Oncogenicity of Virulent Marek's Disease Virus Cloned as Bacterial Artificial Chromosomes

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Virology

• Publication date

  2004-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.78.23.13376-13380.2004PMID 15542691PMCID PMC525015
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Replication-Competent Bacterial Artificial Chromosomes of Marek's Disease Virus: Novel Tools for Generation of Molecularly Defined Herpesvirus Vaccines

  2003cited by this paper
• The RNA Subunit of Telomerase Is Encoded by Marek's Disease Virus

  2003cited by this paper
• Cloning of herpesviral genomes as bacterial artificial chromosomes

  2003cited by this paper
• Differential Cytokine Responses following Marek's Disease Virus Infection of Chickens Differing in Resistance to Marek's Disease

  2003cited by this paper
• Reconstitution of Marek's Disease Virus Serotype 1 (MDV-1) from DNA Cloned as a Bacterial Artificial Chromosome and Characterization of a Glycoprotein B-Negative MDV-1 Mutant

  2000cited by this paper
• Characterisation of two highly oncogenic strains of Marek's disease virus.

  1982cited by this paper
• Influence of oncogenicity of Marek' disease virus on evaluation of genetic resistance.

  1981cited by this paper

• Marek's disease virus-encoded MicroRNA-M6-5p suppresses viral replication by targeting viral major capsid protein-coding gene UL19.

  2025cites this paper
• Marek’s disease virus-encoded microRNA-M6-5p facilitates viral latent infection by targeting histone demethylase KDM2B

  2025cites this paper
• Genome isomerization of Turkey herpesvirus: Identification of inverted unique short genomes and demonstration of protective efficacy against Marek's Disease using BAC clones.

  2025cites this paper
• Marek’s disease virus-1 unique gene LORF1 is involved in viral replication and MDV-1/Md5-induced atrophy of the bursa of Fabricius

  2025cites this paper
• Fast-forwarding evolution—Accelerated adaptation in a proofreading-deficient hypermutator herpesvirus

  2022cites this paper
• Visualization of Marek’s Disease Virus Genomes in Living Cells during Lytic Replication and Latency

  2022cites this paper
• Methods for the Manipulation of Herpesvirus Genome and the Application to Marek’s Disease Virus Research

  2021cites this paper
• Epigenetic Silencing of MicroRNA-126 Promotes Cell Growth in Marek’s Disease

  2021cites this paper
• Comparison of Marek's Disease Virus Challenge Strains and Bird Types for Vaccine Licensing

  2021cites this paper
• The Tegument Protein pUL47 of Marek’s Disease Virus Is Necessary for Horizontal Transmission and Is Important for Expression of Glycoprotein gC

  2020cites this paper
• Marek’s Disease Virus Requires Both Copies of the Inverted Repeat Regions for Efficient In Vivo Replication and Pathogenesis

  2020cites this paper
• Efficient Mutagenesis of Marek’s Disease Virus-Encoded microRNAs Using a CRISPR/Cas9-Based Gene Editing System

  2020cites this paper
• IFNα and IFNγ Impede Marek’s Disease Progression

  2019cites this paper
• Imaging Mass Spectrometry and Proteome Analysis of Marek’s Disease Virus-Induced Tumors

  2019cites this paper
• Targeted Editing of the pp38 Gene in Marek’s Disease Virus-Transformed Cell Lines Using CRISPR/Cas9 System

  2019cites this paper
• Marek's Disease Virus-Encoded MicroRNA 155 Ortholog Critical for the Induction of Lymphomas Is Not Essential for the Proliferation of Transformed Cell Lines

  2019cites this paper
• Pervasive Differential Splicing in Marek’s Disease Virus Can Discriminate CVI-988 Vaccine Strain from RB-1B Very Virulent Strain in Chicken Embryonic Fibroblasts

  2019cites this paper
• Unraveling the role of B cells in the pathogenesis of an oncogenic avian herpesvirus

  2018cites this paper
• Specific transcriptional and post-transcriptional regulation of the major immediate early ICP4 gene of GaHV-2 during the lytic, latent and reactivation phases.

