The changing immunological paradigm in coeliac disease.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Immunology Letters

• Publication date

  2006-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.IMLET.2006.03.004PMID 16647763
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reduced chemokine receptor 9 on intraepithelial lymphocytes in celiac disease suggests persistent epithelial activation.

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• Immune mechanisms in inflammatory bowel disease

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• The B-cell system in inflammatory bowel disease.

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• A unique dendritic cell subset accumulates in the celiac lesion and efficiently activates gluten-reactive T cells.

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• Immunomodulatory dendritic cells in intestinal lamina propria

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• How do DCs interact with intestinal antigens?

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• Anti‐endomysial antibody of IgG1 isotype detection strongly increases the prevalence of coeliac disease in patients affected by type I diabetes mellitus

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• Jejunal secretion of secretory immunoglobulins and gliadin antibodies in celiac disease

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• ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation.

  2005cited by this paper
• Gliadin Fragments Induce Phenotypic and Functional Maturation of Human Dendritic Cells1

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• Effect of elemental diet on mucosal immunopathology and clinical symptoms in type 1 refractory celiac disease.

  2005cited by this paper
• Coeliac disease

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• Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.

  2004cited by this paper
• Pathology, 3rd edn

  2004cited by this paper
• Wheat Gluten Causes Dendritic Cell Maturation and Chemokine Secretion1

  2004cited by this paper
• A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease.

  2004cited by this paper
• Immunopathology of gluten-sensitive enteropathy

  2004cited by this paper
• Intestinal intraepithelial lymphocytes prevent pathogen‐driven inflammation and regulate the Smad/T‐bet pathway of lamina propria CD4+ T cells

  2004cited by this paper
• Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease.

  2003cited by this paper
• Anatomical basis of tolerance and immunity to intestinal antigens

  2003cited by this paper
• Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease.

  2003cited by this paper
• Celiac Disease Association with CD8+ T Cell Responses: Identification of a Novel Gliadin-Derived HLA-A2-Restricted Epitope1

  2003cited by this paper
• Coeliac disease.

  2003cited by this paper
• Activation of macrophages by gliadin fragments: isolation and characterization of active peptide

  2002cited by this paper
• Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues.

  2002cited by this paper
• Coeliac disease: dissecting a complex inflammatory disorder

  2002cited by this paper
• Interferon‐γ‐Secreting T Cells Localize to the Epithelium in Coeliac Disease

  2002cited by this paper
• Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease.

  2002cited by this paper
• Intraepithelial lymphocytes: exploring the Third Way in immunology

  2001cited by this paper
• Increased enterocyte apoptosis and Fas-Fas ligand system in celiac disease.

  2001cited by this paper
• IgG Subclass Profile of Serum Antigliadin Antibodies and Antibody‐Dependent Cell‐Mediated Cytotoxicity in Young Children with Coeliac Disease

  2001cited by this paper
• Selective expansion of intraepithelial lymphocytes expressing the HLA-E–specific natural killer receptor CD94 in celiac disease☆☆☆

  2000cited by this paper
• Interleukin 15 mediates epithelial changes in celiac disease.

  2000cited by this paper
• Persistent mucosal abnormalities in coeliac disease are not related to the ingestion of trace amounts of gluten.

  1999cited by this paper
• Lack of local suppression in orally tolerant CD8-deficient mice reveals a critical regulatory role of CD8+ T cells in the normal gut mucosa.

  1998cited by this paper
• Interaction with secretory component stimulates effector functions of human eosinophils but not of neutrophils.

  1998cited by this paper
• Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease

  1998cited by this paper
• Exposing gliadin as a tasty food for lymphocytes

  1998cited by this paper
• Expanding dendritic cells in vivo enhances the induction of oral tolerance.

  1998cited by this paper
• Phenotypes of T cells in the gut.

  1998cited by this paper
• Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease.

  1998cited by this paper
• Differential distribution of B7.1 (CD80) and B7.2 (CD86) costimulatory molecules on mucosal macrophage subsets in human inflammatory bowel disease (IBD)

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• Production of Antibodies to Gliadin by Peripheral Blood Lymphocytes in Children with Celiac Disease: The Use of an Enzyme-Linked Immunospot Technique for Screening and Follow-Up

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• Identification of tissue transglutaminase as the autoantigen of celiac disease

  1997cited by this paper
• Heterogeneous reactivity patterns of HLA-DQ-restricted, small intestinal T-cell clones from patients with celiac disease.

  1997cited by this paper
• Immunopathology of human inflammatory bowel disease

  1997cited by this paper
• Gliadin Specific, HLA DQ2‐Restricted T Cells are Commonly Found in Small Intestinal Biopsies from Coeliac Disease Patients, but not from Controls

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• Increased proinflammatory cytokine gene expression in the colonic mucosa of coeliac disease patients in the early period after gluten challenge

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• Autoantibodies in coeliac disease: tissue transglutaminase—guilt by association?

