The elucidation of non-classical MHC class II antigen processing through the study of viral antigens.

  2017cites this paper
• Granulocytes: New Members of the Antigen-Presenting Cell Family

  2017cites this paper
• Intracellular “activated” two-photon photodynamic therapy by fluorescent conveyor and photosensitizer co-encapsulating pH-responsive micelles against breast cancer

  2017cites this paper
• CD9 Regulates Major Histocompatibility Complex Class II Trafficking in Monocyte-Derived Dendritic Cells

  2017influential citation
• Complex antigen presentation pathway for an HLA-A*0201-restricted epitope from Chikungunya 6K protein

  2017cites this paper
• Strategies to limit immune-activation in HIV patients

  2017cites this paper
• Juvenile-onset systemic lupus erythematosus (jSLE) - Pathophysiological concepts and treatment options.

  2017cites this paper
• Use of Antimalarial Agents as Adjuvant Therapy

  2017cites this paper
• Nucleated Teleost Erythrocytes Play an Nk-Lysin- and Autophagy-Dependent Role in Antiviral Immunity

  2017cites this paper
• 1 CD 9 regulates MHC-II trafficking in Monocyte-derived Dendritic 1 Cells 2

  2017influential citation
• Halides tuning the subcellular-targeting in two-photon emissive complexes via different uptake mechanisms.

  2017cites this paper
• Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy.

  2017cites this paper
• Chloroquine inhibits human CD4+ T-cell activation by AP-1 signaling modulation

  2017cites this paper
• Targeting mitochondrial DNA with a two-photon active Ru(ii) phenanthroline derivative.

  2016cites this paper
• The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse

  2016cites this paper
• Therapeutic effect of hydroxychloroquine on colorectal carcinogenesis in experimental murine colitis.

  2016cites this paper
• Present Yourself! By MHC Class I and MHC Class II Molecules.

  2016cites this paper
• Discoveries of conventional synthetic disease modifying anti-rheumatic drugs - Serendipity or flawless reasoning?

  2016cites this paper
• TIFA-Mediated Innate Immune Recognition of the Bacterial Metabolite HBP and its Role in Host Defense

  2016cites this paper
• Probe for simultaneous membrane and nucleus labeling in living cells and in vivo bioimaging using a two-photon absorption water-soluble Zn(ii) terpyridine complex with a reduced π-conjugation system

  2016cites this paper
• Variations in MHC Class II Antigen Processing and Presentation in Health and Disease.

  2016cites this paper
• Immunomodulators in SLE: Clinical evidence and immunologic actions.

  2016cites this paper
• Antigen-presenting cells look within during influenza infection

  2015cites this paper
• Manipulating Autophagic Processes in Autoimmune Diseases: A Special Focus on Modulating Chaperone-Mediated Autophagy, an Emerging Therapeutic Target

  2015cites this paper
• Hydroxychloroquine Prevents Antiphospholipid Antibody-Induced Inhibition Of Trophoblast Migration

  2015cites this paper
• Multivalent Antigens for Promoting B and T Cell Activation.

  2015cites this paper
• B CELL REPERTOIRE DEVELOPMENT IN NORMAL PHYSIOLOGY AND AUTOIMMUNE DISEASE

  2015cites this paper
• Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases

  2015cites this paper
• The role of T cell receptor signal intensity in T helper 17 cell development

  2015cites this paper
• Discovering protective CD8 T cell epitopes--no single immunologic property predicts it!

  2015cites this paper
• Chapter 7 – Antigen Processing and Presentation

  2014cites this paper