  2018influential citation
• Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization

  2018cites this paper
• Codon pair bias deoptimization of a major oncogene as an attenuation strategy for Marek’s disease herpesvirus

  2018influential citation
• Differentially expressed genes during spontaneous lytic switch of Marek's disease virus in lymphoblastoid cell lines determined by global gene expression profiling

  2017cites this paper
• Tumor promoting functions of cellular telomerase RNA and viral RNAs in herpesvirus-induced cancer formation

  2017cites this paper
• Evaluation and Identification of Marek's Disease Virus BAC Clones as Standardized Reagents for Research

  2017cites this paper
• ESCDL-1, a new cell line derived from chicken embryonic stem cells, supports efficient replication of Mardiviruses

  2017cites this paper
• Interindividual Spread of Herpesviruses.

  2017cites this paper
• Marek's disease herpesvirus vaccines integrate into chicken host chromosomes yet lack a virus-host phenotype associated with oncogenic transformation.

  2016cites this paper
• Deletion of the BAC sequences from recombinant meq-null Marek's disease (MD) virus increases immunosuppression while maintaining protective efficacy against MD.

  2016cites this paper
• Real-time PCR for differential quantification of CVI988 vaccine virus and virulent strains of Marek’s disease virus

  2016cites this paper
• Virus and host genomic, molecular, and cellular interactions during Marek's disease pathogenesis and oncogenesis

  2016cites this paper
• Oncogenic Marek's disease herpesvirus encodes an isoform of the conserved regulatory immediate early protein ICP27 generated by alternative promoter usage.

  2016cites this paper
• IMMUNOLOGY, HEALTH, AND DISEASE Deletion of the BAC sequences from recombinant meq-null Marek’s disease (MD) virus increases immunosuppression while maintaining protective efficacy against MD protective efficacy

  2016cites this paper
• Genomic deletions and mutations resulting in the loss of eight genes reduce the in vivo replication capacity of Meleagrid herpesvirus 1

  2015cites this paper
• Construction of Recombinant HVT Expressing PmpD, and Immunological Evaluation against Chlamydia psittaci and Marek’s Disease Virus

  2015influential citation
• Third Report on Chicken Genes and Chromosomes 2015

  2015cites this paper
• Pendekatan MolekuleruntukIdentifikasidanKarakterisasi VirusMarek Serotipe 1

  2015cites this paper
• The significance of the individual Meq-clustered miRNAs of Marek's disease virus in oncogenesis.

  2015influential citation
• Réplication, dissémination et morphogénèse du virus de la maladie de Marek en cellules différenciées vers le lignage peau

  2015cites this paper
• Differential expression of Marek's disease virus (MDV) late proteins during in vitro and in situ replication: role for pUL47 in regulation of the MDV UL46-UL49 gene locus.

  2015cites this paper
• Understanding the molecular basis of disease is crucial to improving the design and construction of herpesviral vectors for veterinary vaccines.

  2015cites this paper
• Poly(A) Binding Protein 1 Enhances Cap-Independent Translation Initiation of Neurovirulence Factor from Avian Herpesvirus

  2014cites this paper
• Vaccine and oncogenic strains of gallid herpesvirus 2 contain specific subtype variations in the 5′ region of the latency-associated transcript that evolve in vitro and in vivo

  2014cites this paper
• Virus-encoded miR-155 ortholog is an important potential regulator but not essential for the development of lymphomas induced by very virulent Marek's disease virus.

  2014cites this paper
• Construction of Recombinant Marek's Disease Virus (rMDV) Co-Expressing AIV-H9N2-NA and NDV-F Genes under Control of MDV's Own Bi-Directional Promoter

  2014cites this paper
• The ORF012 Gene of Marek's Disease Virus Type 1 Produces a Spliced Transcript and Encodes a Novel Nuclear Phosphoprotein Essential for Virus Growth

  2014cites this paper
• Cloning of a Very Virulent Plus, 686 Strain of Marek's Disease Virus as a Bacterial Artificial Chromosome

  2013cites this paper
• The UL36-encoded ubiquitin-specific protease in Marek's disease virus replication and tumourigenesis

