An essential role of Cav1.2 L‐type calcium channel for urinary bladder function

No abstract is available for this paper.

• Publication year

  2004

• Venue

  The FASEB Journal

• Publication date

  2004-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1096/fj.04-1516fjePMID 15132976
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Signal Transduction Underlying Carbachol-Induced Contraction of Rat Urinary Bladder. I. Phospholipases and Ca2+ Sources

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• Signal Transduction Underlying Carbachol-Induced Contraction of Rat Urinary Bladder. II. Protein Kinases

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• Ca2+-Dependent Activation of Rho and Rho Kinase in Membrane Depolarization–Induced and Receptor Stimulation–Induced Vascular Smooth Muscle Contraction

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• Impaired insulin secretion and glucose tolerance in β cell‐selective CaV1.2 Ca2+ channel null mice

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• Signaling between SR and plasmalemma in smooth muscle: sparks and the activation of Ca2+-sensitive ion channels.

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• Ca2+-Dependent Activation of Rho and Rho Kinase in Membrane Depolarization–Induced and Receptor Stimulation–Induced Vascular Smooth Muscle Contraction

  2003cited by this paper
• Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase.

  2003influential reference
• Novel insights into muscarinic acetylcholine receptor function using gene targeting technology.

  2003cited by this paper
• Role of the T‐type Ca2+ current on the contractile performance of guinea pig detrusor smooth muscle

  2003cited by this paper
• Expression and functional role of Rho‐kinase in rat urinary bladder smooth muscle

  2003influential reference
• Nifedipine facilitates neurotransmitter release independently of calcium channels

  2003cited by this paper
• Dominant role of smooth muscle L‐type calcium channel Cav1.2 for blood pressure regulation

  2003influential reference
• Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1

  2002cited by this paper
• M3 muscarinic receptors mediate contraction of human urinary bladder

  2002cited by this paper
• Coupling of M2 muscarinic receptor to L-type Ca channel via c-src kinase in rabbit colonic circular smooth muscle.

  2002cited by this paper
• The intracellular pathway of the acetylcholine‐induced contraction in cat detrusor muscle cells

  2002cited by this paper
• Mice Lacking M2 and M3 Muscarinic Acetylcholine Receptors Are Devoid of Cholinergic Smooth Muscle Contractions But Still Viable

  2002cited by this paper
• The role of the L‐type Ca2+ channel in refilling functional intracellular Ca2+ stores in guinea‐pig detrusor smooth muscle

  2002cited by this paper
• M(3) muscarinic receptors mediate contraction of human urinary bladder.

  2002cited by this paper
• L-type Ca2+ channels of the embryonic mouse heart.

  2002cited by this paper
• Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE‐908‐sensitive channels

  2001cited by this paper
• Nifedipine blocks Ca2+ store refilling through a pathway not involving L‐type Ca2+ channels in rabbit arteriolar smooth muscle

  2001cited by this paper
• Pharmacological characterization of muscarinic receptors in mouse isolated urinary bladder smooth muscle

  2001cited by this paper
• Temporally controlled somatic mutagenesis in smooth muscle

  2000influential reference
• Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype.

  2000cited by this paper
• Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse.

  2000cited by this paper
• A comparison of the mode of action of ATP and carbachol on isolated human detrusor smooth muscle.

  1999cited by this paper
• Excitation-contraction coupling in gastrointestinal and other smooth muscles.

  1999cited by this paper
• The contribution of intracellular Ca2+release to contraction in human bladder smooth muscle

  1999cited by this paper
• The A-kinase Anchor Protein MAP2B and cAMP-dependent Protein Kinase Are Associated with Class C L-type Calcium Channels in Neurons*

  1999cited by this paper
• Crucial Role of N Terminus in Function of Cardiac L-type Ca2+ Channel and Its Modulation by Protein Kinase C*

  1998cited by this paper
• Effect of choline ester analogues, noradrenaline and nifedipine on normal and hypertrophied human urinary bladder detrusor muscle.

  1998cited by this paper
• Muscarinic Receptor Subtypes and Receptor‐Coupled Phosphatidylinositol Hydrolysis in Rat Bladder Smooth Muscle

  1997cited by this paper
• Ca2+ signalling in cultured smooth muscle cells from human bladder

  1996cited by this paper
• Muscarinic receptor subtypes and smooth muscle function.

  1996cited by this paper
• A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization.

  1995influential reference
• The role of extracellular Ca2+ in carbachol-induced tonic contraction of the pig detrusor smooth muscle

  1994cited by this paper
• Transfected cGMP-dependent protein kinase suppresses calcium transients by inhibition of inositol 1,4,5-trisphosphate production.

  1993cited by this paper
• Carbachol modulates voltage sensitivity of calcium channels in bronchial smooth muscle of rats.

  1992cited by this paper
• Muscarinic receptor stimulation of phosphoinositide hydrolysis in the human isolated urinary bladder.

  1991cited by this paper
• Agonist-induced contraction and accumulation of inositol phosphates in the guinea-pig detrusor: evidence that muscarinic and purinergic receptors raise intracellular calcium by different mechanisms.

