Signal detection, modularity, and the correlation between extrinsic and intrinsic noise in biochemical networks.

We present an expression for the power spectrum of the output signal of a biochemical network, which reveals that the reactions that allow a network to detect biochemical signals, induce correlations between the extrinsic noise of the input signals and the intrinsic noise of the reactions that form the network. We show that anticorrelations between the extrinsic and intrinsic noise enhance the robustness of zero-order ultrasensitive networks to biochemical noise. We discuss the consequences for a modular description of noise transmission using the mitogen-activated protein kinase cascade.

• Publication year

  2005

• Venue

  Physical Review Letters

• Publication date

  2005-08-20

• Fields of study

  Biology, Medicine, Physics

• Identifiers
  DOI 10.1103/PhysRevLett.97.068102arXiv q-bio/0508027PMID 17026206
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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