Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse.

GPBP was shown to be encephalitogenic in SJL mice by direct challenge and in experiments in which an adoptive transfer system was employed. The three fragments obtained by treating GPBP with pepsin were assessed in the same manner. The encephalitogenic activity resided in the C terminal half of the molecule (residues 89-169). LNC also proliferated to the same fragment in vitro. Fragments 1-37, and, to a lesser extent, 44-48 stimulated sensitized LNC to proliferate but did not induce disease.

• Publication year

  1982

• Venue

  Journal of Immunology

• Publication date

  1982-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.129.3.1209PMID 6179999
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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