  1990cited by this paper
• The effects of Bay K 8644 and nifedipine on the responses of rat urinary bladder to electrical field stimulation, beta,gamma-methylene ATP and acetylcholine.

  1990cited by this paper
• Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

  1990cited by this paper
• The effects of Bay K 8644 and nifedipine on the responses of rat urinary bladder to electrical field stimulation, β,γ‐methylene ATP and acetylcholine

  1990cited by this paper
• Multiple sources of calcium for contraction of the human urinary bladder muscle

  1989cited by this paper
• Effects of calcium, calcium channel blockers and Bay K 8644 on contractions induced by muscarinic receptor stimulation of isolated bladder muscle from rabbit and man.

  1987cited by this paper
• A comparison of spontaneous and nerve‐mediated activity in bladder muscle from man, pig and rabbit.

  1984cited by this paper

• Calcium Channel Blockers and Lower Urinary Tract Symptoms: An Overlooked Adverse Effect with Clinical Consequences

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• Voltage-gated calcium channels (CaV) in GtoPdb v.2025.3

  2025cites this paper
• Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle.

  2024cites this paper
• Drugs Associated with Urinary Retention Adverse Reactions: A Joint Analysis of FDA Adverse Event Reporting System and Mendelian Randomization.

  2024cites this paper
• Voltage-gated calcium channels (CaV) in GtoPdb v.2023.1

  2023cites this paper
• Current and Emerging Pharmacological Targets and Treatments of Urinary Incontinence and Related Disorders

  2023cites this paper
• Smooth Muscle Insulin Receptor Deletion Causes Voiding Dysfunction: A Mechanism for Diabetic Bladder Dysfunction.

  2022cites this paper
• Enhanced RAGE Expression and Excess Reactive-Oxygen Species Production Mediates Rho Kinase-Dependent Detrusor Overactivity After Methylglyoxal Exposure

  2022cites this paper
• Role of calcium channel blockers in lower urinary tract symptoms in benign prostatic hyperplasia: a literature review

  2022cites this paper
• Reviving Cav1.2 as an attractive drug target to treat bladder dysfunction

  2021cites this paper
• Mechanisms and Physiological Implications of Cooperative Gating of Ion Channels Clusters.

  2021cites this paper
• Voltage-gated calcium channels (CaV) in GtoPdb v.2021.3

  2021cites this paper
• Medications and Drug Targets for the Treatment of Diseases of the Urinary Bladder and Urethra

  2021cites this paper
• Voltage-gated calcium channels in GtoPdb v.2021.2

  2021cites this paper
• Molecular pathways underlying tissue injuries in the bladder with ketamine cystitis

  2021cites this paper
• Assessment of lower urinary tract symptoms among calcium channel blocker-users and its impact on quality of life.

  2021cites this paper
• Molecular mechanisms of voiding dysfunction in a novel mouse model of acute urinary retention

  2021cites this paper
• Voltage-gated calcium channels (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

  2020cites this paper
• Detrusor Smooth Muscle KV7 Channels: Emerging New Regulators of Urinary Bladder Function

  2020cites this paper
• Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology

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• Corpus cavernosum smooth muscle cell dysfunction and phenotype transformation are related to erectile dysfunction in prostatitis rats with chronic prostatitis/chronic pelvic pain syndrome

  2020cites this paper
• Urinary bladder smooth muscle ion channels: expression, function, and regulation in health and disease.

  2020cites this paper
• Voltage-gated calcium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

  2019cites this paper
• NK2 receptor mediated detrusor muscle contraction involves Gq/11-dependent activation of voltage-dependent calcium channels and the RhoA-Rho kinase pathway.

  2019cites this paper
• Properties of single-channel and whole cell Cl- currents in guinea pig detrusor smooth muscle cells.

  2019cites this paper
• Channels and Transporters in Cell Signaling Properties of single-channel and whole cell Cl (cid:2) currents in guinea pig detrusor smooth muscle cells

  2019cites this paper
• Targetable purinergic receptors P2Y12 and A2b antagonistically regulate bladder function.

  2019cites this paper
• Targeting the purinome to control hyperactivity of the human urinary bladder

  2018cites this paper
• Transepithelial Fluid and Salt Re-Absorption Regulated by cGK2 Signals

  2018cites this paper
• What are the origins and relevance of spontaneous bladder contractions? ICI‐RS 2017

  2018cites this paper
• Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice

  2018cites this paper
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  2017cites this paper
• Current Understanding of Cannabinoids and Detrusor Overactivity

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• β-Adrenoceptor-mediated Relaxation of Urinary Bladder Muscle in β2-Adrenoceptor Knockout Mice

  2016cites this paper
• Muscarinic Receptor Induced Contractions of the Detrusor are Mediated by Activation of TRPC4 Channels.