  2013cites this paper
• Relationship Between Levels of Very Virulent MDV in Poultry Dust and in Feather Tips from Vaccinated Chickens

  2013cites this paper
• Importance of Differential Expression of Marek's Disease Virus Gene pp38 for the Pathogenesis of Marek's Disease

  2013cites this paper
• Régulation transcriptionnelle et post-transcriptionnelle du gène LAT codant un cluster de microARN et du gène très précoce ICP27 de l'herpesvirus oncogène de la maladie de Marek

  2013influential citation
• Visualization of Marek’s disease virus in vitro using enhanced green fluorescent protein fused with US10

  2013cites this paper
• In Vitro Replication of Recombinant Marek’S Disease Viruses Constructed from Field Strains Lacking Meq and Vtr Oncogenes

  2013cites this paper
• Deletion of Marek's Disease Virus Large Subunit of Ribonucleotide Reductase Impairs Virus Growth In Vitro and In Vivo

  2013cites this paper
• Identification of a Neurovirulence Factor from Marek's Disease Virus

  2013cites this paper
• Latency and Tumorigenesis in Marek's Disease

  2013cites this paper
• Marek's Disease Virus Late Protein Expression in Feather Follicle Epithelial Cells as Early as 8 Days Postinfection

  2012cites this paper
• Selection of a Recombinant Marek's Disease Virus In Vivo Through Expression of the Marek's EcoRI-Q (Meq)–Encoded Oncoprotein: Characterization of an rMd5-Based Mutant Expressing the Meq of Strain RB-1B

  2012cites this paper
• Dynamic equilibrium of Marek’s disease genomes during in vitro serial passage

  2012cites this paper
• Induction of lymphomas by inoculation of Marek's disease virus-derived lymphoblastoid cell lines: prevention by CVI988 vaccination

  2012cites this paper
• mdv1-miR-M7-5p, located in the newly identified first intron of the latency-associated transcript of Marek's disease virus, targets the immediate-early genes ICP4 and ICP27.

  2012influential citation
• Rho-ROCK and Rac-PAK Signaling Pathways Have Opposing Effects on the Cell-to-Cell Spread of Marek's Disease Virus

  2012cites this paper
• Insertion of reticuloendotheliosis virus long terminal repeat into a bacterial artificial chromosome clone of a very virulent Marek's disease virus alters its pathogenicity

  2012cites this paper
• Marek’s Disease Virus Expresses Multiple UL44 (gC) Variants through mRNA Splicing That Are All Required for Efficient Horizontal Transmission

  2012cites this paper
• Marek’s disease virus pathogenesis and latency

  2012influential citation
• Progress toward the development of polyvalent vaccination strategies against multiple viral infections in chickens using herpesvirus of turkeys as vector

  2012cites this paper
• and Nikolaus Osterrieder Horizontal Transmission That Are All Required for Efficient UL 44 ( gC ) Variants through mRNA Splicing Marek ' s Disease Virus Expresses Multiple

  2012cites this paper
• Marek's Disease Virus Expresses Multiple UL44 (gC) Variants through mRNA Splicing That Are All Required for Efficient Horizontal Transmission

  2012cites this paper
• ICP 27 protein of Marek ’ s disease virus interacts with SR proteins and inhibits the splicing of cellular telomerase chTERT and viral vIL 8 transcripts

  2011cites this paper
• THE ROLE OF MAREK'S DISEASE VIRUS MEQ GENE PRODUCTS ON MDV PATHOGENICITY AND ONCOGENICITY

  2011cites this paper
• Virulent Marek's disease virus generated from infectious bacterial artificial chromosome clones with complete DNA sequence and the implication of viral genetic homogeneity in pathogenesis.

  2011cites this paper
• Genotypic characterization of two bacterial artificial chromosome clones derived from a single DNA source of the very virulent gallid herpesvirus-2 strain C12/130.

  2011cites this paper
• Clonal Structure of Rapid-Onset MDV-Driven CD4+ Lymphomas and Responding CD8+ T Cells

  2011cites this paper
• Differential quantification of cloned CVI988 vaccine strain and virulent RB-1B strain of Marek's disease viruses in chicken tissues, using real-time PCR.

