The interaction of titin and α‐actinin is controlled by a phospholipid‐regulated intramolecular pseudoligand mechanism

No abstract is available for this paper.

• Publication year

  2000

• Venue

  EMBO Journal

• Publication date

  2000-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/emboj/19.23.6331PMID 11101506PMCID PMC305858
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• a-Actinin and Vinculin Are PIPz-binding Proteins Involved in Signaling by Tyrosine Kinase*

  2001cited by this paper
• Three-Dimensional Structure of a Vertebrate Muscle Z-band: Implications for Titin and α-Actinin Binding

  2000cited by this paper
• Three-dimensional structure of a vertebrate muscle Z-band: implications for titin and alpha-actinin binding.

  2000cited by this paper
• FATZ, a Filamin-, Actinin-, and Telethonin-binding Protein of the Z-disc of Skeletal Muscle*

  2000cited by this paper
• Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2.

  2000cited by this paper
• Binding of alpha-actinin to titin: implications for Z-disk assembly.

  2000cited by this paper
• Stimulation of Phosphatidylinositol-4-phosphate 5-Kinase by Rho-Kinase*

  2000cited by this paper
• Association of Plectin with Z-Discs Is a Prerequisite for the Formation of the Intermyofibrillar Desmin Cytoskeleton

  2000cited by this paper
• Interaction of hCLIM1, an enigma family protein, with α‐actinin 2

  2000cited by this paper
• MEKK1 interacts with alpha-actinin and localizes to stress fibers and focal adhesions.

  1999cited by this paper
• Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy.

  1999cited by this paper
• CRYSTAL STRUCTURE OF TWO CENTRAL SPECTRIN-LIKE REPEATS FROM ALPHA-ACTININ

  1999cited by this paper
• ZASP: a new Z-band alternatively spliced PDZ-motif protein.

  1999cited by this paper
• Purification and Characterization of an α-Actinin-binding PDZ-LIM Protein That Is Up-regulated during Muscle Differentiation*

  1999cited by this paper
• Structure of the alpha-actinin rod: molecular basis for cross-linking of actin filaments.

  1999cited by this paper
• Cypher, a Striated Muscle-restricted PDZ and LIM Domain-containing Protein, Binds to α-Actinin-2 and Protein Kinase C*

  1999cited by this paper
• Alpha actinin–CapZ, an anchoring complex for thin filaments in Z-line

  1999cited by this paper
• Binding of a native titin fragment to actin is regulated by PIP2

  1998cited by this paper
• Phosphoinositide kinases.

  1998cited by this paper
• Molecular structure of the sarcomeric Z‐disk: two types of titin interactions lead to an asymmetrical sorting of α‐actinin

  1998influential reference
• The N-terminal Z repeat 5 of connectin/titin binds to the C-terminal region of alpha-actinin.

  1997cited by this paper
• CRP1, a LIM Domain Protein Implicated in Muscle Differentiation, Interacts with α-Actinin

  1997cited by this paper
• Actinin-associated LIM Protein: Identification of a Domain Interaction between PDZ and Spectrin-like Repeat Motifs

  1997cited by this paper
• Interaction of PKN with α-Actinin*

  1997cited by this paper
• Further analysis of the role of spectrin repeat motifs in α-actinin dimer formation

  1997cited by this paper
• Binding of the N‐terminal 63 kDa portion of connectin/titin to α‐actinin as revealed by the yeast two‐hybrid system

  1997cited by this paper
• Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin: implications for the nature of vertebrate Z-discs.

  1997cited by this paper
• Connectin/titin, giant elastic protein of muscle

  1997cited by this paper
• Further analysis of the role of spectrin repeat motifs in alpha-actinin dimer formation.

  1997cited by this paper
• Zyxin: Zinc fingers at sites of cell adhesion

  1997cited by this paper
• The N-Terminal Z Repeat 5 of Connectin/Titin Binds to the C-Terminal Region of α-Actinin

  1997cited by this paper
• Binding of the Cytoplasmic Domain of Intercellular Adhesion Molecule-2 (ICAM-2) to α-Actinin*

  1996cited by this paper
• The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition.

  1996cited by this paper
• Cytoskeleton: Titin as a scaffold and spring

  1996cited by this paper
• Rho: theme and variations.

  1996cited by this paper
• Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides

  1996cited by this paper
• The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers.

  1996cited by this paper
• Phosphoinositide kinases.

  1996cited by this paper
• Titin as a scaffold and spring. Cytoskeleton.

  1996cited by this paper
• Identification of a Phosphatidylinositol 4,5-Bisphosphate-binding Site in Chicken Skeletal Muscle α-Actinin (*)

  1996cited by this paper
• Association of structural repeats in the alpha-actinin rod domain. Alignment of inter-subunit interactions.