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• The role of endocannabinoids and their receptors on the regulation of bladder function and detrusor overactivity

  2015cites this paper
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  2015cites this paper
• Smooth Muscle-Like Cells Generated from Human Mesenchymal Stromal Cells Display Marker Gene Expression and Electrophysiological Competence Comparable to Bladder Smooth Muscle Cells

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• Urinary Bladder Dysfunction in Transgenic Sickle Cell Disease Mice

  2015cites this paper
• Role of Nervous System Inurinary Bladder and Diabetes Mellitus: Review

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• Bradykinin Contracts Rat Urinary Bladder Largely Independently of Phospholipase C

  2014cites this paper
• Menthol Inhibits Detrusor Contractility Independently of TRPM8 Activation

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• Current Pharmacologic Treatment of Lower Urinary Tract Symptoms

  2014cites this paper
• Relevant Anatomy, Physiology, and Pharmacology

  2014cites this paper
• L-type CaV1.2 calcium channels: from in vitro findings to in vivo function.

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• Cannabinoid receptors 1 and 2 are associated with bladder dysfunction in an experimental diabetic rat model

  2013cites this paper
• Calcium Antagonists Use and Its Association with Lower Urinary Tract Symptoms: A Cross-Sectional Study

  2013cites this paper
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• Biomechanics of the Human Urinary Bladder

  2013cites this paper
• The Bladder as a Dynamic System

  2013cites this paper
• Bradykinin contracts rat urinary bladder largely independent of phospholipase C*

  2013cites this paper
• The effect of hypercholesterolemia on carbachol-induced contractions of the detrusor smooth muscle in rats: increased role of L-type Ca2+ channels

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• Deletion of Dicer in Smooth Muscle Affects Voiding Pattern and Reduces Detrusor Contractility and Neuroeffector Transmission

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• Commonly used antihypertensives and lower urinary tract symptoms: results from the Boston Area Community Health (BACH) Survey

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• Truncation of Murine Cav1.2 at Asp-1904 Results in Heart Failure after Birth*

  2011cites this paper
• Calcium channel blocker associated lower urinary tract symptoms in males: an Australian retrospective observational study.

  2011cites this paper
• Calcium signaling in smooth muscle.

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• Signaling during Mechanical Strain Injury of the Urinary Bladder: ERK, STAT3 and mTOR Pathways

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• Nerve-released acetylcholine contracts urinary bladder smooth muscle by inducing action potentials independently of IP3-mediated calcium release.

  2010cites this paper
• The validation of an in vitro colonic motility assay as a biomarker for gastrointestinal adverse drug reactions.

  2010cites this paper
• Anticholinergic effects of cis- and trans-isomers of two metabolites of propiverine

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• A complex of CaV1.2/PKC is involved in muscarinic signaling in smooth muscle

  2010cites this paper
• BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.

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• Adreno-muscarinic synergy in the bladder trigone: calcium-dependent and -independent mechanisms.

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• Phospholipase C mediated Ca2+ signals in murine urinary bladder smooth muscle.

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• Amlodipine alone or combined with terazosin improves lower urinary tract disorder in rat models of benign prostatic hyperplasia or detrusor instability: focus on detrusor overactivity

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• Signaling Processes for Initiating Smooth Muscle Contraction upon Neural Stimulation*

  2009cites this paper
• Role of ion channels in bladder function and voiding disorders

  2009cites this paper
• Role of Ion Channels in the Bladder

  2009cites this paper
• Pharmacological treatment of overactive bladder: report from the International Consultation on Incontinence

  2009cites this paper
• Signal transduction pathways of muscarinic receptor mediated activation in the newborn and adult mouse urinary bladder

  2009cites this paper
• cGMP regulated protein kinases (cGK).

  2009cites this paper
• L 3 Differences in the kinase binding modes of imatinib , nilotinib and dasatinib are reflected in Abl transphosphorylation assays

  2009cites this paper
• Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder

  2009cites this paper
• Effects of three metabolites of propiverine on voltage-dependent L-type calcium currents in human atrial myocytes.

  2008cites this paper
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  2008cites this paper
• Exploring the function and pharmacotherapeutic potential of voltage-gated Ca2+ channels with gene-knockout models

  2008cites this paper
• Influence of genetic background and gender on bladder function in the mouse.

  2008cites this paper
• Physiological and pathological regulation of the autonomic control of urinary bladder contractility.

  2008cites this paper
• Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice.

  2008cites this paper
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  2008cites this paper
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• Developmental regulation of smooth muscle contraction in the urinary bladder

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• Muscarinic receptor expression and receptor-mediated detrusor contraction: comparison of juvenile and adult porcine tissue

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  2008cites this paper
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  2008cites this paper
• Bladder outlet obstruction and hypertrophy: mechanisms and consequences

  2008cites this paper
• Ca2+ Signaling in Microdomains

  2007cites this paper
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  2007cites this paper
• Analysis of calcium channels by conditional mutagenesis.

  2007cites this paper
• Intracellular calcium in hypertrophic smooth muscle from rat urinary bladder

  2007cites this paper
• Contribution of Ca2+ influx to carbachol-induced detrusor contraction is different in human urinary bladder compared to pig and mouse.

  2007cites this paper
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  2007cites this paper