  1997cited by this paper
• Differential distribution of B7.1 (CD80) and B7.2 (CD86) costimulatory molecules on mucosal macrophage subsets in human inflammatory bowel disease (IBD)

  1997cited by this paper
• The IgA subclass distributions of endomysium and gliadin antibodies in human sera are different.

  1996cited by this paper
• Differential regulation of human T cell responsiveness by mucosal versus blood monocytes

  1996cited by this paper
• Definition of the initial immunologic modifications upon in vitro gliadin challenge in the small intestine of celiac patients.

  1996cited by this paper
• Mucosal T cells and mast cells share common adhesion receptors.

  1996cited by this paper
• History of Oral Tolerance and Mucosal Immunity a

  1996cited by this paper
• Production of antiendomysial antibodies after in-vitro gliadin challenge of small intestine biopsy samples from patients with coeliac disease.

  1996cited by this paper
• Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma.

  1995cited by this paper
• Human eosinophils express a receptor for secretory component. Role in secretory IgA‐dependent activation

  1995cited by this paper
• Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes.

  1994cited by this paper
• IgA antibodies against reticulin and endomysium in the serum and gastrointestinal secretions of patients with dermatitis herpetiformis.

  1994cited by this paper
• Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients

  1993cited by this paper
• The Serologic and Mucosal Immunologic Basis of Celiac Disease

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• Cytotoxic and interferon gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are strain dependent.

  1993cited by this paper
• Gluten Stimulation of Coeliac Mucosa In Vitro Induces Activation (CD25) of Lamina Propria CD4H T cells and Macrophages but no Crypt‐Cell Hyperplasia

  1993cited by this paper
• Activated T lymphocytes in the celiac lesion: Non‐proliferative activation (CD25) of CD4+ α/β cells in the lamina propria but proliferation (Ki‐67) of α/β and γ/δ cells in the epithelium

  1993cited by this paper
• Serum IgG subclass antibodies to a variety of food antigens in patients with coeliac disease.

  1992cited by this paper
• Association of subepithelial deposition of activated complement and immunoglobulin G and M response to gluten in celiac disease.

  1992cited by this paper
• Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease

  1992cited by this paper
• Epithelial Expression of HLA, Secretory Component (Poly‐Ig Receptor), and Adhesion Molecules in the Human Alimentary Tract a

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• Dissociation between systemic and mucosal humoral immune responses in coeliac disease.

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• Signs of increased leakage over the jejunal mucosa during gliadin challenge of patients with coeliac disease.

  1990cited by this paper
• Chlamydia

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• Secretory immunity in celiac disease: cellular expression of immunoglobulin A subclass and joining chain.

  1990cited by this paper
• Differential upregulation of intercellular adhesion molecule‐1 in coeliac disease

  1990cited by this paper
• Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease.

  1990cited by this paper
• Jejunal immunoglobulin and antigliadin antibody secretion in adult coeliac disease.

  1990cited by this paper
• Intra‐epithelial lymphocytes: interferon‐gamma production and suppressor/cytotoxic activities

  1990cited by this paper
• Gliadin challenge-induced jejunal prostaglandin E2 secretion in celiac disease.

  1990cited by this paper
• IgA-induced eosinophil degranulation.

  1989cited by this paper
• Challenge with gliadin induces eosinophil and mast cell activation in the jejunum of patients with celiac disease.

  1989cited by this paper
• Raised number of jejunal IgG2-producing cells in untreated adult coeliac disease compared with food allergy.

  1989cited by this paper
• Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers.

  1989cited by this paper
• Production of antibodies to gliadin in intestinal mucosa of patients with coeliac disease: a study at the single cell level.

  1989cited by this paper
• The subclass profile and complement activating potential of anti-alpha-gliadin antibodies in coeliac disease.

  1989cited by this paper
• Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes.

  1989cited by this paper
• Neutrophil and eosinophil involvement of the small bowel in patients with celiac disease and Crohn's disease: studies on the secretion rate and immunohistochemical localization of granulocyte granule constituents.

  1989cited by this paper
• Gliadin antibody production by small intestinal lymphocytes from patients with coeliac disease.

  1989cited by this paper
• J-chain expression is more prominent in immunoglobulin A2 than in immunoglobulin A1 colonic immunocytes and is decreased in both subclasses associated with inflammatory bowel disease.

  1988cited by this paper
• IgA immune response patterns to gliadin in serum.

  1988cited by this paper
• Immunoglobulin A antigliadin antibodies in jejunal juice: markers of severe intestinal damage in coeliac children.

  1988cited by this paper
• Expression of Major Histocompatibility Complex Class II Subregion Products by Jejunal Epithelium in Patients with Coeliac Disease

  1987cited by this paper
• Local IgA subclass alterations in ulcerative colitis and Crohn's disease of the colon.

  1987cited by this paper
• Secretion of gliadin antibody by coeliac jejunal mucosal biopsies cultured in vitro.

  1986cited by this paper
• Intestinal and serum antibody in coeliac disease: a comparison using ELISA.

  1986cited by this paper
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  1981cited by this paper
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  1981cited by this paper
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