  1995cited by this paper
• Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion.

  1995cited by this paper
• Titins: Giant Proteins in Charge of Muscle Ultrastructure and Elasticity

  1995cited by this paper
• Release of proteins and peptides from fusion proteins using a recombinant plant virus proteinase.

  1994cited by this paper
• The muscle Z band: lessons in stress management

  1994cited by this paper
• The premyofibril: evidence for its role in myofibrillogenesis.

  1994cited by this paper
• Identification of the vinculin-binding site in the cytoskeletal protein α-actinin

  1994cited by this paper
• Analysis of the phasing of four spectrin-like repeats in alpha-actinin.

  1994cited by this paper
• Phosphatidylinositol 3-kinase binds to alpha-actinin through the p85 subunit.

  1994cited by this paper
• Identification of the vinculin-binding site in the cytoskeletal protein alpha-actinin.

  1994cited by this paper
• alpha-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase.

  1994cited by this paper
• Evidence for a ternary interaction between alpha-actinin, (meta)vinculin and acidic-phospholipid bilayers.

  1993cited by this paper
• Projection image of smooth muscle alpha-actinin from two-dimensional crystals formed on positively charged lipid layers.

  1993cited by this paper
• Mammalian Ras interacts directly with the serine/threonine kinase Raf.

  1993cited by this paper
• Requirement of phosphatidylinositol 4,5-bisphosphate for alpha-actinin function.

  1992cited by this paper
• Myogenesis in the mouse.

  1992cited by this paper
• An Interaction between Zyxin and aActinin

  1992cited by this paper
• Requirement of phosphatidylinositol 4,5-bisphosphate for α-actinin function

  1992influential reference
• An interaction between zyxin and alpha-actinin

  1992cited by this paper
• The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.

  1992cited by this paper
• Association of intercellular adhesion molecule-1 (ICAM-1) with actin- containing cytoskeleton and alpha-actinin

  1992cited by this paper
• Regulation of CapZ, an actin capping protein of chicken muscle, by anionic phospholipids.

  1991cited by this paper
• Properties of the spectrin‐like structural element of smooth‐muscle α‐actinin

  1991cited by this paper
• Properties of the spectrin-like structural element of smooth-muscle alpha-actinin.

  1991cited by this paper
• Differential distribution of subsets of myofibrillar proteins in cardiac nonstriated and striated myofibrils

  1990cited by this paper
• An interaction between alpha-actinin and the beta 1 integrin subunit in vitro

  1990cited by this paper
• Digestion of proteins associated with the Z-disc by calpain

  1990cited by this paper
• Substructure and higher structure of chicken smooth muscle α-actinin molecule

  1990cited by this paper
• Interaction of alpha-actinin and nebulin in vitro. Support for the existence of a fourth filament system in skeletal muscle.

  1990cited by this paper
• Myogenesis in the mouse embryo: differential onset of expression of myogenic proteins and the involvement of titin in myofibril assembly

  1989cited by this paper
• The structure and function of alpha-actinin.

  1989cited by this paper
• The organization and regulation of the macrophage actin skeleton.

  1988cited by this paper
• Terminally differentiated neonatal rat myocardial cells proliferate and maintain specific differentiated functions following expression of SV40 large T antigen.

  1988cited by this paper
• Substructure and higher structure of chicken smooth muscle alpha-actinin molecule.

  1988cited by this paper
• Specific interaction of vinculin with alpha-actinin.

  1987cited by this paper
• Immunocytochemical studies of cardiac myofibrillogenesis in early chick embryos. I. Presence of immunofluorescent titin spots in premyofibril stages

  1987cited by this paper
• Specific interaction of vinculin with α-actinin

  1987cited by this paper
• Diacylglycerol in large α-actinin/actin complexes and in the cytoskeleton of activated platelets

  1985cited by this paper
• Diacylglycerol in large alpha-actinin/actin complexes and in the cytoskeleton of activated platelets.

  1985cited by this paper
• New, rapid methods for purifying alpha-actinin from chicken gizzard and chicken pectoral muscle.

  1980cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• [Digestion of proteins].

  1958cited by this paper

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• Investigation of calmodulin‐like and rod domain mutations suggests common molecular mechanism for α‐actinin‐1‐linked congenital macrothrombocytopenia

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• Three-dimensional structure of the basketweave Z-band in midshipman fish sonic muscle : implications for α-actinin and actin binding

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• Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia

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• The actinin family of actin crosslinking proteins: natural functions and potential applications in synthetic biology

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• Congenital macrothrombocytopenia‐linked mutations in the actin‐binding domain of α‐actinin‐1 enhance F‐actin association

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  2013cites this paper
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  2006cites this paper
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  2006cites this paper
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  2006cites this paper
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