  2011cites this paper
• ICP27 protein of Marek's disease virus interacts with SR proteins and inhibits the splicing of cellular telomerase chTERT and viral vIL8 transcripts.

  2011cites this paper
• Expression profiles of microRNAs encoded by the oncogenic Marek's disease virus reveal two distinct expression patterns in vivo during different phases of disease.

  2011cites this paper
• Fluorescently Tagged pUL47 of Marek's Disease Virus Reveals Differential Tissue Expression of the Tegument Protein In Vivo

  2011cites this paper
• Critical Role of the Virus-Encoded MicroRNA-155 Ortholog in the Induction of Marek's Disease Lymphomas

  2011influential citation
• Recombinant herpesvirus of turkeys as a vector-based vaccine against highly pathogenic H7N1 avian influenza and Marek's disease.

  2011cites this paper
• Epstein-Barr virus genetics: talking about the BAC generation

  2010cites this paper
• Viral control of vTR expression is critical for efficient formation and dissemination of lymphoma induced by Marek’s disease virus (MDV)

  2010cites this paper
• Comparative efficacy of BAC-derived recombinant SB-1 vaccine and the parent wild type strain in preventing replication, shedding and disease induced by virulent Marek's disease virus.

  2010cites this paper
• Chromosomal integration of an avian oncogenic herpesvirus reveals telomeric preferences and evidence for lymphoma clonality

  2010cites this paper
• A direct comparison of strategies for combinatorial RNA interference

  2010influential citation
• Marek’s disease virus-encoded microRNAs: genomics, expression and function

  2010cites this paper
• Herpesvirus Telomerase RNA(vTR)-Dependent Lymphoma Formation Does Not Require Interaction of vTR with Telomerase Reverse Transcriptase (TERT)

  2010cites this paper
• Pathogenicity of a Very Virulent Strain of Marek's Disease Herpesvirus Cloned as Infectious Bacterial Artificial Chromosomes

  2010cites this paper
• Mutagenesis of the repeat regions of herpesviruses cloned as bacterial artificial chromosomes.

  2010cites this paper
• Functional evaluation of the role of reticuloendotheliosis virus long terminal repeat (LTR) integrated into the genome of a field strain of Marek's disease virus.

  2010cites this paper
• A MEQ-Deleted Marek's Disease Virus Cloned as a Bacterial Artificial Chromosome Is a Highly Efficacious Vaccine

  2010cites this paper
• Down-regulation of MHC class I by the Marek's disease virus (MDV) UL49.5 gene product mildly affects virulence in a haplotype-specific fashion.

  2010cites this paper
• Further Analysis of Marek's Disease Virus Horizontal Transmission Confirms That UL44 (gC) and UL13 Protein Kinase Activity Are Essential, while US2 Is Nonessential

  2010cites this paper
• Marek’s disease viruses lacking either R-LORF10 or LORF4 have altered virulence in chickens

  2010cites this paper
• Genome-wide analysis of Marek's disease virus proteins and their role in modulating the innate immune response in chickens

  2010influential citation
• A BAC clone of MDV strain GX0101 with REV-LTR integration retained its pathogenicity

  2009cites this paper
• The Marek’s disease virus (MDV) protein encoded by the UL17 ortholog is essential for virus growth

  2009cites this paper
• Interaction of Marek's disease virus oncoprotein Meq with heat-shock protein 70 in lymphoid tumour cells.

  2009cites this paper
• The 5′ Leader of the mRNA Encoding the Marek's Disease Virus Serotype 1 pp14 Protein Contains an Intronic Internal Ribosome Entry Site with Allosteric Properties

  2009cites this paper
• Targeting Marek's disease virus by RNA interference delivered from a herpesvirus vaccine.

  2009cites this paper
• Homodimerization of the Meq Viral Oncoprotein Is Necessary for Induction of T-Cell Lymphoma by Marek's Disease Virus

  2009cites this paper
• Construction of an infectious Marek's disease virus bacterial artificial chromosome and characterization of protection induced in chickens.

  2009cites this paper